Clinical trials: Bioavailability, open to volunteers
Diet, Healthy
Investigating the Bioavailability of Broccoli Extract Supplements
The goal of this clinical trial is to compare how much glucoraphanin and sulforaphane from 3 different versions of broccoli extract supplements is absorbed into the body and excreted in urine.
- Trial name
- NCT07564674
- Testing
- Avmacol Extra Strength with coating - 1 tablet, Avmacol chewable wafer - 2 tablets, Avmacol Extra Strength with coating - 2 tablets
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Oregon State University
Immunosuppression
Tacrolimus C:D Ratio Measured in Renal Transplant Recipients Treated With Once-daily Prolonged-release Drugs
The goal of this clinical trial is to compare the bioavailability and practicability of two different formulations of tacrolimus in kidney transplant recipients.
- Trial name
- TaC:Drop (NCT06268769)
- Testing
- Tacrolimus Pill, Tacrolimus capsule
- Where
- 9 sites in Germany
- Volunteers
- 300 people
- Sponsor
- Edward Geissler
Obesity, Morbid
Bariatric Surgery and Pharmacokinetics of Valsartan
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines.
- Trial name
- NCT03535376
- Testing
- Valsartan
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Norwegian University of Science and Technology
Diabetes Mellitus
A Clinical Study Comparing the Relative Bioavailability and Safety of SHR-3167 Injection
This study is a randomized, parallel, open-label Phase I clinical trial aimed at comparing the bioavailability and safety of different specifications of SHR-3167 injection, with healthy subjects as the research subjects.
- Trial name
- NCT07489482
- Testing
- SHR-3167 Injection
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Obesity, Morbid
Bariatric Surgery and Pharmacokinetics of Candesartan
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines.
- Trial name
- NCT03460327
- Testing
- Candesartan
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Norwegian University of Science and Technology
Healthy Volunteers
A Study of Abemaciclib (LY2835219) in Healthy Participants
The main purpose of this study is to compare different forms of abemaciclib (LY2835219) to see how much and how quickly each gets into the bloodstream after it is swallowed, and to check for any side effects.
- Trial name
- NCT07818967
- Testing
- Abemaciclib Tablet (Test Formulation), Abemaciclib Tablet (Reference Formulation), Abemaciclib Oral Granules (Test Formulation)
- Where
- Singapore
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Diabetes Mellitus, Type 1
Bioavailability, Biopotency and Food Effect Study of SCD0503 Compared to Subcutaneous Regular Human Insulin
Reason for the study The participants have been diagnosed with type 1 diabetes and are being treated with standard insulin therapy.
- Trial name
- NCT07634770
- Testing
- oral insulin, subcutaneous insulin
- Where
- Germany
- Volunteers
- 16 people
- Sponsor
- Sam Chun Dang Pharm. Co. Ltd.
Healthy Volunteers
Dimotec (Diosmin) 1000 mg Film Coated Tablet Fed Study
This study aims to compare the bioavailability of Dimotec 1000 mg film-coated tablet (Test; Keri Pharma Hungary Kft.) with Detralex 1000 mg film-coated tablets (Reference; Les Laboratoires Servier Industrie, France) in healthy…
- Trial name
- Diosmin (NCT07674446)
- Testing
- Dimotec 1000 mg film-coated tablet, Detralex 1000 mg film-coated tablets
- Where
- India
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Keri Pharma Hungary Kft
Healthy Participants
A Study to Investigate the Relative Bioavailability and Safety of Different Oral Formulations of Elecoglipron in Healthy Participants
The purpose of this study is to measure the pharmacokinetics (PK-how the body processes the study drug) of elecoglipron in healthy participants when taken by mouth as different formulations.
- Trial name
- NCT07723833
- Testing
- Elecoglipron Reference Formulation Dose A, Elecoglipron Test formulation 1 Dose A, Elecoglipron Reference Formulation Dose B
- Where
- 2 sites in United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Glucosamine, Liposomal Encapsulation
Human Absorption Study of Liposomal Glucosamine Supplements
The objective of this study is to evaluate the effects of liposomal encapsulation using different ratios of gum arabic and lecithin on the bioavailability of a liquid glucosamine supplement in humans.
- Trial name
- NCT07843342
- Testing
- High-Emulsified Liposomal Glucosamine Liquid, Low-Emulsified Liposomal Glucosamine Liquid, Glucosamine Liquid without Liposomal
- Where
- Taiwan
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- TCI Co., Ltd.
Healthy Participants
A Study to Evaluate Different Oral Formulations of KT-621
This is a Phase I study to evaluate the relative bioavailability and safety and tolerability of different oral formulations of KT-621 in healthy adult participants.
- Trial name
- NCT07823205
- Testing
- KT-621
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Kymera Therapeutics, Inc.
Asthma With Eosinophilic Phenotype
A Study Comparing a Pre-filled Safety Syringe and an Autoinjector for SHR-1703 Injection in Healthy Participants
This is a single-center, randomized, parallel-group, open-label clinical study designed to compare the bioavailability and safety of SHR-1703 Injection administered subcutaneously using a pre-filled safety syringe (PFS) or a…
- Trial name
- NCT07701239
- Testing
- SHR-1703 Injection
- Where
- China
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Guangdong Hengrui Pharmaceutical Co., Ltd
Diabetes Mellitus
Open, Randomized Crossover Study on PK, PD, Biopotency, and Bioavailability of Insulin Capsules in Healthy Chinese Males
Pharmacokinetics and pharmacodynamics study of 2 formulations (human insulin enteric coated capsules 32mg vs. human insulin injection 5IU) Relative biopotency and bioavailability of human insulin enteric coated capsules 32mg vs.
- Trial name
- NCT06901726
- Testing
- Human insulin enteric coated capsules in dose 32mg, Human Insulin Injection in dose 5IU
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Obesity, Morbid
Bariatric Surgery and Pharmacokinetics of Gabapentin
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines.
- Trial name
- NCT03476538
- Testing
- Gabapentin
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Norwegian University of Science and Technology
Healthy Volunteer Male Subjects
A Comparative Bioavailability Study of Tamsulosin 0.4 mg Prolonged-release Tablets Versus the Reference Drug Omnic Ocas®, Tamsulosin Hydrochloride 0.4 mg, Prolonged-release Film-coated Tablets, in Healthy Adult Male Subjects, Under Fasting Conditions
The aim of this study is to evaluate the bioequivalence and safety of Tamsulosin hydrochloride 0.4 mg, prolonged-release tablets (Synthon Hispania SL, Spain), compared to Omnic Ocas®, Tamsulosin hydrochloride 0.4 mg…
- Trial name
- NCT07156916
- Testing
- Tamsulosin (0.4 mg/j)
- Where
- Armenia
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Berlin-Chemie AG Menarini Group
End Stage Kidney Disease (ESKD), Hemodialysis
Liberalizing Potassium Restrictions in Patients Receiving Hemodialysis
People with end-stage kidney disease who receive hemodialysis are often told to strictly limit foods high in potassium, such as fruits, vegetables, legumes, nuts, and whole grains.
- Conditions
- End Stage Kidney Disease (ESKD), Hemodialysis, Diet Intervention, Hyperkalemia
- Trial name
- LIBERATE-K HD (NCT07772856)
- Testing
- Liberalized Potassium Diet, Low Potassium Diet
- Where
- Canada
- Volunteers
- 148 people
- Sponsor
- University of Ontario Institute of Technology
Postsurgical Pain Management
A Study on TLC590 for Managing Postsurgical Pain
This Phase 2 open-label trial investigates the pharmacokinetics (PK), pharmacodynamics, and safety profile of TLC590 across various surgical procedures.
- Trial name
- NCT06574269
- Testing
- TLC590, Ropivacaine
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- TLC Biopharmaceuticals, Inc.
Healthy Adult Participants, Non-smoking, Healthy Adults
Pharmacokinetic Characterization of Tartaric Acid in Humans
The goal of this clinical trial is to characterize the pharmacokinetics (absorption, distribution, metabolism, and excretion; ADME) and oral bioavailability of tartaric acid in humans after its administration through different…
- Conditions
- Healthy Adult Participants, Non-smoking, Healthy Adults, Normal Weight Adults
- Trial name
- TARBIO (NCT07394101)
- Testing
- Wine, Grape, Juice
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Obesity & Overweight, Type 2 Diabetes
A Phase 1 Clinical Trial to Assess the Safety of DWRX5003 and Relative Bioavailability to DWC202502 and DWC202503 in Healthy Adult Volunteers
Phase 1 Safety and Relative Bioavailability Study of DWRX5003 in Healthy Adults
- Trial name
- NCT07539415
- Testing
- DWRX5003, DWC202502, DWC202503
- Where
- South Korea
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Obesity, Morbid
Bariatric Surgery and Pharmacokinetics of Metoprolol
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines.
- Trial name
- NCT03519906
- Testing
- Metoprolol
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Norwegian University of Science and Technology