Clinical trials: Biological Therapy
Neuroblastoma
Biological Therapy in Treating Patients With Neuroblastoma That Has Not Responded to Previous Treatment
RATIONALE: Monoclonal antibodies, such as monoclonal antibody 3F8, can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells.
- Trial name
- NCT00089258
- Testing
- beta-glucan, monoclonal antibody 3F8, sargramostim
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
IBD
Combination Therapy With Two Biologicals
The efficacy and safety of dual biological therapy.
- Trial name
- Combi (NCT05135221)
- Testing
- dual biological therapy
- Where
- Finland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Pleuropulmonary Blastoma
International Pleuropulmonary Blastoma (PPB) Treatment and Biology Registry
Pleuropulmonary Blastoma (PPB) is very rare and there is no established "standard" or "best" therapy. For many years, children with PPB around the world have been treated according to decisions made case-by-case in many different…
- Trial name
- NCT01464606
- Testing
- Vincristine, Dactinomycin, Cyclophosphamide
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
ITCH
Aprepitant in the Management of Biological Therapies-related Severe Pruritus
Itch is a common side effect of anti-epidermal growth factor receptor antibodies and tyrosine kinase inhibitors. Investigators designed a pilot single-center phase II study evaluating the effects of Aprepitant, a neurokinin…
- Trial name
- AprepIt (NCT01683552)
- Testing
- Aprepitant, Prednisone, Fexofenadine
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- Campus Bio-Medico University
Pharmacogenomics, Systems Biology
Progestagen Type in Postmenopausal Hormone Therapy and Blood Gene Expression Profile
The purpose of this study is to compare combined postmenopausal hormone therapy natural progesterone to the one containing synthetic progestagen (i.e. chlormadinone acetate) at the blood transcriptome level.
- Trial name
- ProGEP (NCT01123538)
- Testing
- Progesterone, Chlormadinone acetate
- Where
- Norway
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital of North Norway
Ulcerative Colitis
Non-Invasive Biomarker Monitoring in UC on Biologics
Ulcerative colitis (UC) is a long-term inflammatory bowel condition. Many patients are treated with intravenous biologic drugs such as infliximab or vedolizumab.
- Trial name
- VIBRANT (NCT07920367)
- Where
- United Kingdom
- Volunteers
- 99 people
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Prostate Cancer
Chemotherapy With or Without Biological Therapy in Treating Patients With Metastatic Prostate Cancer That Has Not Responded to Hormone Therapy
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00005847
- Testing
- recombinant interferon alfa, estramustine phosphate sodium, isotretinoin
- Where
- 19 sites in United States
- Sponsor
- Eastern Cooperative Oncology Group
Uterine Leiomyomas, Fibroids
Biologic Predictors of Leiomyoma Treatment Outcomes
The purpose of this study is to search for the hereditary (genetic) causes of uterine fibroids. Some women with uterine fibroids may have one or more genes that make them more likely to develop uterine fibroids.
- Conditions
- Uterine Leiomyomas, Fibroids, Uterine Fibroids, Myomas
- Trial name
- NCT01936493
- Testing
- DNA analysis, Hormonal analysis
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Elizabeth A. Stewart
Severe Asthma
Educational Needs of Patients With Severe Asthma on Targeted Immunotherapies
Severe asthma is a debilitating disease that affects every aspect of patients' lives: daily life, work, social life, family life, and marital life.
- Trial name
- BASIC (NCT07856407)
- Testing
- Initial assesment interwiew, Intake Interview with the Patient
- Volunteers
- 20 people
- Sponsor
- University Hospital, Angers
Chronic Venous Hypertension With Ulcer
Standard Compression Therapy With/Without Application of Skin Allograft (Theraskin) for Venous Leg Ulcer Treatment
This study will compare the efficacy of using standard compression therapy for treatment of chronic venous leg ulcers vs. the standard compression therapy with the additional use of the application of a human allograft (Theraskin)
- Trial name
- NCT03935386
- Testing
- Standard Multi-layered Compression dressing, Standard Multi-layered Compression dressing with a cryopreserved skin allograft (TheraSkin)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Solsys Medical LLC
Psoriatic Arthritis (PsA), Obesity & Overweight
Combination of Biologic and Anti-obesity Therapies in Psoriatic Arthritis
This is a trial to find out how weight loss (achieved by the use of tirzepatide) or ixekizumab treatment affects the characteristics of skin, joint and fat tissues in patients with Psoriatic Arthritis, Psoriasis and…
- Trial name
- COMBAT-PsA (NCT07443956)
- Testing
- Ixekizumab, Tirzepatide
- Where
- 4 sites in United Kingdom
- Volunteers
- 45 people
- Sponsor
- NHS Greater Glasgow and Clyde
Graft-Versus-Host Disease
Bridging Pediatric and Adult Biomarkers in Graft-Versus-Host Disease
This study is designed to collect longitudinal biological samples from patients after hematopoietic cell transplantation (HCT) cared for at multiple bone marrow transplant centers to validate biomarkers of both acute and chronic…
- Trial name
- NCT02194439
- Where
- United States
- Volunteers
- 415 people
- Sponsor
- Indiana University
Psoriasis
Impact of Clinical and Psychological Factors on Treatment Satisfaction in Psoriatic Patients in Biological Therapy
This study aims to identify, through the use of questionnaires, demographic, clinical and psychological factors that could better correlate with the satisfaction of psoriatic patients in systemic therapy with biological drugs for…
- Trial name
- PsoSAT (NCT06102356)
- Testing
- Questionnaire
- Where
- Italy
- Volunteers
- 104 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Carbapenem Resistant Klebsiella Pneumoniae
Dose Optimization by Pharmacokinetic/Pharmacodynamic of Antibiotics to Improve Clinical Outcome of Carbapenem Resistant Klebsiella Pneumoniae Bloodstream Infections in Critically Ill Patients at Phramongkutklao Hospital
The patients who infected with Carbapenem resistant Klebsiella pneumoniae were high mortality rate. Appropriate antibiotics therapy adjusted by Pharmacokinetic/Pharmacodynamic plays an important role in determining outcomes in…
- Trial name
- NCT05862402
- Testing
- Dose-adjustment by PKPD
- Where
- Thailand
- Volunteers
- 76 people
- Sponsor
- Phramongkutklao College of Medicine and Hospital
Major Depressive Disorder
HypErthermia as an Additional Treatment for the Biology and Experience of Depression
This single-arm feasibility trial administered up to 8 weekly (early phase) or 4 bi-weekly (later phase) whole-body hyperthermia (WBH) sessions and 8 weekly cognitive behavioral therapy (CBT) sessions to adults aged 18 years or…
- Trial name
- HEATBED (NCT05041361)
- Testing
- Cognitive Behavioral Therapy (CBT), Whole-Body Hyperthermia (WBH)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of California, San Francisco
Autoimmune Bullous Dermatosis, Dysimmune Dermatological Diseases
Clinico-biological Collection of Autoimmune, Dysimmune or Auto-inflammatory Dermatological Diseases
The aim of this project is to start a biological and clinical collection of patients presenting autoimmune, dysimmune or auto-inflammatory dermatological diseases.
- Conditions
- Autoimmune Bullous Dermatosis, Dysimmune Dermatological Diseases, Auto-inflammatory Dermatological Diseases, Skin Diseases
- Trial name
- TekAPo (NCT06387654)
- Testing
- Blood sampling, Remainders of samples taken as part of the treatment
- Where
- France
- Volunteers
- 800 people
- Sponsor
- University Hospital, Toulouse
Immunologic and Inflammatory Diseases
Incidence and Risk Factors for Infections in Patient Treated With Corticosteroids, Immunosuppressive Drugs or Biotherapy for Immunologic and Inflammatory Diseases
Infections represent the first cause of death and of morbidity in people treated for immunologic and inflammatory diseases with corticosteroids, immunosuppressive drugs or biotherapy.
- Trial name
- INFIM (NCT02280902)
- Testing
- Blood samples
- Where
- 7 sites in France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Bordeaux
Leukemia, Myelodysplastic Syndromes
Biological Therapy in Treating Patients With Myelodysplastic Syndrome
RATIONALE: Biological therapies use different ways to stimulate the immune system and stop cancer cells from growing. Combining different types of biological therapies may kill more cancer cells.
- Trial name
- NCT00005853
- Testing
- anti-thymocyte globulin, etanercept
- Where
- United States
- Sponsor
- Fred Hutchinson Cancer Center
Psoriasis
A Study to Determine the Efficacy of Taclonex Topical Suspension as a Supplement to Non-biologic Systemic Therapy
Oral therapies for psoriasis, including methotrexate and acitretin, are often less effective when used as monotherapy (without other oral medicines or creams) than are newer biologic injected drugs.
- Trial name
- NCT01761019
- Testing
- Taclonex Topical Suspension
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Pittsburgh
Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)
Biological Therapy in Treating Patients With Advanced Myelodysplastic Syndrome, Acute or Chronic Myeloid Leukemia, or Acute Lymphoblastic Leukemia Who Are Undergoing Stem Cell Transplantation
This phase I/II trial is studying the side effects of biological therapy and to see how well it works in treating patients with advanced myelodysplastic syndrome, chronic myeloid leukemia, acute myeloid leukemia, or acute…
- Conditions
- Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Inv(16)(p13;q22), Adult Acute Myeloid Leukemia With t(15;17)(q22;q12), Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)
- Trial name
- NCT00052520
- Testing
- therapeutic allogeneic lymphocytes, aldesleukin, peripheral blood stem cell transplantation
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Fred Hutchinson Cancer Center
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