Clinical trials: Biological Therapy
Prostate Cancer
Biological Therapy in Treating Patients With Prostate Cancer
RATIONALE: Biological therapies use different ways to stimulate the immune system and stop tumor cells from growing. Treating a person's T cells in the laboratory and then reinfusing them may cause a stronger immune response and…
- Trial name
- NCT00039299
- Testing
- therapeutic autologous lymphocytes
- Where
- United States
- Sponsor
- Jonsson Comprehensive Cancer Center
Infertility, Female
Biological Effects of Treatment With Resveratrol in ART Patients
To evaluate the effects of a new nutraceutical formulation containing resveratrol (trademark GENANTE) on gamete quality in order to improve the reproductive process during ART.
- Trial name
- NCT04386499
- Testing
- Resveratrol, Folic acid
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Of Perugia
Breast Cancer, Breast Carcinoma
A Phase II Randomized Study Evaluating the Biological and Clinical Effects of the Combination of Palbociclib With Letrozole as Neoadjuvant Therapy in Post-Menopausal Women With Estrogen-Receptor Positive Primary Breast Cancer
This study will look at effects the combination of palbociclib and letrozole may have on estrogen receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative breast cancer tumors which have not yet been…
- Conditions
- Breast Cancer, Breast Carcinoma, Breast Tumors
- Trial name
- PALLET (NCT02296801)
- Testing
- Letrozole, palbociclib
- Where
- 52 sites in United States, Canada and 1 more
- Volunteers
- 307 people
- Sponsor
- NSABP Foundation Inc
Heart Failure With Preserved Ejection Fraction
EXercise and Activin Inhibition to Modulate InflammatioN Effects on Heart Failure and Cognition (EXAMINE-HFC)
The goal of this clinical trial is to learn if therapy with activin ligand-trap biological therapy (an investigational drug) combined with exercise training can improve exercise capacity and cognitive function in heart failure…
- Trial name
- EXAMINE-HFC (NCT07202000)
- Testing
- Activin ligand-trap biological therapy
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Massachusetts General Hospital
Metastatic (Stage IV) Melanoma
Clinical Trial Evaluating the Biological Activity of a New Drug Identified as Prifetrastat (PF-07248144), Combined With Fulvestrant for the Treatment of Patients With Hormone Receptor Positive (HR+) and HER2 Negative (HER2-) Breast Cancer Extended to Other Organs.
Although treatments for breast cancer have improved, 20-30% of patients with early disease develop metastases (cancer that spreads to other parts of the body).
- Trial name
- EPIBREAST (NCT07340619)
- Testing
- prifetrastat monotherapy for 15 days then combination with fulvestrant, prifetrastat in combination with fulvestrant
- Where
- 8 sites in France
- Volunteers
- 51 people
- Sponsor
- UNICANCER
Vaginal Atrophy
Comparative Study: Vaginal Promestriene Use, Fractional CO2 LASER and Radiofrequency in the Vaginal Atrophy Treatment
Postmenopausal hypoestrogenism may determine genital atrophy, which may be accompanied by a non-specific inflammatory process and may hinder or even prevent sexual intercourse.
- Trial name
- NCT04717245
- Testing
- Promestriene Vaginal, Fractional CO2 LASER, Microablative Fractional radiofrequency
- Where
- Brazil
- Volunteers
- 75 people
- Sponsor
- University of Sao Paulo General Hospital
Hodgkin Lymphoma, Diffuse Large B Cell Lymphoma
To Decrease Fatigue With Light Therapy
Cancer related fatigue (CRF) is one of the most prevalent and distressing long-term complaints reported by (non-) Hodgkin survivors.
- Trial name
- SPARKLE (NCT03242902)
- Testing
- Light therapy intensity 1, Light therapy intensity 2
- Where
- 9 sites in Netherlands
- Volunteers
- 166 people
- Sponsor
- The Netherlands Cancer Institute
Psoriasis
miRNAs and mRNAs in Psoriasis
PURPOSE - The purpose of this study is to identify and determine miRNA expression and their targets before and during biological treatment of psoriatic patients.
- Trial name
- NCT01604902
- Testing
- 4 mm punch biopsies
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Aortic Valve Disease, Mitral Valve Disease
The Study on the Use of "UniLine" Bioprosthesis in the Treatment of Isolated Aortic and Mitral Valve Diseases
The goal of this open, prospective, multicenter study is analyze long-term outcomes of aortic/mitral valve replacement using the "UniLine" bioprosthesis in patients with acquired aortic or mitral valve diseases.
- Trial name
- Uniline (NCT06025149)
- Where
- Russia
- Volunteers
- 300 people
- Sponsor
- Closed Joint-Stock Company NeoCor
Crohn Disease
Prevention of Postoperative Endoscopic Recurrence With Endoscopy-driven Versus Systematic Biological Therapy
With this prospective, randomized, multicentre, parallel group pragmatic non-inferiority trial, the investigators will evaluate if endoscopy-driven introduction of biological therapy is not leading to more postoperative…
- Trial name
- SOPRANO-CD (NCT05169593)
- Testing
- Biological Drug
- Where
- 28 sites in Belgium, Italy
- Volunteers
- 292 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Psoriasis, Psoriatic Arthritis
Etanercept Therapy for Nails Psoriasis Monitoring With Noninvasive Imaging
OptiSkin is now enrolling a new study to monitor nail changes in patients with nail psoriasis treated with Enbrel® (etanercept) with optical coherence tomography (OCT).
- Conditions
- Psoriasis, Psoriatic Arthritis, Psoriatic Nail
- Trial name
- NCT05135312
- Testing
- Etanercept, OCT
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- OptiSkin Medical
Rheumatoid Arthritis
A Randomized, Multi-Center Biomarker Trial to Predict Therapeutic Responses of Patients With Rheumatoid Arthritis to a Specific Biologic Mode of Action
The purpose of this study is to find biological response patterns of patients with rheumatoid arthritis to drugs with different biologic modes of action.
- Trial name
- NCT01638715
- Testing
- Remicade, Orencia, Ro-Actemra
- Where
- 9 sites in Austria, Czechia and 2 more
- Volunteers
- 115 people
- Sponsor
- Medical University of Vienna
Rheumatoid Arthritis
Association of Fear of Falling and Physical Activity in Rheumatoid Arthritis Comparison Before and After Biological Therapy
Primary Objective: To identify the prevalence and severity of the fear of falling in a rheumatoid population Secondary Objectives: To explore the effect the treatment with biological agents has on fear of falling and physical…
- Trial name
- NCT01071863
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Chronic Diarrhea
Comparative Evaluation of Herbal and Allopathic Drugs for the Treatment of Chronic Diarrhea
Revival of significance and the emergent market of herbal medicinal products necessitate strong commitment by the stakeholders to safeguard the end users.
- Trial name
- HA (NCT02642250)
- Testing
- Metronidazole, Entoban
- Where
- Pakistan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Shifa Ul Mulk Memorial Hospital
Juvenile Idiopathic Arthritis Associated Uveitis
Biologic Therapy in Pediatric JIA Uveitis
Juvenile Idiopathic Arthritis (JIA) remains the most common systemic disorder associated with pediatric uveitis. Studies estimate that 28-67% of patients with JIA-associated uveitis develop ocular complications, with 12%…
- Trial name
- NCT05540743
- Testing
- biologic DMARDs
- Where
- Egypt
- Volunteers
- 250 people
- Sponsor
- Kasr El Aini Hospital
Pediatric Crohn's Disease
Efficacy and Safety of Top-down Therapy in Pediatric Crohn's Disease
Crohn's disease (CD) is an incurable debilitating disorder affecting an increasing number of children. The etiology remains elusive, but a genetically determined aberrant immune response against microbiota appears to be…
- Trial name
- NCT01752790
- Testing
- Top-down, Step-up
- Where
- Italy
- Sponsor
- University of Roma La Sapienza
Metastatic Melanoma Naive to Immune Therapy in Metastatic Setting
Analysis of the Modulation of the Tumor Microenvironment by MK-3475 (Pembrolizumab) Using a Systems Biology Approach (PEMSYS)
This is a monocentric, prospective, interventional and translational phase II study. Metastatic melanoma (mMEL) patients who are naive to immune therapy in the metastatic setting, and for whom an anti-Programmed Cell Death-1…
- Trial name
- NCT03534635
- Testing
- Pembrolizumab, Pembrolizumab - additional treatment
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Obstructive Hypertrophic Cardiomyopathy (oHCM)
Biological Collection for the Purpose of Exploring Genetic and Clinical-biological Factors Associated With Variability in Response to Mavacamten in the Treatment of Obstructive Hypertrophic Cardiomyopathy
The European Medicines Agency has required pre-treatment genotyping of CYP2C19 to determine the initial and maximum dosage, in order to avoid overexposure to mavacamten associated with a decrease in ventricular ejection fraction…
- Trial name
- MAVA PG (NCT07439952)
- Where
- 3 sites in France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ankylosing Spondylitis
Assessment of the Response to Etoricoxib in Patients With Ankylosing Spondylitis and Inadequate Response to ≥2 NSAIDs
The goal of this research is to assess the percentage of non-responders to ≥ 2 NSAIDs candidates a biological therapy that could adequately respond to treatment with etoricoxib This study confirm the result of a previous study in…
- Trial name
- NCT01091675
- Testing
- Etoricoxib
- Where
- 14 sites in Spain
- Volunteers
- 58 people
- Sponsor
- Spanish Foundation of Rheumatology
Colitis, Ulcerative, Crohn Disease
A Study to Observe Vedolizumab and Anti-tumour Necrosis Factors (Anti-TNFs) Outcomes in Real-world Biologic Ulcerative Colitis (UC) and Crohn's Disease (CD) Participants
The purpose of this study is to describe treatment patterns associated with first-line and second line biologic use (vedolizumab or other biologic) and to describe the real-world clinical effectiveness of the use (first-line and…
- Trial name
- EVOLVE-IBERIA (NCT03710486)
- Where
- 26 sites in Portugal, Spain
- Volunteers
- 409 people
- Sponsor
- Takeda
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