Clinical trials: Bioavailability
Bioavailability
Relative Bioavailability Study of PF-07321332/Ritonavir Oral Powder Relative to the Commercial Tablets in Healthy Participants
The purpose of this study is to estimate the relative bioavailability of PF-07321332/ritonavir oral powder relative to the commercial tablet formulation under fasted condition in healthy adult participants.
- Trial name
- NCT05263921
- Testing
- PF-07321332/ritonavir
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Bioavailability
An Relative Bioavailability Study of BH006 for Injection in Healthy Subjects
The study is an open label, randomized, balanced, two period, two sequence, crossover, single dose, relative bioavailability study in healthy subjects.Each subject, meeting all the inclusion criteria and none of the exclusion…
- Trial name
- NCT06427681
- Testing
- BH006 for injection, Fosaprepitant for injection+Palonosetron hydrochloride injection
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Zhuhai Beihai Biotech Co., Ltd
Bioavailability
Blood Bioavailability of Two Different Doses of a β-alanine Supplement (BIo-β)
The purpose of this study is to To study the blood bioavailability of a sustained-release β-alanine granulated supplement of two different doses (10 g and 20 g).
- Trial name
- Bio-β (NCT06214338)
- Testing
- Low dose, High dose
- Where
- Spain
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Bioavailability
Bioavailability of Single-dose Magnesium Salts
Magnesium plays a role in an array of critical body functions, controls normal adenosine triphosphate function, the metabolism of glucose, and cardiac muscle function, as well as the maintenance of cell membrane function.
- Trial name
- NCT04139928
- Testing
- Picometer-ionic form of magnesium chloride, Magnesium citrate or magnesium oxide
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Think Healthy Group, Inc.
Bioavailability
A Stable Isotope Study to Evaluate the Bioavailability of an Oat Protein-based Iron Delivery System
In the current study, the OAT fibril - Fe SA (Fe-oat 1) and OAT fibril - Fe NaOH (Fe-oat 2) will both be studied in vivo, alone are oat fibril powder add iron supplement is soluble in water and oat fibril powder add iron…
- Trial name
- NCT05826899
- Testing
- 54Fe SO4, 57Fe Oat-1, 58Fe Oat-2
- Where
- Thailand
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- The Rainforest Company
Relative Bioavailability
Bioavailability of Tebipenem (SPR994) Crushed Tablet
The purpose of this study is to measure the amount of the antibiotic, tebipenem (SPR994) that is bioavailable after crushing the tablet and administering through a feeding tube with and without tube feeds.
- Trial name
- NCT05296382
- Testing
- Tebipenem tablet form, Tube feeds
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Bioavailability of Amino Acids Following Oral Ingestion of Plant-Based Proteins in Young, Healthy Men
Bioavailability of Plant Protein Amino Acids
This study aims to inform of the mechanism of action of plant-based protein by measuring the bioavailability (i.e. rate of appearance and magnitude of concentration in the circulation following oral ingestion) of key amino acid…
- Trial name
- NCT04872530
- Testing
- Pea-protein concentrate, Fava-bean protein concentrate, Chickpea protein concentrate
- Where
- Ireland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Limerick
Bioavailability
Relative Bioavailability and Effect of Food Study With an Oral Mini-tablet Formulation of Filgotinib in Healthy Subjects
Open label study to assess relative bioavailability of filgotinib oral mini-tablet versus oral tablet formulation and effect of food on the mini-tablet formulation.
- Trial name
- NCT06043739
- Testing
- Filgotinib
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Lakefront Biotherapeutics NV
Melatonin Bioavailability
Kinetic of Compounds of a Melatonin-based Formulation in Healthy Subjects
This study is conducted to clinically document the melatonin and zinc bioavailability of a dietary supplement containing delayed release melatonin, zinc and lemon balm
- Trial name
- NCT05419466
- Testing
- dietary supplement, 1 tablet containing delayed release melatonin, zinc and lemon balm
- Where
- France
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Larena SAS
Bioavailability, Metabolites
Bioavailability Study of Hemp Phenolics
The aim is to determine the bioavailability of the polyphenol fraction form a commercially available hemp hull fiber at two different amounts in generally healthy adults.
- Conditions
- Bioavailability, Metabolites, Excretion
- Trial name
- NCT06098001
- Testing
- Low dose dietary fiber, High dose dietary fiber
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Brightseed
Bioavailability of Vitamin D
Comparison of Bioavailability of Liposomal and Traditional Formulation of Vitamin D3
The aim of the study was to compare the profiles of 25-hydroxyvitamin D serum concentration in healthy adults after 4 weeks of using vitamin D supplementation either in a liposomal or a traditional formulation.
- Trial name
- NCT06010121
- Testing
- Liposomal Vitamin D, Traditional Vitamin D
- Where
- Poland
- Volunteers
- 27 people
- Sponsor
- AronPharma Sp. z o. o.
Bioavailability
Oral Bioavailability of Two Melatonin Supplements
Results from several clinical studies show that orally administered melatonin has low bioavailability and a very short half-life.
- Trial name
- MELFENIL (NCT05835258)
- Testing
- Melatonin with phenyl capsaicin, Melatonin without phenyl capsaicin
- Where
- Spain
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Fundació Eurecat
Pharmacokinetics, Bioavailability
Evaluating the Pharmacokinetic Parameters and Relative Bioavailability of Sorafenib (XS005) in Healthy Male Subjects
This is a single centre, open-label, randomised, single dose, 3-way crossover comparative (PK) and bioavailability study in healthy male subjects comparing a 200 mg Sorafenib (Nexavar®) reference tablet (Regimen A) to XS005…
- Trial name
- NCT05967377
- Testing
- Sorafenib - Period 1, XS005 Sorafenib Capsule A - Period 1, XS005 Sorafenib Tablet A - Period 1
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Xspray Pharma AB
Bioavailability
Bioavailability of Select Nutrients From Two Formulations of a Multivitamin/Mineral Supplement
The objective of this study is to assess the relative bioavailability of select nutrients from two formulations of a multivitamin/mineral supplement in healthy adults.
- Trial name
- NCT05646368
- Testing
- Formulation #1, Formulation #2
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Midwest Center for Metabolic and Cardiovascular Research
Bioavailability
Effect of Iron and Zinc Supplementation on B-carotene Bioavailability in Healthy Males
In vitro studies found supplemental levels of iron and zinc to inhibit the micellization and cellular uptake of β-carotene. Here, we investigated this in vivo, in a double-blind 3-arm crossover human trial.
- Trial name
- NCT05840848
- Testing
- Control beta-carotene supplement plus iron Supplement, Control beta-carotene supplement plus zinc Supplement
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Hohenheim
Bioavailability
Bioavailability of EPA + DHA in a SMEDS Formulation
This study will assess the relative bioavailability of 500 mg eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA) in a self-micro-emulsifying delivery system (SMEDS) formulation compared with a standard omega-3-acid ethyl…
- Trial name
- NCT03443076
- Testing
- EPA + DHA in SMEDS Formulation, Lovaza (active comparator; already FDA approved)
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Midwest Center for Metabolic and Cardiovascular Research
Bioavailability
Bioavailability Study to Compare Liquid vs Two Solid Formulations of IP2015
The study's primary objective is to determine the bioavailability of two solid formulations of IP2015 compared to a liquid formulation of IP2015 in healthy male subjects
- Trial name
- NCT05728671
- Testing
- IP2015
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Initiator Pharma
Sulforaphane Bioavailability
Broccoli Sulforaphane Bioavailability With Mustard
We know that broccoli is a vegetable that is associated with a number of health benefits and is a good choice in a healthy diet.
- Trial name
- NCT04946526
- Testing
- Broccoli seed extract, Broccoli seed extract with mustard seed powder
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Iodine Bioavailability
Impact of the Food Matrix on Iodine Bioavailability
This study is a randomized crossover trial, lasting 12 days in total, which will assess the difference in iodine bioavailability (as a percentage of iodine consumed that is excreted in urine) from three iodine-rich foods…
- Trial name
- NCT04867031
- Testing
- Milk, Fish, Seaweed
- Where
- United Kingdom
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Bioavailability of Coenzyme Q10
Comparative Single-dose Bioavailability Study of Different CoQ10 Formulations
The single-center, randomized, open-label, five-period crossover single-dose bioavailability study with five CoQ10 formulations
- Trial name
- NCT04780074
- Testing
- Single dose intervention with Standard product (SP), Single dose intervention with Investigational product (IP1), Single dose intervention with Investigational product (IP2)
- Where
- Slovenia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Institute of Nutrition, Slovenia (Nutris)