Clinical trials: Beta Blockers
Trauma, Brain Injuries
Beta Blocker Use In Traumatic Brain Injury Based On The High-Sensitive Troponin T Status
Beta blockers (BB) play an important role in protection of end organs that are susceptible for secondary injury by the Traumatic brain injury (TBI)-induced catecholamine surge.
- Conditions
- Trauma, Brain Injuries, Stress Reaction, Beta Blockers
- Trial name
- BBTBBT (NCT04508244)
- Testing
- Propranolol
- Where
- Qatar
- Volunteers
- 771 people
- Sponsor
- Hamad Medical Corporation
Heart Failure With Reduced Ejection Fraction (HFrEF), Sudden Cardiac Death
Comparative Effectiveness of Carvedilol Versus Metoprolol Succinate in Heart Failure Patients With an Implantable Cardioverter Defibrillator
This prospective, multicenter, open-label, randomized comparative effectiveness trial, titled CARVTOP-ICD, evaluates the impact of carvedilol versus metoprolol succinate in patients with heart failure with reduced ejection…
- Conditions
- Heart Failure With Reduced Ejection Fraction (HFrEF), Sudden Cardiac Death, Ventricular Arrhythmia, Implantable Cardioverter Defibrillator (ICD)
- Trial name
- CARVTOP-ICD (NCT06964464)
- Testing
- Metoprolol Succinate, Carvedilol
- Where
- 13 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- University of Rochester
Asthma
Beta Blocker Therapy in Mild to Moderate Asthmatics
Current asthma medicines include inhalers. A common type of inhaler is called a 'beta-agonist' (e.g. salbutamol). They improve asthma symptoms by stimulating areas in the airway causing it to widen.
- Trial name
- ANDA1 (NCT01544634)
- Testing
- Propranolol, Qvar 50, Qvar 100
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- University of Dundee
Osteoporosis, Age-Related
Dose Response and Receptor Selectivity of Beta-blocker Effects on Bone Metabolism
This study is designed to answer the question as to whether the sympathetic nervous system is an important determinant of bone metabolism in humans.
- Trial name
- NCT02467400
- Testing
- Atenolol, Nebivolol, Propranolol
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Hypertension
Evaluation of the Long-term Safety and Tolerability of Metoprolol Versus Nebivolol in Patients With Hypertension
The purpose of this study is to evaluate long-term safety,tolerability and blood pressure effects of metoprolol versus nebivolol in patients with hypertension.
- Trial name
- NCT00142584
- Testing
- Nebivolol (NEB), Metoprolol (MET)
- Where
- United States
- Volunteers
- 336 people
- Sponsor
- Mylan Bertek Pharmaceuticals
Bleeding Gastric Varices, Liver Cirrhosis
A Randomized Trial of GVS Alone vs. Propranolol
Design a randomized trial to compare the effect of endoscopic cyanoacrylate injection obliteration versus non-selective beta-blocker in the primary prevention of gastric variceal bleeding.
- Trial name
- P-GVO (NCT01298271)
- Testing
- propranolol
- Where
- 2 sites in Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Post-Traumatic Stress Disorder
Effectiveness of Propranolol For Treating People With Post-Traumatic Stress Disorder
This study will evaluate the effectiveness of propranolol in reducing symptoms of distress in people with post-traumatic stress disorder.
- Trial name
- NCT00648375
- Testing
- Propanolol, Cognitive therapy workbook
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Weill Medical College of Cornell University
Cardiogenic Shock
Evaluation of Early CRRT InTerventions in Patients With ECMO(ELITE)
Extracorporeal membrane oxygenation (ECMO) is of great value in supporting patients with cardiac shock. More than 80% ECMO patients will develop renal catastrophe that continuous renal replacement therapy (CRRT) is required.
- Trial name
- ELITE (NCT03549923)
- Testing
- Simultaneous CRRT, Conventional-indication CRRT, Esmolol
- Where
- China
- Volunteers
- 131 people
- Sponsor
- Beijing Anzhen Hospital
Portal Hypertension Gastropathy, Esophageal Varices
Study on B-blockers to Prevent Decompensation of Cirrhosis With HTPortal
This is a multicenter, randomized, double-blind, placebo-controlled study on the effectiveness of treatment with beta-blockers to prevent decompensation of cirrhosis with portal hypertension.
- Conditions
- Portal Hypertension Gastropathy, Esophageal Varices, Spontaneous Bacterial Peritonitis, Hepatic Encephalopathy
- Trial name
- PREDESCI (NCT01059396)
- Testing
- propranolol, carvedilol
- Where
- 8 sites in Spain
- Volunteers
- 201 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Leukemia, Hematopoetic Stem Cell Transplantation
Exercise as an Immune Adjuvant for Allogeneic Cell Therapies
This study aims to improve the treatment of blood cancer by using exercise to collect healthier immune cells from donors. Allogeneic adoptive cell therapy is a treatment where immune cells from a healthy donor are given to a…
- Conditions
- Leukemia, Hematopoetic Stem Cell Transplantation, Donor Lymphocyte Infusion, CAR T-Cell Therapy
- Trial name
- Allo-X (NCT06643221)
- Testing
- Exercise, Isoproterenol, Bisoprolol Fumarate Tablet 10 mg
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Cirrhosis, Decompensated Cirrhosis of Liver
Effect of Non-Selective Beta-Blockers on Outcomes in Cirrhosis Patients After Hospitalization: A Retrospective Cohort Using Target Trial Design
The goal of this observational study is to learn if non-selective beta-blockers (NSBB) improve outcomes in patients with chronic hepatitis B or C who are discharged after hospitalization for acute decompensation of cirrhosis.
- Trial name
- NCT06977685
- Testing
- Non-selective beta-blockers
- Where
- South Korea
- Volunteers
- 7,725 people
- Sponsor
- Samsung Medical Center
Myocardial Bridge
Myocardial Bridge Evaluation Towards Personalised Medicine: the RIALTO Registry
Myocardial bridge (MB) is a congenital anomaly of epicardial circulation characterized by an intramural course of a coronary segment.
- Trial name
- RIALTO (NCT05111418)
- Where
- 5 sites in Italy
- Volunteers
- 444 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Cirrhosis, Variceal Bleeding
Endoscopic Band Ligation (EBL) Versus Endoscopic Band Ligation and Propranolol for the Prevention of Variceal Rebleeding
Both propranolol and endoscopic band ligation (EBL) are effective for prevention of variceal rebleeding. Recently several studies compared the efficacy of EBL alone and with a combination of propranolol and EBL.
- Trial name
- NCT00966121
- Testing
- endoscopic band ligation, EBL+Propranolol
- Where
- South Korea
- Volunteers
- 180 people
- Sponsor
- Korea University
Renal Angiomyolipomas, Tuberous Sclerosis
Treatment of Renal Angiomyolipomas in Tuberous Sclerosis by Beta-blockers
Treatment of angiomyolipomas is based on invasive techniques such as surgery or embolization. Development of anti-angiogenic therapies is a major and growing field of research in hypervascularized tumors.
- Trial name
- STBETA (NCT02104011)
- Testing
- Propranolol
- Where
- France
- Volunteers
- 2 people
- Sponsor
- University Hospital, Bordeaux
Heart Rate Control in ICD Patients With Heart Failure
Effect of Ivabradine and Beta-blockers Combination Versus Beta-blockers Up-titration on Right Ventricular Pacing
The aim of this prospective, randomized and controlled trial is to evaluate the use of the ivabradine in combination to a low-dose of beta-blocker (bisoprolol) versus up-titration of beta-blocker (bisoprolol) to obtain heart rate…
- Trial name
- NCT01868880
- Testing
- Ivabradine plus beta-blocker (bisoprolol), betablocker titration
- Where
- Italy
- Sponsor
- Policlinico Casilino ASL RMB
Pulmonary Disease, Chronic Obstructive, Asthma
Tolerability of Metoprolol-Succinate-ER and Carvedilol in COPD
Use of beta-blockers has proven beneficial in patients with hypertension, heart failure, and in people who have suffered a heart attack.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Asthma, Adverse Effect of Beta-adrenoreceptor Antagonists
- Trial name
- NCT03370835
- Testing
- Metoprolol succinate ER, Carvedilol
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- VA Greater Los Angeles Healthcare System
Acute Variceal Bleed
Comparative Efficacy of Various Non-invasive Methods in Assessing Response to Beta-blockers as Secondary Prophylaxis for Acute Variceal Bleed.
Portal hypertension (PH) is a common complication of chronic liver disease and a major cause of morbidity and mortality in cirrhotic patients.
- Trial name
- NCT05166317
- Testing
- This is an observational study
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Asthma
Beta Blockers for the Treatment of Asthma
Current asthma medicines include inhalers. A common inhaler used in asthma is called a beta-agonist (for example salbutamol). They improve asthma symptoms by stimulating areas in the human airway resulting in widening of the…
- Trial name
- NCT01074853
- Testing
- propranolol
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- University of Dundee
Hypertension, Tachycardia
Intravenous Beta-blockade for Improvement of Autonomic Activity
Chronic beta-adrenoceptor blockade is known to improve outcome of high risk patients whereas amelioration of autonomic activity was demonstrated to be a major cause of outcome improvement.
- Conditions
- Hypertension, Tachycardia, Heart Rate Variability
- Trial name
- NCT00700466
- Testing
- i.v. beta-blocker infusion (metoprolol)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University Hospital Schleswig-Holstein
Small Abdominal Aortic Aneurysm
Comparison of Beta-blocker Versus Angiotensin Receptor Blocker for Suppression of Aneurysm Expansion in Patients With Small Abdominal Aortic Aneurysm and Hypertension (BASE Trial)
Various medical therapies have been proposed to prevent abdominal aortic aneurysm expansion. However, there have been very few randomized clinical trials to support use of any of these treatments.
- Trial name
- NCT01904981
- Testing
- Beta-blocker-Atenolol 50mg, PO(peroral), Once daily, Angiotensin receptor blocker-Valsartan 80mg, PO(peroral), Once daily
- Where
- South Korea
- Volunteers
- 19 people
- Sponsor
- Yonsei University