Clinical trials: Biomarker in Early Diagnosis
Triple Negative Breast Cancer
PET Dynamics to Response-Adapted Neoadjuvant Therapy in TNBC
Eligible patients with stage 2 and 3 triple negative breast cancer will be treated with 4 cycles of neoadjuvant paclitaxel/carboplatin/pembrolizumab. A PET scan will be performed at baseline and after 1 cycle of therapy.
- Trial name
- NeoADAPT (NCT06245889)
- Testing
- Paclitaxel, Carboplatin, Pembrolizumab
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Type 1 Diabetes
T1D Risk Assessment in Kids With Relatives
The purpose of this study is to determine whether early immunological markers (activation of autoreactive T lymphocytes) precede and are predictive of the appearance of autoantibodies in children born from type 1 diabetic parents.
- Trial name
- TRAKR (NCT02184676)
- Testing
- Analysis of early immune modifications, Collection of clinical and socio-demographic data
- Where
- France
- Volunteers
- 512 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Colorectal Neoplasms
The Predictive Value of Guangzhou Panel for Recurrence in Early-stage Colorectal Cancer
This study aims to evaluate the predictive value of a four-gene methylation assay called Guangzhou Panel in early-stage colorectal cancer. Patients will be divided into two groups: high risk group and low risk group.
- Trial name
- NCT03923335
- Testing
- DNA methylation detection
- Where
- China
- Volunteers
- 287 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Huntington Disease
Early Biomarkers in Premanifest Huntington's Disease Gene Carriers: a Pilot Study
The goal of this clinical trial is to investigate if new, early biomarkers of the disease are available in presymptomatic genetic carriers of Huntington\'s diesase compared to healthy subjects.
- Trial name
- BIO-MH (NCT06626308)
- Testing
- brain functional MRI
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Early Renal Dysfunction in Diabetes, Diabetic Nephropathy
MMP-9/NGAL Modulation by Piper Crocatum in Early Diabetic Nephropathy
The goal of this clinical trial is to determine whether functional foods made with Piper crocatum (red betel leaf) can reduce kidney damage markers in people with diabetes who have early kidney dysfunction.
- Conditions
- Early Renal Dysfunction in Diabetes, Diabetic Nephropathy, Inflammation and Oxidative Stress in Diabetic Patients
- Trial name
- MMP-9/NGAL (NCT06676124)
- Testing
- Piper crocatum Extract Cookie
- Where
- Indonesia
- Volunteers
- 387 people
- Sponsor
- Hasanuddin University
Neovascular Age-related Macular Degeneration
Study of Innovative Multimodal Imaging Biomarkers to Predict Anatomical Outcome in Naive Patients With wAMD Treated With Brolucizumab.
The purpose of this study was to identify innovative early imaging parameters as predictors of the long-term clinical response to brolucizumab in terms of fluid resolution in patients with wet Age-related Macular Degeneration…
- Trial name
- IMAGINE (NCT04774926)
- Testing
- Brolucizumab
- Where
- 20 sites in Italy
- Volunteers
- 122 people
- Sponsor
- Novartis Pharmaceuticals
Parkinson Disease
Identification of a Biomarker Predictive of Evolution of Parkinson Disease
Phase II, Open-labeled, Prospective, Multi-center study of assessing the link between microglial activation and dopaminergic denervation kinetics in the early stage of Parkinson disease, by using the imaging of [18F]DPA-714 a new…
- Trial name
- GLIAPARK (NCT03230526)
- Testing
- [18F]DPA-714 PET scan
- Where
- 4 sites in France
- Volunteers
- 31 people
- Sponsor
- Nantes University Hospital
Gestational Diabetes
To Identify Urinary Biomarkers Associated With Gestational Diabetes Mellitus [GDM]
Gestational diabetes mellitus(GDM) is one of the most common complications of pregnancy. The incidence of GDM is higher in Asian than in other regions, and GDM can increase the risk of a series of perinatal complications.
- Trial name
- NCT05992974
- Where
- 2 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Peking Union Medical College Hospital
Pancreatic Fistula
Study of Pancreatic Enzymes in the Drains as Early Biomarkers of Post-operative Pancreatic Fistula and Its Clinical Repercussions
Surgery is the principal treatment for benign and malignant pancreatic tumours. This surgery can be accompanied by complications among which the main one is pancreatic fistula, which leads to the flow of pancreatic juices into…
- Trial name
- LIPA-DRAIN (NCT02784990)
- Testing
- Lipase, amylase and CRP (C-reactive protein) dosages
- Where
- 10 sites in France
- Volunteers
- 770 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Tuberculosis, Inflammation Biomarkers
Effects of Adjunct Omega-3 Long Chain Polyunsaturated Fatty Acids in Pulmonary Tuberculosis Patient: an Early Bactericidal Activity and Inflammatory Trial
The goal of this randomized controlled trial is to evaluate the early bactericidal activity, early inflammatory response, and safety of omega-3 long chain polyunsaturated fatty acid (n-3 PUFA) supplementation in adult patients…
- Conditions
- Tuberculosis, Inflammation Biomarkers, Liver Function Tests, Iron Status
- Trial name
- TREAT 3 (NCT07118059)
- Testing
- Omega-3 (EPA+DHA)
- Where
- South Africa
- Volunteers
- 40 people
- Sponsor
- North-West University, South Africa
Rheumatoid Arthritis
Ultrasonography as a Biomarker in Early Rheumatoid Arthritis
This is a prospective, observational study designed to look at ultrasound images of the joint at baseline and over time, and investigate whether there is a correlation between ultrasound images and progression of disease.
- Trial name
- NCT00781989
- Where
- United Kingdom
- Volunteers
- 101 people
- Sponsor
- Imperial College London
Systemic Sclerosis, Raynaud Phenomena
The Effect of High Dose Methylprednisolone on Nailfold in Early Systemic Sclerosis ( SSc )
This is a 12 week double-blind randomized placebo controlled trial in which 30 patients with very early SSc, fulfilling the Very Early Diagnosis Of Systemic Sclerosis (VEDOSS) criteria (9) will be randomized in a 2:1 fashion to…
- Trial name
- NCT03059979
- Testing
- Methylprednisolone, sodium chloride
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
HIV Infection, Renal Function Disorder
Utility of Urinary beta2 Microglobulin as an Early Marker of Renal Dysfunction in Vietnamese HIV-Infected Patients
This study is to investigate clinical utility of beta2 microglobulin as an early marker for renal dysfunction caused by Tenofovir in Vietnamese HIV-infected patients.
- Conditions
- HIV Infection, Renal Function Disorder, Renal Tubular Disorder
- Trial name
- NCT02256579
- Volunteers
- 1,800 people
- Sponsor
- National Center for Global Health and Medicine, Japan
Non-Small-Cell Lung Carcinoma
Molecular Imaging With Erlotinib and Bevacizumab
The patients will be treated with erlotinib and bevacizumab for a six-week period. Imaging procedures will be performed at baseline, after one week of therapy and after the six weeks of treatment.
- Trial name
- MIMEB (NCT01047059)
- Testing
- Erlotinib, Bevacizumab, Fluoro-D-glucose, Fluoro-L-thymidine
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University of Cologne
Lymphoma, Large B-Cell, Diffuse
Biomarker Driven Intensified ChemoImmunotherapy With Early CNS Prophylaxis
This study is testing whether stratification of the patients according to biological risk factors for different treatment groups will improve the outcome of patients with clinically high diffuse large B-cell lymphoma (DLBCL).
- Trial name
- Bio-CHIC (NCT03293173)
- Testing
- R-CHOEP, DA-EPOCH-R
- Where
- 16 sites in Denmark, Finland and 2 more
- Volunteers
- 120 people
- Sponsor
- Nordic Lymphoma Group
Early Alzheimer's Disease
Long-term Extension of Phase 3 Study of ALZ- 801 in APOE4/4 Early AD Subjects
This study is being conducted to evaluate the long-term safety and efficacy of ALZ-801 in Early Alzheimer's disease (AD) subjects with the APOE4/4 genotype. This is an open-label trial of treatment with ALZ-801.
- Trial name
- APOLLOE4-LTE (NCT06304883)
- Testing
- Experimental: ALZ-801
- Where
- 41 sites in United States, Canada and 1 more
- Volunteers
- 163 people
- Sponsor
- Alzheon Inc.
Class III Malocclusion, Root Resorption
Determining the Presence of RAP in Orthognathic Patients and Its Effect on Root Resorption by Biomarkers
A prospective clinical trial to what extent inflammatory biomarkers are affected by the medication after orthognathic surgery in early surgical cases and whether these biomarkers affects the amount of maxillary or mandibular…
- Trial name
- RAP (NCT04823325)
- Testing
- Orthognathic Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Oesophageal Squamous Cell Carcinoma, Oesophageal Cancer
Volatile Organic Compounds as Breath Biomarkers in Squamous Oesophageal Neoplasms
Oesophageal Squamous Cell Carcinoma (OSCC) is a cancer of the food pipe that affects around 2000 patients in the UK every year. It is often detected at an advanced stage, resulting in poor survival (5-year survival less than…
- Trial name
- ViSON (NCT06169163)
- Testing
- Exhaled breath sampling
- Where
- 13 sites in United Kingdom
- Volunteers
- 518 people
- Sponsor
- Imperial College London
Schizophrenia, Physical Activity
Physical Exercise in Patients With Schizophrenia
Randomised clinical trial on a cohort of subjects with a diagnosis of schizophrenia of legal age, of both sexes, recruited in the mental health clinics of the Salamanca University Assistance Complex and who will be randomly…
- Conditions
- Schizophrenia, Physical Activity, Telomere Shortening, Premature Aging
- Trial name
- NCT05978921
- Testing
- Strength physical exercise programme, Normal life
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- University of Salamanca
Melanoma
Neoadjuvant T-VEC in High Risk Early Melanoma
Despite the recent notable advances in the treatment of advanced melanoma with application of growing immunotherapies, patterns of response and factors resulting in treatment failure are poorly understood.
- Trial name
- NCT04427306
- Testing
- T-Vec
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of California, Davis