Clinical trials: Bile Duct Stones
Choledocholithiasis, Common Bile Duct Stones
Hyoscine Butylbromide During Transcystic Papillary Balloon Dilation for Choledocholithiasis
The purpose of the PAPRELAX study is to evaluate the intraoperative effect of intravenous hyoscine butylbromide during laparoscopic transcystic balloon dilation of the papilla of Vater in adult patients undergoing surgical…
- Trial name
- PAPRELAX (NCT07814976)
- Testing
- Hyoscine Butylbromide
- Where
- Latvia
- Volunteers
- 50 people
- Sponsor
- Riga East Clinical University Hospital
Gallstone, Bile Duct Obstruction
Treatment Outcomes in Bile Duct Stones
This registry is to evaluate the procedural and clinical outcomes in patients undergoing endoscopic treatment of bile duct stones when utilizing an algorithmic management approach.
- Conditions
- Gallstone, Bile Duct Obstruction, Bile Duct Diseases
- Trial name
- NCT04145843
- Testing
- endoscopic retrograde cholangiopancreatography
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- AdventHealth
Calculus; Gallbladder, With Cholecystitis
Two Institutes Experience in Laparo-Endoscopic Rendezvous Technique for Gallbladder and Bile Duct Stones
The management of gallbladder stones (lithiasis) concomitant with bile duct stones is controversial. The management of CBD stones has evolved considerably since the advent of laparoscopic surgery.
- Trial name
- NCT05734144
- Testing
- The intraoperative ERCP has been performed immediately before LC, POES followed by LC
- Volunteers
- 432 people
- Sponsor
- Zagazig University
Biliary Stricture, Biliary Obstruction Due to Common Bile Duct Stone
SpyGlass AMEA Registry
The purpose of this study is to document indications for cholangioscopy and clinical utility of the SpyGlass Direct Visualization System (DVS) throughout the AMEA (Asia, Middle-East, Africa) region when used per standard of…
- Conditions
- Biliary Stricture, Biliary Obstruction Due to Common Bile Duct Stone, Periampullary Tumor, Hemobilia
- Trial name
- NCT02281019
- Testing
- ERCP (Endoscopic Retrograde Cholangiopancreatography), SpyGlass DVS and SpyGlass Digital Simple (DS)
- Where
- 20 sites in Australia, Hong Kong and 8 more
- Volunteers
- 526 people
- Sponsor
- Boston Scientific Corporation
Acute Pancreatitis, Acute Pancreatic Necrosis
coMpliAnce With evideNce-based cliniCal Guidelines in the managemenT of Acute biliaRy pancreAtitis
Acute pancreatitis (AP) is an inflammatory disease of the pancreas, most commonly caused by gallstones, or excessive use of alcohol. It represents a management challenge and a significant healthcare burden.
- Conditions
- Acute Pancreatitis, Acute Pancreatic Necrosis, Acute Pancreatitis Due to Gallstones, Acute Pancreatic Fluid Collection
- Trial name
- MANCTRA-1 (NCT04747990)
- Testing
- Early Definitive Treatment
- Where
- 3 sites in Italy, Spain
- Volunteers
- 600 people
- Sponsor
- University of Cagliari
Gallstones, Cholelithiasis
Chinese Registry Study on Treatment of Cholecysto-Choledocholithiasis
Patients with gallstone and confirmed common bile duct stones are registered in this study. The three managements for common bile duct stones are endoscopic sphincterotomy (EST), laparoscopic common bile duct exploration (LCBDE)…
- Conditions
- Gallstones, Cholelithiasis, Cholecystolithiasis, Choledocholithiasis
- Trial name
- CREST Choles (NCT02554097)
- Testing
- endoscopic sphincterotomy, laparoscopic common bile duct exploration, laparoscopic transcystic common bile duct exploration
- Where
- China
- Volunteers
- 2,700 people
- Sponsor
- Beijing Friendship Hospital
Cholecystectomy, Gallbladder
EUS-Guided Gallbladder Drainage Versus Conservative Management in Patients Unfit for Surgery After a Biliary Event Without Cholecystitis. DRECON Study
Cholecystectomy is considered the standard definitive treatment after an acute biliary event (biliary colic, acute pancreatitis, cholangitis, or choledocholithiasis).
- Conditions
- Cholecystectomy, Gallbladder, Endoscopic Ultrasound (EUS), Cholelithiasis
- Trial name
- DRECON (NCT07655778)
- Testing
- EUS-guided gallbladder drainage (EUS-GBD), Conservative management (CM)
- Volunteers
- 110 people
- Sponsor
- Hospital Mutua de Terrassa
Choledocholithiasis, Common Bile Duct Calculi
SpyGlass Versus ESWL for Large Common Bile Duct Stones
Overall stone clearance with endoscopic retrograde cholangiopancreatography (ERCP) for choledocholithiasis is a big problem, especially for stones with a diameter greater than 3cm.
- Trial name
- NCT05186350
- Testing
- ERCP+ SpyGlass, ESWL+ ERCP
- Where
- China
- Volunteers
- 65 people
- Sponsor
- First People's Hospital of Hangzhou
Common Bile Duct Stone
Common Bile Duct Stones - Natural History and Interventions
The aims of this study were to 1. investigate what measures were taken when common bile duct stones (CBDS) were found intraoperatively in Sweden during the period May 2005 to December 2009 by using data from this population-based…
- Trial name
- NCT01734720
- Volunteers
- 3,828 people
- Sponsor
- Karolinska Institutet
Primary Sclerosing Cholangitis, Primary Biliary Cirrhosis
Repeatability and Reproducibility of Quantitative MRCP
This study aims to determine the repeatability and reproducibility of Quantitative Magnetic Resonance Cholangiopancreatography (MRCP).
- Conditions
- Primary Sclerosing Cholangitis, Primary Biliary Cirrhosis, Gallstones, Liver Diseases
- Trial name
- NCT03809559
- Testing
- MRCP+
- Where
- 2 sites in United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Perspectum
Bile Duct Stones
Identification of Predictive Factors for Failure of Cholangioscopy-assisted Lithotripsy in the Management of Complex Bile Duct Stones: a Retrospective Study
This study aims to optimize the management of complex biliary stones by identifying predictive factors for SpyGlass lithotripsy failure.
- Trial name
- CLEVER (NCT06974695)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Central Hospital, Nancy, France
Cholangiopancreatography, Endoscopic Retrograde, Choledocholithiasis
Explore the Effects and Mechanisms of ERCP and EST on Biliary Microecology
The objective of this observational study is to explore the structure of biliary flora in normal people, explore the dynamic impact of ERCP and EST on biliary microecology, study the marker flora, metabolites and functional genes…
- Conditions
- Cholangiopancreatography, Endoscopic Retrograde, Choledocholithiasis, Gallstones
- Trial name
- NCT05592795
- Testing
- Whether ERCP or EST is carried out
- Where
- 3 sites in China
- Volunteers
- 75 people
- Sponsor
- Qi-Yong Li
Cholecystolithiasis, Common Bile Duct Gall Stones
ChOlanGiography Performed Routinely Versus Selectively During Cholecystectomy: A NAtional Registry-based Randomized Controlled Trial
Common bile duct stones (CBDS) may be asymptomatic but can cause pancreatitis, obstructive jaundice, and/or cholangitis. In Sweden, intraoperative cholangiography (IOC) is usually performed during gallstone surgery in order to…
- Trial name
- COGNAC (NCT07002619)
- Testing
- Routine cholangiography, Selective cholangiograpy
- Where
- Sweden
- Volunteers
- 6,000 people
- Sponsor
- Karolinska Institutet
Choledocholithiasis, Jaundice, Obstructive
Immediate vs. Elective Endoscopic Removal of Large CBD Stones in High-Risk Elderly Patients
The goal of this clinical trial is to compare two different approaches for removing large or multiple stones from the common bile duct in older adults with chronic diseases.
- Trial name
- NCT06948279
- Testing
- The endoscopic retrograde cholangiopancreatography (ERCP) with insertion of a plastic stent., The endoscopic retrograde cholangiopancreatography (ERCP) with immediate stone extraction attempts.
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- National Liver Institute, Egypt
Cholangiocarcinoma, Pancreatic Cancer
T-EUS for Gastrointestinal Disorders: A Multicenter Registry
The purpose of this registry is to record information and evaluate the impact of Endoscopic Ultrasound (EUS) Guided Endoscopic retrograde cholangiopancreatography (ERCP) on the management of pancreatico-biliary disorders.
- Conditions
- Cholangiocarcinoma, Pancreatic Cancer, Bile Duct Cancer, Biliary Stricture
- Trial name
- EUSERCPReg (NCT01522573)
- Testing
- EUS guided ERCP
- Where
- 2 sites in United States, Brazil
- Volunteers
- 1,000 people
- Sponsor
- Weill Medical College of Cornell University
Gallbladder Diseases, Cholecystitis
Gallbladder Cryoablation in High-Risk Patients
Benign gallbladder disease, including acute cholecystitis, chronic cholecystitis, biliary dyskinesia, and biliary colic, is very common, with over 300,000 surgical cholecystectomies performed per year in the US.
- Conditions
- Gallbladder Diseases, Cholecystitis, Biliary Colic, Gallstone; Cholecystitis
- Trial name
- NCT04915651
- Testing
- Gallbladder Cryoablation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Arizona
Obesity, Diabetes
Prediction Model for Early Biliary Stasis After Bariatric Surgery
Developing and validating a predictive model to estimate the risk of early biliary stasis following bariatric surgery
- Conditions
- Obesity, Diabetes, Gallstones, Biliary Stasis
- Trial name
- PM-EBS-BS (NCT06385860)
- Volunteers
- 200 people
- Sponsor
- China-Japan Friendship Hospital
Common Bile Duct Gall Stones, Common Bile Duct GallStones
Rate of Duodenal-biliary Reflux Increases in Patients With Recurrent Common Bile Duct Stones
ERCP is the primary choice for removal of common bile duct stone (CBDS) currently. However, 4-24% patients underwent recurrence after successful clearance of CBDS.
- Trial name
- NCT02329977
- Testing
- standard barium meal examination
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Air Force Military Medical University, China
Acute Cholecystitis
Magnetic Resonance Cholangiography and Intraoperative Cholangiography in Acute Cholecystitis
The treatment of choice for acute cholecystitis is cholecystectomy performed as soon as possible after onset of symptoms. Up to 9-22% of patients undergoing cholecystectomy due to cholecystitis have common bile duct stones.
- Trial name
- NCT04059601
- Testing
- Magnetic resonance cholangiography, Intraoperative cholangiography
- Where
- Finland
- Volunteers
- 180 people
- Sponsor
- Jyväskylä Central Hospital
Gall Stone, Gall Stones, Common Bile Duct
Influence of Gut Microbiome in Gallstone Disease
The goal of this prospective observational study is to explore the role of the gut microbiome in patients with gallstone disease.
- Conditions
- Gall Stone, Gall Stones, Common Bile Duct, Pancreatitis, Acute Cholecystitis
- Trial name
- NCT05732480
- Where
- United Kingdom
- Volunteers
- 75 people
- Sponsor
- East Kent Hospitals University NHS Foundation Trust