Clinical trials: Beta-blockers
Heart Failure, Cardiomyopathy
Mechanisms of Improvement With Beta-Blocker Treatment in Heart Failure
The overall hypothesis of this application is that the improvement in LV ejection performance following treatment with betablockers is due, at least in part, to improvement in intrinsic myocardial contractility.
- Trial name
- NCT01261065
- Testing
- carvedilol
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Michael E. DeBakey VA Medical Center
Congestive Heart Failure, Medication Adherence
Assay to Measure Beta Blocker Adherence
This study will assess the feasibility and efficacy of using serum assay developed by Quest Diagnostics to detect the presence of beta blockers, specifically carvedilol and metoprolol succinate, in patients with heart failure.
- Trial name
- NCT05251974
- Testing
- Quest beta blocker assay
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Summa Health System
Chronic Obstructive Pulmonary Disease
Beta Blocker Therapy in Moderate to Severe COPD
Beta blockers are a type of medication mainly used for heart disease. They are commonly used to treat 'angina' and to prevent heart attacks.
- Trial name
- ANDA2 (NCT01656005)
- Testing
- Carvedilol, Bisoprolol, Beclometasone/formoterol
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- University of Dundee
Cirrhosis, Esophageal and Gastric Varices
Apixaban-PK Trial: Preventing Portal Hypertension Complications in Cirrhosis
The APIXABAN-PK trial is a prospective, randomized, single-blind, placebo-controlled study designed to evaluate the efficacy and safety of apixaban in combination with carvedilol versus placebo with carvedilol in preventing…
- Conditions
- Cirrhosis, Esophageal and Gastric Varices, Ascites, Hepatic Encephalopathy
- Trial name
- APIXABAN-PK (NCT07521332)
- Testing
- Apixaban, Carvedilol
- Where
- Pakistan
- Volunteers
- 220 people
- Sponsor
- Asian Institute Of Medical Sciences
Cirrhosis
Secondary Prophylaxis Gastric Variceal Bleed
The investigators conducted a randomized, controlled trial (RCT) to study the efficacy of beta blockers versus endoscopic cyanoacrylate injection in the prevention of gastric variceal (GOV2 or IGV1) rebleeding and improvement in…
- Trial name
- NCT00888784
- Testing
- Endoscopic Cyanoacrylate injection, beta-blocker (propranolol)
- Where
- India
- Volunteers
- 64 people
- Sponsor
- Govind Ballabh Pant Hospital
Retinopathy of Prematurity
Safety and Efficacy of Propranolol in Newborns With Retinopathy of Prematurity
The purpose of this study is to determine whether the administration of propranolol is effective in the treatment of the retinopathy of the prematurity.
- Trial name
- PROP-ROP (NCT01079715)
- Testing
- Propranolol
- Where
- 2 sites in Italy
- Volunteers
- 52 people
- Sponsor
- Meyer Children's Hospital IRCCS
Myocardial Bridge
Myocardial Bridge Evaluation Towards Personalised Medicine: the RIALTO Registry
Myocardial bridge (MB) is a congenital anomaly of epicardial circulation characterized by an intramural course of a coronary segment.
- Trial name
- RIALTO (NCT05111418)
- Where
- 5 sites in Italy
- Volunteers
- 444 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Heart Failure
Beta-Blockers in Heart Failure: Pharmacy-level Intervention Comparison
The overall objective of the proposed pilot study is to begin evaluation of two methods for promoting adherence to guidelines for beta-blocker therapy in heart failure.
- Trial name
- NCT01002456
- Testing
- Level 1: (provide site-specifi information), Level 2 (Provide site- and patient-specific information)
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- US Department of Veterans Affairs
Multiple Trauma, Cardiovascular Diseases
Use of Beta Blockers in Elderly Trauma Patients
Advances in medical care have increased the proportion of elderly Americans and enabled them to remain more physically active. This has resulted in an unprecedented increase in the number of geriatric patients admitted to trauma…
- Conditions
- Multiple Trauma, Cardiovascular Diseases, Aged
- Trial name
- NCT00302692
- Testing
- Esmolol, Metoprolol
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- University of Texas Southwestern Medical Center
Intraoperative Awareness, Postoperative Pain
Role of Intraoperative Beta Blocker for Morbid Obese Patients Undergoing Laparoscopic Bariatric Surgery
Using esmolol during anesthetic maintenance of laparoscopic bariatric surgery significantly decreases anesthetic, analgesic requirements, postoperative pain, PNV and postoperative hypoxia.
- Trial name
- NCT04086940
- Testing
- Esmolol
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Cirrhosis, Diabetes Mellitus
Efficacy of Esmolol in the Identification of Cardiovascular Disorders by Cirrhosis, Diabetes Mellitus and Cardiotoxic Treatments
The purpose of this study is to assess the superiority of esmolol echocardiography over conventional echocardiography in the diagnosis of subclinical myocardial involvement associated with diabetes mellitus 2, cirrhosis and…
- Conditions
- Cirrhosis, Diabetes Mellitus, Oncologic Disorders
- Trial name
- CIBERbBECHO (NCT05769868)
- Testing
- Esmolol Injection [Brevibloc]
- Where
- 6 sites in Spain
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Consorcio Centro de Investigación Biomédica en Red (CIBER)
Heart Failure
Guideline Directed Medical Therapy in Patients With Heart Failure
The TEAM-MGH study will formerly evaluate impact of the GDMT Clinic versus matched usual care patients on the proportion of GDMT administration over a 12 week period in approximately 300 total patients with HF across the spectrum…
- Trial name
- TEAM-MGH (NCT06700213)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Massachusetts General Hospital
Myocardial Infarction With Non-obstructive Coronary Arteries
Randomized Evaluation of Beta Blocker and ACEI/ARB Treatment in MINOCA Patients - MINOCA-BAT
Myocardial infarction with non-obstructive coronary arteries" (MINOCA) occurs in 5-10% of all patients with AMI. There are neither any randomized clinical trials in MINOCA patients evaluating effects of secondary preventive…
- Trial name
- MINOCA-BAT (NCT03686696)
- Testing
- Beta blocker, ACEI, ARB
- Where
- 32 sites in Australia, New Zealand and 3 more
- Volunteers
- 198 people
- Sponsor
- Uppsala University