Clinical trials: Beta Blockers
Myocardial Infarction Type 2
Effect of Classic Secondary Prevention in Type 2 MI: A Target Trial Emulation Study
A classic heart attack is caused by a blockage to the coronary arteries that supplies the heart muscle with oxygenated blood. The medical term for this condition is type 1 myocardial infarction.
- Trial name
- NCT06736353
- Testing
- Beta Blocker Therapy or No Therapy (Control), RAAS blocker Therapy or No therapy (Control), Statin Therapy or No Therapy (Control)
- Where
- Sweden
- Volunteers
- 14,000 people
- Sponsor
- Uppsala University
Bleeding
EVL Plus Drug to Prevent Variceal Rebleeding
Both medications with beta-blockers and isosorbide-5-mononitrate and endoscopic variceal ligation have been proven plausible in the prevention of variceal rebleeding.
- Trial name
- NCT00371943
- Testing
- band ligation
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Science and Technology Council, Taiwan
Heart Failure, Beta-blocker
N-of-1 Trial to Promote Beta-Blocker Titration in Heart Failure
In this study we seek to understand whether N-of-1 trials using a crossover withdrawal/reversal design with 1-5 three-week periods can be used to identify the highest tolerated beta-blocker dose for patients with Heart Failure…
- Conditions
- Heart Failure, Beta-blocker, Older Adults
- Trial name
- NCT07489352
- Testing
- N-of-1 trials, Enhanced usual care
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Brigham and Women's Hospital
Hemangioma
Efficacy and Safety of Propranolol Versus Acebutolol on the Proliferative Phase of Infantile Hemangioma
There is no effective treatment for hemangioma regardless of immediate severity. That is in this respect a orphan disease. These hemangiomas, sometimes large, will have a phase of proliferation of several months (very scary for…
- Trial name
- NCT01743885
- Testing
- Acebutolol, Propanolol
- Where
- 4 sites in France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Montpellier
Healthy
Effects of Sodium Intake on (PK/PD) Relationship of a Single Dose of a Renin Angiotensin System-Blocker
The impact of sodium intake on plasma drug concentrations has previously been reported in the literature for verapamil and quinidine but, to the investigators' knowledge, never with renin-angiotensin system blockers such as AT1R…
- Trial name
- NCT00310778
- Testing
- high sodium diet, low sodium diet, ramipril 10 mg
- Where
- France
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Esophageal Varices in Cirrhosis of the Liver
HVPG-Guided Therapy Versus EVL Plus NSBB in Second Prophylaxis of Esophageal Variceal Bleeding
A single-center randomized controlled study comparing endoscopic or interventional therapy guided by the hepatic venous pressure gradient (HVPG) , to standard endosopic variceal ligation plus nonselective beta-blocker therapy…
- Trial name
- NCT03687216
- Testing
- HVPG-guided therapy, Routing Therapy
- Where
- China
- Volunteers
- 160 people
- Sponsor
- West China Hospital
Dilated Cardiomyopathy
Withdrawal of Medication in Recovered DCM
Randomized study of medication withdrawal in patients who have recovered LV function in Dilated Cardiomyopathy.
- Trial name
- WrecEF (NCT02770443)
- Testing
- withdrawal, standard of CARE
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- McGill University
Trauma, Brain
Beta Blocker Effects in Traumatic Brain Injury
The study will be conducted on polytrauma patient who are admitted from emergency room or postoperative with head trauma to evaluate effects of beta blocker on patients with TBI.
- Trial name
- NCT05195996
- Testing
- Propranolol, Saline
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Menoufia University
Variceal Bleeding, Cirrhosis
A Trial of Ligation Plus Nadolol Versus Nadolol Alone in the Prophylaxis of First Variceal Bleeding in Cirrhosis
The value of banding ligation plus beta blocker in the prophylaxis of first episodes of variceal bleeding has not yet been evaluated.
- Trial name
- NCT00921349
- Testing
- Ligation of varices, Nadolol
- Volunteers
- 140 people
- Sponsor
- National Science and Technology Council, Taiwan
Cardiac Arrest, Sudden Cardiac Death
Treatment of Ventricular Tachyarrhythmias Refractory To Shock With Beta Blockers: The SHOCK and BLOCK Trial
The purpose of this research study is to evaluate the effectiveness of metoprolol, a "beta blocker," in treating patients in the hospital with a cardiac arrest. It will be given intravenously (given into a vein).
- Conditions
- Cardiac Arrest, Sudden Cardiac Death, Ventricular Fibrillation, Tachycardia, Ventricular
- Trial name
- Shock n Block (NCT00401882)
- Testing
- Epinephrine, Metoprolol
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- David Haines, MD
Spinal Tumor, Spinal Hemangioma
The Efficacy and Safety of Beta-blockers Drugs in Adults With Spinal Hemangioma
Spinal hemangioma is one of the most common benign vertebral tumours. Being mostly asymptomatic, it is still associated with a pain syndrome especially if encroaches into the neural canal.
- Conditions
- Spinal Tumor, Spinal Hemangioma, Beta Blocker Toxicity
- Trial name
- NCT05106179
- Testing
- Atenolol Pill, Propranolol Pill
- Where
- Russia
- Volunteers
- 1,000 people
- Sponsor
- Center for Vascular Pathology, Moscow
Atrial Fibrillation, Heart Diseases
IvaBRAdine blocK of Funny Current for Heart Rate Control in permanEnt Atrial Fibrillation. (BRAKE-AF Study).
The BRAKE-AF Study is a phase III, randomised, controlled, multicentric, open-label clinical trial to prove the noninferiority of ivabradine versus digoxin in the treatment of permanent atrial fibrillation.
- Trial name
- BRAKE-AF (NCT03718273)
- Testing
- Ivabradine, Digoxin
- Where
- 10 sites in Spain
- Volunteers
- 68 people
- Sponsor
- Adolfo Fontenla
Glaucoma
Safety and Efficacy of Changing to DuoTrav in Patients Uncontrolled on Timolol
The purpose of this study was to assess the safety and intraocular pressure (IOP)-lowering efficacy of changing to DuoTrav® from prior timolol 0.5% monotherapy in participants with open-angle glaucoma or ocular hypertension.
- Trial name
- NCT01336569
- Testing
- Travoprost 0.004%/timolol maleate 0.5% fixed combination
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Alcon Research