Clinical trials: Biliary Tract Diseases
Primary Biliary Cholangitis
A Study of Elafibranor in Adult Japanese Participants With Primary Biliary Cholangitis (PBC)
The purpose of this study is to find out about the safety and how well the study intervention (elafibranor) works in participants with PBC.
- Trial name
- ELONSEN (NCT06730061)
- Testing
- Elafibranor
- Where
- 16 sites in Japan
- Volunteers
- 18 people
- Sponsor
- Ipsen
Cholecystitis, Gallstones
Fluorescence Cholangiography During Cholecystectomy - a RCT
The primary objective is to compare the success rates of intraoperative fluorescent cholangiography using indocyanine green versus conventional X-ray cholangiography for the identification of bile duct anatomy during laparoscopic…
- Trial name
- NCT02344654
- Testing
- Indocyanine green, Near-infrared illumination, Urografin
- Volunteers
- 120 people
- Sponsor
- Hvidovre University Hospital
Common Bile Duct Stone
Treatment of Common Bile Duct Stones
ABSTRACT Introduction: Common bile duct (CBD) stone is a common clinical situation, especially in Asia area. Laparotomy and laparoscopic surgical procedure are often used for treatment.
- Trial name
- NCT03442205
- Testing
- LC + LCBDE + ENBD + primary closure of CBD, ERCP technique + LC, LC + LCBDE + primary closure of CBD
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Tongji Hospital
Pancreatic Cancer, Common Bile Duct Diseases
A Prospective Study on the Safety and Efficacy of Robot-assisted Pancreaticoduodenectomy
Further studies are needed to investigate the prognosis and perioperative safety of patients undergoing robotic-assisted pancreaticoduodenectomy.
- Conditions
- Pancreatic Cancer, Common Bile Duct Diseases, Periampullary Carcinoma
- Trial name
- NCT05755594
- Testing
- Robot-assisted Pancreaticoduodenectomy
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital of University of South China
Calculus Biliary
Management for Concomitant Gallstones and Common Bile Duct Stones.
Choledocholithiasis is identified in approximately 3-10 % of patients with cholelithiasis. (1-3) While laparoscopic cholecystectomy (LC) is considered the treatment of choice in patients with gall bladder stones, there is a…
- Trial name
- NCT04758923
- Testing
- Cholecystectomy
- Volunteers
- 64 people
- Sponsor
- Assiut University
Advanced or Metastatic Biliary Tract Cancer, Advanced or Metastatic Solid Tumors
A Study of Varlitinib in Japanese Subjects With Advanced or Metastatic Solid Tumours
The purpose of this study is to explore safety and efficacy of varlitinib administered as monotherapy in Japanese subjects with advanced or metastatic solid tumors, and administered as combination with capecitabine in Japanese…
- Trial name
- NCT03082053
- Testing
- varlitinib, capecitabine
- Where
- Japan
- Volunteers
- 24 people
- Sponsor
- ASLAN Pharmaceuticals
Cerebral Hypoperfusion, Cerebral Occlusion
Evaluation of Cerebral Blood Flow and Cerebral Oxygenation With Transcranial Doppler and NIRS in Laparoscopic Cholecystectomy Cases
The goal of this clinical trial is to test intracranial blood flow and cerebral oxygenisation changes in patients who have pneumoperitoneum in laparoscopic cholecystectomy procedure.
- Conditions
- Cerebral Hypoperfusion, Cerebral Occlusion, Cholecystitis; Gallstone, Cholecystitis/Cholelithiasis
- Trial name
- NIRS L/C (NCT06036498)
- Testing
- Near Infrared Spectrophotometry Device, Transcranial Doppler Ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Uludag University
Gallstones, Gallbladder Cholesterolosis
Gallbladder Cholesterolosis, Body Mass Index and Serum Cholesterol and Triglycerides
Cholesterolosis is a common finding in biopsy specimens of gallbladders surgically removed for cholelithiasis. To the best of the investigators knowledge no study has analyzed the relationships of Body Mass Index, serum…
- Trial name
- NCT00528632
- Testing
- Specimen biopsy and serum laboratory tests
- Where
- Chile
- Volunteers
- 406 people
- Sponsor
- Cirujanos la Serena
Primary Biliary Cirrhosis
PBC Induced Fatigue Treated With Thiamine
Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease characterised by destruction of the intrahepatic bile ducts leading to liver inflammation and fibrosis, and ultimately liver cirrhosis and end-stage liver…
- Trial name
- PIFT (NCT04893993)
- Testing
- Thiamine
- Where
- Denmark
- Volunteers
- 36 people
- Sponsor
- Henning Grønbæk
Autoimmune Hepatitis, Primary Sclerosing Cholangitis
A-LiNK: Improving Outcomes in Autoimmune Liver Disease
The Autoimmune Liver disease Network for Kids (A-LiNK) is a multi-institutional group with the mission to deliver the best care to kids with pediatric autoimmune liver disease (AILD).
- Trial name
- ALINK (NCT05750498)
- Testing
- No interventions
- Where
- 8 sites in United States
- Volunteers
- 800 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Biliary Tract Neoplasms, Pancreatic Carcinoma
A Prospective Study of UCAD for Diagnosing Benign or Malignant Biliary Obstruction and Follow-up
Chromosomal instability (CIN) refers to ongoing chromosome segregation errors throughout consecutive cell divisions. CIN is a hallmark of human cancer, and it is associated with poor prognosis, metastasis, and therapeutic…
- Conditions
- Biliary Tract Neoplasms, Pancreatic Carcinoma, Gallbladder Cancer, Pancreatic Head Carcinoma
- Trial name
- NCT05237193
- Testing
- The level of CIN
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Inflammatory Bowel Diseases
Gallstones and Risk of Inflammatory Bowel Disease
The purpose of this study was to evaluate the association between gallstone disease and the risk of inflammatory bowel disease.
- Trial name
- NCT05882006
- Testing
- gallstones
- Where
- 4 sites in China
- Volunteers
- 5,035 people
- Sponsor
- Hepatopancreatobiliary Surgery Institute of Gansu Province
Primary Sclerosing Cholangitis (PSC)
Open Label Study to Evaluate Safety and Efficacy of LUM001 in Patients With Primary Sclerosing Cholangitis
The study is an open-label study in adults with primary sclerosing cholangitis to evaluate the safety, tolerability, and effect of 14-weeks of daily dosing of LUM001.
- Trial name
- CAMEO (NCT02061540)
- Testing
- LUM001
- Where
- 9 sites in United States, Canada and 1 more
- Volunteers
- 27 people
- Sponsor
- Mirum Pharmaceuticals, Inc.
Acute Pancreatitis Due to Gallstones
Ursodeoxycolic Acid for the Prevention of Relapsing Complications After Gallstone Acute Pancreatitis
Acute pancreatitis is a common disease (3rd cause of hospital admission for digestive causes), which is associated with significant patient suffering, a 2-4% probability of death and considerable healthcare costs.
- Trial name
- OSOPOLAR (NCT04924868)
- Testing
- Ursodeoxycholic Acid
- Where
- 18 sites in Spain
- Volunteers
- 332 people
- Sponsor
- Hospital General Universitario de Alicante
Bile Duct Carcinoma, Gall Bladder Cancer
Sequential Anti-Angiogenic Therapy After Immunotherapy in Advanced Biliary Tract Cancer
Brief Summary: This study is for patients with advanced biliary tract cancer (cancer of the bile ducts or gallbladder). The purpose is to find out if using anti-blood vessel formation drugs after immunotherapy treatment can help…
- Conditions
- Bile Duct Carcinoma, Gall Bladder Cancer, Biliary Tract Cancer, Cholangiocarcinoma
- Trial name
- SAIB (NCT07025174)
- Testing
- PD-1/CTLA-4 Dual Functional Antibody, Gemcitabine, Cisplatin, Anlotinib
- Where
- China
- Volunteers
- 60 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Malignant Neoplasm Other Gallbladder/Extrahepatic Bile Duct
Clinical Trial of Adjuvant Chemotherapy Followed by Concurrent Chemoradiotherapy Compared With Adjuvant Chemotherapy Alone in Patients With Gallbladder Carcinoma and Extrahepatic Cholangiocarcinoma
The present study is designed to determine whether adjuvant concurrent chemoradiotherapy improves overall survivals.
- Trial name
- NCT02798510
- Testing
- Concurrent Chemoradiotherapy, capecitabine, gemcitabine
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Fudan University
Biliary Tract Diseases, Pancreatic Diseases
A Register on the Quality of ERCP and Training of Endoscopists in Italy
This is a prospective observational longitudinal study Aim of the study is to collect information: on the organization models of the Endoscopic Units performing ERCP in Italy on the previous and/or ongoing training of the…
- Trial name
- REQUEST (NCT02971579)
- Testing
- ERCP
- Where
- Italy
- Volunteers
- 1,800 people
- Sponsor
- ASST Rhodense
Primary Biliary Cirrhosis
Fuzhenghuayu in Combination With Ursodeoxycholic Acid in Primary Biliary Cirrhosis
Ursodeoxycholic acid (UDCA) has been the only treatment for PBC approved by US and European drug administrations. Long-term use of UDCA (13-15 mg/kg/day) in patients with PBC improves serum liver biochemistries and survival free…
- Trial name
- NCT02916290
- Testing
- Fuzhenghuayu, UDCA
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Biliary Tract Cancer
A Population-Based Case-Control Study of Biliary Tract Cancers in Shanghai, China
The key aims of this study include estimation of possible risk associated with a history of gallstones, bacterial infection for the biliary tract, other medical history, diet, use of tobacco and alcohol, obesity, reproductive…
- Trial name
- NCT00339560
- Where
- China
- Volunteers
- 2,624 people
- Sponsor
- National Cancer Institute (NCI)
Extrahepatic Cholangiocarcinoma and Gallbladder Carcinoma
Efficacy and Safety of Postoperative Concurrent Chemoradiotherapy for Extrahepatic Cholangiocarcinoma and Gallbladder Carcinoma: A Multicenter Prospective Phase II Study
This is a multicenter, open-label, single-arm, prospective Phase II clinical trial. The study enrolls patients with extrahepatic cholangiocarcinoma or gallbladder carcinoma who have undergone curative resection and harbor…
- Trial name
- NCT07636824
- Testing
- Postoperative radiotherapy, Capecitabine or S-1
- Where
- China
- Volunteers
- 92 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences