Clinical trials: Biological Therapy
Thyroid Cancer
Anaplastic Thyroid Cancer and Follicular Thyroid Cancer-derived Exosomal Analysis Via Treatment of Lovastatin and Vildagliptin and Pilot Prognostic Study Via Urine Exosomal Biological Markers in Thyroid Cancer Patients
The investigators expected to enroll 30 patients with papillary, follicular or anaplastic thyroid cancer, and collect their urine samples before operation, immediately after operation, post-operative 3, 6 12 months.
- Trial name
- NCT02862470
- Volunteers
- 22 people
- Sponsor
- National Taiwan University Hospital
Breast Neoplasms
Neoadjuvant Platinum-based Chemoradiation Therapy for Locally Advanced Triple Negative Breast Cancer
The purpose of this study is to determine whether platinum-based chemotherapy (either cisplatin or carboplatin), when given with radiation therapy prior to surgery, is effective in improving response to treatment in triple…
- Trial name
- NCT01167192
- Testing
- Cisplatin, Carboplatin, Radiation therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Washington University School of Medicine
Chronic Pelvic Pain Syndrome
Resolution of Pudendal Neuralgia in Chronic Pelvic Pain Using a Novel Biologic Therapy
This goal of this study is to determine whether a novel biologic, i.e., an "amniotic suspension allograft" (ASA) will reduce pain and improve quality of life (QoL) in women stricken with chronic pelvic pain (CPP).
- Trial name
- NCT06425575
- Testing
- Amniotic suspension allograft
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Thomas Jefferson University
Healthy
Study of Belimumab Administered Subcutaneously to Healthy Subjects
The purpose of this study is to measure the amount of belimumab in the blood when given as an injection under the skin (subcutaneously; SC) and to evaluate the safety and tolerability of multiple injections under the skin in…
- Trial name
- NCT01583530
- Testing
- Single Dose Group: Belimumab IV 240 mg, Single Dose Group: Belimumab SC 2 x 120 mg, Single Dose Group: Belimumab SC 1 x 240 mg
- Where
- 4 sites in United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Human Genome Sciences Inc.
Peri-implant Mucositis
Adjunctive Diode Laser Therapy for Peri-Implant Mucositis
Peri-implant mucositis is an inflammatory condition affecting the soft tissues surrounding dental implants. Conventional non-surgical treatment is primarily based on mechanical removal of bacterial biofilm, although complete and…
- Trial name
- NCT07895667
- Testing
- Conventional Non-Surgical Treatment, FOX III Diode Laser Therapy
- Volunteers
- 144 people
- Sponsor
- Universidad Europea de Valencia
Obsessive - Compulsive Disorder
Clinical and Biological Correlates of Obsessive-Compulsive Disorder and Online Mindfulness-Based Cognitive Therapy
The study has two main objectives: (1) to evaluate the acceptability and feasibility of a specialized Mindfulness-Based Cognitive Therapy (MBCT) program for Obsessive-Compulsive Disorder (OCD), delivered via videoconference in a…
- Trial name
- MIND-DOC (NCT07834567)
- Testing
- Mindfulness-based Cognitive Therapy for OCD
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- IRCCS Centro San Giovanni di Dio Fatebenefratelli
Pulmonary Emphysema
Low Cost Biological Lung Volume Reduction Therapy for Advanced Emphysema
The clinical utility of bronchoscopic methods for achieving lung volume reduction has been evaluated in patients with advanced emphysema because these procedures are uniformly safer than surgical volume reduction.
- Trial name
- BLVR (NCT02107209)
- Testing
- Bronchoscopic Lung volume reduction
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- Mansoura University
Social Anxiety Disorder
Cannabidiol as a Treatment for Social Anxiety Disorder (R61)
The R61 will include two CBD dose levels vs placebo (PBO) and examine potential engagement with two primary targets in a 3-week randomized controlled trial design.
- Trial name
- NCT05571592
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- NYU Langone Health
Attention-deficit/Hyperactivity Disorder
Attention-deficit/Hyperactivity Disorder Translational Center for Identifying Biomarkers
The purpose of this study was to identify genetic, brain morphologic, and environmental biomarkers that contribute to the pathophysiology of attention-deficit/hyperactivity disorder (ADHD).
- Trial name
- NCT02623114
- Testing
- methylphenidate, atomoxetine
- Where
- South Korea
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Seoul National University Childrens Hospital
Stunting of Growth, Chronic Malnutrition
Pilot Study of a Modified Therapeutic Food Compared With a Standard Nutrient Supplement in Young Children in Rural Guatemala
The goal of this clinical trial is to learn whether a modified food supplement is acceptable and well tolerated by children aged 12 to 24 months with mild-to-moderate stunting in rural Guatemala.
- Trial name
- NCT07804667
- Testing
- Modified Therapeutic Food Formulation, Nutri Listo SQ-LNS
- Where
- Guatemala
- Volunteers
- 36 people
- Sponsor
- Wuqu' Kawoq, Maya Health Alliance
Colorectal Cancer
A Study of the Safety and Biological Activity of Intraperitoneal (IP) EGEN-001 Administered Alone and in Combination With Standard Chemotherapy in Colorectal Peritoneal Carcinomatosis Patients
Colorectal cancer may be caused by a build-up of genetic defects, or damaged genes within the body's cells. When genes are damaged, the body may be unable to produce a group of proteins, called cytokines, used by the immune…
- Trial name
- NCT01300858
- Testing
- EGEN-001-301
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- EGEN, Inc.
Pancreatic Cancer
Chemotherapy Compared to Biological Therapy in Treating Patients With Cancer of the Pancreas
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Biological therapies use different ways to stimulate the immune system and stop cancer cells from growing.
- Trial name
- NCT00003780
- Testing
- tumor infiltrating lymphocyte therapy, gemcitabine hydrochloride
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Meyer Pharmaceuticals
Lymphoma
Combination Chemotherapy, Bone Marrow or Peripheral Stem Cell Transplantation, and/or Biological Therapy in Treating Patients With Stage III or Stage IV Mantle Cell Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell or bone marrow transplantation may allow the doctor to give…
- Trial name
- NCT00004231
- Testing
- aldesleukin, filgrastim, recombinant interferon alfa
- Where
- United States
- Sponsor
- Northwestern University
Metastatic, Breast Cancer
Cohort Study of Prospective Validation of Predictive Factors and Biological Imaging of Response to Bevacizumab and Paclitaxel in Patients With Metastatic Breast Cancer
Bevacizumab plus chemotherapy improves response rates and prolongs PFS when used as first- and second-line therapy for advanced breast cancer. However, bevacizumab has not improved OS in the individual studies currently reported.
- Trial name
- COMET (NCT01745757)
- Testing
- Bevacizumab, paclitaxel
- Where
- 19 sites in France
- Volunteers
- 510 people
- Sponsor
- UNICANCER
HIV Seropositivity, HIV Infection
Safety and Efficacy of Ampligen in the Treatment of HIV Patients Failing HAART
This is an open-label, prospective, randomized, controlled study of the safety and efficacy including clinical, immunologic, and virologic assessments of adding Ampligen to "HAART" in HIV infected patients with CD4 counts >300…
- Trial name
- NCT00035581
- Testing
- poly I-poly C12U
- Where
- 7 sites in United States
- Volunteers
- 16 people
- Sponsor
- AIM ImmunoTech Inc.
Neuroblastoma
Multiple Therapies in Treating Patients With Advanced Neuroblastoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of…
- Trial name
- NCT00040872
- Testing
- filgrastim, monoclonal antibody 3F8, sargramostim
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Punch Biopsy Wounds, Healing Times
Healing of Punch Graft Wounds. Comparative Study Between MariGen and Oasis: a Non-inferiority Study
The objective is to determine, if healing of punch biopsy wounds treated with the fish skin derived MariGen Wound dressing is non-inferior to healing with wounds treated with pig intestines derived Oasis Sheet wound dressing.
- Trial name
- NCT01917591
- Testing
- Punch biopsies treated with MariGen Wound ECM dressing, Punch biopsies treated with Oasis ECM dressing
- Where
- Iceland
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Kerecis Ltd.
Pulpal Inflammation
Characterization of Pulp Inflammation: an Observational Study Using Biological Samples Collected During Routine Dental Care
Background: Vital pulp therapy (VPT) is a cornerstone of minimally invasive dentistry and aims to preserve pulp vitality whenever clinically feasible.
- Trial name
- INFLAPULP (NCT07533396)
- Volunteers
- 1,200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Non-small Cell Lung Cancer Metastatic
Predictive Multimodal Signatures Associated With Response to Treatment and Prognosis of Patients With Stage IV Non-small Cell Lung Cancer
Predicting response to therapy and disease progression in stage IV NSCLC patients treated with pembrolizumab monotherapy, chemotherapy-pembrolizumab combination therapy or chemotherapy alone in the first-line setting.
- Trial name
- DEEP-Lung-IV (NCT04994795)
- Testing
- Predictive models (data collection)
- Where
- 30 sites in United States, Brazil and 6 more
- Volunteers
- 4,000 people
- Sponsor
- Sophia Genetics SAS
Sarcoma
Combination Chemotherapy and Biological Therapy in Treating Patients With High-Risk Ewing's Sarcoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Biological therapies use different ways to stimulate the immune system and stop cancer cells from growing.
- Trial name
- NCT00003667
- Testing
- cyclophosphamide, dexrazoxane hydrochloride, disaccharide tripeptide glycerol dipalmitoyl
- Where
- 2 sites in United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
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