Clinical trials: Biologic Implant
Aortic Valve Disease
Health Status of Patients After Surgically Implanted Biological and Mechanical Aortic Valves: a Population-based Retrospective Analysis (2010-2018)
The overall project aim is to study outcomes following aortic valve replacement with either mechanical valves or bioprostheses by retrieving data from the main social security carriers in Austria for the years 2010-2018.
- Trial name
- NCT04900909
- Testing
- Aortic Valve Replacement
- Volunteers
- 13,993 people
- Sponsor
- Medical University of Vienna
Implant Complication
This Study Will be Directed Toward Evaluating Peri-implant Tissue Behavior, Pink Esthetic Score, Patient Satisfaction and Marginal Accuracy Associated With Biologically Oriented Preparation Technique for Implant Supported Crowns.
patients will be divided into two groups (n=10) according to the type of abutment used: Group (1): will receive conventional shoulder abutment.
- Trial name
- NCT07760064
- Testing
- customized biologically oriented prepared implant abutment
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Kholoud Mohamed Mahmoud Soliman
Periodontitis, Peri-implant Mucositis
Biological Responses Affecting Early-stage Dental Implant Placement in Patients With History of Periodontitis
This prospective parallel, double-blind, four-arm randomised controlled clinical study is planned to assess the difference in the level of the inflammatory biomarkers expressed following the placement of the first dental implant…
- Conditions
- Periodontitis, Peri-implant Mucositis, Peri-Implantitis
- Trial name
- NCT05834946
- Testing
- Megagen implant placement, Biomate-Swiss implant
- Where
- Malaysia
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Edentulism, Dental Implants
Dental Implant Healing With TNF-Alpha Inhibitors
The goal of this pilot study is to learn about healing after dental implant placement in patients taking a class of biologic drug called Tumor Necrosis Factor or TNF-alpha antagonist or inhibitor.
- Conditions
- Edentulism, Dental Implants, TNF-alpha Inhibitors
- Trial name
- NCT06538870
- Testing
- Placement of dental implants
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Implant Complication
Prosthetic and Biological Complications of Implant Supported Prostheses
complications of implant retained prostheses
- Trial name
- NCT05297253
- Testing
- telescopic overdenture
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Research Centre, Egypt
Arrhythmia, Cardiovascular Diseases
Diagnostic Investigation of Sudden Cardiac Event Risk
The overall objective of the DISCERN study is to develop and validate a genomic diagnostic assay to identify patients at increased risk for lethal ventricular arrhythmias and sudden cardiac death (SCD).
- Conditions
- Arrhythmia, Cardiovascular Diseases, Heart Failure, CVD
- Trial name
- DISCERN (NCT00500708)
- Where
- 8 sites in United States
- Volunteers
- 1,564 people
- Sponsor
- CardioDx
Breast Neoplasms, Breast Diseases
Evaluating Outcomes of Immediate Breast Reconstruction (POBRAD-M)
Some women with breast cancer have their whole breast removed as part of their treatment (mastectomy). Of these women, around 31% have more surgery to create a new breast.There are two main ways to create a new breast(i)using…
- Trial name
- POBRAD-M (NCT02557906)
- Testing
- Breast reconstruction - implant and an ADM (SurgiMend), Breast reconstruction- autologous tissue, Breast reconstruction- implant + dermal sling/LD flap
- Where
- 6 sites in United Kingdom
- Volunteers
- 209 people
- Sponsor
- King's College London
Malignant Tumors
PET/CT-Guided Biological Target Volume Delineation and Dose Optimization for Radioactive Seed Implantation Therapy in Malignant Tumors
This prospective, open-label Phase I/II trial evaluates a PET/CT-guided planning strategy for radioactive seed implantation therapy in malignant solid tumors.
- Trial name
- NCT07327515
- Testing
- CT-Guided Radioactive Seed Implantation, PET/CT-Guided Radioactive Seed Implantation, PET/CT-Guided Radioactive Seed Implantation (Biological Dose Optimization)
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Li Min
Fecal Incontinence, Anal Incontinence
Comparison of the Efficacy of a Biological Implant to Reinforce Overlapping Sphincter Repair Versus Overlapping Sphincter Repair Alone
The aim of this study is to compare the efficacy of Biodesign™ Surgisis® Tissue Graft to reinforce an overlapping sphincter repair versus the standard overlapping sphincter repair in controlling episodes of incontinence in…
- Trial name
- NCT01044589
- Testing
- Biodesign Tissue Repair Graft, Overlapping Sphincter Repair
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Massarat Zutshi
Dental Implant, Primary Sjögren Syndrome
Prognosis of Dental Implants in Patients With Primary Sjögren's Syndrome
Primary Sjögren's Syndrome (PSS) is a chronic autoimmune inflammatory disease primarily involving the salivary and lacrimal glands. Few data exist regarding survival and success rate of dental implants in patients with PSS.
- Trial name
- NCT04960605
- Testing
- Dental implants
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Dental Implants
Clinical and Radiographic Outcomes of Implant-supported Prostheses With Cantilever Extensions After 10 Years of Function
A retrospective examination was performed on patients who had received treatment with dental implants supporting a prosthesis with a cantilever extension for at least 10 years of function.
- Trial name
- Cantilevers (NCT06534398)
- Testing
- Dental implant prosthesis with cantilever extension
- Where
- Greece
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Dental Implant Failed
Immediate Implant Placement With Subepithelial Connective Tissue Grafting and Probiotics
The present study aims to evaluate and compare the clinical, radiographic, and biological peri-implant tissue outcomes of platelet-rich fibrin versus probiotics as adjuncts to immediate implant placement combined with…
- Trial name
- NCT07596758
- Testing
- Platelet-Rich Fibrin, Probiotics
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Edentulism, Biological Aging
Biological Aging Following Full-Arch Implant-Supported Fixed Rehabilitation in Edentulous Patients
This study aims to investigate the association between full-arch implant-supported fixed dental rehabilitation and changes in biological aging among adults with complete tooth loss (edentulism).
- Trial name
- NCT07890753
- Testing
- Full-Arch Implant-Supported Fixed Dental Rehabilitation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Junyu Shi
Ventricular Arrhythmias, Implantable Defibrillator User
Scandinavian Multicenter Study to Advance Risk Stratification in Heart Disease- Ventricular Arrhythmias
The purpose of this study is to identify markers of increased risk for incident ventricular arrhythmias and cardiovascular events in patients already being treated with an implantable cardioverter-defibrillator (ICD) by exploring…
- Conditions
- Ventricular Arrhythmias, Implantable Defibrillator User, Biological Markers, Heart Disease
- Trial name
- SMASH 1 (NCT02864771)
- Where
- Norway
- Volunteers
- 504 people
- Sponsor
- University Hospital, Akershus
Peri-Implantitis
The Influence of Implant Position on the Occurrence of Biological Complications
The primary objective of this study will be to study the correlation between implant position (malposition), evaluated through periapical radiographs of peri-implantitis vs healthy implants, and the occurrence of peri-implant…
- Trial name
- NCT05358782
- Testing
- Dental implant positioning
- Where
- Italy
- Volunteers
- 130 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Dental Implant
Impact of Biological Factors on Dental Implant
The goal of this randomized controlled trial is to compare the response of different bone densities to treatment with Platelet Rich Fibrin (PRF) in patients who need treatment with dental implant.
- Trial name
- NCT06037070
- Testing
- Platelet Rich Fibrin
- Where
- Iraq
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Al-Mustansiriyah University
Post Operative Pancreatic Fistula, Pancreatic Resection
Efficacy of Amniotic Membrane Over Pancreatic Anastomosis After Pancreaticoduodenenctomy to Preventing Pancreatic Fistula
Post-operative pancreatic fistula (POPF) after pancreatic resection is a potentially life-threatening complication occuring in up to 27% of patients undergoing a pancreatic resection.
- Conditions
- Post Operative Pancreatic Fistula, Pancreatic Resection, Biological Dressing
- Trial name
- POPF (NCT03891225)
- Testing
- Amniotic Membrane implantation
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Casa di Cura Dott. Pederzoli
Dental Implantation, Guided Bone Regeneration
Effects of the SIS Membrane on GBR and Early Loading of Maxillary Anterior Dental Implants
The aim of this randomized controlled trial (RCT) is to determine whether early implant loading that shortens the healing period to 6 weeks can be safely and effectively applied to implants with good initial stability in the…
- Trial name
- NCT06574815
- Testing
- Early implant loading, Delayed implant loading, GBR using an SIS membrane
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Beijing Stomatological Hospital, Capital Medical University
Edentulism
Evaluation of the ACE Dental Implant
Dental implants are small metal posts that look like miniature screws. They are surgically implanted into the jawbone where they serve as substitute tooth roots.
- Trial name
- ACE-2005 (NCT00641576)
- Testing
- ACE CONNECT Endosseous dental implant
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Miscarriage, Early Pregnancy Loss
Cohort of Patients Presenting Unexplained Recurrent Miscarriages and Identification of Early Miscarriage Recidivism Factors
About 1 to 3% of women of childbearing age suffer repeated early spontaneous miscarriages (RCF) defined by at least 3 fetal losses before 14 weeks of gestation.
- Trial name
- FALCO (NCT05557201)
- Where
- France
- Volunteers
- 700 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris