Clinical trials: Bilateral Cataracts
Congenital Cataract
Comparison of the Effect of Minimal Invasive Lens Surgery and Traditional Cataract Surgery
Previously, the investigators have developed a minimal invasive lens surgery in the purpose of reduce post-operative complications of congenital cataract.
- Trial name
- NCT03908359
- Testing
- traditional cataract surgery, minimal invasive lens surgery
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Sun Yat-sen University
Cataracts Infantile
Clobetasol Propionate Ophthalmic Nanoemulsion, 0.05% in the Treatment of Inflammation After Cataract Surgery in Pediatric Population
Multicenter, randomized, evaluator-blinded clinical trial compared to Prednisolone acetate, 1% in the treatment of inflammation and pain after cataract surgery in pediatric population.
- Trial name
- CLOSE-3 (NCT05724446)
- Testing
- Clobetasol Propionate, Prednisolone acetate ophthalmic suspension, 1%
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Salvat
Epiretinal Membrane, Macular Hole
Study of OT-551 Eye Drops to Prevent or Delay Progression of Nuclear Cataracts Following Vitreous Removal
The purpose of this trial is to compare the ability of two doses of OT-551 ophthalmic solution and drug-free solution to safely and effectively prevent or delay the progression of nuclear cataracts that frequently develop as a…
- Trial name
- NCT00333060
- Testing
- OT-551 ophthalmic solution
- Where
- 16 sites in United States
- Volunteers
- 164 people
- Sponsor
- Othera Pharmaceuticals
Congenital Cataracts
Effects of Visual Reconstruction on Brain Function and Structure in Children With Congenital Cataract
Children have considerable plasticity of the visual system during the formation and maturation of various visual functions at different ages. Congenital cataracts are the leading cause of treatable blindness in children.
- Trial name
- NCT05527925
- Testing
- MRI
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Cataract
An Interocular Comparative Study of Unilateral Cataract
The purpose of this cross-sectional study is to compare bilateral anterior segment parameters, macular thickness, and BCVA at 3 months after uncomplicated unilateral pediatric cataract extraction with primary IOL implantation to…
- Trial name
- NCT02765230
- Where
- China
- Volunteers
- 53 people
- Sponsor
- Sun Yat-sen University
Cataract
Randomized Contralateral Clinical Trial With Single-piece (SN60WF) vs. Three Piece (MA60AC) AcrySof Intraocular Lenses (IOLs) on Development of Posterior Chamber Opacification (PCO).
Randomized contralateral clinical trial with single piece (Model SN60WF) vs. three piece (Model MA60AC) AcrySof Intraocular Lenses (IOLs) on development of Posterior Chamber Opacifiation (PCO).
- Trial name
- NCT00758745
- Testing
- Model SN60WF, Model MA60AC
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Alcon Research
May-Hemalin, Fechtner Syndrome (Disorder)
Phenotypic and Genotypic Identification and Characterization of MYH9-related Constitutional Thrombocytopenia
The research involves the establishment of a cohort including as much as possible cases of macrothrombocytopenia related to a "MYH9 syndrome" and the study of mutations and polymorphisms of MYH9 gene in all these patients.
- Conditions
- May-Hemalin, Fechtner Syndrome (Disorder), Epstein Syndrome (Disorder), MYH9 Related Disorders
- Trial name
- MAGIC-MYH9 (NCT00925236)
- Where
- France
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Aphakia
Clinical Investigation of the AcrySof IQ Vivity Extended Vision Intraocular Lens (IOL)
The purpose of this study is to compare the visual disturbance profile of an intraocular lens (IOL) using nondiffractive optics, the VIVITY IOL, to two diffractive IOLs in subjects requiring bilateral cataract surgery.
- Trial name
- NCT04098367
- Testing
- VIVITY, SYMFONY, AT LARA
- Where
- 12 sites in Australia, New Zealand
- Volunteers
- 222 people
- Sponsor
- Alcon Research
Cataract
Vivinex Impress XY1-EM vs RayOne EMV
Comparison of the outcomes of bilateral implantation of extended depth of vision (EDOF) intraocular lenses (IOLs): the Rayone EMV and the Vivinex Impress XY1-EM in patients with cataract
- Trial name
- NCT06891092
- Testing
- RayOne EMV, Vivinex Impress
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Bialystok
Cataract
A Prospective, Randomized, Subject and Vision-assessor Masked, Multicenter Study Comparing Bilateral Clareon PanOptix, Bilateral Clareon PanOptix Pro, and Mixed Clareon PanOptix Pro/Vivity Intraocular Lens Implantation in Cataract Subjects
Prospective, randomized, multicenter, multi-arm, subject and vision-assessor-masked, two stage study with Stage 1 as a three-arm initial enrollment period, followed by Stage 2 as a head-to-head study refined based on the Stage 1…
- Trial name
- NCT06922084
- Testing
- Clareon PanOptix, Clareon PanOptix PRO, Mix-and-Match PanOptix/Vivity
- Where
- 2 sites in United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Berkeley Eye Center
Cataracts, Astigmatism
AcrySof Toric Clinical Results
This study is an evaluation of visual outcomes of subjects implanted with the AcrySof Toric Intraocular Lenses (IOLs) Models SN60T3, SN60T4, and SN60T5.
- Trial name
- NCT01214863
- Testing
- T3, T4, T5
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Alcon Research
Cataracts
Endothelial Cell Loss After Cataract Surgery
The purpose of this study is to compare two cataract surgical technique variations for removing the nucleus of the lens (central part of the lens) in terms of damage to the inner layer of the cornea which is called the…
- Trial name
- NCT00932191
- Testing
- Standard phacoemulsification, Reduced ultrasound phacoemulsification
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of California, San Francisco
Cataract
Evaluation of the EpiGlare Tester for the Measurement of Glare-Induced Changes in BSCVA in Subjects With and Without Cataracts
The EpiGlare Tester will identify visual disability resulting from the glare experienced by subjects with cataracts in the glare-induced change in best spectacle corrected visual acuity (BSCVA).
- Trial name
- NCT04739397
- Testing
- Glare Testing
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Epico, LLC
Dry Eye, Dry Eye Disease (DED)
Temporary Tear Duct Filling With Hyaluronic Acid Gel and Assessment of Dry Eye Disease (DED) After Bilateral Cataract Surgery
Dry eye disease can occur or worsen after cataract surgery and may cause ocular discomfort and reduced visual quality. Standard treatment commonly includes artificial tear eye drops, which provide temporary lubrication.
- Conditions
- Dry Eye, Dry Eye Disease (DED), Dry Eye Sensation After Cataract Surgery
- Trial name
- TANAMI (NCT07809022)
- Testing
- LACRIFILL® Canalicular Gel administration
- Where
- Austria
- Volunteers
- 25 people
- Sponsor
- Medical University of Vienna
Cataract
Myopic Monovision: EDOF vs. Monofocal IOL
Comparison of EDOF IOLs versus monofocal IOLs with mini-monovision concerning intermediate and near visual acuity.
- Trial name
- NCT05194670
- Testing
- enhanced depth of focus IOL, monofocal IOL
- Where
- Austria
- Volunteers
- 62 people
- Sponsor
- Vienna Institute for Research in Ocular Surgery
Cataracts
Comparison of Tetracaine 0.5% and Lidocaine 2% Jelly for Topical Phacoemulsification Cataract Surgery
The purpose of this study is to determine if there is a difference on the penetration of betadine 5% when using lidocaine 2% jelly versus topical tetracaine 0.5% in topical cataract surgery.
- Trial name
- NCT00827073
- Testing
- tetracaine 0.5%, Lidocaine 2% Jelly
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hermann Eye Center
Cataract
Visual Function With Bilateral AcrySof® ReSTOR® Aspheric SN6AD1
The objective of this study is to prospectively evaluate the visual parameters in a series of patients after phacoemulsification cataract surgery in a series of patients bilaterally implanted with the AcrySof® ReSTOR® Aspheric…
- Trial name
- NCT00710931
- Testing
- AcrySof ReSTOR Aspheric IOL model SN6AD1
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Alcon Research
Nuclear Sclerosis of the Lens, Phacoemulsification Cataract Surgery
This Clinical Trial Compares Two Phacoemulsification Systems Used in a Bilateral Cataract Surgery Subjects in Order to Study CDE and Ultrasound Time During Cataract Removal
This clinical trial compares two phacoemulsification systems used in a bilateral cataract surgery subjects, in order to study CDE and Ultrasound time during cataract removal
- Conditions
- Nuclear Sclerosis of the Lens, Phacoemulsification Cataract Surgery, Cataract Bilateral
- Trial name
- CDE (NCT07468877)
- Testing
- Cataract extraction with phacoemulsification comparing two systems
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Nicole Fram M.D.
Aphakia, Presbyopia
Evaluation of AcrySof IQ Vivity Extended Vision Intraocular Lenses
The purpose of this post-market study is to describe the long-term safety and performance of AcrySof IQ Vivity and AcrySof IQ Vivity Toric intraocular lens (IOL) models in a real-world setting through routine clinical practice.
- Conditions
- Aphakia, Presbyopia, Residual Refractive Cylinder
- Trial name
- NCT06541795
- Testing
- AcrySof IQ Vivity Extended Vision IOL
- Where
- United States
- Sponsor
- Alcon Research
Age Related Cataracts
Posterior Capsule Opafication of Two Different Hydrophobic Acrylic Intraocular Lenses
On the day of surgery, the first eye to be operated is randomised to receive a Vivinex , HOYA Surgical Optics GmbH or an SN60WF, Alcon, Fort Worth, Texas. The second eye to be operated receives the other IOL type.
- Trial name
- Acryvivi (NCT04196673)
- Testing
- Alcon SN60WF, Hoya Vivinex
- Volunteers
- 80 people
- Sponsor
- Medical University of Vienna