Clinical trials: Biological Aging
Idiopathic Infertility, Infertility Unexplained
Biological Aging Hallmarks-Guided Integrative TCM and Conventional Medicine in Post-Treatment Unexplained Female Infertility
The goal of this clinical trial is to determine whether telomere profiling and other biological aging hallmarks can help identify underlying mechanisms of persistent infertility in women with post-treatment unexplained…
- Conditions
- Idiopathic Infertility, Infertility Unexplained, Infertility (IVF Patients), Infertility Assisted Reproductive Technology
- Trial name
- TECMI (NCT07404969)
- Testing
- 1. Aging Hallmarks Biomarker Profiling (Telomere-Based), 2. Integrative Botanical and Nutraceutical Intervention, 3. Natural Conception or Assisted Reproductive Technologies
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- BEYOND GENOMiX SA, AG, Ltd
Biological Aging, Healthy Aging
Multi-Modal Longevity Protocol Including Autologous Cell-Free Conditioned Media
This pilot study evaluated a multi-modal longevity protocol combining lifestyle optimisation, nutritional supplementation, and autologous cell-free conditioned media derived from peripheral blood-derived pro-regenerative cells…
- Conditions
- Biological Aging, Healthy Aging, Longevity
- Trial name
- NCT07322224
- Testing
- Multi-Modal Longevity Protocol
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- BlueBird Age Reversal SA
BIOLOGICAL CLOCKS
Aging, Sleep, Cognitive Process
The aim of the study is to determine the impact of aging, circadian rhythms and sleep deprivation on executive performances. Volunteers will complete a 40-hour extended wakefulness period in constant condition (semi-recumbent…
- Trial name
- SOMVIE (NCT00804804)
- Testing
- Sleep deprivation and multiple rest
- Where
- 3 sites in France
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Aging, Polypharmacy
Biological Aging, Medication, Malnutrition and Inflammation Among Acutely Ill and Healthy Elderly.
In this study, the investigators will investigate and characterize acute medical patients in order to optimize patient courses in the acute care departments, especially with regard to polypharmacy and undernourishment.
- Conditions
- Aging, Polypharmacy, Malnutrition, Inflammation
- Trial name
- FAM-CPH (NCT03052192)
- Where
- Denmark
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Acute Kidney Injury, Acute Kidney Disease
The Effect of Preoperative Biological Age on Hemodynamics and Renal Function
Background The aim of this study is to explore the potential value of preoperative biological age as a predictor of intraoperative hemodynamic changes and postoperative renal function injury.
- Conditions
- Acute Kidney Injury, Acute Kidney Disease, Intraoperative Hypotension, Post-induction Hypotension
- Trial name
- NCT07080086
- Volunteers
- 268,833 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Acute Coronary Syndromes (ACS), Iron Deficiencies
Effect of Intravenous Iron on Quality of Life in Older Patients With Acute Coronary Syndrome
The goal of this phase IV, open-label, randomized clinical trial is to evaluate whether intravenous iron improves quality of life in adults aged 65 years and older with iron deficiency after an acute coronary syndrome (ACS).
- Conditions
- Acute Coronary Syndromes (ACS), Iron Deficiencies, Elderly (People Aged 65 or More)
- Trial name
- HI-COR-65 (NCT07476859)
- Testing
- Ferric Carboxymaltose Injection [Ferinject]
- Where
- 9 sites in Spain
- Volunteers
- 538 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Cancer, Malignant Neoplasm
Measuring Changes in Body Composition and Physical Function in Patients With Childhood Cancers
The primary objective of this study is to evaluate the feasibility and acceptability of obtaining repeated measurements of lean muscle mass, physical function, and biological aging in children receiving active cancer therapy.
- Trial name
- NCT05823740
- Testing
- Bioelectrical impedance Analysis (BIA), D3-Creatine Dilution (D3Cr), 6-Minute Walk Test (6MWT)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Cardiovascular Disease, Skin Health
Effects of Anthocyanin on Skin Health and Markers of Cardiovascular Disease Risk
The purpose of this study is to determine whether short-term exposure to a compound found in some fruits and vegetables (anthocyanin), is effective in improving skin health and reducing the levels of various markers of…
- Conditions
- Cardiovascular Disease, Skin Health, Postmenopause
- Trial name
- NCT00574574
- Testing
- anthocyanin
- Where
- United Kingdom
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Healthy Aging, Lifestyle Risk Reduction
Biological Age Applied at Ubberup
In a previous study the investigators have developed a novel biological age model. Assessing biological age is the assessment of the present health status and functional capacity/physiological reserve of that person in comparison…
- Trial name
- NCT04279366
- Testing
- Lifestyle intervention
- Where
- 2 sites in Denmark
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Brain, Aging
Biobank and Brain Health in Bordeaux.
B cube is a new generation cohort to study the determinants and natural history of brain aging, using molecular epidemiology, in a representative sample (N=2000) of the general population from the age of 55 (the approximate age…
- Conditions
- Brain, Aging, Cognitive Aging, Immunosenescence
- Trial name
- B-cube (NCT05322343)
- Testing
- Questionnaires, Fasting blood sampling., Saliva collection and nasal or nasopharyngeal swab
- Where
- France
- Volunteers
- 2,050 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Strength Aerobic Training Elderly Lymphoma Sarcopenia Aging
Strength and Aerobic Training in Elderly Lymphoma Patients During Chemotherapy and Its Impact on Treatment Outcomes, Patients Functioning and Biological Markers of Aging
Frailty, one of geriatric syndromes, is considered a major obstacle for recovery from physiological stress. Such stress is imposed on patients with cancer by virtue of the disease itself but even more so by the treatment.
- Trial name
- NCT03100175
- Testing
- physiotherapy
- Volunteers
- 100 people
- Sponsor
- Rabin Medical Center
Obesity and Obesity-related Medical Conditions
Impact of Bariatric and Metabolic Surgery on the Reduction of Premature Aging.
We invite the participants to take a part in a research study conducted at the 2nd Department of General Surgery of the Jagiellonian University Medical College.
- Trial name
- NCT06618846
- Testing
- laparoscopic sleeve gastric bypass
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- University Hospital in Krakow
Arterial Stiffening, Aging
Sex Hormones and Atherosclerosis Prevention in Perimenopausal Women
The purpose of this study is to find out why women's arteries stiffen as they go through menopause, and how this is affected by estrogen loss.
- Conditions
- Arterial Stiffening, Aging, Menopause
- Trial name
- SHAPE (NCT00608062)
- Testing
- GnRHant - Ganirelix acetate, Transdermal estradiol patch
- Where
- United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Biological Aging
Healthy Aging Through Time- Restricted Eating in Adults With Overweight/Obesity and Incipient Liver Disease: ENSATI
The goal of this clinical trial is to evaluate the effect of a time-restricted eating (TRE) regimen on hallmarks of aging, in comparison with traditional caloric restriction and an unrestricted diet in adults with…
- Trial name
- ENSATI (NCT05880095)
- Testing
- Unrestricted Mediterranean diet, Energy-reduced Mediterranean diet, Mediterranean diet with time-restricted eating
- Where
- Spain
- Volunteers
- 176 people
- Sponsor
- IMDEA Food
Biological Aging
The Inspire Bio-resource Research Platform for Healthy Aging INSPIRE Platform
Since aging is a systemic (not organ-specific) phenomenon, the main objective of Inspire Bio-resource Research Platform for Healthy Aging is to build a comprehensive research platform gathering biological, clinical (including…
- Trial name
- INSPIRE (NCT04224038)
- Testing
- The Inspire Bio-resource Research Platform for Healthy Aging
- Where
- France
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Head and Neck Cancer
Finding Predictors of Side Effects to Chemoradiation Treatment in Elderly Patients With Head and Neck Cancer
To look at what types of measures can be used to predict how an older person will tolerate chemoradiation treatment for head and neck cancer. This study uses surveys and a blood draw to look at the different measures.
- Trial name
- NCT01688323
- Testing
- Collect Blood and Survey Instruments
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Depression, Hypertension
Biological CVD Risk Factors in Older Depressed Patients
The purpose of this study is to determine if improvements in mood will ameliorate autonomic dysregulation, HPA dysfunction and typical (e.g.
- Conditions
- Depression, Hypertension, Hypercholesterolemia
- Trial name
- NCT00318864
- Testing
- Cognitive behavioral therapy
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Stanford University
Quercetin, Lipid Metabolism
Effects of Quercetin on Metabolic Health
Quercetin is a natural flavonoid compound widely found in vegetables, fruits, and nuts. It has a long history of use as a dietary supplement.
- Conditions
- Quercetin, Lipid Metabolism, Aging
- Trial name
- NCT05297032
- Testing
- Quercetin Phytosome
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Thorne HealthTech, Inc
Aging, Healthy
Biological Age in Health Promotion - Novel Health Technology
The purpose of this cross-sectional study is to collect relevant molecular markers of aging and measures of physiological function.
- Trial name
- BATE (NCT03680768)
- Testing
- Health Assessment
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Non-Small Cell Lung Cancer
Cancer of the Lung And SeneScencE - Prospective Cohort 1
The main objective is to identify and assess the predictive value of ageing and senescence biomarkers (methylome, telomeres, inflammageing) and senescent cells in tissues to improve prognosis assessment older patients with…
- Trial name
- CLASSE-P1 (NCT06923618)
- Testing
- Blood samples
- Where
- France
- Volunteers
- 385 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris