Clinical trials: Biomarker
High Blood Pressure
Microcirculation and Inflammatory Markers in Patients With Resistant, Stages 1/2 Hypertension and Normal Blood Pressure
Nailfold videocapillaroscopy (NVC), Venous occlusion Plethysmography (VOP) and inflammatory biomarkers have been used to study endothelial function in patients with resistant hypertension, stages 1 and 2 hypertension and…
- Trial name
- MICRORAH (NCT02759276)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Daniel Alexandre Bottino
FSHD
New Biomarkers in Facioscapulohumeral Muscular Dystrophy, Multispectral Optoacoustic Tomography.
Facioscapulohumeral Muscular Dystrophy (FSHD) is one of the most frequent muscular dystrophies in the adulthood. Multi-spectral optoacoustic tomography (MSOT) is an innovative imaging technique able to non-invasively characterize…
- Trial name
- MSOT-FSHD (NCT05902884)
- Testing
- MSOT Acuity Echo
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Food Preferences
A Trial of Behavioral Economic Interventions Among Food Pantry Clients
Obesity, unhealthy dietary habits, and food insecurity are major public health concerns, especially affecting individuals living in poverty.
- Trial name
- NCT04011384
- Testing
- Behavioral economic intervention of online purchasing at a food pantry
- Where
- United States
- Volunteers
- 286 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine
Kidney Transplant Rejection
ddcfDNA in Kidney Transplant Recipients
The objective of this study is to predict subclinical Antibody-Mediated Rejection (ABMR) occurrences in de novo DSA-positive recipients maintaining stable renal function after transplantation.
- Trial name
- NCT06013358
- Testing
- AlloSeq cfDNA
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Seoul National University Hospital
Myocardial Infarction
Accelerated Rule Out of Myocardial Infarction
Every year > 50.000 people in Denmark are hospitalized with a suspected acute myocardial infarction (AMI). The majority has other explanations of their chest discomfort and most are discharged again without any initiation of…
- Trial name
- AROMI (NCT02666326)
- Testing
- Accelerated, combined biomarker rule-out strategy for MI
- Where
- 3 sites in Denmark
- Volunteers
- 4,516 people
- Sponsor
- Aarhus University Hospital Skejby
Barrett Esophagus, Esophageal Adenocarcinoma
Aspirin in Preventing Disease Recurrence in Patients With Barrett Esophagus After Successful Elimination by Radiofrequency Ablation
This randomized phase II trial studies the safety of and how well aspirin works in preventing Barrett's esophagus from returning after it has been successfully eliminated by radiofrequency ablation.
- Trial name
- NCT02521285
- Testing
- Aspirin, Laboratory Biomarker Analysis, Questionnaire Administration
- Where
- 10 sites in United States, Canada
- Volunteers
- 21 people
- Sponsor
- National Cancer Institute (NCI)
Irritable Bowel Syndrome (IBS)
Abdominal Symptom Phenotype Study in Children
Children and adults commonly suffer from recurrent abdominal (stomach) pain. One type is called irritable bowel syndrome (IBS). IBS in adults and children is one of the most common and costly health care problems in the US.
- Trial name
- ASPPNB (NCT01204515)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Migraine
Hypersensitivity to CGRP as a Predictive Biomarker of Migraine Prevention With Erenumab
To explore the relationship between clinical response to erenumab and response to intravenous infusion of calcitonin gene-related peptide in individuals with migraine.
- Trial name
- NCT04592952
- Testing
- Calcitonin Gene-Related Peptide, Erenumab
- Where
- Denmark
- Volunteers
- 400 people
- Sponsor
- Danish Headache Center
Hyperlipidemia
A Comparative Study of Rosuvastatin and Atorvastatin in Patients With Hyperlipidemia
This study will be conducted to assess the status of oxidative stress inflammation and thrombogenesis in patients with hyperlipidemia and to compare the antioxidative, anti-inflammatory and antithrombogenic effects of…
- Trial name
- NCT02979704
- Testing
- Rosuvastatin, Atorvastatin
- Where
- Bangladesh
- Volunteers
- 90 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Sepsis
Serum Albumin Ratios Can Improve Sepsis Mortality Prediction
Sepsis remains a leading cause of mortality in hospitalized patients, despite advancements in critical care. Existing clinical scores for predicting sepsis outcomes often lack generalizability and complexity, hindering accurate…
- Trial name
- NCT06640504
- Testing
- serum albumin, C-Reactive Protein, Serum procalcitonin
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Benha University
Pancreatic Cancer, Cancer Cachexia
Florida Pancreas Collaborative Next Generation Biobank
The goal of this study is to partner with individuals known or suspected to have pancreatic cancer to build a biobank dedicated to minimizing disparities and personalizing care for individuals affected by pancreatic cancer.
- Trial name
- NCT03851133
- Testing
- Blood Sample Collection, Tumor Sample collection, Data Collection
- Where
- 14 sites in United States
- Volunteers
- 500 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Inflammation, Somatization
Mindfulness Meditation: Alleviating Symptoms and Inflammation in Nurses
Background: Nurses have experienced several stressors, the most important of which are increased workloads, long shifts, patients' negative results, some patients not responding to treatment, death at high rates, late detection…
- Trial name
- NCT06635278
- Testing
- Mindfulness meditation
- Where
- Jordan
- Volunteers
- 102 people
- Sponsor
- Jordan University of Science and Technology
Iron Overload, Hemochromatosis
Confounder-Corrected Quantitative MRI Biomarker of Hepatic Iron Content
The purpose of this multi-site research is to validate a rapid magnetic resonance based confounder-corrected R-2 mapping method as a quantitative imaging biomarker of liver iron concentrations.
- Conditions
- Iron Overload, Hemochromatosis, Hemosiderosis
- Trial name
- NCT02025543
- Testing
- MRI
- Where
- 4 sites in United States
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Epithelial Ovarian Cancer
Development of a Biomarker to Predict the Efficacy of Anti-angiogenic Therapy in Ovarian Cancer
Epithelial ovarian cancer (EOC) is a highly angiogenic tumor and drug targeting of angiogenesis is effective in some selected groups of EOC patients.
- Trial name
- OutCoME (NCT05874115)
- Testing
- liquid biopsy
- Where
- Italy
- Volunteers
- 75 people
- Sponsor
- Centro di Riferimento Oncologico - Aviano
Ependymoma
Carboplatin as a Radiosensitizer in Treating Childhood Ependymoma
This is a phase II study evaluating the feasibility of concurrent carboplatin given with focal radiation therapy in children age 12 months to < 21 years with newly diagnosed localized ependymoma who have no or minimal residual…
- Trial name
- NCT01088035
- Testing
- Carboplatin
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Colon Cancer, Liver Tumors
A Study of Imaging, Blood, and Tissue Samples to Guide Treatment of Colon Cancer and Related Liver Tumors
The purpose of this study is to explore novel ways of diagnosing colon cancer and predicting its propensity to spread to other organs such as the liver.
- Trial name
- NCT03432806
- Testing
- blood draws, colectomy or hepatectomy, Fibroscan test
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Alzheimer's Disease, Multiple Sclerosis
A Biospecimen and Clinical Data Study on Patients for Drug & Biomarker Discovery
The purpose of this research project is to collect and store blood samples and clinical data. Researchers can then use the stored samples in future studies.
- Conditions
- Alzheimer's Disease, Multiple Sclerosis, Parkinson's Disease, Huntington's Disease
- Trial name
- NCT01592552
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sanguine Biosciences
Sepsis, Obstructive Shock
Use of Renin Versus Lactic Acid as Tissue Perfusion Biomarkers for Mortality Prediction in Hypotensive Critically Ill Patients
Measurement of Whole Blood Lactate Concentrations Whole blood lactate concentrations will be measured at the time of study enrollment and at 24, 48, and 72 hours.
- Conditions
- Sepsis, Obstructive Shock, Critical Illness, Hypotensive
- Trial name
- NCT05810415
- Testing
- Renin levels and lactic acid levels
- Where
- 2 sites in Egypt
- Volunteers
- 84 people
- Sponsor
- Al-Azhar University
Endothelial Dysfunction
Endothelial Microparticles as Potential Biomarkers of Endothelial Dysfunction
Endothelial microparticles (EMP) have a promising role as a diagnostic and prognostic tool in the assessment of endothelial function.
- Trial name
- NCT04512404
- Testing
- HMG-CoA Reductase Inhibitor
- Where
- Malaysia
- Volunteers
- 48 people
- Sponsor
- Universiti Sains Malaysia
Alzheimer´s Disease
Safety, Tolerability and Biomarker-based Efficacy of NPI-001 (AT-001) in Subjects With MCI or Alzheimer's Disease (AD)
The study aims to measure safety, tolerability and biomarker-based efficacy of NPI-001 (AT-001) in Subjects with MCI or Alzheimer's Disease (AD).
- Trial name
- AD Biomarker (NCT07741526)
- Testing
- NPI-001
- Where
- 4 sites in Denmark, Iceland
- Volunteers
- 33 people
- Sponsor
- Arctic Therapeutics