Clinical trials: Biopsy
Pain Measurement
Safety and Efficacy of Methoxyflurane for Treatment of Incident Pain
This study aims to provide further supportive evidence that Methoxyflurane, a potent analgesic, administered using the Penthrox Inhaler is safe and efficacious in adult participants, specifically those who experience incident…
- Trial name
- NCT00524927
- Testing
- Methoxyflurane, Normal Saline
- Where
- Australia
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Medical Developments International Limited
Menorrhagia, Endometrial Neoplasms
Evaluation of the Goldstein SonoBiopsy™ Catheter for Diagnosing Endometrial Pathology
To assess the adequacy of an endometrial biopsy sample obtained using sonohysterography.
- Conditions
- Menorrhagia, Endometrial Neoplasms, Polycystic Ovary Syndrome, Uterine Neoplasms
- Trial name
- NCT01969396
- Testing
- SonoBiopsy Catheter, Endometrial biopsy catheter
- Where
- Panama
- Volunteers
- 2 people
- Sponsor
- Cook Group Incorporated
Breast Lesions
A Registry Study Evaluating Outcomes in Breast Biopsy With the Intact™ Breast Lesion Excision System (BLES)
The purpose of this registry study is to collect use and clinical outcomes data following breast lesion excision or sampling with the Intact BLES.
- Trial name
- NCT03520127
- Testing
- Intact Breast Lesion Excision System (BLES)
- Where
- 7 sites in United States
- Volunteers
- 176 people
- Sponsor
- Medtronic Surgical Technologies
Human Papillomavirus
Alinity m HR HPV Specimen Collection Study From Women Undergoing Routine Cervical Cancer Screening
A prospective multicenter interventional study will be conducted to enroll women undergoing routine cervical cancer screening to collect cervical liquid-based cytology (LBC) specimen(s).
- Trial name
- NCT04746872
- Testing
- Alinity m HR HPV
- Where
- 63 sites in United States
- Volunteers
- 14,935 people
- Sponsor
- Abbott Molecular
Immunity, Innate, Prostatic Neoplasm
Measurement of Natural Killer Cell Activity in Whole Blood in Men Being Screened for Prostate Cancer With Biopsy
This study will look at measuring the activity of natural killer (NK) cells using the in vitro diagnostic device NK Vue in subjects being screened for prostate cancer using prostate biopsy.
- Trial name
- ANKA-PCA (NCT03242265)
- Testing
- IVDD for NK cell activity in whole blood
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- ATGen Canada Inc
Prostate Cancer
Open Registry Measuring Impact of Genomic Testing on Treatment of Prostate Cancer Patients
This registry is intended to evaluate the impact of genomic test results towards selecting a first-line therapy option for newly diagnosed localized prostate cancer patients.
- Trial name
- NCT01954004
- Where
- United States
- Volunteers
- 1,270 people
- Sponsor
- Myriad Genetic Laboratories, Inc.
Osteoporosis
Bone Histomorphometry in Postmenopausal Men and Women With Osteoarthritis Undergoing Total Hip Replacement
The primary objective of this study is to determine the incidence of modeling-based bone formation in the femoral neck in participants who have received denosumab and are undergoing total hip replacement (THR).
- Trial name
- NCT02576652
- Testing
- Tetracycline, Demeclocycline, Total Hip Replacement
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Amgen
Renal Function, Liver Transplant
Efficacy, Safety and Tolerability of Everolimus in Combination With Reduced Exposure Cyclosporine or Tacrolimus in Paediatric Liver Transplant Recipients.
This study was designed to assess the evolution of renal function and to collect efficacy, safety, and tolerability data of everolimus in co-exposure with reduced CNI in paediatric liver transplant recipients.
- Trial name
- NCT01598987
- Testing
- Introduction of everolimus with reduced cyclosporine or tacrolimus dose, the earliest 1 month and the latest 6 months after liver transplantation.
- Where
- 32 sites in United States, Australia and 10 more
- Volunteers
- 56 people
- Sponsor
- Novartis Pharmaceuticals
Wounds
Platelets for Acute Wound Healing
This study will examine whether platelet gel positively affects wound healing. Platelet gel will be used to treat punch biopsy wounds and the results will be compared to results from wounds treated with a control treatment.
- Trial name
- NCT00125086
- Testing
- autologous platelet gel
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Medtronic
Metastatic Lung Cancer, Metastatic Gastrointestinal Cancer
A Study to Evaluate the Impact of Liquid Biopsy in Participants With a Clinical Diagnosis of Advanced Cancer
This is an international, prospective study to assess the impact of concomitant early use of liquid biopsy (FoundationOne® Liquid CDx) within the diagnostic pathway, compared with the standard of care diagnostic pathway, on the…
- Trial name
- L1st (NCT05846594)
- Testing
- FoundationOne® Liquid CDx Assay, Standard of Care Diagnostic Pathway
- Where
- 18 sites in France, Germany and 2 more
- Volunteers
- 463 people
- Sponsor
- Hoffmann-La Roche
Type 1 Diabetes, Pancreatectomy; Hyperglycemia
Collection of Human Liver Biopsy and Whole Blood Samples From T1DM, TP or PP Patients for Potential Use for Insulin Producing Cells in Future Clinical Studies
In this study, liver samples will be collected, processed and stored in a specialized, clinical grade, cell bank for potential future clinical use.
- Trial name
- NCT04038931
- Testing
- Liver biopsy collection
- Volunteers
- 20 people
- Sponsor
- Orgenesis Ltd.
Breast Cancer Female
Brevera™ Breast Biopsy System Data Collection Study
The Brevera Breast Biopsy System integrates tissue acquisition, real time imaging, and post biopsy handling all during the same procedure.
- Trial name
- NCT03456583
- Testing
- Brevera Breast Biopsy System
- Where
- 6 sites in France, Germany and 4 more
- Volunteers
- 500 people
- Sponsor
- Hologic, Inc.
Glomerulonephritis, IGA, Immunoglobulin A Nephropathy
Study to Evaluate the Impact of Iptacopan on Top of SOC on Biopsy Changes in Kidneys of Adult Patients With IgAN
A study to investigate the impact of iptacopan treatment on the underlying immunopathology in patients with IgAN by assessing changes in key clinical and molecular markers from baseline to 9 months.
- Trial name
- NCT06797518
- Testing
- Iptacopan
- Where
- 19 sites in United States, Argentina and 3 more
- Volunteers
- 20 people
- Sponsor
- Novartis Pharmaceuticals
Nonalcoholic Steatohepatitis (NASH)
A Study of BOS-580 in Obese Subjects at Risk for, or With Biopsy-confirmed, Nonalcoholic Steatohepatitis (NASH) With an Extension
This is a randomized, blinded, placebo-controlled study of Efimosfermin in obese participants at risk for, or with biopsy-confirmed, nonalcoholic steatohepatitis (NASH), with a single arm open-label extension.
- Trial name
- NCT04880031
- Testing
- Efimosfermin
- Where
- 48 sites in United States
- Volunteers
- 231 people
- Sponsor
- GlaxoSmithKline
Neoplasms, Gastrointestinal Tract
Study For Patients With Untreated Gastric Cancer Who Will Receive Capecitabine And Lapatinib
The study will determine if changes in expression of markers involved in the 5-FU pathways are associated with response to treatment with the combination of lapatinib and capecitabine independent of tumor erbB2 status.
- Trial name
- NCT00526669
- Testing
- Lapatinib and Capecitabine
- Where
- 22 sites in United States, Canada and 4 more
- Volunteers
- 68 people
- Sponsor
- GlaxoSmithKline
Melanoma
Pharmacodynamics Study of MRX34, MicroRNA Liposomal Injection in Melanoma Patients With Biopsy Accessible Lesions
This study is designed to investigate the biomarkers, pharmacodynamics and pharmacokinetics of the liposomal micro-ribonucleic acid-34 (microRNA-34, miR-34).
- Trial name
- MRX34-102 (NCT02862145)
- Testing
- MRX34, Dexamethasone
- Sponsor
- Mirna Therapeutics, Inc.
Amyloidosis
Multiple Treatment Session Study to Assess GSK2398852 Administered Following and Along With GSK2315698
The study is intended to evaluate whether monthly repeated courses of administration of GSK2315698 followed by GSK2398852 is associated with a reduction in cardiac amyloid load in patients with cardiac amyloidosis, monitored by…
- Trial name
- NCT03044353
- Testing
- GSK2315698 (CPHPC), GSK2398852 (anti-SAP mAb)
- Where
- 3 sites in United States, United Kingdom
- Volunteers
- 7 people
- Sponsor
- GlaxoSmithKline
Psoriasis, Immunomodulation
Multiple Dose Escalation Study In Medically Stable Subjects With Psoriasis
This study was conducted in subjects with psoriasis to evaluate drug activity in this patient population by analysis of changes in psoriatic lesion biopsy characteristics.
- Trial name
- NCT01736696
- Testing
- tofacitinib
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Pfizer
Colorectal Cancer, Tumor
Microbiome in Colorectal Cancer Onset and Progression
This is an observational study with the goal to improve the robustness of the scientific evidence linking Fusobacterium nucleatum (Fn) and/or other microorganisms to colorectal cancer (CRC) onset and/or progression.
- Conditions
- Colorectal Cancer, Tumor, CRC, GI Cancer
- Trial name
- NCT05368688
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Viome
Primary Sclerosing Cholangitis (PSC)
Simtuzumab (GS-6624) in the Prevention of Progression of Liver Fibrosis in Adults With Primary Sclerosing Cholangitis (PSC)
The purpose of this study is to evaluate whether simtuzumab (GS-6624) is effective at preventing the progression of liver fibrosis in adults with primary sclerosing cholangitis (PSC).
- Trial name
- NCT01672853
- Testing
- Simtuzumab
- Where
- 75 sites in United States, Belgium and 8 more
- Volunteers
- 235 people
- Sponsor
- Gilead Sciences