Clinical trials: Beta-endorphin
Breast Cancer, Fatigue
Role of Beta-Endorphin in Cancer Therapy Fatigue
The investigators aim to test whether beta-endorphin, a substance our bodies make in response to painful and stressful stimuli, plays a causative role in radiation-induced fatigue that cancer patients receiving radiation therapy…
- Trial name
- NCT01113905
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Massachusetts General Hospital
Homozygous or Compound Heterozygous POMC, LEPR or PCSK1 Gene Mutation
RM-493 Treatment Trial in Proopiomelanocortin (POMC) Deficient Patients
The purpose of this study is to evaluate the effects of a once daily subcutaneous (SC) injection of RM-493, in subjects with POMC (propiomelanocortin) or other related rare genetic mutations, on body weight, metabolic function…
- Trial name
- NCT02507492
- Testing
- RM-493
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Charite University, Berlin, Germany
Adrenal Incidentaloma, Subclinical Hypercortisolism
Evaluation of New Diagnostic Indicator of Subclinical Hypercortisolism
The purpose of this study is to evaluate the serum dehydroepiandrosterone sulfate in subclinical hypercortisolism
- Trial name
- NCT04833192
- Testing
- experimental group
- Where
- China
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Obesity, Childhood, Hyperphagia
Early Genetic Identification of Obesity
TITLE: Whole genetic approach in Early Genetic Identification of Obesity (WEGIO) DESIGN: Multicenter epidemiological study STUDY POPULATION: Participants at risk for a syndromic or a monogenic genetic obesity, incl.
- Conditions
- Obesity, Childhood, Hyperphagia, Retinopathy, Syndactyly
- Trial name
- WEGIO (NCT06239064)
- Testing
- Genetic testing via blood collection
- Where
- 37 sites in Germany
- Volunteers
- 1,000 people
- Sponsor
- Rolfs Consulting und Verwaltungs-GmbH (RCV)
Primary Aldosteronism, Aldosterone-Producing Adenoma
Effect of Adrenocorticotropic Hormone Stimulation During Adrenal Vein Sampling in Primary Aldosteronism
The purpose of our research is to evaluate the value of ACTH stimulation in AVS especially in lateralization is still controversial.
- Conditions
- Primary Aldosteronism, Aldosterone-Producing Adenoma, Idiopathic Hyperaldosteronism
- Trial name
- NCT05826080
- Where
- China
- Volunteers
- 59 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Bardet-Biedl Syndrome, POMC Deficiency Obesity
Setmelanotide in Pediatric Participants With Rare Genetic Diseases of Obesity
This is a phase 3 open-label, clinical study to evaluate the efficacy, safety and tolerability of setmelanotide over 1 year of treatment, in pediatric participants aged 2 to <6 years with obesity due to either biallelic variants…
- Conditions
- Bardet-Biedl Syndrome, POMC Deficiency Obesity, PCSK1 Deficiency Obesity, LEPR Deficiency Obesity
- Trial name
- NCT04966741
- Testing
- Setmelanotide
- Where
- 6 sites in United States, Australia and 2 more
- Volunteers
- 12 people
- Sponsor
- Rhythm Pharmaceuticals, Inc.
Cocaine-Related Disorders, Cocaine Addiction
Effects of Corticorelin Administration on Dopamine Transmission, Craving, and Mood in Cocaine Dependence
This study will, in a sample of cocaine-dependent and healthy control subjects, administer corticorelin and compare dopamine release between groups.
- Conditions
- Cocaine-Related Disorders, Cocaine Addiction, Substance-Related Disorders
- Trial name
- NCT01984177
- Testing
- Corticotropin-Releasing Hormone
- Where
- Canada
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Cushing Syndrome
Pharmacokinetic (PK), Pharmacodynamic (PD) and Tolerability of Osilodrostat in Pediatric Patients With Cushing's Syndrome
Multicenter, open-label, non-comparative study to evaluate the pharmacokinetics, pharmacodynamics, and tolerability of osilodrostat in children and adolescent patients with Cushing's syndrome.
- Trial name
- NCT03708900
- Testing
- LCI699
- Where
- 15 sites in United States, Belgium and 5 more
- Volunteers
- 12 people
- Sponsor
- RECORDATI GROUP
Psoriatic Arthritis
Protocol for H.P. Acthar Gel in Moderately to Severely Active Psoriatic Arthritis
Psoriatic arthritis is a heterogeneous chronic inflammatory disorder involving joints, tendon sheaths, entheses, and the axial skeleton as well as skin and nails. This is an open-label trial with H.P.
- Trial name
- NCT01939132
- Testing
- Open label H.P. Acthar Gel
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Fiechtner, Justus J., M.D., P.C.
Breastfeeding, Lactation
Epidural Analgesia, Beta-Endorphin Concentrations in Colostrum, and Infant Neurobehavior as Breast-Feeding Predictors
Presently, the literature addressing the relationship between epidural analgesia and likelihood of breast-feeding is inconclusive.
- Conditions
- Breastfeeding, Lactation, Analgesia
- Trial name
- NCT01191970
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- MetroHealth Medical Center
Irritable Bowel Syndrome
Effect of Acupuncture on Symptoms of Diarrhea and Pain in IBS
Acupuncture has been used for centuries in China in the treatment of diarrhea. Our hypothesis is that acupuncture is effective in the treatment of abdominal pain and diarrhea in patients with diarrhea-predominant IBS
- Trial name
- NCT00219505
- Testing
- acupuncture
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Penn State University
Nephrotic Syndrome in Children
Study of Adrenocorticotropic Hormone on Children With Frequent Relapse or Steroid-dependent Nephrotic Syndrome: a Prospective, Multicenter, Randomized，Open-label Clinical Trial.
Primary nephrotic syndrome accounts for approximately 90% of the total number of nephrotic syndrome in childhood and it is the most common glomerular disease in children.
- Trial name
- NCT06079788
- Testing
- Adrenocorticotrophic Hormone, Steroid
- Where
- 8 sites in China
- Volunteers
- 140 people
- Sponsor
- Mao Jianhua
Liver Transplant; Complications
The Effect of Foot Reflexology on Pain, Comfort and Beta Endorphin Levels in Patients With Liver Transplantation
Reflexology application is an effective method in pain control by stimulating the release of endorphins. The Research was carried out to determine the effect of foot reflexology applied to patients with liver transplantation on…
- Trial name
- NCT04828356
- Testing
- Reflexology
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Inonu University
Hypercortisolism
A Study of the Efficacy and Safety of Relacorilant in Patients With Cortisol-Secreting Adrenal Adenomas
This is a Phase 3, randomized, double-blind, placebo-controlled study to assess the efficacy, and safety of relacorilant to treat hypercortisolism in patients with cortisol-secreting adrenal adenoma or hyperplasia associated with…
- Trial name
- GRADIENT (NCT04308590)
- Testing
- Relacorilant
- Where
- 45 sites in United States, Austria and 7 more
- Volunteers
- 137 people
- Sponsor
- Corcept Therapeutics
Multiple Sclerosis
Effect of Adrenocorticotropin Injection With Weekly Interferon Beta in Patients With Relapsing Remitting Multiple Sclerosis (MS)
The purpose of this study is to evaluate whether the use of ACTH in addition to Avonex is effective in the treatment of relapsing remitting multiple sclerosis.
- Trial name
- ACTH (NCT00986960)
- Testing
- repository corticotropin injection, Saline
- Where
- United States
- Sponsor
- University at Buffalo