Clinical trials: Berberine
Glucose Metabolism Disorders
Berberine and Altered Fasting Glucose
The aim of the study was to evaluate the effectiveness of a food supplement, berberine phytosome, which contributes to the control of blood sugar and the improvement of insulin resistance.
- Trial name
- NCT05031715
- Testing
- Berberine Phytosome
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Azienda di Servizi alla Persona di Pavia
Helicobacter Pylori Infection, Chronic Gastritis
Study on The Efficacy and Safety of Berberine-containing Triple Therapy in Helicobacter Pylori First-Line Eradication
The purpose of this study is to assess the efficacy and safety of berberine, amoxicillin and vonoprazan containing triple therapy in Helicobacter Pylori first-line eradication.
- Trial name
- NCT05014334
- Testing
- Berberine, Vonoprazan, Amoxicillin
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital of Digestive Diseases
Berberine, COVID-19
The Effect of Berberine on Intestinal Function and Inflammatory Mediators in Severe Patients With Covid-19
Coronavirus disease 2019 (COVID-19) rapidly spread across China and throughout the world, causing hundreds of thousands died. Studies had shown that "cytokine storms" and subsequent multiple organ dysfunction (MODS) are important…
- Trial name
- BOIFIM (NCT04479202)
- Testing
- Berberine, Montmorrillonite
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Chinese Medical Association
Pharmacokinetics
Pharmacological Profile of Different Berberine Formulations, and Effects on Blood Sugar Levels
The primary objective of this study is to evaluate the gastrointestinal absorption of berberine (hydrochloride) in a novel formulation in healthy adult volunteers by comparing it with free berberine (hydrochloride) formulation.
- Trial name
- NCT05370261
- Testing
- Berberine LipoMicel, Regular Berberine hard-gels
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Factors Group of Nutritional Companies Inc.
Dyslipidemias, Dysglycemia
Effect of the Association of Berberine Fitosoma® and Monacolin K MonaKoPure® on Glyco-metabolic Parameters in Dysglycemic and Dyslipidemic Patients.
The objective of this study is to evaluate the effectiveness of the association Berberina Fitosoma® and monacolin K MonaKoPure® (Berberol® K supplement) compared to placebo on glucidic and lipid parameters in subjects with…
- Trial name
- NCT06348550
- Testing
- Berberol® K
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- University of Pavia
Diabetes Mellitus
A Pilot Study of Berberine (Soloways ™) in Patients with Type 2 Diabetes Mellitus Carrying TCF7L2 Polymorphisms
This pilot, genotype-stratified clinical trial aims to investigate the safety and preliminary efficacy of berberine supplementation in adult patients with type 2 diabetes mellitus (T2DM) who carry a specific high-risk TCF7L2…
- Trial name
- NCT06863922
- Testing
- Berberine
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- S.LAB (SOLOWAYS)
Hyperlipidemia, Low-density-lipoprotein-type
Combined Effects of Bioactive Compounds in Lipid Profile
The aim of this study is to demonstrate whether, along with dietary recommendations, Armolipid Plus ® can improve the profile of patients with elevated plasma LDL-C acting as a change of lifestyle therapy (TLC) according to the…
- Conditions
- Hyperlipidemia, Low-density-lipoprotein-type, Elevated Triglycerides
- Trial name
- ARM-PLUS-LDL (NCT01562080)
- Testing
- Armolipid Plus
- Where
- Spain
- Volunteers
- 118 people
- Sponsor
- Rottapharm Spain
Metabolic Syndrome, Insulin-resistance
Metabolic and Cardiovascular Effects of Armolipid Plus in Subjects With Metabolic Syndrome
Aim of the study is to evaluate the effects of Armolipid Plus on insulin sensitivity in patients with MetS and increased LV mass.
- Conditions
- Metabolic Syndrome, Insulin-resistance, Left Ventricular Hypertrophy
- Trial name
- ARMP-11 (NCT02295176)
- Testing
- Armolipid Plus
- Where
- 3 sites in Italy
- Volunteers
- 159 people
- Sponsor
- Rottapharm
Hyperlipidemia
Study on the Sex-specific, Lipid- and Lipoprotein-lowering Effects of Berberine
The goal of this clinical trial is to learn if berberine works to affect lipids and lipoproteins in Chinese females aged 20 to 65 years with hyperlipidaemia.
- Trial name
- NCT06782646
- Testing
- Berberine
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- The University of Hong Kong
Intestinal Discomfort, Abdominal Pain/ Discomfort
Evaluation of the Synergistic Effect of Combining a Prebiotic and a Postbiotic on Intestinal Discomfort
This study aims to investigate the beneficial effects of the daily consumption of a synbiotic formulation-combining a prebiotic (Berberine, BBR) and a postbiotic (inactivated Bifidobacterium Longum, B.longum)-in adults…
- Trial name
- Synfood (NCT07420231)
- Testing
- Berberine, Bifidobacterium longum, Bifidobacterium longum and Berberine
- Where
- Belgium
- Volunteers
- 140 people
- Sponsor
- Université Catholique de Louvain
Healthy
The Absorption of Bioactive Berberine in Human
Berberine from medicinal plants has therapeutic activities against multiple chronic diseases. But its absorption rate is very low.
- Trial name
- NCT03438292
- Testing
- Berberine, TPGS emulsified berberine, Quillaja extract emulsified berberine
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Florida
Dysglycemia
Berberine, Curcumin, Inositol, Banaba and Chromium Picolinate in Patients With Fasting Dysglycemia
Dysglycemia is an important pre-risk condition which can potentially lead to diabetes if not adequately treated. The variation of glycemic balance can lead to cardiovascular disorders.
- Trial name
- NCT04107987
- Testing
- Reglicem
- Where
- Italy
- Volunteers
- 148 people
- Sponsor
- University of Pavia
Schizophrenia, Schizophrenia Spectrum and Other Psychotic Disorders
Berberine as Adjuvant Treatment for Schizophrenia Patients
One double-blind, randomized, placebo-controlled trial is designed to examine whether berberine added to current antipsychotic drugs could produce significantly greater efficacy in reducing atypical antipsychotic-induced…
- Conditions
- Schizophrenia, Schizophrenia Spectrum and Other Psychotic Disorders, Metabolic Syndrome x
- Trial name
- BER (NCT02983188)
- Testing
- Berberine, Antipsychotic Agents
- Where
- Hong Kong
- Volunteers
- 113 people
- Sponsor
- The University of Hong Kong
Obesity, Obesity, Abdominal
Effects of Berberine in Reducing Abdominal Visceral Adipose Tissue Among Individuals with Obesity and NAFLD
This multicenter, double-blinded, randomized controlled trial aims to evaluate the effect of berberine in reducing visceral and liver adipose tissue among individuals with obesity and non-alcoholic fatty liver disease (NAFLD) in…
- Conditions
- Obesity, Obesity, Abdominal, NAFLD
- Trial name
- BRAVO (NCT05647915)
- Testing
- Berberine plus lifestyle intervention
- Where
- China
- Volunteers
- 337 people
- Sponsor
- China National Center for Cardiovascular Diseases
Ulcerative Colitis
Berberine Chloride in Preventing Colorectal Cancer in Patients With Ulcerative Colitis in Remission
This randomized, pilot phase I trial studies the side effects of berberine chloride in treating patients with ulcerative colitis and who are in remission (a decrease in or disappearance of signs and symptoms of cancer) to reduce…
- Trial name
- NCT02365480
- Testing
- Berberine Chloride, Laboratory Biomarker Analysis
- Where
- 2 sites in United States, China
- Volunteers
- 18 people
- Sponsor
- National Cancer Institute (NCI)
Hyperglycemia
The Therapeutic Effects of Insulin and Berberine on Stress Hyperglycemia
Berberine is a conventional component in Chinese medicine. In recent years, effects of Berberine on improvement of glucose metabolism have been explored.
- Trial name
- NCT02806999
- Testing
- Berberine; Insulin, Insulin
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Guangdong Provincial People's Hospital
Prediabetic State
RCT of a Polyherbal Dietary Supplement for Prediabetes
The primary purpose of this study is to evaluate the impact of a polyherbal dietary supplement (Designs for Health - GlucoSupreme™ Herbal) on markers of glycemic control and other structure/function outcomes among a sample of…
- Trial name
- NCT03388762
- Testing
- GlucoSupreme™ Herbal
- Where
- 4 sites in United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Diabetes Mellitus, Type 2, Metabolic Syndrome
Efficacy and Safety of Berberine in the Treatment of Diabetes With Dyslipidemia
Berberine has showed effective in lowering blood sugar levels in db/db mice and anti-dyslipidemia in human. These findings have not been tested in a clinical trial.
- Trial name
- NCT00462046
- Testing
- Berberine
- Volunteers
- 120 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine