Clinical trials: Biological Therapy
Healthy
Calanus Oil Supplementation and Maximal Oxygen Uptake
Copepod oil is extracted from the marine copepod Calanus finmarchicus, the dominant plankton species in the marine food web in the Norwegian Sea.
- Trial name
- NCT02908828
- Testing
- Calanus oil
- Where
- 2 sites in Norway
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Inflammatory Bowel Diseases, Crohn Disease
Therapeutic Effect of New Biologics in Crohn's Disease
New types of biologics have brought advantages in therapy strategies for Crohn's disease. However, clinical data evaluating their efficacy and adverse in China is lacking.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis, Treatment Side Effects
- Trial name
- NCT04923100
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Solid Tumor
A Study of Recombinant Oncolytic Virus M1(VRT106) in Patients With Solid Tumors
To Evaluate the safety and tolerability of single and multiple intratumoral injections of recombinant oncolytic virus M1 (VRT106) in patients with locally advanced/metastatic solid tumors.
- Trial name
- NCT06368921
- Testing
- VRT106
- Where
- 3 sites in China
- Volunteers
- 30 people
- Sponsor
- Guangzhou Virotech Pharmaceutical Co., Ltd.
Arthritis, Rheumatoid, Spondyloarthritis
Effect of Pharmaceutical Consultations Just Before Rheumatology Consultations on Improving Knowledge and Skills for Patients With Inflammatory Arthritis With Subcutaneous Biologic DMARDs
There is a lack of knowledge among patients concerning their treatment with bDMARDs. To increase knowledge and safety skills, patient education is essential.
- Conditions
- Arthritis, Rheumatoid, Spondyloarthritis, Biological Therapy
- Trial name
- NCT04499001
- Testing
- Pharmacist's consultation
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Hôpital Cochin
Soft Tissue Sarcoma
A Study of Olaratumab (LY3012207) in Participants With Soft Tissue Sarcoma
The purpose of this study is to evaluate potential biomarkers and method of action, efficacy and safety of olaratumab in participants with soft tissue sarcoma (STS).
- Trial name
- NCT02783599
- Testing
- Olaratumab, Doxorubicin, External Beam Radiotherapy
- Where
- 14 sites in United States, France and 3 more
- Volunteers
- 51 people
- Sponsor
- Eli Lilly and Company
Knee Osteoarthritis
A Randomized Trial Comparing High Tibial Osteotomy Plus Non-Surgical Treatment and Non-Surgical Treatment Alone
The purpose of this study is to compare patients with knee osteoarthritis (OA) receiving optimized non-surgical treatment plus surgical realignment of the tibia, or optimized non-surgical treatment only.
- Trial name
- NCT02003976
- Testing
- Medial Opening Wedge High Tibial Osteotomy (HTO), Non-Surgical Treatment Program
- Where
- Canada
- Volunteers
- 71 people
- Sponsor
- Western University, Canada
Severe Asthma
Severe Asthma Exacerbations and Mepolizumab Treatment
This is a hypothesis-generating project to investigate a) infective etiology and b) inflammatory profile of the exacerbations of asthma in severe asthmatic patients treated with the humanized monoclonal antibody against…
- Trial name
- ESAM-BIO (NCT04914078)
- Testing
- Mepolizumab 100 MG
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Università degli Studi di Ferrara
Non Metastatic Breast Cancer
Biological Response to Tamoxifen (TAM) in Patients With Breast Cancer Non Metastatic RH+
The biological response to treatment with tamoxifen in the preoperative situation is studying in this protocol. This study will enrolls patients with non-metastatic breast cancer HR +.
- Trial name
- TAM (NCT01220076)
- Testing
- tamoxifen
- Where
- 3 sites in France
- Volunteers
- 140 people
- Sponsor
- Institut Cancerologie de l'Ouest
Rheumatic Diseases
Nurse-led Clinic for Patients With Rheumatic Diseases and Biological Treatment
Randomized controlled trial including 100 subjects with rheumatic diseases and biological treatment with a 28 point-Disease Activity Score(DAS28)3.2 or less.
- Trial name
- NCT01071447
- Testing
- Nurse-led clinic vs rheumatologist-led clinic
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Spenshult Hospital
Eosinophilic Asthma, Chronic Sinusitis
Eosinophils Endotypes in Chronic Airway Inflammatory Diseases
Asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) are frequently described as unified airway inflammatory diseases. Both heavily impacts quality of life with substantial productivity loss.
- Conditions
- Eosinophilic Asthma, Chronic Sinusitis, Eosinophilic Rhinitis
- Trial name
- PLEIAD (NCT04187976)
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Lille
Spondylitis, Ankylosing
Prediction of Treatment Response at 6 Months by Combinatorial Analysis of Serum Biomarkers in Biotherapy Naive SpA
The main objective of this trial is to search for biomarkers associated with the success of adalimumab treatment in order to generate an algorithm to predict the response to this treatment at 6 months in spondyloarthritis and to…
- Trial name
- PRESHUM (NCT03561649)
- Testing
- Adalimumab
- Where
- 5 sites in France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Grenoble
Cancer, Radiotherapy Side Effect
Attribution of Toxicities Due to Radiotherapy and Immuno-Biological Therapies
Every year, new molecular agents enter the market with more and more patients receiving these treatments, especially in the metastatic setting.
- Trial name
- AtTRIBut (NCT04115267)
- Testing
- Radiotherapy
- Where
- Canada
- Volunteers
- 3,600 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
COVID-19, Vaccine Adverse Reaction
National Vaccine Adverse Event Reporting Survey and Etiology
If your serious vaccine-induced adverse event has been entered in the CDC Vaccine Adverse Event Reporting System (VAERS) we are interested in enrolling you for this study in order to log your symptoms.
- Conditions
- COVID-19, Vaccine Adverse Reaction, Vaccine Reaction, Vaccine or Biological Substance, Unspecified Causing Adverse Effects in Therapeutic Use
- Trial name
- NVAERS (NCT05095844)
- Testing
- vaccinated
- Where
- United States
- Volunteers
- 100,000 people
- Sponsor
- Neuroganics LLC
IBD (Inflammatory Bowel Disease)
MICI-BIO: Study on Patient With Chronic Inflammatory Bowel Disease
This is a monocentric, non-profit prospective cohort study with longitudinal biological sampling. The study will include patients with IBD starting biological therapy with infliximab.
- Trial name
- MICI-BIO (NCT07470502)
- Testing
- Infliximab level analysis in biological samples
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Meyer Children's Hospital IRCCS
Axial Spondyloarthritis
Explore the Associations of Behavioral Factors With Treatment Adherence in Axial Spondyloarthritis Patients Treated With Biotherapy.
The management of chronic inflammatory rheumatism, including spondyloarthritis (SpA), has been revolutionized in recent decades with the arrival of biological therapy.
- Trial name
- MAINTAIN II (NCT04925037)
- Testing
- self-questionnaire to patients undergoing SpAax follow-up
- Where
- 5 sites in France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Clermont-Ferrand
Anoperineal Lesions, Crohn's Disease Relapse
Description of the Radiological Response of Anoperineal Fistulizing Lesions of Crohn's Disease
The presence of ano-perineal lesions (APL) in Crohn's disease is common and represents a major burden for the patient. More than one-third of patients with Crohn's disease will develop at least one ano-perineal lesion during the…
- Trial name
- PéricrohnIRM (NCT07152977)
- Testing
- Radiological evolution of ano-perineal lesions by MRI
- Where
- France
- Volunteers
- 52 people
- Sponsor
- University Hospital, Rouen
Periodontal Diseases, Periodontal Attachment Loss
Clinical Effectiveness of Biologic Agents as an Adjunct to Non-surgical Periodontal Therapy of Intrabony Defects
The aim of the present study is to clinically and radiographically compare the efficacy of recombinant human platelet-derived growth factor (rhPDGF), Leukocyte-Platelet Rich Fibrin (L-PRF) and Enamel Matrix Derivatives (EMD) in…
- Conditions
- Periodontal Diseases, Periodontal Attachment Loss, Pocket, Periodontal, Intrabony Periodontal Defect
- Trial name
- NCT05858411
- Testing
- SRP+rhPDGF, SRP+L-PRF, MINST alone
- Where
- Albania
- Volunteers
- 88 people
- Sponsor
- G. d'Annunzio University
Ovarian Cancer
Intraperitoneal tgDCC-E1 and Intravenous Paclitaxel in Women With Platinum-Resistant Ovarian Cancer
The goal of this clinical research study is to find the highest safe dose of intraperitoneal tgDCC-E1A that can be given in combination with paclitaxel as a treatment for patients with recurrent, platinum-resistant ovarian…
- Trial name
- NCT00102622
- Testing
- Intraperitoneal tgDCC-E1A, Paclitaxel
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- M.D. Anderson Cancer Center
Rheumatoid Arthritis (RA)
Masitinib in Refractory Active Rheumatoid Arthritis
The objective is to compare efficacy and safety of masitinib at 3 and 6 mg/kg/day to methotrexate, with a randomisation 1:1:1, in treatment of patients with active rheumatoid arthritis with inadequate response to 1.
- Trial name
- NCT01410695
- Testing
- masitinib 3 mg, masitinib 6.0 mg, methotrexate
- Where
- Czechia
- Volunteers
- 324 people
- Sponsor
- AB Science
Breast Cancer
Combination Chemotherapy Plus Biological Therapy in Treating Patients With Stage II or Stage III Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Biological therapies use different ways to stimulate the immune system and stop tumor cells from growing.
- Trial name
- NCT00022230
- Testing
- aldesleukin, filgrastim, sargramostim
- Where
- United States
- Sponsor
- Roger Williams Medical Center
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