Clinical trials: Bioavailability, open to volunteers
Malnutrition
Pancrelipase With Nutritional Supplement in Patients at Risk of Malnutrition (EFFORT-ENZO)
This study investigates if pancreatic enzymes in combination with oral nutritional supplement can improve nutrient bioavailability in older people with malnutrition or at risk of malnutrition.
- Trial name
- NCT06826105
- Testing
- Zenpep
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Philipp Schuetz
Healthy Adult Male and Female Volunteers
A Comparative Bioavailability Study of Two Torasemide 10 mg Tablets Formulations in Healthy Adult Participants Under Fasting Conditions:
The purpose of this study is to evaluate the bioavailability, safety and tolerability of Torasemide 10 mg tablets (Berlin-Chemie AG), compared to Unat® 10 tablets (Viatris Healthcare GmbH) in healthy adult participants under…
- Trial name
- NCT07201584
- Testing
- Torasemide tablet 10 mg, Unat® 10 tablets (Torasemide 10 mg)
- Where
- Kazakhstan
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Berlin-Chemie AG Menarini Group
Obesity, Morbid
Bariatric Surgery and Pharmacokinetics of Ibuprofen
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines.
- Trial name
- NCT03476577
- Testing
- Ibuprofen
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Norwegian University of Science and Technology
Iron Deficiencies, Low Ferritin
A Pilot Study to Evaluate the Ability of Lactoferrin to Modulate Iron Homeostasis and Exercise Performance in Exercising Females
This randomized, double-blind, active-controlled trial will evaluate the effects of human lactoferrin supplementation combined with low-dose iron on iron status, aerobic performance, and lactate metabolism in exercising women…
- Conditions
- Iron Deficiencies, Low Ferritin, Iron Deficiency, Exercise Performance of Fit Athletes
- Trial name
- EFF (NCT07546591)
- Testing
- Lactoferrin 100 mg, Lactoferrin 300 mg, Iron Supplementation (5 mg)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Lindenwood University
Obesity, Morbid
Bariatric Surgery and Pharmacokinetics of Lercanidipine
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines.
- Trial name
- NCT03497156
- Testing
- Lercanidipine
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Norwegian University of Science and Technology
Healthy Volunteers
Single and Multiple Dose Study to Evaluate Safety and Pharmacokinetics of BMS-986533 in Healthy Participants and Assessments of Food and pH Effects on Relative Bioavailability, and Drug-Drug Interaction Potential in Healthy Participants
The purpose of this study is to evaluate the safety and pharmacokinetics of BMS-986533 in healthy participants receiving single and multiple doses, to assess food and pH effects on the relative bioavailability of BMS-986533, and…
- Trial name
- NCT07629999
- Testing
- BMS-986533, Famotidine, Dabigatran Etexilate
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Obesity, Morbid
Bariatric Surgery and Pharmacokinetics of Hydrochlorothiazide
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines.
- Trial name
- NCT03476551
- Testing
- Hydrochlorothiazide
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Norwegian University of Science and Technology
Diabetes Mellitus
Open, Randomized Crossover Study on PK, PD, Biopotency, and Bioavailability of Insulin Capsules in Healthy Chinese Males
Pharmacokinetics and pharmacodynamics study of 2 formulations (human insulin enteric coated capsules 32mg vs. human insulin injection 5IU) Relative biopotency and bioavailability of human insulin enteric coated capsules 32mg vs.
- Trial name
- NCT06901726
- Testing
- Human insulin enteric coated capsules in dose 32mg, Human Insulin Injection in dose 5IU
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Metabolic Dysfunction-Associated Steatohepatitis
ECC4703 Food Effect and Relative Bioavailability Study in Healthy Adult Participants
This is a Phase I, open-label, randomized, single-dose, 2-part study designed to evaluate the food effect and relative bioavailability of ECC4703 in healthy adult participants.
- Trial name
- NCT07334080
- Testing
- ECC4703 F0 formulation, ECC4703 F1 formulation, ECC4703 F2 formulation
- Where
- Australia
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Eccogene
Bioavailability and Pharmacokinetics
To Assess Dose Proportionality and Pharmacokinetic Linearity of Saninova Tablets in Healthy Participants Under Fasting Conditions
An open-label, randomized, single dose study to assess dose proportionality and pharmacokinetic linearity in healthy participants under fasting condition.
- Trial name
- Saninova (NCT07664657)
- Testing
- Vitamin C, Vitamin B2, Astragalus Root dry extract etc
- Where
- India
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Sichuan Credit Pharmaceutical Co., Ltd.
Obesity, Gastric Reflux
The Bioavailability and Effect on Pouch pH of Esomeprazole After Gastric Bypass
The objective of this study is to investigate the effect of Esomeprazol administered in tablets (Esomeprazol MUT Sandoz® 40mg) or in solution (Esomeprazol MUT Sandoz® 40mg in 10ml tap water) on acid production in the gastric…
- Conditions
- Obesity, Gastric Reflux, Ulcer, Gastric
- Trial name
- NCT05320796
- Testing
- upper endoscopy
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Prof Urs Zingg
Healthy
A Relative Bioavailability and Bioequivalence Study of Varegacestat in Healthy Participants
This is an open-label, randomized, crossover study to evaluate the relative bioavailability (rBA) and bioequivalence (BE) of a test capsule formulation of varegacestat compared to reference capsules formulation under fasting…
- Trial name
- NCT07610005
- Testing
- Varegacestat Reference Formulation, Varegacestat Test Formulation A, Varegacestat Test Formulation B
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Immunome, Inc.
Obesity, Morbid
Bariatric Surgery and Pharmacokinetics of Ramipril
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines.
- Trial name
- NCT03440177
- Testing
- Ramipril
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Norwegian University of Science and Technology
Locally Advanced or Metastatic Solid Tumor
AZD5305 hADME in Patients With Advanced Solid Malignancies
This Phase I, open-label study aims to study to absolute bioavailability of Saruparib (AZD5305) and the absorption, distribution, metabolism and excretion (ADME) of [14C]-Saruparib in patients with advanced solid malignancies.
- Trial name
- AZD5305 (NCT06713369)
- Testing
- Saruparib (AZD5305), [14C]-AZD5305 microtracer, [14C]-AZD5305 (therapeutic dose)
- Where
- 2 sites in United Kingdom
- Volunteers
- 8 people
- Sponsor
- AstraZeneca
Healthy
Study to Evaluate Pharmacokinetics, Relative Bioavailability, Palatability of Obefazimod Minitablet Formulation
The sponsor is developing a pediatric minitablet formulation as part of the overall pharmaceutical development strategy. In vitro dissolution and physiological-based bio-pharmaceutics modelling and simulation have been used to…
- Trial name
- NCT07453784
- Testing
- Obefazimod 50 mg Capsule, Obefazimod Minitablet 50 mg
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Abivax S.A.
Obesity, Morbid
Bariatric Surgery and Pharmacokinetics of Gabapentin
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines.
- Trial name
- NCT03476538
- Testing
- Gabapentin
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Norwegian University of Science and Technology
Obesity, Morbid
Bariatric Surgery and Pharmacokinetics of Lamotrigine
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines.
- Trial name
- NCT03497143
- Testing
- Lamotrigine
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Norwegian University of Science and Technology