Clinical trials: Biological Therapy
Crohn Disease
Exocrine Pancreatic Insufficiency's Prevalence in Active Crohn's Disease
This study aims to assess the prevalence of exocrine pancreatic insufficiency (EPI) in a population of patients with active Crohn's disease. Studies already describe a prevalence rate around 18-66%.
- Trial name
- IPEC (NCT03915262)
- Testing
- Search for exocrine pancreatic insufficiency at week 0 and 12
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Back Pain, Chronic Low Back Pain
Treatment of Symptomatic Lumbar Internal Disc Disruption (IDD) With the Biostat® System
The purpose of this investigation is to establish the safety and efficacy of the Biostat System when used for treatment of chronic low back (lumbar) pain due to symptomatic internal disc disruptions (IDD) by comparing safety and…
- Conditions
- Back Pain, Chronic Low Back Pain, Internal Disc Disruption, Degenerative Disc Disease
- Trial name
- NCT01011816
- Testing
- BIOSTAT BIOLOGX, Saline
- Where
- 20 sites in United States
- Volunteers
- 220 people
- Sponsor
- Spinal Restoration, Inc.
Healthy Volunteers
Bioavailability Study Comparing 10 mg Amlodipine Besylate Orally Disintegrating Tablets (ODT) And 10 mg Amlodipine Besylate Capsules
This study is being performed to determine the bioavailability, or extent of absorption into the body, of a 10 mg amlodipine besylate orally disintegrating tablet (ODT) as compared to the bioavailability of a 10 mg amlodipine…
- Trial name
- NCT01177293
- Testing
- Amlodipine - reference, Amlodipine ODT - test
- Where
- India
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Esophageal Cancer
Oxaliplatin, Gefitinib, and Radiation Therapy in Treating Patients With Locally Advanced or Metastatic Esophageal Cancer
RATIONALE: Drugs used in chemotherapy, such as oxaliplatin, work in different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00093652
- Testing
- gefitinib, oxaliplatin, conventional surgery
- Where
- United States
- Sponsor
- Roswell Park Cancer Institute
Kidney Cancer
Biological Therapy Plus Chemotherapy in Treating Patients With Metastatic or Recurrent Kidney Cancer
RATIONALE: Biological therapies use different ways to stimulate the immune system and stop cancer cells from growing. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00003585
- Testing
- aldesleukin, recombinant interferon alfa, fluorouracil
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of New Mexico
Discoid Lupus Erthematosus of the Scalp
Discoid Lupus Erythematosus of the Scalp and a Trial of Biologic Therapy With Raptiva
The purpose of this study is to investigate the efficacy of Raptiva (efalizumab) in the treatment of discoid lupus erythematosus (DLE).
- Trial name
- NCT00308204
- Testing
- Raptiva
- Where
- United States
- Sponsor
- The Cleveland Clinic
High-grade Glioma
Integrating Biology for Safe Intensification of Glioblastoma Hypofractionated Treatment on the MR-Linac
This is a phase 1 study to examine the safety and tolerability of biology-guided dose intensified hypofractionated radiation therapy (RT) using MR-Linac for patients with high grade glioma (HGG).
- Trial name
- INSIGHT MRL (NCT07457307)
- Testing
- MR-Linac System, Radiation Therapy, Temozolomide
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- NYU Langone Health
Healthy Volunteers
Bioavailability Study Comparing 10 Mg Amlodipine Besylate Orally Disintegrating Tablet (ODT) And 10 Mg Amlodipine Besylate Tablets
This study is being performed to determine the bioavailability, or extent of absorption into the body, of a 10 mg amlodipine besylate orally disintegrating tablet (ODT) as compared to the bioavailability of a 10 mg amlodipine…
- Trial name
- NCT01138826
- Testing
- Amlodipine - reference, Amlodipine ODT - test
- Where
- India
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
High-risk Prostate Cancer
Conventional Versus Hypofractionated Radiation in High Risk Prostate Patients
Hypofractionated regimen in high-risk prostate cancer will allow the investigators to deliver higher biological doses to targets in order to improve tumor control and with acceptable rectal toxicity compared to conventional…
- Trial name
- CHIRP (NCT01488968)
- Testing
- Standard Radiation Treatment, Hypofractionated radiation treatment
- Where
- Canada
- Volunteers
- 111 people
- Sponsor
- AHS Cancer Control Alberta
Melanoma (Skin)
Chemotherapy Followed by Biological Therapy in Treating Patients With Stage IV Melanoma That Cannot be Treated With Surgery
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Biological therapies such as interleukin-2 and interferon alfa stimulate a person's white blood cells to kill…
- Trial name
- NCT00014092
- Testing
- aldesleukin, recombinant interferon alfa, sargramostim
- Where
- 3 sites in United States
- Sponsor
- WVU Medicine Thomas Hospitals
Psoriatic Arthritis
Continuation Study of Zasocitinib in Adults With Psoriatic Arthritis
Psoriatic arthritis (PsA) is a long-term inflammatory disease that affects the joints and skin. The purpose of this study is to check how safe zasocitinib is, how well it is tolerated and how well it works in adults with PsA over…
- Trial name
- NCT07286058
- Testing
- Zasocitinib
- Where
- 78 sites in United States, Australia and 14 more
- Volunteers
- 1,182 people
- Sponsor
- Takeda
B Cell Leukemia, B Cell Lymphoma
A Study Evaluating UCART019 in Patients With Relapsed or Refractory CD19+ Leukemia and Lymphoma
Autologous T cells engineered to express chimeric antigen receptors (CARs) against leukemia antigens such as CD19 on B cells have shown promising results for the treatment of relapsed or refractory B-cell malignancies.
- Trial name
- NCT03166878
- Testing
- UCART019
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Chinese PLA General Hospital
Kidney Cancer
KidneyCare Cohort Study (KCC-S)
This research study aims to learn how lifestyle factors (e.g., obesity) impact the risk of developing kidney cancer and impact survival after nephrectomy (removal of a kidney).
- Trial name
- KCC-S (NCT06898632)
- Where
- United States
- Volunteers
- 161 people
- Sponsor
- University of Utah
Pityriasis Rubra Pilaris
A Pilot Study of Alefacept for the Treatment of Pityriasis Rubra Pilaris
The purpose of this study is to determine whether the biologic medication alefacept (Amevive) is effective and safe in the treatment of Pityriasis Rubra Pilaris.
- Trial name
- NCT00815633
- Testing
- Alefacept
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Joshua Zeichner
Cervical Cancer
Biological Drivers of Cervical Cancer and Side Effects From Radiation Therapy
The goal of this observational study is to learn more about the biology of cervical cancer in women who receive radiation therapy for this condition.
- Trial name
- NCT07121543
- Testing
- Brachytherapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Diego
Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
Preoperative Stapokibart for Endoscopic Sinus Surgery in Chronic Rhinosinusitis With Nasal Polyps
This is a single-center, randomized, double-blinded, placebo-controlled clinical trial in adults with moderate-to-severe chronic rhinosinusitis with nasal polyps (CRSwNP) who have no previous nasal surgery.
- Trial name
- NCT07616609
- Testing
- Stapokibart
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Beijing Tongren Hospital
CLASS II DIVISION 1 MALOCCLUSION
Response of Individuals With Class II Malocclusion
This investigation aims at distinguishing the subjects that react in a favorable way to the treatment protocol we propose for the Class II treatment
- Trial name
- NCT00248014
- Testing
- Mandibular Advancement Via A Functional Appliance
- Where
- Greece
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Severe Asthma, Biotherapy
Impact of Respiratory Allergy on Response to Initiation of Biotherapy in Severe Asthma in Adult Severe Asthmatic Patients Followed at Poitiers University Hospital on Biotherapy
The aim of this study is to take stock of the situation of adult patients with severe asthma on biotherapy, followed up at Poitiers University Hospital, and in particular to increase our knowledge of factors predictive of…
- Conditions
- Severe Asthma, Biotherapy, Respiratory Allergy
- Trial name
- IARBASP (NCT06916104)
- Testing
- search for respiratory allergies
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Poitiers University Hospital
Melanoma, Melanoma in Situ
BioMEL- Diagnostic and Prognostic Factors in Melanoma.
The investigators' hypothesis is that cutaneous melanoma, melanoma in situ, dysplastic nevi and benign nevi all differ in not only clinical characteristics but also molecular and genotypic characteristics.
- Conditions
- Melanoma, Melanoma in Situ, Dysplastic Nevi, Mole (Dermatology)
- Trial name
- BioMEL (NCT05446155)
- Testing
- Imaging
- Where
- 4 sites in Sweden
- Volunteers
- 2,000 people
- Sponsor
- Region Skane
Malnutrition
Biological Assessment of Clinical Nutrition and Its Application
1. Clinical nutritional support therapy is an important progress of modern medicine. 2. Conventional methods of clinical nutrition assessment (Anthropometric, lab, etc.) not just lack of accuracy and immediacy but also difficult…
- Trial name
- NCT02102659
- Testing
- Upper Limit Nutrition Support Therapy, Formula Nutrition Support Therapy
- Where
- China
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Huazhong University of Science and Technology
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