Clinical trials: Biological Therapy
Kidney Cancer
UroCCR Database: French Research Network for Kidney Cancer -UroCCR
Kidney cancer management has become increasingly complex with the diversification of treatment options and the integration of multidisciplinary care.
- Trial name
- UroCCR (NCT03293563)
- Testing
- Radical nephrectomy versus partial nephrectomy (according surgeon judgement)
- Where
- 68 sites in Belgium, France and 2 more
- Volunteers
- 30,000 people
- Sponsor
- University Hospital, Bordeaux
Ulcer, Herpes Genitalis
Anti-Herpetic Treatment of Genital Ulcer : Effect on HIV & Herpes Shedding (ANRS 1212)
Herpes virus type 2 (HSV-2) infection - as a cofactor of human immunodeficiency virus (HIV) transmission - can be targeted by anti-herpetic specific drugs, either as a continuous prophylactic treatment during its asymptomatic…
- Trial name
- NCT00158483
- Testing
- Acyclovir (ACV)
- Where
- 3 sites in Central African Republic, Ghana
- Volunteers
- 449 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
Stress Urinary Incontinence
Autologous Versus Synthetic Versus Biological Sling for Trans-obturator Correction of Urinary Stress Incontinence
The treatment of urinary stress incontinence with trans-obturator approach, know as transobturatory tape (TOT), is a largely used sling-adopting procedures.
- Trial name
- NCT00744198
- Testing
- Autologous transobturator tape procedure, Synthetic transobturator tape procedure, Biological transobturator tape procedure
- Where
- Italy
- Volunteers
- 8 people
- Sponsor
- University Magna Graecia
Ankylosing Spondylitis, Spinal Fractures
Effect of Biological Disease Modifying Anti Rheumatic Drug (bDMARD) Treatment on Spinal Fracture Incidence in Patients With Ankylosing Spondylitis (AS)
Ankylosing spondylitis (AS) is a rheumatoid disease affecting all segments of the axial skeleton, leading to the complete fusion of all spinal segments - the bamboo-spine.
- Trial name
- NCT02840695
- Testing
- bDMARD treatment
- Volunteers
- 9,858 people
- Sponsor
- Uppsala University
Severe Asthma
Experience of Biologic Treatments for Severe Asthma: a Survey
Severe asthma is a disease characterised by respiratory and non-respiratory symptoms. The respiratory symptoms can include breathlessness, wheeze and asthma attacks.
- Trial name
- SHARP EoB (NCT06903780)
- Testing
- Survey using a questionnaire.
- Where
- United Kingdom
- Volunteers
- 400 people
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Breast Cancer
Biological and Clinical Effects of Palbociclib With Ovarian Suppression and Letrozole in the Neoadjuvant Treatment of Breast Cancer
This study will look at the safety and effectiveness of the combination of palbociclib and letrozole and ovarian suppression for premenopausal patients who have ER-positive/HER2-negative breast cancer that has not yet been…
- Trial name
- NCT03628066
- Testing
- Letrozole, Palbociclib, Goserelin
- Where
- 15 sites in United States, Canada
- Volunteers
- 24 people
- Sponsor
- NSABP Foundation Inc
Rheumatoid Arthritis
Clinical Trial to Evaluate Efficacy and Safety of Acellbia® (JSC "BIOCAD") With Methotrexate in First Line Biological Therapy of Patients With Active Rheumatoid Arthritis
The mail goal of this study is to establish superiority in efficacy of Acellbia® applied in a dose of 600 mg (Day 1 and Day 15) in combination with methotrexate in patients with active RA seropositive previously untreated with…
- Trial name
- ALTERRA (NCT02744196)
- Testing
- Acellbia, Methotrexate
- Volunteers
- 159 people
- Sponsor
- Biocad
HIV Disease
Advanced Neuroimaging Evaluation of the Central Nervous System Biological Changes Associated With Efavirenz Therapy and Switch to an Elvitegravir-based Regimen
In this study we will use a multi-modal imaging approach of MRS and fMRI to comprehensively assess the biological changes in the brain associated with EFV-based regimen (EFV/FTC/TDF), specifically alterations in the brain…
- Trial name
- NCT01929759
- Testing
- Stribild (elvitegravir, cobicistat, emtricitabine and tenofovir)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Cervical Intraepithelial Neoplasia
Imiquimod Treatment of Residual or Recurrent CIN Lesions: a Study Protocol
The purpose of this study is to investigate if imiquimod can be used as a non-invasive option in the treatment of residual/recurrent CIN lesions.
- Trial name
- TopIC-2 (NCT02669459)
- Testing
- Imiquimod, LLETZ
- Where
- Netherlands
- Volunteers
- 433 people
- Sponsor
- Erasmus Medical Center
Rheumatoid Arthritis
REstore Working Ability in RheumatoiD Arthritis
The purpose of the study is to assess whether a 6-month treatment with adalimumab added on the treatment with conventional antirheumatic drugs (DMARD) will decrease the number of days on sick leave compared to placebo.
- Trial name
- REWARD (NCT01405326)
- Testing
- adalimumab
- Where
- 4 sites in Finland
- Volunteers
- 160 people
- Sponsor
- The Rheumatological Center of Helsinki
Crohn's Disease
MRE Predictors of Disease Relapse After Stopping Biologics
This study aims to investigate if MR Enterography (MRE) improves the ability to predict which Crohn's disease patients will relapse quickly (disease comes back) after stopping biologic medication.
- Trial name
- METEOR (NCT06124287)
- Testing
- MR Enterography (MRE)
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- University College, London
Stomach Cancer, Stomach Cancer Recurrent
TIL Therapy Combined With Pembrolizumab for Advanced or Metastatic Refractory Stomach and Esophageal Cancer
This Phase I/II study evaluates the safety and efficacy of autologous tumor-infiltrating lymphocytes (TIL) therapy combined with Pembrolizumab (Keytruda) immunotherapy in patients with advanced or metastatic refractory stomach…
- Conditions
- Stomach Cancer, Stomach Cancer Recurrent, Stomach Cancer, Adenocarcinoma, Esophageal Cancer
- Trial name
- BAH250 (NCT06532799)
- Testing
- Tumor Infiltrating Lymphocytes (TIL), Cyclophosphamid, Fludarabine
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Essen Biotech
Reproductive Physiological Phenomena
CoQ10 Treatment to Improve Fertility in Elderly Patients
Delaying first childbirth is a progressive trend in the developed societies. Several theories tried to explain the reproductive aging, in purpose to hasten it. One of the theories include mitochondrial dysfunction with aging.
- Trial name
- NCT02010164
- Testing
- Co-enzyme Q10
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Hadassah Medical Organization
Plaque Psoriasis
Trial of an Injectable Biologic and U0279 as Combination Therapy for Severe Plaque-Type Psoriasis
The purpose of the study is to assess the safety and efficacy of an injectable biologic and U0279 as combination therapy compared to that of an injectable biologic alone for severe plaque-type psoriasis.
- Trial name
- NCT00832364
- Testing
- Acitretin (also called U0279), Etanercept
- Where
- 3 sites in United States
- Sponsor
- Stiefel, a GSK Company
Major Depressive Disorder
Cognitive Dysfunction in MDD Patients
Major Depressive Disorder (MDD) is one of the most prevalent mental diagnosis within the worldwide population. Although there is evidence about relationship between MDD and cognitive dysfunction, still the correlations between…
- Trial name
- NCT03187093
- Testing
- Vortioxetine, Escitalopram
- Where
- Ukraine
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Oleg Levada
Rheumatoid Arthritis
Safety Study of Abatacept to Treat Rheumatoid Arthritis (A)
The purpose of this study is to compare the incidence rates of infection among patients with rheumatoid arthritis who are treated with abatacept and those who are treated with other anti-rheumatic medications
- Trial name
- NCT01088321
- Volunteers
- 81,332 people
- Sponsor
- Bristol-Myers Squibb
Infertility
Study to Estimate Seedchrony's Predictive Capacity in the Success of Embryo Implantation.
In Vitro Fertilization (IVF) success is below 40%, with Embryo Transfer the leading cause of IVF failure. This clinical investigation aims to evaluate if the levels of an intrauterine biomarker dissolved in the uterine fluid…
- Trial name
- Seedchrony02 (NCT06259084)
- Testing
- Seedchrony
- Where
- Spain
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Manina Medtech
Orthodontic Treatment Efficiency
Bilogical Assesment During Intrusion of Lower Incisors
biological assesment during intrusion of lower incisors
- Trial name
- NCT07514403
- Testing
- Corticision
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Chronic Myeloproliferative Disorders, Leukemia
Decitabine in Treating Patients With Melanoma or Other Advanced Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of decitabine in treating patients with stage III or stage…
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00002980
- Testing
- decitabine
- Where
- 4 sites in United States
- Sponsor
- California Cancer Consortium
Breast Cancer Female
Mind Programme for Women With Breast Cancer
The Mind programme for cancer patients was developed by this project PI through the integration of ACT, mindfulness and CFT components specifically adapted to the needs of a cancer population.
- Trial name
- MIND (NCT05642897)
- Testing
- Mind, Support Group
- Where
- Portugal
- Volunteers
- 150 people
- Sponsor
- University of Coimbra
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