Clinical trials: Biological Therapy
Rheumatoid Arthritis
Synovial Tissue and Blood Signature of Rheumatoid Arthritis Patients With Disease Flare After Treatment Discontinuation for Sustained Remission.
Flares of immune-mediated inflammatory diseases, as Rheumatoid Arthritis (RA), are a major burden for patients in routine care. They occur unpredictably, adding to the physical and psychological burden of the condition.
- Trial name
- NCT05767801
- Testing
- Evaluation of subclinical inflammation
- Where
- 3 sites in Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Revascularization of Immature Permenant Teeth
Revascularization of Immature Teeth With Our Different Scaffolds
the study concern with the patients who loss the vitality of their teeth before completion of root development and apply new treatment approaches to restore their vitality through different scaffolds applied in inside the root…
- Trial name
- NCT07913880
- Testing
- Blood Clot, Platelet Rich Plasma, Platelet Rich Fibrin
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Tanta University
Asthma (Diagnosis)
Sustained Asthma Remission and Reduced Relapse Using a Comprehensive Management Strategy (SARRE-COMS)
The goal of this pilot clinical trial is to learn whether it is feasible to conduct a future larger trial of a comprehensive management strategy for adults with severe asthma who are starting biologic therapy.
- Trial name
- SARRE-COMS (NCT07816718)
- Testing
- Comprehensive Biomarker-Guided Management Strategy, Standard of Care
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Hana Serajeddini
Breast Neoplasms
The IDEA Study (Individualized Decisions for Endocrine Therapy Alone)
This study will collect rates of local/regional recurrence in select patients who do not receive radiation treatment after lumpectomy surgery.
- Trial name
- NCT02400190
- Testing
- endocrine therapy alone without radiotherapy
- Where
- 13 sites in United States
- Volunteers
- 202 people
- Sponsor
- University of Michigan Rogel Cancer Center
Breast Cancer
Presurgical Therapy With Lapatinib to Explore Molecular Determinants of Response to EGFR/erbB2 Targeted Therapy
The purpose of this study is to see what kinds of breast tumors will respond to lapatinib. Lapatinib is an experimental medicine which may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
- Trial name
- NCT00343759
- Testing
- Lapatinib
- Where
- United States
- Sponsor
- University of Pennsylvania
Breast Cancer
Trastuzumab or Lapatinib Ditosylate in Treating Women With Early Breast Cancer
RATIONALE: Monoclonal antibodies, such as trastuzumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread.
- Trial name
- EPHOS-B (NCT01104571)
- Testing
- trastuzumab, lapatinib ditosylate, laboratory biomarker analysis
- Where
- United Kingdom
- Volunteers
- 257 people
- Sponsor
- Institute of Cancer Research, United Kingdom
Arthritis, Psoriatic
A Study to Evaluate the Efficacy and Safety of JNJ-77242113 (Icotrokinra) in Biologic-naïve Participants With Active Psoriatic Arthritis
The purpose of this study is to evaluate the efficacy of icotrokinra compared to placebo in participants with active psoriatic arthritis (PsA) by assessing the reduction in signs and symptoms of PsA.
- Trial name
- ICONIC-PsA 1 (NCT06878404)
- Testing
- Icotrokinra, Active reference comparator
- Where
- 155 sites in United States, Argentina and 14 more
- Volunteers
- 552 people
- Sponsor
- Janssen Research & Development, LLC
Primacy Immune Thrombocytopenia
Eltrombopag in Second Line Adult Primary Immune Thrombosytopenia
A clinical study to evaluate the efficacy of a drug called eltrombopag in adult patients affected of primary immune thrombocytopenia as first treatment to address the disease.
- Trial name
- NCT02402998
- Testing
- Eltrombopag
- Where
- 14 sites in Italy
- Volunteers
- 55 people
- Sponsor
- Gruppo Italiano Malattie EMatologiche dell'Adulto
Major Depressive Disorder
Canadian Biomarker Integration Network for Depression Study
This study is a pilot to assess feasibility of the protocol in patients and controls across six participating sites. The goal is to identify biological markers (biomarkers)that can be measured at baseline or early in treatment to…
- Trial name
- CAN-BIND-1 (NCT01655706)
- Testing
- escitalopram, aripiprazole
- Where
- 6 sites in Canada
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
COPD (Chronic Obstructive Pulmonary Disease), COPD
Dupilumab in Type 2-Inflamed COPD Across the Full Spectrum of Airflow Limitation: An Italian Multicentre Retrospective Cohort Study
This multicentre retrospective cohort study describes lung function and patient-reported outcomes in adults with chronic obstructive pulmonary disease (COPD) and type 2 inflammation who received add-on dupilumab in routine…
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), COPD, Eosinophilia
- Trial name
- DUPICENTRO (NCT07788092)
- Testing
- Dupilumab
- Where
- 6 sites in Italy
- Volunteers
- 40 people
- Sponsor
- Azienda Ospedaliera di Perugia
Rheumatoid Arthritis
Rheumatoid Arthritis Treatment and Biopsy Study Assessing Certolizumab Pegol (Cimzia)
The purpose of this study is to conduct an Investigator-Sponsored Study to determine the potential immunomodulatory effects of Certolizumab Pegol (CZP) treatment at the site of disease activity (synovial lining) in subjects with…
- Trial name
- NCT01374971
- Testing
- Certolizumab Pegol (CZP), Arthroscopic synovial tissue biopsy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Nathan Wei, MD, FACP, FACR:
Ulcerative Colitis
Vedolizumab in Pediatric Ulcerative Colitis- Comparison With Infliximab
This is a multicenter, double-blind, randomized study to compare the safety, effectiveness and immunogenicity (antibodies against drug) of two biological drugs administered intravenously - vedolizumab (a drug not registered in…
- Trial name
- VEDI-UC (NCT06614387)
- Testing
- Infliximab
- Volunteers
- 60 people
- Sponsor
- JAROSLAW KIERKUS
Breast Cancer, Cervical Cancer
Vaccine Therapy and Biological Therapy in Treating Patients With Advanced Cancer
RATIONALE: Vaccines made from a person's white blood cells mixed with tumor proteins may make the body build an immune response to kill tumor cells. Interleukin-2 may stimulate a person's white blood cells to kill tumor cells.
- Conditions
- Breast Cancer, Cervical Cancer, Colorectal Cancer, Lung Cancer
- Trial name
- NCT00019084
- Testing
- aldesleukin, mutant p53 peptide pulsed dendritic cell vaccine, ras peptide cancer vaccine
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
DMARD Resistant Rheumatoid Arthritis
Low Dose Rituximab as a First Line Biologic Therapy for the Treatment of DMARD Resistant Patients With Rheumatoid Arthritis
In this project the investigators decide to evaluate the efficacy and safety of half dose mabthera (it means 500 mg infusion two weeks apart) in conventional drug resistant cases of rheumatoid arthritis.
- Trial name
- NCT01593332
- Testing
- Rituximab
- Where
- Iran
- Volunteers
- 44 people
- Sponsor
- Mashhad University of Medical Sciences
Hepatitis B, Chronic
Safety, Efficacy, Immunogenicity Study of GSK Biologicals' HBV Viral Vector and Adjuvanted Proteins Vaccine (GSK3528869A) in Adult Patients With Chronic Hepatitis B Infection
A First-Time-In-Human study on GSK's therapeutic vaccines to evaluate the reactogenicity, safety, immunogenicity and efficacy on reduction of serum HBV surface antigen in HBV suppressed participants under nucleo(s)tide treatment.
- Trial name
- NCT03866187
- Testing
- ChAd155-hIi-HBV low dose formulation, ChAd155-hIi-HBV high dose formulation, HBc-HBs/AS01B-4 low dose formulation
- Where
- 43 sites in Belgium, France and 7 more
- Volunteers
- 236 people
- Sponsor
- GlaxoSmithKline
Implant Therapy
Osseodensification Versus Conventional Drilling Effect on Implant Stability
A total of 80 implants were placed in the posterior region of the maxilla in 40 patients in a split-mouth design. Bone quality was classified into type I, II, III, IV, or V as assessed preoperatively on cone-beam computed…
- Trial name
- NCT05824949
- Testing
- osseodensification drilling, conventional drilling
- Where
- Palestinian Territories
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Arab American University (Palestine)
Psoriatic Arthritis, Rheumatoid Arthritis
Optimization of Psoriatic and Seronegative Rheumatoid Arthritis Patients Selection and Treatment Outcomes of Biologic Therapies.
Different classes of biological targeted therapies (b-DMARDs) are available for psoriatic arthritis (PsA) and seronegative rheumatoid arthritis (RA) (TNF inhibitors, anti-IL23, anti-IL17).
- Trial name
- NCT05767814
- Testing
- Phenotyping of synovial immune and stromal cells
- Where
- 2 sites in Italy, United Kingdom
- Volunteers
- 135 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Plaque Psoriasis
A Study to Assess the Effects of Switching From a Biologic Treatment to Tildrakizumab Using Patient-reported Outcomes in Adult Participants With Moderate to Severe Plaque Psoriasis
The main aim of this study is to assess the effects of switching from another biologic to tildrakizumab on patient-reported outcomes and to assess psoriasis intensity, patient's quality of life prior and after switching and the…
- Trial name
- NCT06030076
- Testing
- Tildrakizumab
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Almirall, S.A.
Uveitis
Outcome of Treatment of Uveitis With Biologic Drugs in Resistant Cases Vogt-koyanagi-Harada Disease
Reviewing the characteristics of patients with uveitis caused by Vogt-Koyanagi-Harada Syndrome treated at Assiut University Hospital at the Department of Ophthalmology and Department of Rheumatology, Physical Medicine, and…
- Trial name
- NCT05349747
- Testing
- Biologic drugs
- Volunteers
- 50 people
- Sponsor
- Assiut University
Psoriasis
Impact of Clinical and Psychological Factors on Satisfaction With Treatment in Psoriatic Patients on Biological Therapy
Psoriasis is a chronic-recurrent inflammatory disease with a significant impact on patients' physical and psychological well-being.
- Trial name
- PsoSAT (NCT07498543)
- Testing
- Questionnaire
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- Catholic University of the Sacred Heart
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