Clinical trials: Bipolar, open to volunteers
Bipolar Disorder
A Study of Olanzapine in Participants With Bipolar Disorder.
This study aimed to identify treatment patterns in patients with bipolar disorder receiving olanzapine according to demographic and clinical characteristics and to evaluate the effectiveness of education on weight gain, a side…
- Trial name
- NCT07263191
- Testing
- Olanzapine
- Where
- South Korea
- Volunteers
- 3,000 people
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Bipolar Disorder
A Study of Brenipatide in Adult Participants With Bipolar Disorder (RENEW-Bipolar-1)
The purpose of this study is to assess the efficacy and safety of brenipatide when administered with standard of care (SoC), compared with placebo plus SoC in delaying the worsening of bipolar disorder symptoms.
- Trial name
- NCT07286175
- Testing
- Brenipatide
- Where
- 87 sites in United States, Argentina and 6 more
- Volunteers
- 400 people
- Sponsor
- Eli Lilly and Company
Schizophrenia, Bipolar Disorder
App and Body Fat Scale in the Management of Overweight Patients
This study tests whether using a health app (Huawei Health) and a smart body fat scale can help overweight patients with schizophrenia or bipolar disorder lose weight and stay engaged in their health. What We're Testing: 1.
- Conditions
- Schizophrenia, Bipolar Disorder, Metabolic Syndrome, Overweight and Obesity
- Trial name
- NCT05866107
- Testing
- Effectiveness and Feasibility of Self-Monitoring for Weight Management in Individuals with Mental Disorders Using Digital Intervention ("SWIM" trial)
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Capital Medical University
Treatment-Resistant Depression, Bipolar Depression
Magnetic Resonance-Guided Focused Ultrasound Bilateral Capsulotomy for the Treatment of Refractory Bipolar Depression
The goal of this clinical trial is to evaluate the safety and initial effectiveness of MR-guided focused ultrasound (MRgFUS) bilateral capsulotomy in patients with treatment-resistant bipolar depression (TRBD).
- Trial name
- NCT07108257
- Testing
- ExAblate Neuro 4000
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Sunnybrook Health Sciences Centre
Major Depressive Disorder, Mood Disorders
Psychobiological Markers to Improve Diagnosis and to Predict Affective Episodes in Bipolar Disorder
This trial has two studies. In study 1, the investigators will explore the relationships between three psychobiological factors (sleep patterns, motor activity, and decision-making ability).
- Conditions
- Major Depressive Disorder, Mood Disorders, Bipolar Disorder (BD)
- Trial name
- MoodCatcher (NCT07427966)
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Depression, Bipolar Disorder
Neuro-computational Study of Thymic Fluctuations in Mood Disorders
Depression and bipolar disorder are frequent, debilitating conditions. Both are thought to be primarily caused by an impaired regulation of mood, which is why they are sometimes referred to as "mood disorders".
- Conditions
- Depression, Bipolar Disorder, Recurrent Depression, Mood Disorders
- Trial name
- MOODELING (NCT07033923)
- Testing
- Brain magnetic resonance imaging (MRI) with structural (anatomical) and functional sequences (optional), Computerized cognitive tests, Daily longitudinal monitoring by mobile MOODELING application
- Where
- 2 sites in France
- Volunteers
- 588 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Bipolar Disorder (BD), Cognitive Impairment
TMS for Improving Cognitive Function in Bipolar Disorder
Bipolar disorder is a highly disabling psychiatric illness, and cognitive impairment is common in patients with bipolar depression as well as during remission, contributing substantially to functional disability and poorer…
- Trial name
- NCT07414147
- Testing
- Active Intermittent Theta Burst Stimulation, Online Cognitive Training
- Where
- China
- Volunteers
- 88 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Trigeminal Neuralgia, Refractory Pain
Fluoroscopic-Guided Bipolar Versus Monopolar Pulsed Radiofrequency for Refractory Trigeminal Neuralgia
A prospective exploratory study aiming at comparing pulsed bipolar versus pulsed unipolar radiofrequency ablation in patients with medically refractory trigeminal neuralgia.
- Trial name
- NCT06779578
- Testing
- Bipolar pulsed radiofrequency, Mopolar pulsed radiofrequency
- Where
- 2 sites in Egypt
- Volunteers
- 20 people
- Sponsor
- Alexandria University
Bipolar Disorder (BD), Bipolar Disorder (BPD)
Testing a New Gold Nanoparticle-Based Lithium Delivery Method for Bipolar Disorder in Laboratory Models
This preclinical translational study aims to evaluate a new method of delivering lithium using gold nanoparticles for the treatment of bipolar disorder.
- Trial name
- GLAD (NCT07732933)
- Testing
- Peripheral blood sampling for PBMC isolation
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Major Depressive Disorder, Bipolar Disorder, Mixed
Chinese Longitudinal and Systematic Study of Bioplar Disorder
Affective disorders (mainly including major depressive disorder and bipolar disorder) are common, chronic and highly disabling mental disorders, which lack of objective biological markers.
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Mixed, Affective; Disorder, Organic
- Trial name
- CLASS-BD (NCT05480150)
- Testing
- Escitalopram Oxalate Tablets, Quetiapine Fumarate Tablets, Lurasidone
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Sacroiliac Joint Pain
Comparison Between Traditional Bipolar Radiofrequency and Cooled Radiofrequency in Sacroiliac Joint Pain Patients
Sacroiliac joint pain is contributor to chronic low back pain, accounting for 15-30% of cases. It is a synovial and syndesmotic articulation plays a role in load transfer between spine and lower extremities.
- Trial name
- NCT07749599
- Testing
- Traditional bipolar radiofrequency, Cooled radiofrequency
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Assiut University
Bipolar-I Disorder With Mania or Mania With Mixed Features
A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder
The purpose of this study is to evaluate the efficacy and safety of KarXT for the treatment of manic episodes in Bipolar-I Disorder
- Trial name
- BALSAM-1 (NCT06951698)
- Testing
- KarXT
- Where
- 74 sites in United States, Argentina and 7 more
- Volunteers
- 274 people
- Sponsor
- Bristol-Myers Squibb
Adolescent, Bipolar Depression
HD-tDCS for Adolescent Bipolar Depression Targeting S1
This randomized, double-blind, sham-controlled clinical trial aims to evaluate the efficacy and underlying biological mechanisms of HD-tDCS targeting the primary somatosensory cortex in adolescents with bipolar depression.
- Conditions
- Adolescent, Bipolar Depression, tDCS, Primary Somatosensory Cortex
- Trial name
- NCT07246044
- Testing
- Active HD-tDCS, Antipsychotics, mood stabilizers, etc.
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Jiangsu Province Nanjing Brain Hospital
Bipolar Disorder Type I With Mania or Mania With Mixed Features
A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-2)
This is a Phase 3, randomized, double-blind, placebo-controlled, multicenter, inpatient study in participants with bipolar disorder experiencing an acute episode of mania or mania with mixed features.
- Trial name
- NCT06951711
- Testing
- KarXT
- Where
- 85 sites in United States, China and 9 more
- Volunteers
- 274 people
- Sponsor
- Bristol-Myers Squibb
Psychosis
Immune Mechanisms of Antipsychotic Treatment Response
The aim of this study is to investigate the role of the immune system in psychotic symptoms and their response to treatment. The investigators will collect blood and cerebrospinal fluid samples from participants with psychosis…
- Trial name
- IMAT (NCT06687694)
- Where
- United Kingdom
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- King's College London
Bipolar Disorder and Major Depressive Disorder
Social Cognition, Memory, and Executive Functions in Bipolar Disorder and Major Depressive Disorder
Bipolar disorder (BD) are common psychiatric disorders often misdiagnosed, leading to delayed treatment. Even during stable phases, individuals with bipolar disorder experience residual cognitive impairments that affect their…
- Trial name
- COMET (NCT06740331)
- Testing
- Analysis of social cognition, memory functioning, and executive functioning processes
- Where
- France
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Migraine
Stimulation of External Carotid Artery Circulation
This study is testing a new approach to help people with migraine headaches. Researchers want to find out if using electrical stimulation to affect blood flow in the external carotid artery is safe and practical for helping…
- Trial name
- MMA-Stim (NCT07402954)
- Testing
- Cadwell Cascade 32 PRO
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Mood Disorders, Depressive Disorder
An Innovative Master Platform for Clinical Trials in Mood Disorders
Mood disorders such as depression and bipolar disorder affect over 350 million people around the world. While several effective treatments exist, it is often difficult to match the right treatment to an individual person.
- Conditions
- Mood Disorders, Depressive Disorder, Bipolar and Related Disorders
- Trial name
- ENABLE (NCT06408012)
- Where
- 9 sites in Canada
- Volunteers
- 2,200 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Healthcare Hamilton
Mood Disorders, Schizophrenia Disorders
Psychiatric Disorders in Child and Adolescent Offspring of Parents with Schizophrenia and Bipolar Disorders.
Offspring of parents with bipolar disorder (BD) and schizophrenia (SZ) are vulnerable and at high risk for these disorders. Despite the fact that positive family history of SZ or BD is the strongest predictor for the development…
- Trial name
- NCT06874075
- Volunteers
- 50 people
- Sponsor
- Assiut University
Alcohol Abuse, Alcohol Use Disorder
The Effect of Comorbid Alcohol/Substance Use
Study Design This study was designed as a comparative, cross-sectional case-control study examining the effect of comorbid alcohol and substance use disorder (ASUD) on clinical course and social inclusion among individuals with…
- Conditions
- Alcohol Abuse, Alcohol Use Disorder, Substance Use Disorders, Severe Mental Disorder
- Trial name
- NCT07692984
- Testing
- case (comorbid diagnosis), control
- Where
- Turkey (Türkiye)
- Volunteers
- 297 people
- Sponsor
- Abant Izzet Baysal University