Clinical trials: Biological Rhythm
Obesity
Nantes Bariatric Surgery Cohort
While current research suggests that inflammation of adipose tissue in obesity is linked to accelerated aging, it has yet to be determined in humans how this could enhance preventative and personalized medicine for obese…
- Trial name
- NBC (NCT06625762)
- Testing
- Nantes bariatric surgery cohort
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Nantes University Hospital
Circadian Rhythm Disorders, Sepsis
Functionality of Endogenous Biological Clock in Sepsis
The aim of the current study is to demonstrate dysregulation of immune system΄s circadian rhythms as a consequence of sepsis, as well as marked malfunction of the central circadian clock in comparison with patients without sepsis…
- Trial name
- NCT04063332
- Where
- 2 sites in Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Athens
Biological Clock Dysfunction, Optic Nerve Hypoplasia
Biological Clock Dysfunction in Optic Nerve Hypoplasia
Background: Optic Nerve Hypoplasia (ONH) is a leading cause of blindness in children. For unclear reasons, the incidence of ONH is increasing, with ONH affecting about 1 in 10,000 live-born infants.
- Trial name
- NCT00825591
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Yale University
Acute Brain Injury Coma
Circadian Rhythmicity During Coma Awakening
Acute brain injury is a major cause of admission to intensive care units, as well as of mortality and morbidity, worldwide and for all age groups.
- Trial name
- COMARHYTHM (NCT06245434)
- Testing
- Repeated behavioural assessment, Act-Pass paradigm, Biological measures of circadian and monoamines biomarkers
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Hospices Civils de Lyon
Attention Deficit Hyperactivity Disorder (ADHD), Sleep
Examination of the Dynamic Relationships of Sleep, Physical Activity, and Circadian Rhythmicity With Neurobehavioral Heterogeneity in ADHD
Attention deficit/hyperactivity disorder (ADHD) can present differently in individuals, with some individuals having difficulty with attentional control, hyperactivity, impulsivity, emotion dysregulation, and/or neurobehavioral…
- Conditions
- Attention Deficit Hyperactivity Disorder (ADHD), Sleep, Physical Activity
- Trial name
- NCT06810180
- Testing
- Go/No-Go Task, Delay discounting task, Mirror Tracing Persistence Task
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Hodgkin Lymphoma, Diffuse Large B Cell Lymphoma
To Decrease Fatigue With Light Therapy
Cancer related fatigue (CRF) is one of the most prevalent and distressing long-term complaints reported by (non-) Hodgkin survivors.
- Trial name
- SPARKLE (NCT03242902)
- Testing
- Light therapy intensity 1, Light therapy intensity 2
- Where
- 9 sites in Netherlands
- Volunteers
- 166 people
- Sponsor
- The Netherlands Cancer Institute
Early Childhood Caries
Effectiveness of SDF in Arresting Dental Caries in Preschool Children
Background: Tooth decay in children (Early childhood caries, or ECC) is a common childhood disease. Poor dentition significantly affects the nutrition, growth, development and general health of children.
- Trial name
- NCT02385474
- Testing
- 12% SDF, 38% SDF
- Where
- China
- Volunteers
- 888 people
- Sponsor
- The University of Hong Kong
Suicidal Ideation, Self-Injurious Behavior
Youth Suicide and Self-Harm Intervention: Clinical and Biological Outcomes Study
The goal of this clinical trial is to develop and evaluate youth-focused intervention programs for suicide and self-harm that are tailored to the psychological, developmental, and cultural characteristics of Korean adolescents…
- Conditions
- Suicidal Ideation, Self-Injurious Behavior, Suicide, Attempted
- Trial name
- SHIELD (NCT07395752)
- Testing
- Self-Harm Intervention and Education for Long-term Development (SHIELD) Program, General Mental Health Education
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Ajou University School of Medicine
Compensated Cirrhosis
Screening of Hepatocellular Carcinoma in Patients With Compensated Cirrhosis
Liver carcinoma is becoming the main complication of cirrhosis. Treatment of symptomatic or large tumors is disappointing. Regular ultrasonographic screening of small (curable) tumors is currently recommended, but the best…
- Trial name
- NCT00190385
- Testing
- Ultrasonographic screening
- Where
- France
- Volunteers
- 1,200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Migraine, Sleep Disturbance
The Effect of Bright Light Therapy on Migraine With Sleep Disturbance
Migraine is a common disabling disorder and its substantial burden is associated with considerable negative impact on quality of life.
- Trial name
- NCT04890691
- Testing
- Feel Bright Light
- Volunteers
- 60 people
- Sponsor
- Hungkuang University
Circadian Rhythm, Chronobiology Disorders
The Effect of Nursing Care on Circadian Rhythm
The aim of this project is to determine the effect of nursing care provided to intensive unit care patients according to their circadian rhythms on sleep quality, pain, anxiety and delirium.
- Conditions
- Circadian Rhythm, Chronobiology Disorders, Biological Clock Disturbance, Nursing Care
- Trial name
- NCT04934436
- Testing
- sleeping glasses and earplug
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Sakarya University
Human Sleep and Chronobiology
Benefits and Risks of Artificial Light Exposure: Characterisation of Effects on Alertness, Sleep, Cognitive Performance, Mood and Biological Rhythms
The purpose of this project is to study the influence of light on sleep, wakefulness, EEG activity and cognitive performances.
- Trial name
- LumEnColor (NCT05232383)
- Testing
- polychromatic light, red light, green light
- Where
- France
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Unspecified Disorder of Vestibular Function, Bilateral
Biological Rhythms and Vestibular System
The purpose of this study is to study the relationship between the vestibular system and chronobiology
- Trial name
- REHAB_Rn'V (NCT01839409)
- Testing
- vestibular stimulation
- Where
- France
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Critical Care, Phototherapy
HEaling LIght Algorithms for the ICU Patient
The purpose of this prospective, randomized controlled trial is to investigate if mechanically ventilated patients who are treated with a Light Scheduling Algorithm with high circadian effective irradiances are better able to…
- Trial name
- HELIA-ICU (NCT05556811)
- Testing
- Dynamic Light Therapy Device, LSA-1, Dynamic Light Therapy Device, LSA-2, Dynamic Light Therapy Device, LSA, 3
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Charite University, Berlin, Germany
Sleep Initiation and Maintenance Disorders, Circadian Rhythm Sleep Disorders
Light Exposure to Treat Sleep Disruption in Older People
The purpose of this study is to test whether shifts in the timing of the biological clock to a later hour (phase delay shifts of the human circadian system) can be produced in response to four successive evenings of light…
- Conditions
- Sleep Initiation and Maintenance Disorders, Circadian Rhythm Sleep Disorders, Hypersomnia
- Trial name
- NCT00427323
- Testing
- light exposure
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Oligomenorrhea, Amenorrhea
Ultrasound Characterization of Ovarian Follicle Dynamics in Women With Amenorrhea
In women with regular menstrual cycles, antral follicles have been shown to grow in synchronous cohorts, called waves, 2-3 times in a menstrual cycle.
- Conditions
- Oligomenorrhea, Amenorrhea, Polycystic Ovary Syndrome (PCOS)
- Trial name
- NCT01927432
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Cornell University
Physiological Stress, Cognitive Dysfunction
DEEPTIME: Human Adaptation in Time Underground Isolation
The objectives of this scientific expedition are: a/ Evaluation of temporal cognitive perception and collective synchronization in a temporally anomalous universe (underground environment), b/ Influence of group living on the…
- Conditions
- Physiological Stress, Cognitive Dysfunction, Sleep
- Trial name
- DEEPTIME (NCT05603780)
- Testing
- exploratory protocol
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Insomnia
Melatonin Receptor Agonist and Peripheral Biological Markers
People who have insomnia typically co-occur with mental disorders, especially anxiety and depression. It has been documented that the melatonin phase in the depressed patients was reached with a delay.
- Trial name
- NCT03432091
- Testing
- melatonin
- Volunteers
- 40 people
- Sponsor
- National Science and Technology Council, Taiwan
Breast Cancer
Relaxation for Women With Breast Cancer Undergoing Radiotherapy
The goal of this behavioral research study is to compare two different forms of relaxation programs that will include stretching and relaxation techniques, in order to learn if and how well they may help to improve physical and…
- Trial name
- NCT01202851
- Testing
- Relaxation Program, Questionnaires, Saliva Testing
- Where
- United States
- Volunteers
- 681 people
- Sponsor
- M.D. Anderson Cancer Center
Rhythm Nodal, Metabolism and Nutrition Disorder
The Biological Rhythm of Human Metabolite
The circadian regulation in mammals have been known for a long time. A special group of clock genes, organized in feedback loops, are responsible for the circadian regulation in both the SCN and peripheral organs.
- Conditions
- Rhythm Nodal, Metabolism and Nutrition Disorder, Metabolism Disorder, Lipid
- Trial name
- NCT03669809
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shandong Provincial Hospital