Clinical trials: Biologic Markers
Tobacco Use Disorder, Nicotine Dependence
Novel Determinants and Measures of Smokeless Tobacco Use: Study 2
The research project will determine the level of nicotine in ST products that will lead to the greatest reduction in toxicant exposure
- Trial name
- NCT01067599
- Testing
- Low nicotine, Medium nicotine, High nicotine
- Where
- 2 sites in United States
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Breast Neoplasms, Carcinoma, Ductal, Breast
Signatera-Guided CDK4/6 Inhibitor Therapy in Breast Cancer
The purpose of this study is to evaluate the efficacy and safety of ctDNA-guided initiation of CDK4/6 inhibitor therapy using the Signatera™ Designed on Genome test (referred to as "Signatera Genome") in participants with…
- Conditions
- Breast Neoplasms, Carcinoma, Ductal, Breast, Receptors, Estrogen (for ER-positive Requirement)
- Trial name
- SIGNAL-ER 101 (NCT07214532)
- Testing
- ctDNA-Guided Treatment Strategy
- Where
- 49 sites in United States
- Volunteers
- 725 people
- Sponsor
- Natera, Inc.
Mucopolysaccharidosis III-A
A Natural History Study of Biomarkers and Clinical Outcomes in Mucopolysaccharidosis Type IIIA (MPS IIIA; Sanfilippo Syndrome)
This protocol is a decentralized, single cohort, natural history and biomarker study enrolling up to 20 participants with MPS IIIA (Sanfilippo syndrome).
- Trial name
- NCT05523206
- Testing
- No intervention
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Sanguine Biosciences
Healthy Aging, Cognitive Function 1, Social
Understanding Cerebral Blood Flow Dynamics for Alzheimer's Disease Prevention Through Exercise
Dementia is one of the leading causes of disability worldwide. Underlying biological mechanisms are crucial in preclinical stages of Alzheimer's disease (AD).
- Conditions
- Healthy Aging, Cognitive Function 1, Social, Cerebrovascular Circulation, Blood Flow
- Trial name
- flADex (NCT06584656)
- Testing
- Aerobic exercise condition, Resistance exercise condition
- Where
- 2 sites in Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Heart Rate Variability, Biomarker of Stress, Stress and Anxiety
Virtual vs. Traditional CPR Training: Effects on Stress
This medical education study investigates stress levels among undergraduate medical students during basic life support (BLS) training.
- Trial name
- NCT07147322
- Testing
- Medical education, basic life support training
- Where
- Finland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Oulu University Hospital
Ovarian Cancer
Predictive Biomarkers for IGF1R Targeted Therapy in Ovarian Cancer: a Retrospective Study
The main goal of this study is to employ a novel proteomic approach to identify predictive tumor biomarkers that will increase the efficacy of insulin-like growth factor (IGF1R) targeted therapy in epithelial ovarian cancer.
- Trial name
- NCT02719041
- Testing
- Immunohistochemistry staining method
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Hillel Yaffe Medical Center
HIV
Impact on T Cell Immune Activation and Inflammation of Triptolide Woldifii in HIV-infected Immunological Non-responders
This study is a prospective, multicenter, randomized, placebo-controlled clinical trial, to evaluate impact of Triptolide wilfordii on T cell immune activation and inflammation biomarkers in HIV-infected immunological…
- Trial name
- CACTrip12 (NCT01817283)
- Testing
- Triptolide, cART
- Where
- China
- Volunteers
- 150 people
- Sponsor
- LI Taisheng
Frontotemporal Dementia
GENetic Fronto Temporal Dementia Initiative in Lille
GENFI Lille is a French cohort that belongs to the international initiative GENFI2, a five year longitudinal biomarker cohort study of genetic FTD and its associated disorders (including MND/ALS) investigating members of families…
- Trial name
- GENFI-LILLE (NCT04639622)
- Testing
- Investigation procedures
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Prostate Cancer, Healthy Donors
Comparative Study of Diagnostic and Prognosis Biomarkers of Prostate Cancer in Liquid Biopsy (HOPE)
Constitution of a biological collection within the framework of the establishment of a diagnostic, prognostic and active surveillance test for prostate cancer from long non-coding RNA biomarkers, in 3 cohorts of patients, with…
- Trial name
- HOPE (NCT05141383)
- Testing
- Urine sampling
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Institut Curie
Traumatic Brain Injury
Deployment of a Novel National Institute of Neurological Disorders and Stroke Clinical, Biomarker, Imaging, and Modifiers (CBI-M) Classification Framework for Emergency Department Patients With Glasgow Coma Scale 15 Traumatic Brain Injury (PIONEER-Prognosis)
This study is being done to learn how information from blood tests, medical records, and wearable devices that track sleep, activity, and heart rate can help predict how people recover after a concussion.
- Trial name
- NCT07858266
- Where
- 5 sites in United States
- Volunteers
- 500 people
- Sponsor
- University of Michigan
Hepatocellular Carcinoma Non-resectable
Evaluation of Treatment Predictors Reflecting Beta-catenin Activation in Hepatocellular Carcinoma
This prospective clinical trial will evaluate PET/CT and genomic liquid biopsy based biomarkers as predictors of clinical therapeutic response to immune-checkpoint inhibitor (ICI) therapy for patients with inoperable…
- Trial name
- ExTRACT-HCC (NCT04965454)
- Testing
- Fluorine-18 fluorocholine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Queen's Medical Center
Parkinson Disease
The Personalized Parkinson Project (PPP)
Background Our understanding of PD has stagnated, partly due to the limited patient diversity and brief followup captured in most study cohorts.
- Trial name
- PPP (NCT03364894)
- Where
- Netherlands
- Volunteers
- 520 people
- Sponsor
- Radboud University Medical Center
Breast Cancer
miRNA and Relevant Biomarkers of BC Patients Undergoing Neoadjuvant Treatment
MicroRNA (miRNA) is a type of endogenous non-coding RNA. They are responsible for post-transcriptional regulation and participate in many vital biological processes.
- Trial name
- NCT03779022
- Testing
- microRNA
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Cui Yimin
Critical Illness
Dose of Early Therapeutic Mobility: Does Type or Frequency Matter?
This study will examine the effects of once and twice daily activity performed with patients who are breathing with the aid of a machine in an intensive care unit. Activity can occur in bed.
- Trial name
- ETM (NCT00999011)
- Testing
- once daily mobility activity, twice daily mobility activity
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Case Western Reserve University
Major Depression, Dual Diagnosis
Ostrobothnia Depression Study (ODS). A Naturalistic Follow-up Study on Depression and Related Substance Use Disorders
Ostrobothnia Depression Study (ODS) was conducted in the South Ostrobothnia hospital district of Finland during 2009-2014. ODS is a naturalistic, open label, non-randomized follow-up study on depression and related substance use…
- Conditions
- Major Depression, Dual Diagnosis, Anxiety Disorders, Substance Related Disorders
- Trial name
- ODS (NCT02520271)
- Testing
- Behavioral Activation, Motivational Interview
- Where
- Finland
- Volunteers
- 242 people
- Sponsor
- Seinajoki Central Hospital
Autoimmune Liver Disease, Primary Sclerosing Cholangitis
MRI Based Biomarkers in Pediatric Autoimmune Liver Disease
Autoimmune liver diseases (AILD), which include Primary Sclerosing Cholangitis (PSC) and Autoimmune Hepatitis (AIH) are a common etiological factors for chronic liver disease among adolescents.
- Conditions
- Autoimmune Liver Disease, Primary Sclerosing Cholangitis, Autoimmune Hepatitis
- Trial name
- NCT03175471
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
COVID-19 Infection, Encephalitis
Neurodegeneration Markers and Neurological Course in Severe Covid-19 Infection
Emergence of Covid-19 virus is associated with high frequency of extremely severe clinical pictures, with minor signs of CNS impairment (e.g. anosmia, headache).
- Trial name
- MARNEVO-Covid (NCT04361344)
- Testing
- blood samples
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Centre Hospitalier de PAU
Eosinophilic Esophagitis
Exhaled Nitric Oxide as a Biomarker of Disease Activity in Eosinophilic Esophagitis
There is currently no reliable, noninvasive biomarker for eosinophilic esophagitis (EoE), a chronic allergic diseases characterized by significant infiltration of eosinophils in the esophagus.
- Trial name
- NCT01170234
- Testing
- NIOX MINO® Airway Inflammation Monitor
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Tufts Medical Center
Breast Carcinoma
Effects of White Button Mushroom on Inflammation in Obese Postmenopausal Women at High Risk of Breast Cancer
This clinical trial studies the effects of dietary white button mushroom on inflammation (the body's process of fighting against harmful things) and immune cells (white blood cells) in postmenopausal women with both high body…
- Trial name
- NCT04913064
- Testing
- Questionnaire Administration, White Button Mushroom Extract
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Sepsis
Prediction of Disease Severity in Young Children Presenting With Acute Febrile Illness in Resource-limited Settings
Note that this is a study that is co-sponsored by Medecins Sans Frontieres, Spain, and the University of Oxford. The primary objective is to develop a risk prediction algorithm, combining measurements of host biomarkers and…
- Trial name
- SPOT-SEPSIS (NCT04285021)
- Where
- 6 sites in Bangladesh, Cambodia and 3 more
- Volunteers
- 3,433 people
- Sponsor
- Medecins Sans Frontieres, Spain