Clinical trials: Bipolar Affective Disorders
Psychotic Disorders, Schizophrenia
Critical Time Intervention-Peer Support
There is increasing awareness of the importance of providing mental health services and support that promote a recovery-oriented and human rights-based approach.
- Conditions
- Psychotic Disorders, Schizophrenia, Bipolar Disorder, Schizo Affective Disorder
- Trial name
- CTI-PS (NCT05945277)
- Testing
- Critical Time Intervention - Peer Support
- Where
- 3 sites in Portugal
- Volunteers
- 60 people
- Sponsor
- Lisbon Institute of Global Mental Health - LIGMH
Schizophrenia, Schizo Affective Disorder
Brain Stimulation and Cognitive Training - Efficacy
People with serious mental illness often experience difficulties with thinking skills like memory. These difficulties can make it harder to perform day-to-day activities.
- Conditions
- Schizophrenia, Schizo Affective Disorder, Bipolar Disorder
- Trial name
- NCT05111548
- Testing
- tDCS (Active), BrainHQ, tDCS (Inactive)
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Michigan
Schizophrenia, Schizotypal and Delusional Disorders, Bipolar Affective Disorder
Improving Work Outcome for People With Severe Mental Illness
The purpose of this study is to investigate the efficacy of IPS in Denmark and compare effects of 1. Individual Placement and Support (IPS) vs. 2. IPS + cognitive remediation and work-related social skills training vs. 3.
- Conditions
- Schizophrenia, Schizotypal and Delusional Disorders, Bipolar Affective Disorder, Recurrent Depressive Disorder
- Trial name
- NCT01722344
- Testing
- Individual Placement and support (IPS), IPS plus
- Where
- Denmark
- Volunteers
- 717 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Depressive Disorder, Anxiety Disorders
Electronic Communication Augmented Mental Health Care
Mood and anxiety disorders are the most common mental health conditions in the United States, and are associated with significant morbidity, mortality and overall impairment in functioning.
- Conditions
- Depressive Disorder, Anxiety Disorders, Bipolar Affective Disorder
- Trial name
- NCT03925038
- Testing
- Augmented Care: Electronic Media Dashboard, Treatment as Usual
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Johns Hopkins University
Catatonia, Schizophrenia
Personalized Prospective Study Evaluation of the Efficacy and Safety of Noninvasive Neuromodulation of TMS in Subjects With Catatonia
Evaluation effectiveness and safety of TMS in subjects with catatonia
- Conditions
- Catatonia, Schizophrenia, Schizo Affective Disorder, Bipolar Affective Disorder
- Trial name
- RECATA (NCT06176456)
- Testing
- rTMS
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Moscow Psychiatric Hospital No. 1 Named after N.A. Alexeev
Major Depressive Disorder, Bipolar Affective Disorder, Currently Depressed, Moderate
The Role of Negr1 In Modulating Neuroplasticity in Major Depression (RONIN)
Patients belonging to Group 1 (Major Depression) and 2 (Bipolar Disorder) will be tested with psychometric and functional scales at baseline (T0) and after 4 weeks of pharmacological therapy (T1), to evaluate clinical and…
- Trial name
- RONIN (NCT06131268)
- Testing
- Venlafaxine
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Schizophrenia Agitation, Schizo Affective Disorder
Evaluating Sublingual Dexmedetomidine For Moderate To Severe Agitation In Inpatients With Schizophrenia Or Bipolar Disorder
An open-label, randomized, active control inpatient trial to evaluate the efficacy and tolerability of sublingual dexmedetomidine for the treatment of agitation in inpatients with schizophrenia or bipolar disorder as measured by…
- Conditions
- Schizophrenia Agitation, Schizo Affective Disorder, Bipolar Disorder, Dexmedetomidine
- Trial name
- NCT06093451
- Testing
- Dexmedetomidine, Lorazepam 2 MG/ML
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Temple University
Major Depressive Disorder, Bipolar Disorder
Naturalistic Study of Ketamine in the Treatment of Depression
This study aims to examine the effect of ketamine in decreasing the risk of suicide in patients with depression and its effectiveness as an antidepressant agent.
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Bipolar Depression, Bipolar I Disorder
- Trial name
- NCT05249309
- Testing
- Ketamine
- Where
- 2 sites in Brazil
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Schizophrenia, Schizo Affective Disorder
Financial Incentives to Improve Medication Adherence
Medication adherence is a challenge in all of medicine and is associated with multiple negative outcomes. Strategies to better measure and enhance adherence to medication are urgent and necessary to minimize unwanted health…
- Conditions
- Schizophrenia, Schizo Affective Disorder, Bipolar Disorder, Depression
- Trial name
- NCT04191876
- Testing
- Wellth - Financial Incentives
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Northwell Health
Bipolar Affective Disorder, Major Depressive Disorder
Exosome for Early Diagnosis of Bipolar Affective Disorder
Objectives: Bipolar disorder (BD) is a chronic and recurrent mental illness characterized by depressive episodes and manic or hypomanic episodes, leading to severe functional impairment and cognitive damage.
- Trial name
- NCT05915312
- Where
- China
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Tianjin Anding Hospital
Bipolar Affective Disorder
Compassion-Focused Therapy for Distressing Mood Swings: A Case Series
The goal of this case series is to investigate whether a brief compassion-focused intervention is a safe, acceptable and feasible therapy for clients with bipolar affective disorder.
- Trial name
- NCT05860101
- Testing
- Compassion-Focused Therapy
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Institute of Psychiatry, London
Social Functioning, Alexithymia and Sense of Coherence , Bipolar Disorders
The Effect of Physical Exercises Program on Social Functioning, Alexithymia and Sense of Coherence Among Patients With Bipolar Disorders
The aim of this study is to: Investigate the effect of applying physical exercises program on social functioning, alexithymia and sense of coherence among patients with bipolar disorders Research Hypotheses Clients who…
- Trial name
- NCT05741281
- Testing
- Physical exercises program
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Bipolar Disorder, Bipolar I Disorder
Using Neuroplasticity-Based Computerized Training to Improve Emotion Regulation in Bipolar Disorder (BRAINS)
The goal of this study is to evaluate the feasibility and potential benefit of a behavioral intervention designed to improve emotion regulation in individuals with bipolar disorder.
- Conditions
- Bipolar Disorder, Bipolar I Disorder, Bipolar Affective Disorder, Bipolar Disorder I
- Trial name
- BRAINS (NCT05683431)
- Testing
- Cognitive Control of Emotion (CCE) Training
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Schizophrenia, Bipolar Disorder
Restoration of Cognitive Function With TDCS and Training in Serious Mental Illness
Development of interventions that can effectively target and remediate the cognitive and functional impairment associated with serious mental illness is a treatment priority.
- Conditions
- Schizophrenia, Bipolar Disorder, Schizo Affective Disorder
- Trial name
- NCT03208036
- Testing
- TDCS, Cognitive Remediation, Bridging Group
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- VA Office of Research and Development
Major Depressive Disorder, Bipolar Disorder, Mixed
Chinese Longitudinal and Systematic Study of Bioplar Disorder
Affective disorders (mainly including major depressive disorder and bipolar disorder) are common, chronic and highly disabling mental disorders, which lack of objective biological markers.
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Mixed, Affective; Disorder, Organic
- Trial name
- CLASS-BD (NCT05480150)
- Testing
- Escitalopram Oxalate Tablets, Quetiapine Fumarate Tablets, Lurasidone
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Affective Disorders, Unipolar Depression
Reducing the Rate and Duration of Re-ADMISsions Among Patients With Unipolar Disorder and Bipolar Disorder Using Smartphone-based Monitoring and Treatment - The RADMIS Trials
Unipolar and bipolar disorder combined account for nearly half of all morbidity and mortality due to mental and substance use disorders, and burden society with the highest health care costs of all psychiatric and neurological…
- Conditions
- Affective Disorders, Unipolar Depression, Bipolar Disorder
- Trial name
- RADMIS (NCT03033420)
- Testing
- A smartphone-based monitoring system including a) an integrated feedback loop between patients and clinicians and b) context-aware CBT modules
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Psychiatric Centre Rigshospitalet
Schizophrenia, Schizo Affective Disorder
Aripiprazole Once-Monthly in Hospitalized Patients (INITIATE)
To characterize the real-life clinical use of AOM in a hospitalized patient population with schizophrenia, schizoaffective disorder or BP1 requiring LAI therapy and evaluate its short-term effectiveness associated with its…
- Conditions
- Schizophrenia, Schizo Affective Disorder, Bipolar I Disorder
- Trial name
- INITIATE (NCT04907279)
- Testing
- Aripiprazole Once-Monthly (AOM)
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Otsuka Canada Pharmaceutical Inc.
Bipolar Affective Disorder
Effect of Regulated Add -on Sodium Chloride Intake on Stabilization of Serum Lithium Concentration in Bipolar Disorder
Bipolar affective disorder or manic -depressive psychosis (MDP) is a mood disorder affecting 2.4% of the global population . Lithium is considered as the "gold standard" for the treatment of bipolar disorder but the clinical use…
- Trial name
- NCT04222816
- Testing
- Lithium Carbonate, Sodium chloride
- Where
- India
- Volunteers
- 60 people
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
Bipolar Affective Disorder
Seroquel ® in Patients With Bipolar Disorder in Remission With Signs of Impaired Impulse Control
In this study, the task was to evaluate the effectiveness of prescribing small doses of quetiapine (25-75 mg) for bipolar patients in remission in order to relieve symptoms of impulsivity.
- Trial name
- NCT05098353
- Testing
- Quetiapine
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Federal Stare Budgetary Scientific Institution, Mental Health Research Center
Bipolar Disorder, Bipolar Depression
Cannabidiol as an Adjunctive Treatment for Bipolar Depression
Depressive symptoms are associated with significant psychosocial impairment. However, current treatments of bipolar depression are only partially effective.
- Conditions
- Bipolar Disorder, Bipolar Depression, Bipolar Affective Disorder
- Trial name
- CBDBD (NCT03310593)
- Testing
- Cannabidiol
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- Hospital de Clinicas de Porto Alegre