Clinical trials: Bioavailability Study, open to volunteers
Healthy Adults
A Study to Learn About How Food Affects the Uptake of Study Medicine Prifetrastat Into the Blood in Healthy Adults
The purpose of the study is to assess the effect of food (high-fat, high-calorie meal) on the total and peak drug exposure of the planned to be marketed tablet formulation of prifetrastat.
- Trial name
- NCT07731100
- Testing
- Prifetrastat
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy Male Adults, Food Effect in Healthy Volunteers
A Study to Evaluate the Effect of Food on the Bioavailability of AJ201, and Safety, Tolerability, and Pharmacokinetics of AJ201 in Japanese and White Healthy Male Participants
This is a Phase 1, randomized, single-dose, open-label, two-way crossover study to evaluate the effect of food on AJ201, and to evaluate the safety, tolerability, and pharmacokinetics of AJ201 in Japanese and White healthy male…
- Trial name
- NCT07549919
- Testing
- AJ201
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- AnnJi Pharmaceutical Co., Ltd.
Drug Absorption
Effect of Gamma-cyclodextrin on the Bioavailability of Berberine
In this study, we will evaluate the relative bioavailability of Berberine (BB) from capsules containing Indian Barberry (Berberis aristate DC.) Bark and Root Extract in the blood plasma of healthy subjects after oral…
- Trial name
- NCT04918667
- Testing
- Berberine incorporated in gamma cyclodextrin, Berberine
- Where
- 4 sites in Armenia, Sweden
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- EuroPharma, Inc.
Postprandial Carotenoid Response
Effect of Co-consuming Different Dietary Protein Sources With Salad on the Bioavailability of Carotenoids
The goal of this clinical trial is to learn if different protein types will affect carotenoid responses in humans when co-consumed with salad.
- Trial name
- NCT07795372
- Testing
- Salad only, Salad + Chicken, Salad + Tuna
- Where
- Singapore
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Lipoprotein Disorder
Phase I Clinical Study Evaluating the Relative Bioavailability of Different Formulations of HRS-5346 in Healthy Participants
This study is a single center, randomized, open label crossover trial planned to include 50 healthy participants to evaluate the relative bioavailability of HRS-5346 new and old formulations in healthy participants.
- Trial name
- NCT07752069
- Testing
- HRS-5346
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
Healthy Participants
A Study to Investigate the Relative Bioavailability and Safety of Different Oral Formulations of Elecoglipron in Healthy Participants
The purpose of this study is to measure the pharmacokinetics (PK-how the body processes the study drug) of elecoglipron in healthy participants when taken by mouth as different formulations.
- Trial name
- NCT07723833
- Testing
- Elecoglipron Reference Formulation Dose A, Elecoglipron Test formulation 1 Dose A, Elecoglipron Reference Formulation Dose B
- Where
- 2 sites in United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Bioavailability, Gut Microbiome
Curcumin and Retinal Study
To test how two weeks of curcumin supplementation would cross the blood brain barrier (BBB) and attach to amyloid beta proteins, to assess the feasibility (safety and bioavailability), and to explore the resulting…
- Conditions
- Bioavailability, Gut Microbiome, Safety
- Trial name
- NCT05774704
- Testing
- Low curcumin group, High curcumin group
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
High Blood Sugar, High Blood Pressure
Understanding the Health Effect of a Bioactive Peptide From Egg: A Pilot Study
Bioactive peptides derived from food proteins show potential for improving human health. One of such promising peptides is namely IRW made from egg white hydrolysate and composed of three peptides.
- Conditions
- High Blood Sugar, High Blood Pressure, Overweight and Obesity
- Trial name
- NCT06555393
- Testing
- Egg White Powder
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Obesity & Overweight, Type 2 Diabetes
A Phase 1 Clinical Trial to Assess the Safety of DWRX5003 and Relative Bioavailability to DWC202502 and DWC202503 in Healthy Adult Volunteers
Phase 1 Safety and Relative Bioavailability Study of DWRX5003 in Healthy Adults
- Trial name
- NCT07539415
- Testing
- DWRX5003, DWC202502, DWC202503
- Where
- South Korea
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Healthy Volunteers
A Study to Assess the Relative Bioavailability of BMS-986435 and Food Effect on the BMS-986435 in Healthy Adult Participants
This study is designed to evaluate the relative bioavailability (rBA) of multiple test tablet formulations of BMS-986435 compared to an equal dose of the BMS-986435 reference tablet formulation.
- Trial name
- NCT07226817
- Testing
- BMS-986435
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Metabolic Dysfunction-Associated Steatohepatitis
ECC4703 Food Effect and Relative Bioavailability Study in Healthy Adult Participants
This is a Phase I, open-label, randomized, single-dose, 2-part study designed to evaluate the food effect and relative bioavailability of ECC4703 in healthy adult participants.
- Trial name
- NCT07334080
- Testing
- ECC4703 F0 formulation, ECC4703 F1 formulation, ECC4703 F2 formulation
- Where
- Australia
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Eccogene
Glucosamine, Liposomal Encapsulation
Human Absorption Study of Liposomal Glucosamine Supplements
The objective of this study is to evaluate the effects of liposomal encapsulation using different ratios of gum arabic and lecithin on the bioavailability of a liquid glucosamine supplement in humans.
- Trial name
- NCT07843342
- Testing
- High-Emulsified Liposomal Glucosamine Liquid, Low-Emulsified Liposomal Glucosamine Liquid, Glucosamine Liquid without Liposomal
- Where
- Taiwan
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- TCI Co., Ltd.
Micronutrient Status
Bioavailability of Micronutrients With a Special Focus on Vitamin K Dependent on Consumed Diet
Objectives The main objectives are: Study part II: to investigate the effect of a plant-based diet on micronutrient status compared to an average Danish diet Hypotheses Study part II: it is hypothesised that the status of some…
- Trial name
- BioMicro (NCT06921018)
- Testing
- change in diet
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Healthy Volunteers
A Study to Investigate the Relative Bioavailability of 2 Tablet Formulations and the Effect of Food on the Pharmacokinetics of BGB-58067 in Healthy Participants
This study is being done to understand how the body processes 2 different tablet formulations of the study drug (BGB-58067) and how food intake influences the processing of the study drug by the body.
- Trial name
- NCT07712640
- Testing
- BGB-58067 Tablet (F-01 Formulation), BGB-58067 Tablet (F-02 Formulation)
- Where
- Australia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- BeOne Medicines
Iron Deficiency (Without Anemia)
Effect of Chitin and Ascorbic Acid on Dietary Insect Iron Absorption
Iron is involved in many vital metabolic processes such as oxygen transport, electron transport in cells, DNA synthesis and repair, and muscle metabolism.
- Trial name
- INSECTE (NCT06822062)
- Testing
- Meal A, Meal B, Meal C
- Where
- Switzerland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Swiss Distance University of Applied Sciences
Healthy
Study to Evaluate Pharmacokinetics, Relative Bioavailability, Palatability of Obefazimod Minitablet Formulation
The sponsor is developing a pediatric minitablet formulation as part of the overall pharmaceutical development strategy. In vitro dissolution and physiological-based bio-pharmaceutics modelling and simulation have been used to…
- Trial name
- NCT07453784
- Testing
- Obefazimod 50 mg Capsule, Obefazimod Minitablet 50 mg
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Abivax S.A.
Alzheimer's Disease, Healthy Participants
A Study to Evaluate the Drug Levels, Absolute Bioavailability, Safety, Tolerability, and Immunogenicity of Single-Dose of BMS-986446 in Healthy Adults After Single-dose Administration, and Participants With Early Alzheimer's Disease After Multiple Dose Administration
The purpose of this study is to evaluate the drug levels, absolute bioavailability, safety, tolerability, and immunogenicity of single-Dose of BMS-986446 in healthy adults after single-dose administration, and participants with…
- Trial name
- NCT07780383
- Testing
- BMS-986446
- Where
- 6 sites in United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Healthy Volunteers
A Study to Evaluate the Safety, Tolerability, and Drug Levels of BMS-986521 in Healthy Participants.
The purpose of this study is to evaluate the safety, tolerability, and drug levels of BMS-986521 following single and multiple ascending doses of BMS-986521 in healthy adult participants, and to evaluate potential food effects on…
- Trial name
- NCT07283263
- Testing
- BMS-985521
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
HIV Infections
Mass Balance and Absolute Oral Bioavailability of [14C]VH4524184
The purpose of the study is to assess the bioavailability, mass balance, pharmacokinetics, metabolism and excretion of radiolabeled (14C) VH4524184.
- Trial name
- NCT07636928
- Testing
- VH4524184, [14C]VH4524184 microdose, [14C]VH4524184
- Where
- Netherlands
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Iron Absorption, Iron Deficiencies
Maximizing the Benefits of Iron in Ready-to-Use Therapeutic Foods for Malnourished Children in Kenya
Reports from the Kenya Red Cross Society (KRCS) in Kwale County, southern Kenya, indicate a limited impact of Ready-to-Use Therapeutic Foods (RUTFs) on malnutrition or anemia.
- Conditions
- Iron Absorption, Iron Deficiencies, Severly Acutely Malnourished Children, Malnutrition in Children
- Trial name
- SAMI (NCT07315295)
- Testing
- Iron absorption from RUTF on Day 0, Treatment with RUTF for 80 days, Iron absorption from RUTF on Day 20
- Where
- 2 sites in Kenya, Switzerland
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- ETH Zurich