Clinical trials: Biological Rhythm, active
Biological Rhythm, Drug Metabolism and Pharmacokinetics
A Temporal Variability Study of Remimazolam for General Anesthesia Induction and Maintenance
The purpose of this study was to observe and compare the differences in plasma concentration, dosage and carboxylesterase 1 activity of remimazolam when remimazolam is used for general anesthesia induction and maintenance at…
- Trial name
- NCT07079800
- Where
- China
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Jie Chen
Metabolic Regulation
Bath Myorhythms Project
Human Physiology is coordinated by a circadian timing system that synchronises daily cycles of light-dark, wake- sleep, activity-rest and feeding-fasting.
- Trial name
- NCT06997315
- Testing
- Time of exercise, No exercise
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Bath
Depression, Postpartum, Anxiety State
From Prevention to Treatment: How Biological Rhythms Can Maintain Perinatal Mental Health
Depression and anxiety are significant public health issues during pregnancy and the postnatal period, particularly affecting those in developing countries.
- Trial name
- NCT06246214
- Testing
- Blue Light Therapy, ControlLT
- Where
- Brazil
- Volunteers
- 150 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
T1DM, Sleep Disorders, Circadian Rhythm
Influence of Circadian Clock on Hormonal, Metabolic, Neurocognitive Markers in Adolescents With and Without Diabetes
Type 1 diabetes mellitus (T1DM), makes its appearance during childhood and youth, but management implications last till late adulthood.
- Conditions
- T1DM, Sleep Disorders, Circadian Rhythm, ADHD, Memory Impairment
- Trial name
- NCT04054934
- Testing
- Reversed Circadian Rhythm, Normal Circadian Rhythm
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Prediabetic State
Restoring 24-hour Substrate Rhythmicity to Improve Glycemic Control by Timing of Lifestyle Factors
Exercise is well-known to improve skeletal muscle energy metabolism and is an established intervention to improve muscle insulin sensitivity and to counter the development of type 2 diabetes (T2D).
- Trial name
- TIMED (NCT05123963)
- Testing
- High-intensity interval training
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- Université de Sherbrooke
Rhythm Nodal, Metabolism and Nutrition Disorder
The Biological Rhythm of Human Metabolite
The circadian regulation in mammals have been known for a long time. A special group of clock genes, organized in feedback loops, are responsible for the circadian regulation in both the SCN and peripheral organs.
- Conditions
- Rhythm Nodal, Metabolism and Nutrition Disorder, Metabolism Disorder, Lipid
- Trial name
- NCT03669809
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shandong Provincial Hospital
Suicide, Bereavement
Risk and Resilience to Suicide Following Late-Life Spousal Bereavement
The purpose of the RISE study is to examine how the 24-hour rhythm of sleep and social activity relate to mood and suicidal ideation among older adults that recently lost a spouse or life partner.
- Trial name
- RISE (NCT06191484)
- Testing
- WELL Behavioral Probe
- Where
- United States
- Volunteers
- 169 people
- Sponsor
- University of Pittsburgh
Attention Deficit Hyperactivity Disorder (ADHD), Sleep
Examination of the Dynamic Relationships of Sleep, Physical Activity, and Circadian Rhythmicity With Neurobehavioral Heterogeneity in ADHD
Attention deficit/hyperactivity disorder (ADHD) can present differently in individuals, with some individuals having difficulty with attentional control, hyperactivity, impulsivity, emotion dysregulation, and/or neurobehavioral…
- Conditions
- Attention Deficit Hyperactivity Disorder (ADHD), Sleep, Physical Activity
- Trial name
- NCT06810180
- Testing
- Go/No-Go Task, Delay discounting task, Mirror Tracing Persistence Task
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Suicidal Ideation, Self-Injurious Behavior
Youth Suicide and Self-Harm Intervention: Clinical and Biological Outcomes Study
The goal of this clinical trial is to develop and evaluate youth-focused intervention programs for suicide and self-harm that are tailored to the psychological, developmental, and cultural characteristics of Korean adolescents…
- Conditions
- Suicidal Ideation, Self-Injurious Behavior, Suicide, Attempted
- Trial name
- SHIELD (NCT07395752)
- Testing
- Self-Harm Intervention and Education for Long-term Development (SHIELD) Program, General Mental Health Education
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Ajou University School of Medicine
Patients With Home Parenteral Nutrition
Chronobiology and Home Parenteral Nutrition Study. CHRONO-HPN Study
Medical Nutritional Therapy (MNT) is critical for patients with impaired oral intake and is typically administered via parenteral nutrition (PN).
- Trial name
- NCT07554703
- Testing
- Patient recieving home parenteral nutrition
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Circadian Misalignment, Sex Differences
Does Circadian Misalignment Have Sex-Specific Effects on Metabolism?
This study will test whether biological sex influences how the body responds to circadian misalignment-a mismatch between the internal body clock and the timing of sleep and eating (as can occur with shift work or jet lag).
- Trial name
- NCT07441265
- Testing
- Day shift, Night shift
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Breast Cancer
Relaxation for Women With Breast Cancer Undergoing Radiotherapy
The goal of this behavioral research study is to compare two different forms of relaxation programs that will include stretching and relaxation techniques, in order to learn if and how well they may help to improve physical and…
- Trial name
- NCT01202851
- Testing
- Relaxation Program, Questionnaires, Saliva Testing
- Where
- United States
- Volunteers
- 681 people
- Sponsor
- M.D. Anderson Cancer Center
Migraine
Biological Profiles of Neuropeptides, Neurotrophins and miRNA in Migraine
There are still no reliable biomarkers for migraine; the diagnosis is based on symptomatology, and the pathogenesis remains largely a mystery.
- Trial name
- BioM (NCT07832032)
- Testing
- Rimegepant 75 MG
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Nordlandssykehuset HF
Acute Brain Injury Coma
Circadian Rhythmicity During Coma Awakening
Acute brain injury is a major cause of admission to intensive care units, as well as of mortality and morbidity, worldwide and for all age groups.
- Trial name
- COMARHYTHM (NCT06245434)
- Testing
- Repeated behavioural assessment, Act-Pass paradigm, Biological measures of circadian and monoamines biomarkers
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Hospices Civils de Lyon
Polycystic Ovary Syndrome, Diminished Ovarian Reserve
Clinical Trial of Anovulatory Infertility
This project aims to study the expression of clock genes and related proteins in follicular fluid and granulosa cells, depicting the periodic, amplitude, and phase changes of biological clock genes and related proteins in women…
- Conditions
- Polycystic Ovary Syndrome, Diminished Ovarian Reserve, Ovulation Disorder
- Trial name
- NCT06601452
- Testing
- a compound prescription of Chinese medicine
- Where
- China
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital of Nanjing University of Chinese Medicine
Hospitalised Patients With Enteral Nutrition
Chronobiology and Enteral Nutrition
Medical Nutritional Therapy (MNT) is critical for patients with impaired oral intake and is typically administered via enteral nutrition (EN).
- Trial name
- NCT07554716
- Testing
- Patient recieving enteral nutrition, Hospitalised Patients Receiving EN: 24-hour EN + Melatonin, Control treatment arm
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Obesity
Nantes Bariatric Surgery Cohort
While current research suggests that inflammation of adipose tissue in obesity is linked to accelerated aging, it has yet to be determined in humans how this could enhance preventative and personalized medicine for obese…
- Trial name
- NBC (NCT06625762)
- Testing
- Nantes bariatric surgery cohort
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Nantes University Hospital
Suicidal Ideation, Circadian Rhythm Disorders
Mind After Midnight
This study examines whether wakefulness during the biological night (2:00-4:00 AM) is associated with increased negative mood, impaired decision-making, and suicidal thoughts.
- Conditions
- Suicidal Ideation, Circadian Rhythm Disorders, Sleep Deprivation, Sleep Wake Disorders
- Trial name
- MaM (NCT07438912)
- Testing
- Sleep Pressure Manipulation
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Arizona