Clinical trials: Berberine
Diabetes Mellitus, Chronic Kidney Disease
Berberine Prevent Contrast-induced Nephropathy in Patients With Diabetes
The number of cardiac angiography and percutaneous coronary interventions (PCI) has increased steadily in recent years. This has resulted in the increasing incidence of contrast-induced nephropathy (CIN).
- Trial name
- NCT02808351
- Testing
- Berberine
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Gastritis, Peptic Ulcer
Helicobacter Pylori Eradication With Berberine Quadruple Therapy Versus Clarithromycin Quadruple Therapy
This study aims at evaluating efficacy and safety of berberine-containing quadruple therapy(berberine, lansoprazole, bismuth and amoxicillin) versus clarithromycin-containing quadruple therapy (clarithromycin,lansoprazole…
- Conditions
- Gastritis, Peptic Ulcer, Dyspepsia
- Trial name
- NCT02633930
- Testing
- Berberine, clarithromycin, Bismuth
- Where
- 2 sites in China
- Volunteers
- 566 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Type 1 Diabetes Mellitus, Autoimmune Diabetes
Effects Of Berberine Plus Inulin On Diabetes Care in Patients With LADA
The primary purpose of this study is to evaluate the effects of oral berberine (BBR) and inulin combined with insulin therapy on diabetes care in patients with LADA.
- Trial name
- NCT04698330
- Testing
- Berberine, Inulin
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Second Xiangya Hospital of Central South University
Metabolism Disorder, Nutraceutical
A Clinical Trial to Assess the Efficacy and Tolerance of a Berberine-based Nutraceutical Formula to Aid Blood Sugar Regulation and Metabolism
This randomized, triple-blind, placebo-controlled study will evaluate the efficacy of Diaberine, a berberine-based nutraceutical, in aiding blood sugar regulation and metabolism in 80 participants over 24 weeks.
- Trial name
- NCT06700915
- Testing
- Diaberine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Ultimate International, Inc.
Metabolic Syndrome, HIV-1-infection
Effect of Berberine on Metabolic Syndrome, Efficacy and Safety in Combination With Antiretroviral Therapy in PLWH.
With current antiretroviral therapy, people living with HIV reach virological suppression faster, which in turn leads to a higher life expectancy.
- Conditions
- Metabolic Syndrome, HIV-1-infection, Glucose Intolerance, Dyslipidemias
- Trial name
- BERMESyH (NCT04860063)
- Testing
- Berberine
- Volunteers
- 40 people
- Sponsor
- Hospital Civil de Guadalajara
Non-alcoholic Steatohepatitis
Efficacy and Safety of Berberine in Non-alcoholic Steatohepatitis
The purpose of this study is to evaluate the efficacy and safety of berberine treatment on Non-alcoholic Steatohepatitis.
- Trial name
- EASYBEinNASH (NCT03198572)
- Testing
- Lifestyle intervention, Berberine
- Where
- 6 sites in China
- Volunteers
- 89 people
- Sponsor
- Fudan University
Diabetes Mellitis
Comparative Efficacy of Metformin and Berberine Among TCF7L2 (rs7903146) TT vs. CC Genotype Carriers With Type 2 Diabetes
This pilot 12-week randomized open-label study compares metformin and berberine in newly diagnosed type 2 diabetes patients stratified by the TCF7L2 (rs7903146) genotype (TT vs. CC).
- Trial name
- NCT06911983
- Testing
- Metformin, Berberine
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- S.LAB (SOLOWAYS)
Irritable Bowel Syndrome
Effect of Oral Combined Berberine and Curcumin Pharmacological Therapy on IBS
Irritable bowel syndrome (IBS) is a prevalent, chronic functional gastrointestinal (GI) disorder, characterized by recurrent abdominal discomfort (pain) associated with altered bowel movements.
- Trial name
- NCT06187298
- Testing
- A combined supplement of Berberine and Curcumin (Enterophytol® PLUS) alongside standard of care
- Where
- Pakistan
- Volunteers
- 146 people
- Sponsor
- Liaquat University of Medical & Health Sciences
Schizophrenia, Schizophrenia Spectrum and Other Psychotic Disorders
Berberine as Adjuvant Treatment for Schizophrenia Patients
One double-blind, randomized, placebo-controlled trial is designed to examine whether berberine added to current antipsychotic drugs could produce significantly greater efficacy in reducing atypical antipsychotic-induced…
- Conditions
- Schizophrenia, Schizophrenia Spectrum and Other Psychotic Disorders, Metabolic Syndrome x
- Trial name
- BER (NCT02983188)
- Testing
- Berberine, Antipsychotic Agents
- Where
- Hong Kong
- Volunteers
- 113 people
- Sponsor
- The University of Hong Kong
Polycystic Ovary Syndrome
Treatment Benefits of Berberine Supplementation for Women With PCOS
Berberine is a plant alkaloid, reportedly possesses a wide range of pharmacological activities, including anti-obesity and anti-dyslipidemia.
- Trial name
- NCT05480670
- Testing
- Berberine
- Where
- Pakistan
- Volunteers
- 120 people
- Sponsor
- Ayub Teaching Hospital
Metabolic Syndrome, Female
Berberine Treat Metabolic Syndrome in Schizophrenia
In early clinical study investigators confirmed that berberine could prevent glucose and lipid metabolism disorder in schizophrenia, so investigators intend to verify the effect and safety of berberine in treatment for metabolic…
- Conditions
- Metabolic Syndrome, Female, Schizophrenia
- Trial name
- NCT03251716
- Testing
- berberine
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Tianjin Anding Hospital
Hyperlipidemia
Study on the Sex-specific, Lipid- and Lipoprotein-lowering Effects of Berberine
The goal of this clinical trial is to learn if berberine works to affect lipids and lipoproteins in Chinese females aged 20 to 65 years with hyperlipidaemia.
- Trial name
- NCT06782646
- Testing
- Berberine
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- The University of Hong Kong
Pharmacokinetic Study in Healthy Volunteers
Sex Differences in Berberine Pharmacokinetics
The influence of genetic variants of the CYP2D6 enzyme and the Organic Cation Transporter 1 on the kinetics of berberine (BERKI-1) has recently been studied.
- Trial name
- BERKI-2 (NCT05845931)
- Testing
- Berberine
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Diabetes Mellitus, Type 2, Metabolic Syndrome
Efficacy and Safety of Berberine in the Treatment of Diabetes With Dyslipidemia
Berberine has showed effective in lowering blood sugar levels in db/db mice and anti-dyslipidemia in human. These findings have not been tested in a clinical trial.
- Trial name
- NCT00462046
- Testing
- Berberine
- Volunteers
- 120 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Pharmacokinetic Study in Healthy Volunteers
Impact of OCT1 and CYP2D6 Genotypes on Pharmacokinetics of Berberine in Healthy Volunteers
This study should investigate the differences of berberine pharmacokinetic parameters in three cohorts of healthy volunteers with distinct genotypes of the organic cation transporter 1 (OCT1) gene and the cytochrome P450 2D6…
- Trial name
- BERKI-1 (NCT05463003)
- Testing
- Berberine
- Where
- Germany
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Prediabetic State
RCT of a Polyherbal Dietary Supplement for Prediabetes
The primary purpose of this study is to evaluate the impact of a polyherbal dietary supplement (Designs for Health - GlucoSupreme™ Herbal) on markers of glycemic control and other structure/function outcomes among a sample of…
- Trial name
- NCT03388762
- Testing
- GlucoSupreme™ Herbal
- Where
- 4 sites in United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Type 2 Diabetes
Therapeutic Effects of Berberine in Patients With Type 2 Diabetes
The purpose of this study is to determine whether berberine is effective in the treatment of type 2 diabetes.
- Trial name
- NCT00425009
- Testing
- Berberine, Metformin
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Stable Coronary Artery Disease, Percutaneous Coronary Intervention
Effect of Berberine for Endothelial Function and Intestinal Microflora in Patients With Coronary Artery Disease
The purpose of this study is to conduct a single-center, randomized, open-label, controlled, dose-escalating, parallel-group study, evaluating the effects and change of endothelial function and gut microbiota after berberine…
- Trial name
- NCT04434365
- Testing
- Berberine, Aspirin, Clopidogrel
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Peking Union Medical College Hospital
Dyslipidemias
The Therapeutic Effects of Statins and Berberine on the Hyperlipemia
Statins are cholesterol-lowering medications that are often prescribed for patients with high cholesterol and who are at risk for cardiovascular disease (CVD).
- Trial name
- NCT01697735
- Testing
- Berberine;Atorvastatin or Rosuvastatin, Atorvastatin or Rosuvastatin
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Wenzhou Medical University
Diabetes
Berberine and Cinnamon in Management of Diabetes
In this randomized clinical trial, patients with diabetes will be randomly assigned to receive either Berberine, and Cinnamon supplements or placebo for 12 weeks. Then the glycemic characteristics will be compared in two groups.
- Trial name
- NCT05570357
- Testing
- Berberine+Cinnamon (TDS)
- Where
- Iran
- Volunteers
- 44 people
- Sponsor
- National Nutrition and Food Technology Institute