Clinical trials: Biliary Tract Cancer
Advanced Biliary Tract Cancer
Cadonilimab Plus Regorafenib and Gem-Cis Chemotherapy in Advanced Biliary Tract Cancer
To evaluate the efficacy and safety of Cadonilimab in combination with Regorafenib and Gem-Cis chemotherapy in advanced biliary tract Cancer
- Trial name
- NCT05820906
- Testing
- Cadonilimab+Regorafenib+GC
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Biliary Tract Cancer
Covered Versus Uncovered Biliary Stents for Biliary Malignancies
Patency duration of covered metal stents as compared with uncovered metal stents in the management of malignant strictures of the extra-hepatic biliary tree.
- Trial name
- NCT02102984
- Testing
- covered biliary stents, uncovered biliary stents
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Nuovo Ospedale Civile S.Agostino Estense
Biliary Tract Cancer (BTC)
Yueju Pill Combined With Standard Therapy In Advanced Biliary Tract Cancer
This study is a multicenter, randomized, double-blind, placebo-controlled clinical trial designed to evaluate the impact of Yueju Pill on quality of life and treatment efficacy in patients with advanced biliary tract cancer (BTC)…
- Trial name
- YJ-BTC (NCT07169916)
- Testing
- Yueju Pill + Standard Anti-tumor Therapy
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Fudan University
Gastric Cancer, Gastroesophageal Junction Cancer
AZD0901 in Participants With Advanced Solid Tumours Expressing Claudin18.2
The purpose of this study is to assess the safety, tolerability, efficacy, pharmacokinetics (PK), and immunogenicity of AZD0901 as monotherapy and in combination with anti-cancer agents in participants with locally advanced…
- Conditions
- Gastric Cancer, Gastroesophageal Junction Cancer, Biliary Tract Cancer, Pancreatic Ductal Adenocarcinoma
- Trial name
- NCT06219941
- Testing
- AZD0901, 5-Fluorouracil, Leucovorin
- Where
- 52 sites in United States, Australia and 12 more
- Volunteers
- 226 people
- Sponsor
- AstraZeneca
Hepatic Neoplasms, Biliary Tract Neoplasms
Clinical Outcomes of Preoperative and Postoperative Rehabilitation in the Patients With HBP Malignancy
Clinical Outcomes of Preoperative and Postoperative Rehabilitation in the Patients With HBP Malignancy.
- Conditions
- Hepatic Neoplasms, Biliary Tract Neoplasms, Pancreatic Neoplasms
- Trial name
- PReHeBP (NCT02784353)
- Testing
- Perioperative rehabilitation program, Conventional
- Where
- South Korea
- Volunteers
- 158 people
- Sponsor
- Asan Medical Center
Cholelithiases, Appendicitis
Effect of Intravenous Lignocaine Infusion on Intraoperative End Tidal Desflurane Concentration Requirements
Lignocaine is a local anaesthetic that is widely used in all medical and surgical fields. Many clinical studies have shown that intravenous (IV) lignocaine given in the perioperative period was safe, reduced airway complications…
- Conditions
- Cholelithiases, Appendicitis, Ovarian Cysts
- Trial name
- NCT06064331
- Testing
- Lignocaine
- Where
- Malaysia
- Volunteers
- 48 people
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Biliary Tract Cancer, Cholangiocarcinoma
Neoadjuvant Bintrafusp Alfa in Patients With Resectable Biliary Tract Cancer
The NEOBIL study aims to investigate the feasibility, safety and efficacy of neoadjuvant Bintrafusp alfa in patients with resectable biliary tract cancer.
- Trial name
- NEOBIL (NCT04727541)
- Testing
- Bintrafusp alfa
- Where
- 2 sites in Germany
- Volunteers
- 3 people
- Sponsor
- AIO-Studien-gGmbH
Gallbladder Cancer
AK112 Combined With GAP Conversion Therapy for Locally Advanced Gallbladder Cancer
The goal of this clinical trial is to evaluate the efficacy and safety of AK112 combined with the GAP regimen as conversion therapy for patients with locally advanced gallbladder cancer who are initially considered unsuitable for…
- Trial name
- ICORE-GBC (NCT07767994)
- Testing
- AK112, Gemcitabine, Cisplatin
- Volunteers
- 22 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Common Bile Duct Diseases, Common Bile Duct Calculi
Effects of Dexamethasone on Common Bile Duct Cannulation Time
The main aim of this clinical trial is to evaluate the effects of dexamethasone on common bile duct cannulation time during endoscopic retrograde cholangiopancreatography (ERCP) in patients with biliary pathologies.
- Conditions
- Common Bile Duct Diseases, Common Bile Duct Calculi, Common Bile Duct Stricture, Common Bile Duct Neoplasms
- Trial name
- NCT05945797
- Testing
- Dexamethasone 4mg
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- Gujranwala medical college District Headquarters Hospital, Gujranwala
Pancreatic Neoplasms, Stomach Neoplasms
PET Imaging of Solid Tumors by a Novel Tracer, 68Ga-FAPI
Cancers of the pancreas, bile ducts, stomach and ovaries are dismal diseases with most patients being diagnosed in advanced stages leading to a bad prognosis.
- Conditions
- Pancreatic Neoplasms, Stomach Neoplasms, Bile Duct Neoplasms, Epithelial Ovarian Cancer
- Trial name
- NCT05172310
- Testing
- 68Ga-FAPI-46, PET/CT
- Where
- Sweden
- Volunteers
- 410 people
- Sponsor
- Karolinska University Hospital
Metastatic Breast Carcinoma, Locally Advanced Breast Cancer
Repeatability of 68-GaNOTA-Anti-HER2 VHH1 PET/CT in Breast Carcinoma Patients
Study objective: Cohort 1: To quantify the uptake of 68GaNOTA-Anti-HER2 VHH1 in local or distant metastases from breast carcinoma patients and to assess repeatability of the image-based HER2 quantification.
- Conditions
- Metastatic Breast Carcinoma, Locally Advanced Breast Cancer, Cancer of Pancreas, Solid Tumor With Intermediate or High HER2 Expression
- Trial name
- VUBAR (NCT03924466)
- Testing
- 68GaNOTA-Anti-HER2 VHH1
- Where
- Belgium
- Volunteers
- 55 people
- Sponsor
- Universitair Ziekenhuis Brussel
Metastatic Biliary Tract Cancer, Locally Advanced Biliary Tract Cancer
Randomized Trial of Gemcitabine/Cisplatin Versus S-1/Cisplatin in Advanced Biliary Cancer
The purpose of this study is to compare the efficacy between gemcitabine/cisplatin and S-1/cisplatin in the first-line treatment in advanced biliary tract cancer.
- Trial name
- NCT01096745
- Testing
- Gemcitabine, Cisplatin, S-1, Cisplatin
- Where
- South Korea
- Volunteers
- 78 people
- Sponsor
- Gyeongsang National University Hospital
Biliary Cancer, Bile Duct Cancer
A Study of CDX-1140, a CD40 Agonist, in Combination With Capecitabine and Oxaliplatin (CAPOX) and Keytruda in Subjects With Biliary Tract Carcinoma (BTC)
Background: Biliary tract carcinoma (BTC) is cancer of the slender tubes that carry fluids in the liver. People with advanced BTC have few treatment options, and their survival rates are very low.
- Conditions
- Biliary Cancer, Bile Duct Cancer, Cancer of the Bile Duct
- Trial name
- NCT05849480
- Testing
- oxaliplatin, capecitabine, Keytruda
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Cancer Institute (NCI)
Biliary Tract Tumors
QL1706 Combined With Lenvatinib and GEMOX as First - Line Treatment for Unresectable Biliary Tract Tumors
QL1706 Combined with Lenvatinib and GEMOX as First - Line Treatment for Unresectable Biliary Tract Tumors：A Single - Arm, Open - Label, Multi - Center, Prospective Phase II Clinical Trial (Spring Study)
- Trial name
- Spring (NCT06892925)
- Testing
- QL1706
- Where
- China
- Volunteers
- 59 people
- Sponsor
- Eastern Hepatobiliary Surgery Hospital
Biliary Tract Cancer
A Study of TQB2102 for Injection in the Treatment of HER2-positive Biliary Tract Cancer
To evaluate the efficacy and safety TQB2102 for injection in the treatment of patients with Her2-positive biliary tract cancer.
- Trial name
- NCT06431490
- Testing
- TQB2102 for injection
- Where
- 43 sites in China
- Volunteers
- 102 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd.
Biliary Tract Cancer
Ivonescimab in Combination With Liposomal Irinotecan and 5-FU/LV in Potentially Resectable Biliary Tract Malignancies
This Phase II, single-arm, single-center study evaluates the conversion to resectability and safety of Ivonescimab combined with liposomal irinotecan and 5-FU/LV in patients with potentially resectable biliary tract malignancies.
- Trial name
- NCT06993025
- Testing
- Ivonescimab+chemotherapy
- Where
- 2 sites in China
- Volunteers
- 30 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Advanced Solid Tumor, Advanced Malignant Neoplasm
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
The Phase 2 monotherapy portion of this study is currently enrolling and will evaluate the efficacy and safety of PC14586 (INN rezatapopt) in participants with locally advanced or metastatic solid tumors harboring a TP53 Y220C…
- Conditions
- Advanced Solid Tumor, Advanced Malignant Neoplasm, Metastatic Cancer, Metastatic Solid Tumor
- Trial name
- NCT04585750
- Testing
- rezatapopt, pembrolizumab
- Where
- 76 sites in United States, Australia and 7 more
- Volunteers
- 300 people
- Sponsor
- PMV Pharmaceuticals, Inc
Cancer, Neoplasms
Phase I/II Clinical Study to Evaluate VB15010 Tablets in Patients With Advanced Solid Tumors
This research is designed to determine if experimental treatment with PARP1 inhibitor, VB15010 is safe, tolerable, and has anti-cancer activity in patients with advanced solid tumors.
- Conditions
- Cancer, Neoplasms, Neoplasms, Breast, Tumor
- Trial name
- NCT06819215
- Testing
- VB15010
- Where
- China
- Volunteers
- 188 people
- Sponsor
- Zhejiang Yangli Pharmaceutical Technology Co., Ltd.
Cholangiocarcinoma, Cancer of the Head of the Pancreas
Pancreatico-biliary Tumor Mutation Profiling in Bile Samples
The differential diagnosis between benign and malignant bile duct strictures is a difficult and demanding task for clinicians. Clinical, biochemical, and radiological characteristics of malignant biliary strictures are…
- Trial name
- ONCOBIL (NCT02893085)
- Testing
- bile sample analysis, biochemical markers, VEGF and MMPs, in bile samples
- Where
- France
- Volunteers
- 100 people
- Sponsor
- CHU de Reims
Stage II Gallbladder Cancer, Stage IIIA Gallbladder Cancer
Triapine and Gemcitabine Hydrochloride in Gallbladder Cancer
This phase II trial is studying how well giving 3-AP together with gemcitabine works in treating patients with unresectable or metastatic bile duct or gallbladder cancer.
- Conditions
- Stage II Gallbladder Cancer, Stage IIIA Gallbladder Cancer, Stage IIIB Gallbladder Cancer, Stage IVA Gallbladder Cancer
- Trial name
- NCT00075504
- Testing
- triapine, gemcitabine
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)