Clinical trials: Beta Blockers
Chronic Obstructive Pulmonary Disease
Beta Blocker Therapy in Moderate to Severe COPD
Beta blockers are a type of medication mainly used for heart disease. They are commonly used to treat 'angina' and to prevent heart attacks.
- Trial name
- ANDA2 (NCT01656005)
- Testing
- Carvedilol, Bisoprolol, Beclometasone/formoterol
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- University of Dundee
Glaucoma, OHT - Ocular Hypertension
Aqueous Humor Dynamic Components That Determine Intraocular Pressure Variance
Glaucoma is a major cause of blindness. The inability to predict a patient's IOP response to medications is a critical barrier for the clinician to consistently provide highly effective IOP-based treatments.
- Trial name
- NCT04412096
- Testing
- Timolol 0.5% ophthalmic solution, Latanoprost 0.005% Ophthalmic Solution
- Where
- 3 sites in United States
- Volunteers
- 59 people
- Sponsor
- Ohio State University
Heart Failure, Reduced Ejection Fraction
Does the Sequence of Heart Failure Medication Matter
This study will tests whether a strategy of upfront prescription of mineralocorticoid receptor antagonists (MRA) is different from usual care, where MRA are usually prescribes as the last drug of the four drug classes used in the…
- Trial name
- NCT06637618
- Testing
- up front use of mineralocorticoid receptor antagonist
- Volunteers
- 16,000 people
- Sponsor
- Aarhus University Hospital
Stable Angina Pectoris
Comparison of Carvedilol and Atenolol on Anti-anginal and Metabolic Effects in Patients With Stable Angina Pectoris
There are few data regarding anti-anginal effects between beta-blockers with and without vasodilating property. Beta-blocker without vasodilating property is generally known to have unfavorable effects on glucose and lipid…
- Trial name
- NCT02547597
- Testing
- Carvedilol, Atenolol
- Where
- South Korea
- Volunteers
- 99 people
- Sponsor
- Gachon University Gil Medical Center
Retinopathy of Prematurity
Safety and Efficacy of Propranolol in Newborns With Retinopathy of Prematurity
The purpose of this study is to determine whether the administration of propranolol is effective in the treatment of the retinopathy of the prematurity.
- Trial name
- PROP-ROP (NCT01079715)
- Testing
- Propranolol
- Where
- 2 sites in Italy
- Volunteers
- 52 people
- Sponsor
- Meyer Children's Hospital IRCCS
Premature Ventricular Complex
Beta-blocker vs. Ic Antiarrhythmic Drug for PVC
The standard medical therapy of idiopathic premature ventricular complex consists of beta blocker and Ic antiarrhythmic agent. However, the difference in the efficacy of two drugs has not been well investigated.
- Trial name
- NCT03561935
- Testing
- Propafenone, Indenol
- Where
- South Korea
- Sponsor
- Yong Seog Oh
Coronary Artery Disease
Effects of Beta-Blocker Therapy and Phosphodiesterase Inhibition on Cardiac Neurohormonal Activation
Previous clinical investigations have demonstrated the utility of β-adrenergic blockade in reducing perioperative ischaemic events, ultimately translating into a decrease in cardiac morbidity and mortality.
- Trial name
- NCT00348101
- Testing
- Combined therapy with enoximone and esmolol
- Where
- Germany
- Volunteers
- 75 people
- Sponsor
- Klinikum Ludwigshafen
Heart Failure, Cardiomyopathy
Mechanisms of Improvement With Beta-Blocker Treatment in Heart Failure
The overall hypothesis of this application is that the improvement in LV ejection performance following treatment with betablockers is due, at least in part, to improvement in intrinsic myocardial contractility.
- Trial name
- NCT01261065
- Testing
- carvedilol
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Michael E. DeBakey VA Medical Center
Gastroesophageal Varices Hemorrhage, Hepatocellular Carcinoma
A Trial of EVL\GVS Alone vs. EVL\GVS Combined Propranolol (S-HCC)
Patients with hepatocellular carcinoma and esophageal varices bleeding were randomized to undergo endoscopic ligation alone (group A) and additive propranolol treatment (group B) after stabilization of their first acute bleeding.
- Trial name
- NCT01451658
- Testing
- propranolol
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Healthy Subjects
Clinical Study to Investigate Safety and Effects on Heart Rate, Blood Pressure, and Pharmacokinetic Interactions of ACT-334441
The aim of the study is to investigate the safety of the concomitant administration of ACT-334441 with cardiovascular drugs.
- Trial name
- NCT02479204
- Testing
- ACT-334441 2 mg, ACT-334441 4 mg, Atenolol
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Viatris Innovation GmbH
Heart Failure
REBEAT Resynchronisation and Beta-Blocker European Trial
This protocol will evaluate the effect of cardiac resynchronization therapy (CRT) combined with beta-blocker therapy in patients with symptomatic heart failure in whom beta-blocker therapy was either not tolerated or could not be…
- Trial name
- NCT00305526
- Testing
- Contak Renewal (CRT-D)
- Where
- 3 sites in Italy, Switzerland
- Volunteers
- 354 people
- Sponsor
- Guidant Corporation
Cardiac Surgery With Cardiopulmonary Bypass
Beta Blocker Use in Cardiac Surgery and Association With Postoperative Course
The objective of this study is to describe in a cohort of cardiac surgery patients the use of beta-blockers before surgery and their maintenance or withdraw according to international recommendations in order to compare patients…
- Trial name
- BLOCK (NCT04769752)
- Testing
- collection of the allocated treatment, collection of medical complications
- Where
- France
- Volunteers
- 1,789 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Pancreatic Neoplasms
Perioperative Intervention to Reduce Metastatic Processes in Pancreatic Cancer Patients Undergoing Curative Surgery
In Israel, of the ~1000 patients diagnosed annually with pancreatic cancer (PC), approximately 250 (25 percent) will be eligible for curative surgery, of which 80 percent will succumb to post-surgical metastatic disease.
- Trial name
- BC-PC (NCT03838029)
- Testing
- Propranolol and etodolac
- Where
- 3 sites in Israel
- Volunteers
- 210 people
- Sponsor
- Assaf-Harofeh Medical Center
Gastric Varices Bleeding, Endoscopic Ultrasound
Primary Prevention of Gastric Varices Bleed
Primary prophylaxis of gastric varices is an important area of research, as gastric varices are a common complication of cirrhosis of the liver.
- Trial name
- NCT05859009
- Testing
- EUS-Guided Therapy of Glue and Coil, Non-Selective Beta Blockers (Propanolol)
- Sponsor
- Unity Health Toronto
Chronic Obstructive Pulmonary Disease
Effects of Cardioselective β-blockers on Dynamic Hyperinflation in COPD
Patients with chronic obstructive pulmonary disease (COPD) are at greater risk of suffering from diseases for which beta-blockers may be indicated and effective.
- Trial name
- NCT01273298
- Testing
- Bisoprolol
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- Laval University
Hypertension
Atenolol Exposure as Risk for Adverse Metabolic Responses to Beta Blockers
The researchers hypothesize that the impact of increasing systemic exposure to atenolol leads to increased risk for adverse metabolic effects from atenolol therapy in hypertension.
- Trial name
- NCT00607347
- Testing
- Glucose
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Florida
Alcohol Drinking
Does Propranolol, a Beta Blocker, Attenuate Stress-Induced Drinking?
For this protocol, the investigators plan to conduct a pilot study evaluating the effect of propranolol on alcohol consumption. Using a parallel design, the investigators plan to randomize 20 non-treatment seeking adults with…
- Trial name
- NCT03588754
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Yale University
Acute Coronary Syndrome
Real-world Use and Prognosis of Beta Blocker in Patients With Acute Coronary Syndrome in the Central China
Beta Blocker therapy is a mainstay of treatment following acute coronary syndromes (ACS), particularly acute myocardial infarction (MI).
- Trial name
- UPB-ACS (NCT03116854)
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
Liver Cirrhosis, Peptic Ulcer
Proton Pump Inhibitor Plus Propranolol Versus Proton Pump Inhibitor Alone on Peptic Ulcer Healing in Patients With Liver Cirrhosis
Proton pump inhibitor plus propranolol versus proton pump inhibitor alone on peptic ulcer healing in patients with liver cirrhosis: a randomized trail
- Trial name
- PU (NCT04140591)
- Testing
- Proton-pump inhibitor, Propranolol+Proton-pump inhibitor
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Breast Cancer, Myocardial Injury After Noncardiac Surgery (MINS)
Impact of Propranolol Strategies on Myocardial Injury After Breast Cancer Surgery
This study aims to evaluate the impact of using propranolol, a non-selective beta-blocker, on preventing myocardial injury after non-cardiac surgery (MINS) in breast cancer patients who also have hypertension or angina.
- Trial name
- B-BIT (NCT07583134)
- Testing
- propranolol, Usual Care
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Chang-Ik Yoon