Clinical trials: Berberine
Metabolic Syndrome, HIV-1-infection
Effect of Berberine on Metabolic Syndrome, Efficacy and Safety in Combination With Antiretroviral Therapy in PLWH.
With current antiretroviral therapy, people living with HIV reach virological suppression faster, which in turn leads to a higher life expectancy.
- Conditions
- Metabolic Syndrome, HIV-1-infection, Glucose Intolerance, Dyslipidemias
- Trial name
- BERMESyH (NCT04860063)
- Testing
- Berberine
- Volunteers
- 40 people
- Sponsor
- Hospital Civil de Guadalajara
Hypertension, Endothelial Dysfunction
Effect of Berberine Hydrochloride on Blood Pressure and Vascular Endothelial Function in Patients With Hypertension
Hypertension is a progressive cardiovascular syndrome caused by multiple causes, which can lead to changes in the function and structure of the heart and blood vessels. It is the leading risk factor of cardiovascular disease.
- Conditions
- Hypertension, Endothelial Dysfunction, Blood Pressure
- Trial name
- NCT04790942
- Testing
- berberine hydrochloride, lifestyle intervention group
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Jun Tao
Colorectal Adenomas
A Research of Berberine Hydrochloride to Prevent Colorectal Adenomas in Patients With Previous Colorectal Cancer
Experimental studies in animals and observational studies in humans suggest that fusobacterium nucleatum is associates with stages of colorectal neoplasia development, and Berberine Hydrochloride could rescue Fusobacterium…
- Trial name
- NCT03281096
- Testing
- Berberine hydrochloride
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Diabetes Mellitus
Berberine Hyperglycemic Clamp
Berberine (BBR) is a traditional Chinese medicine used to treat diabetes mellitus for thousands of years in China. The glucose-lowering effect of BBR has been confirmed in numerous studies.
- Trial name
- BBR HC (NCT03972215)
- Testing
- Berberine Chloride
- Where
- China
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Jin-Kui Yang
Stable Coronary Artery Disease, Percutaneous Coronary Intervention
Effect of Berberine for Endothelial Function and Intestinal Microflora in Patients With Coronary Artery Disease
The purpose of this study is to conduct a single-center, randomized, open-label, controlled, dose-escalating, parallel-group study, evaluating the effects and change of endothelial function and gut microbiota after berberine…
- Trial name
- NCT04434365
- Testing
- Berberine, Aspirin, Clopidogrel
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Peking Union Medical College Hospital
Metabolic Syndrome, Female
Berberine Treat Metabolic Syndrome in Schizophrenia
In early clinical study investigators confirmed that berberine could prevent glucose and lipid metabolism disorder in schizophrenia, so investigators intend to verify the effect and safety of berberine in treatment for metabolic…
- Conditions
- Metabolic Syndrome, Female, Schizophrenia
- Trial name
- NCT03251716
- Testing
- berberine
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Tianjin Anding Hospital
T2DM (Type 2 Diabetes Mellitus)
Efficacy and Safety of Berberine Ursodeoxycholate (HTD1801) in Patients With Type 2 Diabetes
The goal of this clinical study is to evaluate the efficacy and safety of Berberine Ursodeoxycholate (HTD1801) compared to placebo in patients with type 2 diabetes, inadequately controlled with diet and exercise alone.
- Trial name
- SYMPHONY-1 (NCT06350890)
- Testing
- HTD1801
- Where
- 56 sites in China
- Volunteers
- 408 people
- Sponsor
- Shenzhen HighTide Biopharmaceutical Ltd.
Nonalcoholic Fatty Liver Disease
Role of Pioglitazone and Berberine in Treatment of Non-Alcoholic Fatty Liver Disease
The purpose of this study is to evaluate the effects and safety of pioglitazone and berberine on the basis of lifestyle intervention to non-alcoholic fatty liver disease patients with impaired glucose regulation or type 2…
- Trial name
- NCT00633282
- Testing
- Life style intervention, pioglitazone, berberine
- Where
- 3 sites in China
- Volunteers
- 184 people
- Sponsor
- Xin Gao
Irritable Bowel Syndrome
Effect of Oral Combined Berberine and Curcumin Pharmacological Therapy on IBS
Irritable bowel syndrome (IBS) is a prevalent, chronic functional gastrointestinal (GI) disorder, characterized by recurrent abdominal discomfort (pain) associated with altered bowel movements.
- Trial name
- NCT06187298
- Testing
- A combined supplement of Berberine and Curcumin (Enterophytol® PLUS) alongside standard of care
- Where
- Pakistan
- Volunteers
- 146 people
- Sponsor
- Liaquat University of Medical & Health Sciences
T2DM (Type 2 Diabetes Mellitus)
Effects of Berberine Ursodeoxycholate (HTD1801) Versus Dapagliflozin in Patients With Type 2 Diabetes Inadequately Controlled With Metformin
The goal of this clinical study is to evaluate the efficacy and safety of berberine ursodeoxycholate (HTD1801) compared to dapagliflozin in patients with type 2 diabetes inadequately controlled with metformin alone.
- Trial name
- HARMONY (NCT06415773)
- Testing
- HTD1801, Dapagliflozin
- Where
- 53 sites in China
- Volunteers
- 367 people
- Sponsor
- Shenzhen HighTide Biopharmaceutical Ltd.
Diabetes Mellitus
Berberine on the Secretion of Incretin
Berberine (BBR) is the main active ingredient of the ancient Chinese herb medicine Coptis. The hypoglycemic effect of BBR has been demonstrated in numerous studies.
- Trial name
- NCT05947370
- Testing
- Berberine Chloride
- Where
- 2 sites in China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital
Metabolic Syndrome
Evaluating the Tolerability and Effects of Berberine on Major Metabolic Biomarkers: A Pilot Study
Berberine is a dietary supplement that comes from the roots, stems, and bark of various plants and has been used for centuries in traditional Chinese medicine.
- Trial name
- NCT03976336
- Testing
- Berberine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Kansas Medical Center
Metabolic Syndrome
Cardiovascular Diseases and Diabetes Prevention Programme in Metabolic Syndrome (CDPP)
The metabolic syndrome population is at high-risk of cardiovascular diseases and diabetes. How to effectively control the risk factors of this population is the key to primary prevention of cardiovascular diseases and diabetes in…
- Trial name
- CDPP (NCT05105321)
- Testing
- Berberine, Healthy lifestyle intervention
- Where
- China
- Volunteers
- 5,200 people
- Sponsor
- Tang Yida
Non-Alcoholic Fatty Liver Disease
Berberine and Non-Alcoholic Fatty Liver Disease (NAFLD)
Non-alcoholic fatty liver disease (NAFLD), one of the most common liver dysfunctions, affects about one-fourth of the global adult population and has a significant mortality rate between 6.3% and 33%.NAFLD can lead to other…
- Trial name
- NAFLD (NCT04049396)
- Testing
- Berberine
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- Lida Nejati
Type 2 Diabetes
A Study on the Efficacy and Gut Microbiota of Berberine and Probiotics in Patients With Newly Diagnosed Type 2 Diabetes
The purpose of this study is to conduct a multicenter randomized, double-blind, placebo-controlled clinical trial, evaluating the effects and change of gut microbiota after berberine and/or probiotics administration in patients…
- Trial name
- NCT02861261
- Testing
- 1. Berberine hydrochloride tablets ; 2. ProMetS probiotics powder
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Pharmacokinetic Study in Healthy Volunteers
Sex Differences in Berberine Pharmacokinetics
The influence of genetic variants of the CYP2D6 enzyme and the Organic Cation Transporter 1 on the kinetics of berberine (BERKI-1) has recently been studied.
- Trial name
- BERKI-2 (NCT05845931)
- Testing
- Berberine
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Schizophrenia, Metabolic Syndrome
Comparison of Berberine and Metformin for the Treatment for MS in Schizophrenia Patients
Berberine is an isoquinoline alkaloid extracted from medicinal herbs, has been demonstrated to produce beneficial effects on diabetes and hyperlipidemia, fewer study reported its modification on lipid metabolism in schizophrenia.
- Conditions
- Schizophrenia, Metabolic Syndrome, Berberine, Metformin
- Trial name
- NCT03708549
- Testing
- Berberine, Metformin
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Tianjin Anding Hospital
Diabetes Mellitis
Comparative Efficacy of Metformin and Berberine Among TCF7L2 (rs7903146) TT vs. CC Genotype Carriers With Type 2 Diabetes
This pilot 12-week randomized open-label study compares metformin and berberine in newly diagnosed type 2 diabetes patients stratified by the TCF7L2 (rs7903146) genotype (TT vs. CC).
- Trial name
- NCT06911983
- Testing
- Metformin, Berberine
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- S.LAB (SOLOWAYS)
Helicobacter Pylori Infection, Chronic Gastritis
Study on The Efficacy and Safety of Vonoprazan-containing Berberine Triple Therapy in Helicobacter Pylori First-Line Eradication
The purpose of this study was to evaluate the efficacy and safety of the triple therapy of berberine hydrochloride, vonorasan and amoxicillin for the primary eradication of Helicobacter pylori.It is hypothesized that berberine…
- Trial name
- NCT06514274
- Testing
- Berberine, Vonoprazan, Amoxicillin
- Where
- China
- Volunteers
- 558 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital of Digestive Diseases
Diabetes-Related Complications
Study on the Molecular Mechanism of Berberine to Improve Type 2 Diabetes Mellitus Complicated With Depression
The incidence of type 2 diabetes with comorbid depression (T2DD) is notably high, characterized by prolonged disease duration and susceptibility to recurrence.
- Trial name
- SBDD (NCT06979440)
- Testing
- No intervention
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Affiliated Hospital of Nantong University