Clinical trials: Biological Therapy
Ulcerative Colitis
COLISURG : Exploratory Analysis of Sexual Function and the Impact of Biotherapies on Postoperative Morbidity.
The surgical treatment of the ulcerative colitis (UC) remains associate to a significant morbidity (up to 60%). Anastomotic fistula and pelvic sepsis are the most severe complications which could dramatically compromise the…
- Trial name
- COLISURG (NCT03504930)
- Testing
- Impact of biotherapy on postoperative morbidity in ulcerative colitis
- Where
- 22 sites in France
- Volunteers
- 330 people
- Sponsor
- Hospices Civils de Lyon
Proliferative Diabetic Retinopathy
Biological Changes in Fibrovascular Membranes of Patients With Proliferative Diabetic Retinopathy Following Faricimab Injection
DR is a common microvascular complication of DM that significantly impacts vision. Approximately one-third of DM patients develop DR, with 10% progressing to PDR.
- Trial name
- NCT07144865
- Testing
- conbercept ophthalmic injection （0.5mg）, Faricimab
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Bojie Hu
Axial Spondyloarthritis
AScalate: Treat-to-target in Axial Spondyloarthritis
This was a randomized, parallel-group, open-label, multicenter study in patients with active axSpA. The aim of the study was to demonstrate that the efficacy of a T2T approach (with secukinumab as a first-line biologic) was…
- Trial name
- AScalate (NCT03906136)
- Testing
- Secukinumab/Adalimumab-Biosimilar, Standard-of-care
- Where
- 47 sites in France, Germany
- Volunteers
- 304 people
- Sponsor
- Novartis Pharmaceuticals
Crohn's Disease
Crohn's Disease: Efficacy, Safety, and Pharmacokinetics of Upadacitinib in Pediatric Subjects With Moderately to Severely Active Crohn's Disease
Crohn's disease (CD) is a long-lasting disease that causes severe inflammation (redness, swelling), in the digestive tract, most often affecting the bowels.
- Trial name
- U-EMPOWER (NCT06332534)
- Testing
- Upadacitinib
- Where
- 85 sites in United States, Australia and 16 more
- Volunteers
- 111 people
- Sponsor
- AbbVie
Rheumatoid Arthritis
A Study to Understand How Effective is Tofacitinib When Compared to Other Advanced Treatments in Patients With Rheumatoid Arthritis
The purpose of this study is to learn how different types of medicines may improve disease activity in people with rheumatoid arthritis (RA). RA is a kind of joint disease that causes pain and swelling.
- Trial name
- NCT06418529
- Testing
- tofacitinib, tumor necrosis factor inhibitors (TNFi), abatacept
- Where
- United States
- Volunteers
- 21,340 people
- Sponsor
- Pfizer
Rheumatoid Arthritis
Safety Study of Abatacept in Rheumatoid Arthritis Participants
A observational study to assess whether biologic disease-modifying (BDM) treatment initiation with abatacept for rheumatoid arthritis is associated with an increased risk of serious infection and cancer
- Trial name
- NCT03696173
- Testing
- Non-Interventional
- Where
- United States
- Volunteers
- 5,800 people
- Sponsor
- Bristol-Myers Squibb
Juvenile Idiopathic Arthritis
Treatment Tapering in JIA With Inactive Disease
As biologic treatments are expensive and associated with some concerns regarding long-term safety, investigator hypothesize that early tapering and then withdrawal of biological agent, in an homogenous group of children with…
- Trial name
- AJIBIOREM (NCT02840175)
- Testing
- etanercept, adalimumab, Abatacept
- Where
- France
- Volunteers
- 62 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Neuroblastoma
Surgery in Treating Children With Neuroblastoma
RATIONALE: Surgery alone may be effective in treating children with neuroblastoma. PURPOSE: Phase III trial to study the effectiveness of surgery alone in treating children who have neuroblastoma.
- Trial name
- NCT00003119
- Testing
- filgrastim, sargramostim, carboplatin
- Where
- 235 sites in United States, Australia and 5 more
- Volunteers
- 968 people
- Sponsor
- Children's Oncology Group
Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
Anti-IL-5 Therapy With Simple Polypectomy Versus Extended Endoscopic Sinus Surgery for CRSwNP
This study compares two surgical approaches combined with anti-IL-5 therapy in patients with chronic rhinosinusitis with nasal polyps (CRSwNP).
- Trial name
- NCT07200336
- Testing
- Mepolizumab, Simple Polypectomy, Extended Endoscopic Sinus Surgery
- Where
- 17 sites in China
- Volunteers
- 360 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Inflammatory Bowel Disease
Stavanger IBD Study - Cross Sectional
In this cross sectional and longitudinal study, patients with inflammatory bowel disease on biological treatment with infliximab or adalimumab will be included.
- Trial name
- SUSI-CS (NCT02134054)
- Where
- Norway
- Volunteers
- 210 people
- Sponsor
- Helse Stavanger HF
Transplantation Infection, Kidney Diseases
Molecular Biological and Moleculargenetic Monitoring of Therapy After Kidney Transplantation
Molecular monitoring is conducted in blood cells, plasma samples, urine samples and/or tissue from patients after kidney transplantation.
- Trial name
- MoMoTxRes (NCT01515605)
- Where
- Denmark
- Volunteers
- 1,500 people
- Sponsor
- Odense University Hospital
Cardiovascular System Diseases (& [Cardiac])
Evaluation of the Treatment of Thoracic & Cardiovascular Disease With Biological Therapy: ClinicalCellRegistry.Com
This is the clinical registry of cell based therapies that is available to researchers around the world. The registry is web based.
- Trial name
- NCT00130377
- Testing
- cell therapy
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Amit N. Patel MD MS
Clear Cell RCC
A Clinical Gene Therapy Study With Hematopoietic Stem Cells for the Treatment, With Single Dose of Temferon, of Patients Suffering From Metastatic Renal Cell Carcinoma
This is an open label, single-centre phase 1/2 study involving a single dose of Temferon, an investigational Advanced Therapy Medicinal Product (ATMP), to treat patients with metastatic clear cell renal cell carcinoma (RCC) with…
- Trial name
- TEM-GU (NCT06716853)
- Testing
- Temferon, Pembrolizumab, Cabozantinib
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Genenta Science
Atopic Dermatitis (AD), Atopic Dermatitis (Eczema)
Evaluation by Confocal Reflectance Microscopy of the Skin Structure of Patients With Atopic Dermatitis Treated With Tralokinumab Biotherapy.
Atopic dermatitis (AD) is a chronic inflammatory skin disease with pruritus and recurrence of eczematous eruptions. Evaluation of response to treatment are only clinical using Eczema Area Severity Index (EASI), SCOring of Atopic…
- Trial name
- ADUTERCoM (NCT07568665)
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Hôpitaux Drôme Nord
Infections, Pneumococcal, Bowel Diseases, Inflammatory
Anti-pneumococcal Vaccine Strategy in Patients Treated With Immunosuppressants or Biotherapies for CIBD
This is a multicenter, prospective, randomized, open study comparing two anti-pneumococcal vaccination strategies in patients with Chronic Inflammatory Bowel Disease (CIBD) treated by immunosuppressants and/or biotherapies.
- Trial name
- PneumoMICI (NCT02255227)
- Testing
- Prevenar 13, Pneumo 23
- Where
- 8 sites in France
- Volunteers
- 104 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Metastatic Melanoma
Vaccine Biotherapy of Cancer: Autologous Tumor Cells and Dendritic Cells
This protocol was conducted as a single institution trial at Hoag Cancer Center, Hoag Hospital, Newport Beach, California. It was a single-arm phase II trial in which patients with metastatic melanoma received subcutaneous (s.c.)…
- Trial name
- DCVaccineMel (NCT00948480)
- Testing
- Autologous tumor cells plus dendritic cells, GM-CSF
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Hoag Memorial Hospital Presbyterian
Crohn Disease, Calprotectin
STUDY OF THE ADDED VALUE OF A TRANSMURAL EVALUATION IN PATIENTS WITH CROHN'S DISEASE UNDER BIOTHERAPY WITH CLOSE FECAL CALPROTECTIN FOLLOW-UP
Crohn's disease (CD) is a chronic inflammatory bowel disease (IBD) that can dramatically affect the quality of life of patients.
- Conditions
- Crohn Disease, Calprotectin, MRI
- Trial name
- Deeper (NCT04973423)
- Testing
- MRI
- Where
- 17 sites in France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Clermont-Ferrand
Rheumatoid Arthritis
Economic Burden in Adult Patients Diagnosed With Rheumatoid Arthritis (RA) Receiving Treatment With Biologic Disease-modifying Antirheumatic Drugs (bDMARDs)
The purpose of this study is to explore the differences in productivity loss and costs between patients being treated for rheumatoid arthritis (RA) with biologic disease-modifying antirheumatic drugs (bDMARDs) compared to…
- Trial name
- NCT01136694
- Volunteers
- 695 people
- Sponsor
- Bristol-Myers Squibb
PCOS
A Clinical and Biological Research of Combined Chinese and Western Medicine in the Treatment of PCOS
This study evaluates the effects and biological mechanisms of Dingkundan，Diane-35 and the combination of Dingkundan and Diane-35 in the treatment of polycystic syndrome(PCOS) in adults women.
- Trial name
- NCT03264638
- Testing
- Dingkundan, Dingkundan & Diane-35, Diane-35
- Where
- China
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- Aijun Sun
Asthma
Change in Patient-Reported Outcomes in Severe Eosinophilic Asthma Patients Treated With Benralizumab Under Real-life Conditions
The main aim of this study is to investigate the change in asthma control after 6 months of therapy in patients treated with benralizumab biologic therapy for severe eosinophilic asthma under real-life conditions in a pulmonary…
- Trial name
- imPROve (NCT04184284)
- Where
- 50 sites in Germany
- Volunteers
- 246 people
- Sponsor
- AstraZeneca
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