Clinical trials: Bioavailability
Healthy
Bioavailability of Ibuprofen Enantiomers Compared With Standard Brufen Sirup in Healthy Male Volunteers
Pharmacokinetics (relative bioavailability), safety and tolerability
- Trial name
- NCT02182960
- Testing
- Ibuprofen syrup, Brufen syrup
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Healthy Participants
A Study to Investigate the Relative Bioavailability of 2 Different Formulations of AZD4144, the Effect of Food and Omeprazole on the Pharmacokinetics of AZD4144 in Healthy Participants
The main aim of this study to compare the pharmacokinetics (PK) of two formulations of AZD4144 and assess the effect of food and omeprazole on PK of AZD4144 in healthy participants.
- Trial name
- NCT06948006
- Testing
- AZD4144, Omeprazole
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Nausea
Bioavailability Study of Anti Nausea Medication With and Without Food
This study is to assess the effect of food on a single dose of EUR-1025 when taken with a meal and taken on an empty stomach.
- Trial name
- EUR-1025 (NCT00905190)
- Testing
- Ondansetron
- Where
- Canada
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Forest Laboratories
Healthy
Oral Bioavailability of Bilastine
The purpose of this study is to assess the absolute bioavailability of an oral bilastine formulation (test drug) compared to the endovenous administration of an IV bilastine formulation (control drug) in healthy volunteers.
- Trial name
- BIOBI (NCT01124123)
- Testing
- Bilastine
- Where
- Spain
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Faes Farma, S.A.
Advanced Cancer
A Mass Balance Study of [14C]-Nanatinostat and Relative Bioavailability Study of Nanatinostat in Patients With Advanced Cancers
This study will determine how nanatinostat is absorbed, modified, and removed from the body (Part A), the amount of nanatinostat that becomes available to the body (Part B), and will evaluate the safety and tolerability of…
- Trial name
- NCT06302140
- Testing
- [14C]-Nanatinostat, Nanatinostat (free base) tablets in combination with Valganciclovir, Nanatinostat mesylate tablets in combination with Valganciclovir
- Where
- Spain
- Volunteers
- 8 people
- Sponsor
- Viracta Therapeutics, Inc.
Healthy Volunteers
A Study to Compare Eutropin Formulations in Healthy Volunteers for Bioavailability, Safety, and Tolerability
A randomized, Open Label, Single Subcutaneous Dose, 2x2 Crossover Study to Investigate the Relative Bioavailability, Safety and Tolerability among Different Eutropin Formulations in Healthy Volunteers
- Trial name
- NCT06743997
- Testing
- Test Drug (Eutropin Catridge, 48IU/Cartridge), Reference Drug (Eutropin, 4 IU/vial)
- Where
- South Korea
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- LG Chem
Healthy
Food Study of Nitrofurantoin Macrocrystals 100 mg Capsules and Macrodantin® 100 mg
The objective of this study was to evaluate the relative bioavailability of Mylan's nitrofurantoin macrocrystals 100 mg capsules to Procter \& Gamble's Macrodantin® 100 mg capsules following a single, oral 100 mg (1 x 100 mg)…
- Trial name
- NCT00649506
- Testing
- Nitrofurantoin Macrocrystals 100 mg Capsules, Macrodantin® 100 mg Capsules
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Mylan Pharmaceuticals Inc
Healthy Volunteers
Pharmacokinetics Of Celecoxib Test Formulations
The pharmacokinetics of new formulations of celecoxib are being evaluated. They are expected to provide more favorable bioavailability characteristics than the present commercial formulation.
- Trial name
- NCT00925106
- Testing
- Celebrex capsule, Test formulation D1, Test formulation D2
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Hereditary Angioedema
A Relative Bioavailability Study of Two Formulations of BCX7353
This is an open-label, randomized study to investigate the relative bioavailability of two formulations of BCX7353 and to determine if there is a food effect
- Trial name
- NCT03202784
- Testing
- BCX7353
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- BioCryst Pharmaceuticals
Healthy
A Study of LY900020 in Healthy Chinese Participants
This study will evaluate three new formulations of LY900020; a fixed dose, combination drug developed for people with type 2 diabetes mellitus.
- Trial name
- NCT04047940
- Testing
- LY900020, Metformin XR, Atorvastatin
- Where
- Singapore
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Healthy
Influence of a Standardised High Fat Breakfast on the Bioavailability of BI 14332 CL in Healthy Male Volunteers
To investigate the relative bioavailability of BI 14332 CL vs. BI 14332 CL after intake of a standardised high fat breakfast
- Trial name
- NCT02212938
- Testing
- BI 14332 CL, high fat breakfast
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Healthy
Pharmacokinetics/Bioavailability of BIBF 1120 Administered to Healthy Male Volunteers
Study to assess pharmacokinetics and the extend of absorption of a single dose of BIBF 1120 soft gelatine capsule with food effect (BA) in healthy subjects respectively.
- Trial name
- NCT02182076
- Testing
- BIBF 1120
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Male & Female Healthy Volunteers
Bioavailability Study of COQUN ORAL FORMULATION
The goal of the study is to evaluate the best dosage for COQUN ORAL FORMULATION in order to reach a level of plasma concentration which might assure its antioxidant effect if taken on a regular basis.
- Trial name
- NCT03819491
- Testing
- COQUN ORAL FORMULATION
- Where
- Romania
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- VISUfarma SpA
Clinical Trials, Phase I as Topic
BAY 1902607: Single Dose Escalation, Safety and Tolerability, Pharmacokinetics, Bioavailability, Food Effect
This study is a first-in-man study that will investigate the safety, tolerability and pharmacokinetics of ascending single doses of BAY1902607 using a placebo controlled, randomized, single center design.
- Trial name
- NCT03212586
- Testing
- BAY1902607
- Where
- Germany
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Bayer
Bioavailability
Enhanced Absorption of curQ+ or Liposomal Curcumin Formulations Versus 95% Curcumin Powder in Healthy Subjects
This study is intended to evaluate how significantly a proprietary curcumin formulation (curQ+® or liposomal curcumin) results in greater GI absorption compared to 95% curcumin extract over a 6-hour time period following a single…
- Trial name
- NCT06177483
- Testing
- 95% curcumin extract powder, curQ+ curcumin formulation, liposomal curcumin formulation
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- ESM Technologies, LLC
Healthy
A Study to Assess the Relative Bioavailability of 7 Test Tablet Formulations of JNJ-56021927 With Respect to the Capsule Formulation of JNJ-56021927 in Healthy Male Participants
The purpose of this study is to evaluate the pharmacokinetics (what the body does to the medication) and relative bioavailability (the extent to which a medication or other substance becomes available to the body) of JNJ-56021927…
- Trial name
- NCT02031666
- Testing
- JNJ-56021927 capsule, JNJ-56021927 tablet
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Aragon Pharmaceuticals, Inc.
Type 2 Diabetes
Study to Compare the Bioavailability of Extended Release Metformin HCl Tablet Versus Glucophage XR® Tablets in Healthy Human Volunteers Under Fasting Condition
Objective: To compare the bioavailability of Extended Release Metformin HCl Tablet(Test formulation, Torrent Pharmaceuticals Ltd.,India) versus Glucophage XR® Tablets ( Reference formulation, Bristol-Myers Squibb Company, USA) in…
- Trial name
- NCT01089166
- Testing
- Metformin
- Where
- India
- Sponsor
- Torrent Pharmaceuticals Limited
Healthy
A Clinical Trial of Multiple Formulations of MK-4082 in Healthy Overweight and Obese Participants (MK-4082-007)
Researchers are looking for new weight loss medicines for people with higher body weight. The study medicine, MK-4082, is different from similar weight loss medicines because people take it as a pill instead of an injection.
- Trial name
- NCT07748351
- Testing
- MK-4082 Formulation 1 (F1), MK-4082 Formulation 2 (F2), MK-4082 Formulation 4 (F4)
- Where
- 2 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Healthy Volunteer
Relative Bioavailability and Drug-drug Interaction Study With MT-7117 and a Proton Pump Inhibitor
An open label, multicentre, randomised, 2-cohort, sequential and crossover study to assess the relative oral bioavailability of MT-7117 higher content tablets versus MT-7117 lower content tablets and the pharmacokinetics of…
- Trial name
- MT-7117 BA DDI (NCT03688022)
- Testing
- MT-7117, PPI, Acidic beverage
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tanabe Pharma America, Inc.
Healthy
A Study in Healthy People to Compare 2 Different Formulations of Nerandomilast Tablets When Taken With or Without Food
The main objective of this trial is to investigate two different formulations of nerandomilast and the effect of food on the pharmacokinetics of the new formulation following oral administration.
- Trial name
- NCT06624072
- Testing
- Nerandomilast 18 mg - adult formulation, Nerandomilast 1 mg - paediatric formulation
- Where
- Germany
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim