Clinical trials: Biological Rhythm
Obesity
The BioRythm Guided Weight Loss Study Will Test a Novel Behavioral Health Intervention Combined With Fitbit Technology Monitoring in Obese Individuals to Determine if it Promotes Weight Loss, Improves Objective Measures of Sleep Health, and Aids in Developing a Consistent Mealtime Routine
The BioRhythm study will test a novel behavioral health intervention that utilizes personalized behavioral health counseling as well as sleep and activity data obtained via wearable technology to promote weight loss in obese…
- Trial name
- NCT05456386
- Testing
- The Circadian Rhythm Approach to Weight Loss (CRAWL)
- Volunteers
- 65 people
- Sponsor
- Stephen Hutchison
Circadian Rhythms, Feeding Patterns
Effect of Nutrient Delivery Pattern on Biological Rhythms in Human Skeletal Muscle
Recent work has established biological rhythms in human skeletal muscle. It remains unknown how the timing and pattern of meals influences these rhythms.
- Trial name
- NCT03906409
- Testing
- Constant, Bolus
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Bath
Circadian Rhythm Phase Shift
A Study on the Changes of the Biological Rhythm by Display Image Modulation
Effects of Smartphone Use at Night with Light Emitting Diode Display With and Without Blue Light in Healthy Adults: A Randomized, Double-blind, Cross-over, Placebo-controlled Comparison
- Trial name
- NCT02690311
- Testing
- smartphone display
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Critical Care, Phototherapy
Healing Light Algorithms for Nurses in the ICU
The purpose of this study is to investigate the impact of a newly installed device administering a Light Scheduling Algorithm with high circadian effective irradiances to mechanically ventilated patients on the perceived stress…
- Trial name
- ENGAGE-ICU (NCT05949827)
- Testing
- Dynamic Light Therapy Device, LSA-1, Dynamic Light Therapy Device, LSA-2, Dynamic Light Therapy Device, LSA-3
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Charite University, Berlin, Germany
T1DM, Sleep Disorders, Circadian Rhythm
Influence of Circadian Clock on Hormonal, Metabolic, Neurocognitive Markers in Adolescents With and Without Diabetes
Type 1 diabetes mellitus (T1DM), makes its appearance during childhood and youth, but management implications last till late adulthood.
- Conditions
- T1DM, Sleep Disorders, Circadian Rhythm, ADHD, Memory Impairment
- Trial name
- NCT04054934
- Testing
- Reversed Circadian Rhythm, Normal Circadian Rhythm
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Atrial Fibrillation
Waveform Periodicity Analysis in Patients With Persistent Atrial Fibrillation
STUDY DESIGN A prospective study. OBJECTIVE A single center clinical trial on the analysis of intracardiac atrial electrogram waveform periodicity for catheter ablation of persistent atrial fibrillation with OCTARAY™ Mapping…
- Trial name
- NCT06023888
- Testing
- Mapping strategy
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Bipolar Disorder, Schizophrenia
Sleep, Obesity and Mental Disease - Biological Markers for the Evaluation of Circadian Rhythmicity
Introduction 16.8% of the Danish adult population are obese (Body Mass Index> 30 kg / m2). Obesity increases the risk of lifestyle diseases such as type-2 diabetes and non-alcoholic fatty liver.
- Conditions
- Bipolar Disorder, Schizophrenia, Obesity, Circadian Rhythm Disorders
- Trial name
- SOMBER (NCT05413486)
- Testing
- Observational
- Where
- Denmark
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Parkinson, Cerebellar Tumor
Detecting the Rest Tremor Associated With Parkinson's Disease Using Analysis of the Muscle Contractions Rhythmicity
Resting tremors associated with Parkinson's disease (PD) remains difficult to quantify and track during disease progression. This study propose to explore the rhythmicity of distal muscle contractions in the upper limb to…
- Conditions
- Parkinson, Cerebellar Tumor, Rest Tremor, Diagnoses Disease
- Trial name
- TREMORHYTHM (NCT05998486)
- Testing
- EMG in wrist flexor-pronators and extensor-supinators
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Henri Mondor University Hospital
Prediabetic State
Restoring 24-hour Substrate Rhythmicity to Improve Glycemic Control by Timing of Lifestyle Factors
Exercise is well-known to improve skeletal muscle energy metabolism and is an established intervention to improve muscle insulin sensitivity and to counter the development of type 2 diabetes (T2D).
- Trial name
- TIMED (NCT05123963)
- Testing
- High-intensity interval training
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- Université de Sherbrooke
Sleep Disorders, Circadian Rhythm
Effects of Vitamin B12 on the Body's Internal Clock
Circadian rhythms are 24-hour cycles that influence natural functions in the body such as heart rate, blood pressure, and body temperature. Circadian rhythms provide the body with an internal clock and affect sleep patterns.
- Trial name
- NCT00120484
- Testing
- Vitamin B12
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Sleep Deprivation, Metabolic Disturbance
Biorhythms in Metabolic Tissues
Metabolism is increasingly recognized as being highly regulated by anticipatory biological rhythms (circadian rhythms or "biorhythms"), which are driven by molecular feedback loops, and which are approximately 24 hours long…
- Conditions
- Sleep Deprivation, Metabolic Disturbance, Biological Clocks, Healthy
- Trial name
- NCT03276442
- Testing
- Low-fat dietary intervention, High-fat dietary intervention
- Where
- Sweden
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Circadian Dysregulation
Efficacy of Ramelteon on Insomnia Symptoms Associated With Jet Lag in Healthy Adult Volunteers
The purpose of this study to determine the degree to which ramelteon, once daily (QD), can reduce the insomnia symptoms associated with rapid, eastward travel across 5 time zones.
- Trial name
- NCT00492011
- Testing
- Ramelteon
- Where
- 4 sites in United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Takeda
Atrial Fibrillation, Persistent
Waveform Periodicity Analysis of Complex Fractionated Electrograms in Patients With Persistent Atrial Fibrillation
Atrial fibrillation (AF) has been the most frequently occurring, sustained arrhythmia, which causes significant morbidity and mortality. AF may not always be a totally random process.
- Trial name
- NCT05426603
- Testing
- Pulmonary vein isolation, Substrate ablation(PRISM based)
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Atrial Fibrillation, Persistent
Waveform Periodicity Analysis of Complex Fractionated Electrograms in Patients With Persistent Atrial Fibrillation
Atrial fibrillation (AF) has been the most frequently occurring, sustained arrhythmia, which causes significant morbidity and mortality. AF may not always be a totally random process.
- Trial name
- NCT05333952
- Testing
- Pulmonary vein isolation, Substrate ablation(PRISM based)
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Hospitalised Patients With Enteral Nutrition
Chronobiology and Enteral Nutrition
Medical Nutritional Therapy (MNT) is critical for patients with impaired oral intake and is typically administered via enteral nutrition (EN).
- Trial name
- NCT07554716
- Testing
- Patient recieving enteral nutrition, Hospitalised Patients Receiving EN: 24-hour EN + Melatonin, Control treatment arm
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Rheumatoid Arthritis
Circadian RA Study in Rheumatoid Arthritis Subjects
Primary objective: To determine the changes in circadian activity rhythms and disease activity in rheumatoid arthritis (RA) patients from pre-treatment to one month after Enbrel initiation.
- Trial name
- NCT03178955
- Testing
- Etanercept
- Where
- United States
- Sponsor
- University of California, Davis
Respiratory Failure, Critical Illness
Sleep and Circadian Rhythms in Mechanically Ventilated Patients
This study examines the feasibility of assessing sleep and circadian rhythmicity in critically ill patients undergoing mechanical ventilation.
- Trial name
- NCT01276652
- Testing
- Environmental modification
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Iowa
Biological Rhythm, Drug Metabolism and Pharmacokinetics
A Temporal Variability Study of Remimazolam for General Anesthesia Induction and Maintenance
The purpose of this study was to observe and compare the differences in plasma concentration, dosage and carboxylesterase 1 activity of remimazolam when remimazolam is used for general anesthesia induction and maintenance at…
- Trial name
- NCT07079800
- Where
- China
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Jie Chen
Metabolic Regulation
Bath Myorhythms Project
Human Physiology is coordinated by a circadian timing system that synchronises daily cycles of light-dark, wake- sleep, activity-rest and feeding-fasting.
- Trial name
- NCT06997315
- Testing
- Time of exercise, No exercise
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Bath
Sleep Apnea, Obstructive, Anovulation
Using CPAP to Improve Menstruation in Women With Polycystic Ovarian Syndrome and Obstructive Sleep Apnea
The purpose of this study is to determine if treatment of obstructive sleep apnea (OSA) with continuous positive airway pressure in women with both OSA and polycystic ovarian syndrome will improve the regularity of the women's…
- Conditions
- Sleep Apnea, Obstructive, Anovulation, Polycystic Ovarian Syndrome
- Trial name
- NCT03155828
- Testing
- CPAP
- Where
- United States
- Sponsor
- University of Louisville