Clinical trials: Biliary Cancers
Gallbladder Cancer, Obstructive Jaundice
Endoscopic Versus Percutaneous Drainage For Hilar Block in Gall Bladder Cancer
Cancer of the gallbladder (CaGB) is one of the most common causes of malignant obstructive jaundice. Jaundice is the second most common presentation and occurs in 30-60% of patients with CaGB.
- Trial name
- NCT00409864
- Testing
- Endoscopic biliary stenting, Percutaneous biliary stenting
- Where
- India
- Volunteers
- 182 people
- Sponsor
- All India Institute of Medical Sciences
Biliary Tract Cancer
A Trial Evaluating Surufatinib Efficacy and Safety in Biliary Tract Carcinoma Patients
This is a randomized, open-label, active-control, multi-center, phase IIb/III clinical study to evaluate the efficacy and safety of surufatinib vs.
- Trial name
- NCT03873532
- Testing
- Surufatinib, Capecitabine
- Where
- China
- Volunteers
- 298 people
- Sponsor
- Hutchison Medipharma Limited
Stage III Distal Bile Duct Cancer AJCC v8, Stage III Gallbladder Cancer AJCC v8
Gemcitabine Hydrochloride and Cisplatin With or Without Nab-Paclitaxel in Treating Patients With Newly Diagnosed Advanced Biliary Tract Cancers
This phase III trial studies how well gemcitabine hydrochloride and cisplatin given with or without nab-paclitaxel work in treating patients with newly diagnosed biliary tract cancers that have spread to other places in the body.
- Conditions
- Stage III Distal Bile Duct Cancer AJCC v8, Stage III Gallbladder Cancer AJCC v8, Stage III Intrahepatic Cholangiocarcinoma AJCC v8, Stage IIIA Distal Bile Duct Cancer AJCC v8
- Trial name
- NCT03768414
- Testing
- Cisplatin, Gemcitabine Hydrochloride, Nab-paclitaxel
- Where
- 692 sites in United States
- Volunteers
- 452 people
- Sponsor
- SWOG Cancer Research Network
Pancreatic Cancer, Advanced Biliary Cancer
Early Phase I Study of Autologous T Cells (EX02 CAR-T) for Unresectable Pancreatic/Bile Duct Cancer
This is a early Phase 1 open-label study to explore the safety and possible efficacy of EX02 CAR T cell therapy in the treatment of patients with unresectable and/or metastatic pancreatic/bile duct cancer.
- Trial name
- NCT06196658
- Testing
- anti-EX02 CAR T cells
- Volunteers
- 6 people
- Sponsor
- Zhang Xiaofeng,MD
Biliary Obstruction, Pancreatic Cancer
LAMS Choledochoduodenostomies: With or Without Coaxial Plastic Stent
The aim of the study is to evaluate technical, clinical and safety outcomes of lumen-apposing metal stent (LAMS) with and without a coaxial double-pigtail plastic stent (DPS) in EUS-guided choledochoduodenostomies (CDS) for the…
- Conditions
- Biliary Obstruction, Pancreatic Cancer, Biliary Tract Neoplasms
- Trial name
- BAMPI (NCT04595058)
- Testing
- Double pigtail plastic stent through lumen-apposing metal stent, Lumen-apposing metal stent without double pigtail plastic stent
- Where
- 2 sites in Spain
- Volunteers
- 123 people
- Sponsor
- Hospital Universitari de Bellvitge
Pancreatic Tumor, Bile Duct Tumor
Additional Effects of Perioperative Immunonutrition in Patients Undergoing Pancreaticoduodenectomy
The purpose of this study is to investigate whether perioperative immunonutrition has additional effects on cell-mediated immunity in patients undergoing pancreaticoduodenectomy.
- Trial name
- NCT01969110
- Testing
- Oral IMPACT
- Where
- Japan
- Volunteers
- 60 people
- Sponsor
- Chiba University
Biliary Tract Cancer, Candonilimab
Candonilimab in Combination With LM-302 for Claudin 18.2 Positive-advanced Biliary Tract Cancer After Failure of Standard of Chemotherapy and PD1/PD-L1 Antibody
In this clinical study, we will evaluate the efficacy and safety of cardonilimumab (PD1 monoclonal antibody and CTLA-4 monoclonal antibody bisspecific antibodies) and LM-302 (Claudin18.2-ADC) in Claudin18.2-positive advanced BTC…
- Conditions
- Biliary Tract Cancer, Candonilimab, Claudin 18.2
- Trial name
- NCT05994001
- Testing
- cardonilizumab, LM-302
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Shanghai Zhongshan Hospital
Biliary Tract Cancer, HER2 Gene Mutation
Efficacy and Safety of GemCis Plus Trastuzumab Plus Pembrolizumab in Previously Untreated HER2-positive Biliary Tract Cancer
This is a multicenter, single arm, prospective, open-label phase II trial investigating the clinical activity triplet regimen consisting of a combination of chemotherapy (gemcitabine/cisplatin) + trastuzumab + pembrolizumab as…
- Conditions
- Biliary Tract Cancer, HER2 Gene Mutation, HER2
- Trial name
- TRAP-BTC (NCT06178445)
- Testing
- SOC plus trastuzumab and pembrolizumab
- Where
- 8 sites in Germany
- Volunteers
- 24 people
- Sponsor
- Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
Biliary Tract Neoplasms, Jaundice, Obstructive
Covered vs. Uncovered SEMS for Occluded Biliary Metal Stents
Endoscopic retrograde biliary drainage (ERBD) is now widely accepted as the standard intervention for the relief of obstructive jaundice in patients with unresectable malignant biliary obstruction.
- Trial name
- NCT01315522
- Testing
- ComVi stent, Uncovered SEMS
- Where
- 3 sites in South Korea
- Volunteers
- 43 people
- Sponsor
- Seoul National University Hospital
ERCP, Choledocholithiasis
Pre-cut Versus Intentional Double Guidewire for ERCP Cannulation: Prospective, Randomized Controlled Trial
Endoscopic retrograde cholangiopancreatography (ERCP) is an indispensable therapeutic procedure in the management of a wide spectrum of pancreaticobiliary disorders, including choledocholithiasis, benign and malignant biliary…
- Conditions
- ERCP, Choledocholithiasis, Biliary Drainage, Biliary Strictures Caused by Malignant Neoplasms
- Trial name
- PRIDE (NCT07329803)
- Testing
- Precut Sphincterotomy, Double Guidewire Technique
- Volunteers
- 840 people
- Sponsor
- Asian Institute of Gastroenterology, India
Jaundice, Periampullary Cancer
Preoperative Biliary Drainage With Metal Versus Plastic Stents in Periampullary Cancer
Currently, routine preoperative biliary drainage (PBD) was not recommended. However, PBD is still necessary in case of patients with cholangitis or very high level of bilirubin or patients who are expected to receive delayed…
- Trial name
- NCT02787512
- Testing
- Stent
- Where
- 2 sites in South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Adult Primary Hepatocellular Carcinoma, Advanced Adult Primary Liver Cancer
Lapatinib in Treating Patients With Locally Advanced or Metastatic Biliary Tract or Liver Cancer That Cannot Be Removed By Surgery
This phase II trial is studying how well lapatinib works in treating patients with locally advanced or metastatic biliary tract or liver cancer that cannot be removed by surgery.
- Conditions
- Adult Primary Hepatocellular Carcinoma, Advanced Adult Primary Liver Cancer, Localized Unresectable Adult Primary Liver Cancer, Recurrent Adult Primary Liver Cancer
- Trial name
- NCT00101036
- Testing
- lapatinib ditosylate, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- National Cancer Institute (NCI)
Biliary Tract Cancer
Trial of Infusional FOLFIRINOX in First Line Treatment of Advanced Biliary Tract Cancers
This study is to evaluate the response rate and toxicity profile of infusional 5 fluorouracil, leucovorin, oxaliplatin and irinotecan (FOLFIRINOX) in first-line treatment of advanced biliary tract cancers and also to assess…
- Trial name
- FBI-TRAC (NCT03291899)
- Testing
- FOLFIRINOX
- Where
- Saudi Arabia
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- King Faisal Specialist Hospital & Research Center
Common Bile Duct Calculi, Biliary Tract Cancer
Multibending vs Conventional Endoscope for Direct Peroral Cholangioscopy
The aim of this study is to evaluate the usefulness of a newly developed multibending ultra-slim upper endoscope for the successful direct peroral cholangioscopy (POC) without assisting accessory in comparison with conventional…
- Conditions
- Common Bile Duct Calculi, Biliary Tract Cancer, Biliary Stricture, Bile Duct Diseases
- Trial name
- NCT02189421
- Testing
- ultra-slim upper endoscope
- Where
- South Korea
- Volunteers
- 110 people
- Sponsor
- Soonchunhyang University Hospital
Advanced Solid Cancers
A Clinical Trial to Test if the Investigational Drug BNT329 is Safe and Potentially Beneficial for People With Advanced Solid Tumors Known to Express the Tumor Marker CA19-9
The main goal of this study is to evaluate the safety of BNT329 and to identify the best dose of BNT329. This will be done by measuring the number of side effects that participants experience and how severe they are.
- Trial name
- NCT07186842
- Testing
- BNT329, CA19-9-targeting monoclonal antibody
- Where
- 18 sites in United States, Australia and 3 more
- Volunteers
- 245 people
- Sponsor
- BioNTech SE
Biliary Tract Cancer
Phase II Study of Refametinib, a MEK Inhibitor, as Second-line Treatment in Advanced Biliary Tract Adenocarcinoma
Phase II Study of Refametinib, a MEK inhibitor, as second-line treatment in advanced biliary tract adenocarcinoma
- Trial name
- NCT02346032
- Testing
- refametinib
- Volunteers
- 4 people
- Sponsor
- Samsung Medical Center
Biliary Tract Cancer
Circulating Tumor DNA Guided Adjuvant Chemotherapy for Biliary Tract Carcinoma
In recent years, circulating tumor DNA (ctDNA)had achieved encouraging results in monitoring recurrence and metastasis after surgery, and has potential clinical application value.
- Trial name
- NCT06171321
- Testing
- S-1(Intravenous combined with oral)
- Where
- China
- Volunteers
- 94 people
- Sponsor
- Shanghai East Hospital
Biliary Obstruction, Bile Duct Stones
Comparison Between Winged Versus Traditional Plastic Stents for Biliary Drainage
This study was randomized, controlled, blinded trial with a two-arm parallel-group design to directly compare the therapeutic outcomes of winged versus conventional stents in patients with benign or malignant biliopancreatic…
- Conditions
- Biliary Obstruction, Bile Duct Stones, Biliary Tract Cancer
- Trial name
- NCT06960733
- Testing
- Winged plastic stent, Standard plastic stents
- Where
- Germany
- Volunteers
- 21 people
- Sponsor
- University of Leipzig
HER2-positive Colorectal Cancer, HER2-positive Biliary Tract Cancer
KN026 Plus Chemotherapy ± KN-046 in HER2 Positive Colorectal Cancer and Biliary Carcinoma
The goal of this Interventional clinical trial is to learn about the efficacy and safety of KN026 and chemotherapy ± KN046 in HER2-positive metastatic colorectal cancer and biliary tract cancer.
- Trial name
- NCT05985707
- Testing
- KN026, KN046, XELOX
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking University Cancer Hospital & Institute
Advanced Solid Tumors With HER2 Abnormalities, Advanced Solid Tumors With HER3 Abnormalities
A Study of TAS0728 in Patients With Solid Tumors With HER2 or HER3 Abnormalities
This is a First-in-Human (FIH), 2-part, Phase 1/2, open-label, multicenter study design to evaluate the safety, tolerability, PK, pharmacodynamics, PGx, and efficacy of TAS0728.
- Trial name
- NCT03410927
- Testing
- TAS0728
- Where
- 8 sites in United States, France and 2 more
- Volunteers
- 19 people
- Sponsor
- Taiho Oncology, Inc.
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