Clinical trials: Beta Endorphin
Cushings Disease, Cushing Disease
Safety and Efficacy of LCI699 in Cushing's Disease Patients
This exploratory study is a proof of concept study to determine whether LCI699 can safely reduce the level of urinary free cortisol in patients with Cushing's disease.
- Trial name
- NCT01331239
- Testing
- LCI699
- Where
- 10 sites in United States, France and 2 more
- Volunteers
- 31 people
- Sponsor
- Novartis Pharmaceuticals
Skin to Skin Contact
The Effect of Skin to Skin Contact on Postpartum Hemorrhage, Pain And Breastfeeding
The aim of this study was to determine the effect of postpartum hemorrhage, pain and onset of early breastfeeding so that the skin applied at the third stage of birth is in contact with the skin.
- Trial name
- NCT04425096
- Testing
- Skin to skin contact
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Advanced Dry Macular Degeneration
Alpha MSH in Ocular Disease
The purpose of this study is gain a better understanding of a molecule called alpha melanocyte stimulating hormone (alpha MSH) and its potential role in your retinal disease.
- Trial name
- NCT03451578
- Testing
- Alpha MSH assay
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Duke University
Glomerulonephritis
A Dose Escalation Study of Long-acting ACTH Gel in Membranous Nephropathy
Membranous Nephropathy (MN) is an immune-mediated kidney disease that affects the glomerulus or the filter that removes toxins from the blood.
- Trial name
- NCT01093157
- Testing
- Adrenocorticotrophic hormone ACTH
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University Health Network, Toronto
Suicide, Depression
Plasma Beta-endorphin Levels and Suicidal Behavior
It is an interventional research, monocentric, which involves only minimal risks and constraints. Psychological pain is closely associated with suicidal ideation (SI) and suicidal behavior, regardless of the severity of the…
- Conditions
- Suicide, Depression, Beta Endorphin
- Trial name
- BEST (NCT06291467)
- Testing
- Blood samples, questionnaires
- Where
- France
- Volunteers
- 104 people
- Sponsor
- University Hospital, Montpellier
Psoriatic Arthritis
Protocol for H.P. Acthar Gel in Moderately to Severely Active Psoriatic Arthritis
Psoriatic arthritis is a heterogeneous chronic inflammatory disorder involving joints, tendon sheaths, entheses, and the axial skeleton as well as skin and nails. This is an open-label trial with H.P.
- Trial name
- NCT01939132
- Testing
- Open label H.P. Acthar Gel
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Fiechtner, Justus J., M.D., P.C.
Laughter Yoga, Hemodialysis Patients
Effects of Laughter Yoga on Hemodialysis Patients' Plasma-Beta Endorphin Levels, Pain Levels and Sleep Quality
This study aimed to assess the effectiveness of laughter yoga on HD patients' plasma beta endorphin levels, pain levels and sleep quality.
- Trial name
- NCT04175652
- Testing
- Laughter yoga
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Istanbul Sabahattin Zaim University
Adrenal Insufficiency, Osteopenia, Osteoporosis
Effect of Adrenocorticotropic Hormone on Vascular Endothelial Growth Factor Release in Children Study
Bone disease and adrenal suppression are two of the many side effects of steroid use in pediatrics. Evidence has shown that adrenocorticotropic hormone (ACTH) protects against the adverse bone effects of steroids in animals and…
- Conditions
- Adrenal Insufficiency, Osteopenia, Osteoporosis, Steroid Suppression of ACTH Secretion
- Trial name
- NCT03709381
- Testing
- Low Dose Cosyntropin (ACTH) stimulation test, High Dose Cosyntropin (ACTH) stimulation test
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Irritable Bowel Syndrome
Effect of Acupuncture on Symptoms of Diarrhea and Pain in IBS
Acupuncture has been used for centuries in China in the treatment of diarrhea. Our hypothesis is that acupuncture is effective in the treatment of abdominal pain and diarrhea in patients with diarrhea-predominant IBS
- Trial name
- NCT00219505
- Testing
- acupuncture
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Penn State University
Neck Pain, Back Pain
Metabolic and Endocrine Effects of Repeated Epidural and Sacroiliac Joint Corticosteroid Injections
Corticosteroid injections into the epidural space or sacroiliac joint are increasingly used for the treatment of chronic neck, low back, and leg pain.
- Trial name
- NCT01717430
- Where
- Canada
- Volunteers
- 126 people
- Sponsor
- University of Manitoba
Nephrotic Syndrome
Adrenocorticotropic Hormone (ACTH) for Frequently Relapsing and Steroid Dependent Nephrotic Syndrome
In childhood nephrotic syndrome, the kidneys leak protein, causing body swelling and a variety of possible complications such as infection, blood clots, and kidney failure.
- Trial name
- NCT02132195
- Testing
- ACTH
- Where
- 16 sites in United States
- Volunteers
- 31 people
- Sponsor
- Emory University
Stress
Stress Biomarkers:Attaching Biological Meaning to Field Friendly Salivary Measures
Cortisol is a stress hormone that can be measured in saliva. This has provided a convenient way to evaluate the biological impact of day-to-day stressors that people encounter as they go about their lives, since saliva is so easy…
- Trial name
- NCT01673087
- Testing
- Metyrapone, Dexamethasone, Cortrosyn
- Where
- United States
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Primary Aldosteronism, Aldosterone-Producing Adenoma
Effect of Adrenocorticotropic Hormone Stimulation During Adrenal Vein Sampling in Primary Aldosteronism
The purpose of our research is to evaluate the value of ACTH stimulation in AVS especially in lateralization is still controversial.
- Conditions
- Primary Aldosteronism, Aldosterone-Producing Adenoma, Idiopathic Hyperaldosteronism
- Trial name
- NCT05826080
- Where
- China
- Volunteers
- 59 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Chronic Obstructive Pulmonary Disease (COPD)
Acute Effects of Acu-Transcutaneous Electrical Nerve Stimulation (Acu-TENS) on Forced Expiratory Flow Volume in One Second (FEV1) and Blood β-Endorphin Level in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
The objective of this study is to investigate the effectiveness of Acu-TENS (transcutaneous electrical nerve stimulation applied on acupoints) on lung functions, dyspnoeic symptoms and its association with beta endorphin level in…
- Trial name
- NCT00922051
- Testing
- Transcutaneous electrical nerve stimulation (TENS)
- Where
- China
- Volunteers
- 44 people
- Sponsor
- The Hong Kong Polytechnic University
West Syndrome
Prevention of West Syndrome With Low-dose Adrenocorticotropin Hormone (ACTH)
West syndrome (WS) is a specific type of epilepsy (or seizure disorder) that has three features: infantile spasms (type of seizure), loss of milestones, and a specific pattern on electroencephalogram (EEG or brain wave test)…
- Trial name
- PREVENT-WS (NCT01367964)
- Testing
- adrenocorticotropin hormone
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Chronic Low-back Pain
To Observe the Effect of Sphinx Pose (Salamba Bhujangasana) Among Health Care Providers With Chronic Low Back Pain
This Randomized Controlled trial is designed to observe the effect of Sphinx Yoga (Salamba Bhujangasana) on low back pain and variation in the associated physiological parameters that help explain the beneficial effects of yoga…
- Trial name
- CLBP (NCT04721639)
- Testing
- Sphinx Yoga Therapy
- Where
- 2 sites in Pakistan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Karachi
Healthy
Standardized 1µg Adrenocorticotropic Hormone Stimulation Test, and Salivary Cortisol Concentration During the Test
Study objectives: First, to determine whether intravenous injection of 1 mcg adrenocorticotropic hormone (ACTH) through short cannula, in healthy participants, provides reliable results of cortisol response, and whether this…
- Trial name
- NCT02413944
- Testing
- ACTH stimulation test
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bnai Zion Medical Center
Lupus Erythematosus Systemic Exacerbation
Open-label Trial of Acthar Gel in Subjects With Moderate to Severe Active Systemic Lupus Erythematosus
Systemic lupus erythematosus is a serious and potentially life-threatening condition with significant unmet medical need. The aim of this Investigator Initiated, single center, open-label study is to evaluate the efficacy and…
- Trial name
- ACTH (NCT01769937)
- Testing
- H.P. Acthar Gel
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Fiechtner, Justus J., M.D., P.C.
Corticotropin Deficiency, Fasting
Ramadan Fasting in Patients With Corticotrope Deficiency Treated Either by Hydrocortisone or by Prednisolone
Selected patients will be randomised to either hydrocortisone or prednisolone. Each treatment period is of 14 days. Abnormal clinical symptoms, blood glucose and quality of life will be monitored.
- Trial name
- NCT03585829
- Testing
- Hydrocortisone, Prednisolone
- Where
- Tunisia
- Volunteers
- 53 people
- Sponsor
- University Tunis El Manar
Rheumatoid Arthritis
ACTH Gel Therapy in Rheumatoid Arthritis
The purpose of this research study is to evaluate if the study drug, ACTH Gel helps decrease the disease symptoms in people with Rheumatoid Arthritis (RA) who are already taking medications prescribed by their physician and are…
- Trial name
- NCT02030028
- Testing
- ACTHAR gel
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Dana Ascherman