Clinical trials: Biological Therapy
Acute Sciatica, Lumbar Disc Herniation
Chiropractic Spinal Manipulative Therapy for Acute Sciatica Secondary to Lumbar Disc Herniation
Comparisons of surgical and non-operative treatment of patients with acute sciatica secondary to lumbar intervertebral disc herniation (AS/LDH) have shown no appreciable difference in outcome.
- Trial name
- NCT01552486
- Testing
- Chiropractic Spinal Manipulative Therapy, Usual Care
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Vancouver General Hospital
Plaque Psoriasis
A 16-week Randomized Evaluation of the Impact of Mind.Px Application on Response to Biologic Treatment in Patients Suffering From Plaque Psoriasis Through Clinical Utility and Health Outcomes.
This protocol describes randomized, multicenter, blinded (subjects), 16-week, controlled study in parallel balanced groups of psoriasis (Ps) patients to evaluate the impact of Mind.Px on response to biologic treatments.
- Trial name
- MATCH (NCT05036889)
- Testing
- Mind.Px Report
- Volunteers
- 200 people
- Sponsor
- Mindera Health
Systemic Lupus Erythematosus
Monoclonal Antibody Treatment for Systemic Lupus Erythematosus
This study will examine the safety and effects of the monoclonal antibody MRA in patients with systemic lupus erythematosus (SLE). Antibodies normally fight invading organisms.
- Trial name
- NCT00046774
- Testing
- MRA 003 US
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Burn Injury
Use of Progenitor Biological Bandages in Burn Care (Bru_PBB)
Skin, as the outermost organ of the human body, serves as a protective layer from microorganisms and external forces, and allows controlling fluid loss among other important functions (sensory, immune and aesthetic functions).
- Trial name
- Bru_PBB (NCT05339490)
- Testing
- Progenitor Biological Bandages, Jelonet
- Where
- Switzerland
- Volunteers
- 76 people
- Sponsor
- Dr Anthony De Buys Roessingh
COPD
Biomarkers for Diagnosis and Treatment of COPD
COPD is an inflammatory disease characterized by enhanced chronic airway and lung inflammatory responses to noxious agents (e.g. smoke, pollutants) and progressive airflow limitation.
- Trial name
- BmiRCOPD (NCT02633280)
- Where
- 3 sites in Italy
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- University of Catanzaro
Growth Hormone Deficiency, Short Stature
Biological Age in Children With GH Deficiency Undergoing Hormone Replacement Therapy
The primary objective of the study is to evaluate the epigenetic age in children with GH deficiency, before and after 6 months of treatment with growth hormone replacement therapy.
- Trial name
- ETABIOGHD (NCT06294860)
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Istituto Auxologico Italiano
Solid Tumor, Adult, Solid Tumor Cancer
Study of DF6215 in Patients With Advanced Solid Tumors
A Phase I/Ib, First-In-Human, Multi-Part, Open-Label Study to Investigate the Safety, Tolerability, Pharmacokinetics, Biological and Clinical Activity of DF6215 Monotherapy and in Combination Therapy in Patients with Advanced…
- Trial name
- NCT06108479
- Testing
- DF6215, pembrolizumab, KEYTRUDA®
- Where
- 21 sites in United States, Australia and 1 more
- Volunteers
- 35 people
- Sponsor
- Dragonfly Therapeutics
Brain and Central Nervous System Tumors
Biological Therapy in Treating Patients With Glioblastoma Multiforme
RATIONALE: Biological therapies use different ways to stimulate the immune system and stop cancer cells from growing. PURPOSE: Phase II trial to study the effectiveness of biological therapy in treating patients with glioblastoma…
- Trial name
- NCT00003185
- Testing
- autologous tumor cell vaccine, sargramostim, tumor-draining lymph node lymphocyte therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The Cleveland Clinic
Biological Availability
Comparative Bioavailability of XS004 (Dasatinib) Formulation G and SPRYCEL® (Dasatinib) in Healthy, Adult Subjects Under Fasting Conditions
An open label, single-center, balanced, randomized, two-treatment, two-sequence, four-period, full replicate, crossover, single dose, Phase I, oral comparative bioavailability study in healthy, adult participants (male subjects…
- Trial name
- NCT05439408
- Testing
- Dasatinib ASD 100 mg, Dasatinib 140 MG [Sprycel]
- Where
- India
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Xspray Pharma AB
Prostate Cancer
Participation in Procurement of Tissue, Serum, Plasma, Cell Bank, DNA and RNA Samples, and Urine for Biological Studies Related to Prostate Cancer and Prostate Cancer Treatment Follow Up
This research study is being done to collect regular and routine follow-up information related to the outcome of treatment for prostate cancer.
- Trial name
- NCT01098552
- Where
- United States
- Volunteers
- 4,900 people
- Sponsor
- Mayo Clinic
Idiopathic Pulmonary Fibrosis
Safety and Efficacy of QAX576 in Patients With Idiopathic Pulmonary Fibrosis (IPF)
This study is designed to evaluate the safety, tolerability, pharmacokinetics and efficacy of QAX576 in patients with idiopathic pulmonary fibrosis.
- Trial name
- NCT01266135
- Testing
- QAX576
- Where
- 10 sites in United States, United Kingdom
- Volunteers
- 40 people
- Sponsor
- Novartis Pharmaceuticals
Health Services Accessibility, Rural Health
Health Ahead Comparative Effectiveness Study
The Health Ahead Comparative Effectiveness Study is a pragmatic, parallel-arm interventional platform that systematically compares successive changes to preventive health screening on the path toward a fully automated screening…
- Conditions
- Health Services Accessibility, Rural Health, Medically Underserved Area, Preventive Health Services
- Trial name
- HACE (NCT07669168)
- Testing
- AI-Assisted Screening Interpretation (AI Reads), Human-Only Screening Interpretation
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- William Brandenburg, MD
Rheumatoid Arthritis
Effectiveness Registry to Study Therapies for Arthritis and Inflammatory Conditions: The Corrona CERTAIN Sub-study
The CORRONA CERTAIN Sub-study of the Consortium of Rheumatology Researchers of North America, Inc. is a Sub-study of the CORRONA Data Collection Program.
- Trial name
- CERTAIN (NCT01625650)
- Where
- United States
- Volunteers
- 2,795 people, healthy volunteers welcome
- Sponsor
- CorEvitas
Craniopharyngioma, Child
Prospective Pilot Study Identifying Clinically Relevant Biological Targets for Medical Therapy
New data suggests that the current treatment for pediatric adamantinomatous craniopharyngioma (CPA) may not be as effective as it could be.
- Trial name
- NCT03610906
- Testing
- Tumor and Blood Specimens
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Colorado, Denver
Major Depressive Disorder
Acupuncture Therapy Based on Biological Specificity of Acupoints for Major Depressive Disorder
Acupoints are the stimulus points and reactive points for acupuncture to treat the diseases. Therefore, this study is designed to detect the biological specificity of acupoints in healthy participants and major depressive…
- Trial name
- NCT05353543
- Testing
- SSRIs, acupuncture (strong reaction acupoints), acupuncture (weak reaction acupoints)
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The Third Affiliated hospital of Zhejiang Chinese Medical University
Arthritis, Rheumatoid
Persistence of Biological Treatment and Inhibitors of Jak Kinases in Patients With Rheumatoid Arthritis.
One-center observational study aimed at determining the survival of patients with rheumatoid arthritis treated with targeted synthetic disease-modifying drugs (FAMEsd) and biologic disease-modifying drugs (FAMEb).
- Trial name
- Arthritis (NCT05062421)
- Where
- Spain
- Volunteers
- 540 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Psoriasis, Psoriatic Arthritis
IKBKB Gene Polymorphism (Single Nucleotide Polymorphism) (SNP) in Psoriatic and Psoriatic Arthritis Patients
Psoriasis is a chronic inflammatory skin disease characterized by scaly indurated erythema. It impairs patients' quality of life enormously. Psoriasis refers to a persistent inflammatory illness of the skin and joints.
- Trial name
- NCT06729463
- Testing
- Humira
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- South Valley University
Colon Cancer
Neoadjuvant Treatment of Colon Cancer
This study will investigate the effect of preoperative combination chemotherapy in patients with locally advanced colon cancer with mutation in the KRAS, BRAF or PIK3CA gene the effect of preoperative combination chemotherapy in…
- Trial name
- NCT01108107
- Testing
- Oxaliplatin, Capecitabine, Panitumumab
- Where
- 3 sites in Denmark
- Volunteers
- 76 people
- Sponsor
- Vejle Hospital
Covid19
Proof-of-Concept Clinical Pharmacology Trial for COVID-19 Antigen Presentation Therapeutic Biologic Mix
Conducting an initial small, controlled clinical pharmacology trial to assess for therapeutic biologics activity (proof-of-concept) that suggests the potential for clinical benefit of COVID-19 patients with controlled cancers. 1.
- Trial name
- COVSP-BCG (NCT03305341)
- Testing
- COVID-19 Therapeutic Biologic Mix - NOVAVAX COVID-19 VACCINE plus BCG Vaccine Mix for percutaneous use
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Han Xu, M.D., Ph.D., FAPCR, Sponsor-Investigator, IRB Chair
Breast Cancer, Relapse
Study of Autologous CAR-T Cells Targeting B7-H3 in TNBC iC9-CAR.B7-H3 T Cells
This phase 1, single-center, open-label study explores the safety of escalating doses of chimeric antigen receptor T cells (CAR-T) cells in subjects with relapsed/refractory triple-negative breast cancer (TNBC).
- Conditions
- Breast Cancer, Relapse, Resistant Cancer, Triple Negative Breast Cancer
- Trial name
- NCT06347068
- Testing
- iC9-CAR.B7-H3 T Cell Therapy, cyclophosphamide, fludarabine
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
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