Clinical trials: Biochemical Marker
Spinal Stenosis, Ligamentum Flavum Hypertrophy
Cytokines, Neuroplasticity Modulators, and Biomarkers in Spinal Canal Stenosis and Endoscopic Decompression
Research Rationale and Study Design Lumbar spinal stenosis (LSS) is a common degenerative musculoskeletal disorder characterized by narrowing of the spinal canal, often leading to pain and disability.
- Trial name
- NCT07232836
- Testing
- Endoscopic Spinal Canal Decompression
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Poznan University of Physical Education
Low Back Pain
Contextual Effects on Inflammatory Biomarkers and Pain Relief After Spinal Joint Manipulation
The goal of this clinical trial is to learn whether contextual effects created by observational learning can change pain relief and inflammation-related biological responses after spinal joint manipulation in adults with chronic…
- Trial name
- CONTEXT-PAIN (NCT07507604)
- Testing
- Observational Learning, Spinal Joint Manipulation
- Where
- 2 sites in Poland
- Volunteers
- 72 people
- Sponsor
- John Paul II University in Biała Podlaska
Bladder Cancer, Bladder Cancer, Metastatic
Treatment Of Metastatic Bladder Cancer at the Time Of Biochemical reLApse Following Radical Cystectomy
Immunotherapy (checkpoint inhibitors) is approved as first and second line treatment to patients with metastatic bladder cancer.
- Trial name
- TOMBOLA (NCT04138628)
- Testing
- Atezolizumab
- Where
- 5 sites in Denmark
- Volunteers
- 154 people
- Sponsor
- Jørgen Bjerggaard Jensen
Resistance Training
The Effects of Leucine Metabolites in Performance, Body Composition and Biochemical Markers of Muscle Damage
This study aimed to conduct a double-blind randomized pragmatic trial to evaluate the effects of off-the-shelf leucine metabolite supplements HMB-FA, HMB-Ca, alfa-HICA, on resistance training-induced changes in body composition…
- Trial name
- LMET2IMPROVE (NCT03511092)
- Testing
- HMB-FA, HMB-Ca, alfa-HICA
- Where
- Portugal
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Faculdade de Motricidade Humana
Cardiovascular Diseases, Myocardial Infarction
Novel Biomarkers in Patients With Acute Myocardial Infarction
This study seeks to investigate the clinical value of novel biomarkers and echocardiographic indices, including myocardial work parameters, in patients with first acute myocardial infarction.
- Conditions
- Cardiovascular Diseases, Myocardial Infarction, Acute Coronary Syndrome, Biochemical Dysfunction
- Trial name
- CLEAR-AMI (NCT05791916)
- Where
- 2 sites in Greece
- Volunteers
- 500 people
- Sponsor
- Aristotle University Of Thessaloniki
Dyslipidemia, Transplants
The Impact of Ezetimibe on Biochemical Markers of Cardiovascular Risk in Kidney Transplant Patients
In kidney transplant patients atherosclerosis process is accelerated even in asymptomatic patients. This is mainly the consequence of immunosuppressive therapy.
- Trial name
- NCT02103049
- Testing
- Ezetimibe
- Where
- Slovenia
- Volunteers
- 80 people
- Sponsor
- University Medical Centre Ljubljana
Neurological Complication of Procedure (Disorder)
Novel BIochemical Markers for Predicting Type 2 NEurological Complications of Surgical Coronary Revascularization (BINER)
In this single center prospective cohort study a total of 100 patients scheduled for elective off-pump CABG will be recruited. They will be allocated to one study and one control group according to the presence or absence of…
- Trial name
- BINER (NCT03493256)
- Testing
- exposure to type 2 neurological complications
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Collegium Medicum w Bydgoszczy
Cardiovascular Diseases
Efficacy Study of Pioglitazone and Atorvastatin Combination Therapy in Treating Subjects With Elevated Risk for Cardiovascular Disease
The purpose of this study is to determine the effect of pioglitazone, once daily (QD), and atorvastatin combination therapy compared to atorvastatin monotherapy in patients at risk for cardiovascular disease.
- Trial name
- NCT00770575
- Testing
- Pioglitazone and atorvastatin, Atorvastatin
- Volunteers
- 148 people
- Sponsor
- Takeda
Liver Fibrosis
Prospective Evaluation of FibroScan in Patients Treated With Methotrexate
The aim of this study is to evaluate liver fibrosis using FibroScan and biochemical markers in patients treated with methotrexate.
- Trial name
- Methoscan (NCT00673101)
- Where
- France
- Volunteers
- 1,871 people
- Sponsor
- Association HGE CHU Bordeaux Sud
Healthy
Changes in Microbiota in Healthy Subjects Before and After Meditation Practices in a Controlled Environment
The goal of the study is to evaluate the Changes in Microbiota Markers in Healthy Subjects Before, During and After Meditation Practices in a Controlled Environment.
- Trial name
- NCT06306469
- Testing
- Meditation practice
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Pranic Healing Research Institute
Septic Shock
Therapeutic Plasmaexchange in Early Septic Shock
Sepsis is defined by the occurrence of critical organ dysfunction in the context of infection. Unfortunately, its incidence appears to be rising, and the mortality of septic shock remains extraordinary high (> 60%).
- Trial name
- EXCHANGE (NCT04231994)
- Testing
- TPE
- Where
- 2 sites in Germany
- Volunteers
- 40 people
- Sponsor
- Hannover Medical School
Sepsis Abdominal
Perioperative Sepsis. An Epigenetic Perspective
This single-center, prospective, observational study evaluates the impact of perioperative sepsis on inflammatory response, coagulation abnormalities, cardiac dysfunction, and microRNA expression in adult patients undergoing…
- Trial name
- PESE (NCT07442552)
- Testing
- • Presepsin • C-reactive protein (CRP) • Fibrinogen • Aspartate aminotransferase (AST) • Alanine aminotransferase (ALT) • Creatinine • Urea • Creatine kinase (CK) • Creatine kinase-MB (CK-MB) • NT-pro
- Where
- Romania
- Volunteers
- 40 people
- Sponsor
- Carol Davila University of Medicine and Pharmacy
End Stage Renal Disease
Risk Factors for Coronary Artery Calcification and Left Ventricular Hypertrophy in Hemodialysis Patients
Individuals with kidney disease are at a higher risk for heart and vascular diseases, including heart attacks and strokes, than those with normal kidney function.
- Trial name
- NCT01427374
- Where
- 4 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- University of Alberta
Coronary Heart Disease (CHD)
A Biorepository for Coronary Heart Disease in Qatar
Coronary heart disease (CHD) poses a major health burden in the Gulf countries. It is the leading cause of mortality and morbidity in the world and poses an enormous societal burden in the Gulf countries.
- Trial name
- QCBio (NCT03427489)
- Where
- Qatar
- Volunteers
- 2,100 people
- Sponsor
- Hamad Medical Corporation
Prostate Cancer
GTN Therapy on Biomarkers of Immune Escape in Men With Biochemical Recurrence of Prostate Cancer After Primary Therapy
Prostate cancer is the most commonly diagnosed cancer in men in Canada. Over 30% of men over the age of fifty have histological evidence of prostate cancer on biopsy.
- Trial name
- GTN (NCT01704274)
- Testing
- Low Dose GTN 0.0285 mg/hr, High Dose GTN 0.057 mg/hr
- Where
- Canada
- Volunteers
- 43 people
- Sponsor
- Dr. D. Robert Siemens
Physical Exercise, Time Restricted Eating
Effect of Time-restricted Eating and Endurance Training on Markers of the Health of Women and Men
The aim of this project is to demonstrate the synergistic effect of TRE and NW training on health indicators for older women. The women will be divided into four groups, i.e.
- Conditions
- Physical Exercise, Time Restricted Eating, Mental Health Wellness 1, Wellbeing
- Trial name
- NCT05229835
- Testing
- Time restricted eating and exercise
- Where
- Poland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
Mi Q Wave, Coronary Artery Disease
New Time Clock for ST-elevation MI Based on Biochemical Myocardial Infarction Onset Time
ST segment elevation myocardial infarction (STEMI) is one of the leading causes of death across the world and immediate treatment with either thrombolytics or percutaneous coronary intervention (PCI) results in lower mortality.
- Trial name
- BIT-STEMI (NCT04389814)
- Testing
- Biochemical markers
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Tabba Heart Institute
Fatty Liver, Fatty Liver, Nonalcoholic
The Effects of Zataria Multiflora Boiss (Shirazi's Thyme) on Nonalcoholic Fatty Liver Disease
The aim of this study is to evaluate the effects and safety of a dietary supplement, Zataria multiflora Boiss (Shirazi's Thyme) in the treatment of non alcoholic fatty liver disease (NAFLD).
- Trial name
- ThymeLiv (NCT02983669)
- Testing
- Thyme
- Where
- Iran
- Volunteers
- 86 people
- Sponsor
- Shiraz University of Medical Sciences
Neuroendocrine Tumors Metastatic to the Liver
A Phase 1 Study of PV-10 Chemoablation of Neuroendocrine Tumours (NET) Metastatic to the Liver
This study is intended to determine the safety, tolerability and reduction of biochemical markers (Chromogranin A or, if deemed appropriate, 5-hydroxyindoleaceticacid) and troublesome symptoms (particularly diarrhea and flushing)…
- Trial name
- NCT02693067
- Testing
- Rose bengal disodium
- Where
- Australia
- Volunteers
- 12 people
- Sponsor
- Provectus Biopharmaceuticals, Inc.
Systemic Lupus Erythematosus
Omega 3 Fatty Acids and Systemic Lupus Erythematosus
Omega-3 fatty acids have been considered anti-inflammatory lipids based on data from epidemiological studies of Greenland Eskimos whose diet is rich in fish, sources of polyunsaturated fatty acids.
- Trial name
- OM3LES (NCT02524795)
- Testing
- Hiomega-3 supplement of Naturalis® company -
- Volunteers
- 49 people
- Sponsor
- Federal University of Minas Gerais