Clinical trials: Biological Therapy
Rheumatoid Arthritis, Ankylosing Spondylitis
Frequency and Complications of Major Orthopedic Procedures in Medicare Beneficiaries
Background: Orthopedic procedures are common in the United States. These include joint replacement and spine surgeries. Researchers want to study data about these procedures over time.
- Trial name
- NCT02281747
- Where
- United States
- Volunteers
- 521,292 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Rheumatoid Arthritis
Retrospective Evaluation of the Radiographic Efficacy of Conventional and Biologic Treatment
This study involves review and analysis of disease activity in patients with rheumatoid arthritis who where treated with either conventional DMARDs (Disease Modifying Antirheumatic Drugs) or Biologics and have two existing…
- Trial name
- NCT00929357
- Testing
- DMARDs or Biologics
- Where
- Denmark
- Volunteers
- 156 people
- Sponsor
- Pfizer
Chronic Pulmonary Obstructive Disease, Emphysema
A Registry Study of the AeriSeal® System or Lung Volume Reduction in Patients With Advanced Emphysema
The purpose of this study is to provide post market clinical follow-up (PMCF) to obtain long term safety and efficacy information about the AeriSeal System treatment in patients with advanced emphysema.
- Trial name
- NCT01449175
- Where
- 8 sites in Austria, France and 2 more
- Volunteers
- 54 people
- Sponsor
- Aeris Therapeutics
Ulcerative Colitis, Inflammatory Bowel Diseases
Proof of Concept Study Evaluating the Efficacy and Safety of ATH-063 Treatment in Patients With Relapsed/Refractory Moderately to Severely Active Ulcerative Colitis (UC)
The primary objective of this trial is to evaluate the clinical efficacy of ATH-063 in participants with biologic/advanced therapy relapsed/refractory moderately to severely active UC.
- Conditions
- Ulcerative Colitis, Inflammatory Bowel Diseases, Autoimmune Diseases
- Trial name
- Aegean (NCT07513181)
- Testing
- ATH-063
- Where
- 4 sites in United States
- Volunteers
- 120 people
- Sponsor
- Athos Therapeutics Inc
Psoriasis
A Study to Evaluate Infliximab in Subjects With Moderate-to-Severe Psoriasis Not Responding to Standard or Biologic Therapy (Study P04612)
Subjects with moderate-to-severe chronic psoriasis not responding to standard or biologic therapy will be eligible to enroll in this study.
- Trial name
- ESAQUALITY (NCT00687401)
- Testing
- Infliximab
- Volunteers
- 215 people
- Sponsor
- Merck Sharp & Dohme LLC
Inflammatory Bowel Disease (Crohn's Disease; Ulcerative Colitis), Adherence, Patient
Treatment Adherence Among Patients With Inflammatory Bowel Disease Receiving Anti-TNF Therapy
Inflammatory bowel disease (IBD) is a chronic condition characterized by periods of remission and relapse, requiring long-term treatment adherence to maintain disease control and prevent complications.
- Conditions
- Inflammatory Bowel Disease (Crohn's Disease; Ulcerative Colitis), Adherence, Patient, Structured Education
- Trial name
- NCT07652840
- Testing
- Health Belief Model-Based Structured Patient Education, Standard Patient Education
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Izmir Katip Celebi University
Benign Brain Tumors, Proton Therapy
Changes in the MRI Signal in Patients With Benign Tumors of the Brain and Meninges Treated With Proton Therapy: Impact of TEL and the Biological Dose Received
The main objective is to detect with TESLA multiparametric 3 MRI, the MRI secondary changes to protontherapy irradiation and to correlate them with TEL mapping, physical dose and biological dose.
- Trial name
- BRAIN TEL (NCT04584086)
- Testing
- MRI 3 tesla
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Francois Baclesse
Asthma
Craving to Biologics Used in Severe Asthma
Some patients treated with biologics for severe asthma experience a craving to the next biological administration. This phenomenon has never been described before.
- Trial name
- CROCUS (NCT05426538)
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- Frisius Medisch Centrum
Breast Cancer
Trastuzumab Deruxtecan Versus Standard Neoadjuvant Treatment for HER2-positive Breast Cancer
The goal of this clinical trial is to compare trastuzumab deruxtecan (T-DXd) to standard preoperative treatment in patients with non-metastatic HER2-positive breast cancer.
- Trial name
- ARIADNE (NCT05900206)
- Testing
- Trastuzumab deruxtecan, Docetaxel, Paclitaxel
- Where
- 7 sites in Sweden
- Volunteers
- 370 people
- Sponsor
- Karolinska University Hospital
Covid19, SARS-CoV Infection
IVIG in Patients With Severe COVID-19 Requiring Mechanical Ventilation
The purpose of this Pilot Study is to establish a hypothesis of whether or not intravenous immunoglobulin (IVIG) may impact the hospital length of stay, if started within 48 of mechanical ventilation in patients infected with…
- Trial name
- NCT04616001
- Testing
- IVIG
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Sharp HealthCare
Breast Cancer, Breast Carcinoma
TIL Gean Therapy Combined With Immunotherapy for Advanced or Metastatic Refractory Breast Cancer
This Phase I/II study evaluates the safety and efficacy of autologous tumor-infiltrating lymphocytes (TIL) therapy combined with Pembrolizumab (Keytruda) immunotherapy in patients with advanced or metastatic refractory breast…
- Conditions
- Breast Cancer, Breast Carcinoma, Breast Cancer Metastatic, Breast Cancer Triple Negative
- Trial name
- BAH249 (NCT06532812)
- Testing
- Tumor Infiltrating Lymphocytes (TIL), Cyclophosphamid, Fludarabine
- Where
- China
- Volunteers
- 85 people
- Sponsor
- Essen Biotech
Degenerative Arthritis
Safety and Biological Efficacy Study of TisssueGene-C to Degenerative Arthritis
The primary purpose of the this study is to evaluate the safety of TissueGene-C, a gene therapy product that uses allogenic human chondrocytes expressing Transforming Growth Factor(TGF)-β1 by assessing the inflammation at the…
- Trial name
- NCT02341391
- Testing
- TissueGene-C(Low dose), TissueGene-C(Medium dose), TissueGene-C(High dose)
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- Kolon Life Science
Spondyloarthritis
Comparative Analysis of Two Therapeutic Strategies in Patients With Spondyloarthritis Treated With Anti-tnf Biologics
The objective of the study is to evaluate two therapeutic strategies: "early switch" or "therapeutic intensification" in patients with spondyloarthritis in case of secondary treatment failure suspicion to a first monoclonal…
- Trial name
- STRADA (NCT01971918)
- Testing
- anti drug antibodies dosage
- Where
- 7 sites in France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Rouen
Rheumatoid Arthritis
Repository Corticotropin Injection To Treat Rheumatoid Arthritis Patients Who Have Failed Three Biologic Therapies.
It is hypothesized that repository corticotropin injection in combination with other biologic agents will be able to provide relief of both rheumatoid arthritis and acute exacerbations of rheumatoid arthritis for patients with…
- Trial name
- NCT01966718
- Testing
- Repository corticotropin injection
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Arthritis Treatment Center, Maryland
Refractory Chronic Lymphocytic Leukemia
Lower But More Frequent Dose Rituximab to Treat Chronic Lymphocytic Leukemia
This study will test the safety and effectiveness of using lower-dose rituximab given more frequently for treating chronic lymphocytic leukemia (CLL).
- Trial name
- NCT00366418
- Testing
- Rituximab
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
ADHD
Atomoxetine, Diurnal Profiles of Cortisol and α-amylase
Diurnal profiles of markers of the stress system are increasingly recognized as biomarkers of different kinds of depression and related states. They may also serve as markers of treatment success.
- Trial name
- ADHDstress (NCT03075579)
- Testing
- Medication Other, motor measurement and saliva collection
- Where
- 2 sites in Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Praxis für kleine und grosse Leute
Lung Cancer, Lung Cancer Metastatic
TIL Therapy Combined With Pembrolizumab for Advanced or Metastatic Refractory Lung Cancer
This Phase I/II study evaluates the safety and efficacy of autologous tumor-infiltrating lymphocytes (TIL) therapy combined with Pembrolizumab (Keytruda) immunotherapy in patients with advanced or metastatic refractory lung…
- Conditions
- Lung Cancer, Lung Cancer Metastatic, Lung Cancer, Non-small Cell, Lung Cancer Recurrent
- Trial name
- BAH2472 (NCT06538012)
- Testing
- Tumor Infiltrating Lymphocytes (TIL), Cyclophosphamide, Fludarabine
- Where
- China
- Volunteers
- 85 people
- Sponsor
- Essen Biotech
Circadian Dysregulation
Efficacy of Ramelteon on Insomnia Symptoms Associated With Jet Lag in Healthy Adult Volunteers
The purpose of this study to determine the degree to which ramelteon, once daily (QD), can reduce the insomnia symptoms associated with rapid, eastward travel across 5 time zones.
- Trial name
- NCT00492011
- Testing
- Ramelteon
- Where
- 4 sites in United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Takeda
Diabetic Nephropathy, Diabetes Mellitus
Mechanisms of Diabetic Nephropathy in Ecuador
The prevalence of diabetes mellitus (DM) is increasing worldwide, suggesting that 45% of diabetics are undiagnosed. DM induces a kidney disease called diabetic nephropathy (DN) which is the largest single cause of end-stage renal…
- Conditions
- Diabetic Nephropathy, Diabetes Mellitus, Kidney Diseases, Diabetic Kidney Disease
- Trial name
- NCT02237352
- Where
- Ecuador
- Volunteers
- 10,064 people, healthy volunteers welcome
- Sponsor
- Universidad Estatal de Milagro
Melanoma (Skin)
Biological Therapy and Temozolomide in Treating Patients With Metastatic Melanoma
RATIONALE: Biological therapies use different ways to stimulate the immune system and stop cancer cells from growing. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00016055
- Testing
- lymphokine-activated killer cells, temozolomide
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- St. Luke's Medical Center
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