Clinical trials: Bipolar Affective Disorders
Depression, Bipolar Disorders
Enhancing Outcomes, Reducing Costs: Evaluating Peer Support for Mood Disorders
The purpose of this study to evaluate peer-led mutual help organizations (MHOs) that target individuals with psychiatric diagnoses such as mood disorders, and provide evidence either supporting the expansion of such groups and…
- Conditions
- Depression, Bipolar Disorders, Mood Disorders
- Trial name
- NCT02242669
- Where
- 2 sites in United States
- Volunteers
- 371 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Bipolar Disorder
fMRI of Flight of Ideas in Bipolar Disorder
Bipolar disorder is a mental disease characterized by mood dysregulation and arises from manic, depressive or mixed episodes. The observations of the patient's speech and language behaviour due to flight of ideas or loss of goal…
- Trial name
- i-TCP (NCT02794129)
- Testing
- Functional Magnetic Resonance Imaging
- Where
- France
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Depression, Anxiety
The CARE (Collaborative Adolescent Running Experience) Project
This study is being completed to see if participants activity levels may have an impact as a treatment for depression, or depressive symptoms.
- Conditions
- Depression, Anxiety, Major Depressive Disorder, Bipolar Disorder
- Trial name
- CARE (NCT05837351)
- Testing
- Exercise -Running
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Michigan
Major Depressive Disorder
Lithium Versus Paroxetine in Patients With Major Depression Who Have a Family History of Bipolar Disorder or Suicide
This study is being done to look at how well people respond to two very different drug treatments for depression. Clinically, people with depression can respond differently to drug treatments for reasons which are not always…
- Trial name
- NCT00400088
- Testing
- paroxetine, lithium
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- Nova Scotia Health Authority
Schizophrenia, Bipolar Disorder
Approaches For ThE pRioritization of Patients in priMAry Care Post-COVID To Reduce Health Inequities (AFTERMATH)
The COVID-19 pandemic significantly impacted primary care across Canada. Inequities in prevention activities and chronic disease management likely increased but the extent is unknown.
- Trial name
- AFTERMATH (NCT05823805)
- Testing
- Community Health Worker
- Volunteers
- 520 people
- Sponsor
- Unity Health Toronto
Bipolar Disorder, Type II
Internet-based Cognitive Behaviour Therapy (CBT) for Persons Diagnosed With Bipolar II
The aim of the study is to test the feasibility and acceptability of internet-based Cognitive Behaviour Therapy (CBT) for persons diagnosed with bipolar disorder, type II.
- Trial name
- NCT01742351
- Testing
- Guided internet-based cognitive behavior therapy
- Where
- Sweden
- Volunteers
- 7 people
- Sponsor
- Örebro County Council
Bipolar Disorder
The Effect of Omega-3 Polyunsaturated Fatty Acids in the Treatment and Prevention of Relapse of Bipolar Disorder
The whole study will be divided into two major parts: (A) A 12-week, double-blind, randomized controlled, parallel n-3 fatty acids adjunctive therapy study in 30 bipolar disorder patients with mild to moderate depression.
- Trial name
- NCT01371383
- Testing
- n-3 fatty acids
- Where
- Taiwan
- Volunteers
- 61 people
- Sponsor
- National Science and Technology Council, Taiwan
Schizophrenia Disorders, Bipolar Disorders
MonPsy&Moi: A Digital Platform for Collecting Patient-Reported Experience and Outcome Measures in Psychiatry
Mental health disorders, with a 30% annual prevalence rate, are a leading cause of disability and reduced life expectancy. Despite their impact, patient-reported experience measures (PREMs) and outcome measures (PROMs) are…
- Conditions
- Schizophrenia Disorders, Bipolar Disorders, Major Depression
- Trial name
- Mon Psy & Moi (NCT06818227)
- Where
- France
- Volunteers
- 23,660 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Bipolar Disorder, Sub-syndromal Symptoms
Evaluation of Sub-syndromal Symptoms After Acute Depressive Episode in Bipolar Disorder
The study aims to evaluate: the frequency of subsyndromal symptoms or disorders observed during interepisode phases in bipolar patients, particularly after a depressive episode in which these subsyndromal disorders are the most…
- Trial name
- POLARIS (NCT01663974)
- Where
- 86 sites in France
- Volunteers
- 125 people
- Sponsor
- AstraZeneca
Psychosis, Substance Use
Families With Substance Use and Psychosis: A Pilot Study
The purpose of this study is to develop and evaluate an intervention that adapts Community Reinforcement and Family Training (CRAFT) for families experiencing first episode psychosis and substance use delivered via telemedicine…
- Conditions
- Psychosis, Substance Use, Substance Use Disorders, Family
- Trial name
- NCT04284813
- Testing
- CRAFT-FT
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Mood Disorder, Mania
Assessment of Cardiac Autonomic Behavior in Patients With Mood Disorders
The purpose of this study is to characterize the behavior of cardiac patients with Mood Disorders and its clinical course, interpreting the results from a theoretical framework of Chaos Theory and Complexity Theory and Systems as…
- Conditions
- Mood Disorder, Mania, Depression
- Trial name
- NCT01272518
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Sao Jose do Rio Preto Medical School
Bipolar Disorder, Cocaine Dependence
Valproate Efficacy in Cocaine-Bipolar Comorbidity
This proposal will test the efficacy of a promising pharmacological approach for the treatment of comorbid cocaine dependence and bipolar disorder.
- Trial name
- NCT00240110
- Testing
- Valproate, Lithium Carbonate
- Where
- 2 sites in United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- University of Miami
Bipolar Disorder (BD), Major Depressive Episode (MDE)
Validation of a Composite Medical Device Using a Blood Biomarker-based Algorithm and MDQ for the Diagnosis of Bipolar Disorder
The goal of this interventional clinical trial is to assess the diagnostic performance of a composite diagnostic medical devise based on blood-based in vitro diagnostic device and Mood Disorder Questionnaire (MDQ) in identifying…
- Conditions
- Bipolar Disorder (BD), Major Depressive Episode (MDE), Primary Care, Major Depression
- Trial name
- BIPOVITE (NCT07031817)
- Testing
- Venous blood sample for measuring blood biomarkers related to bipolar disorder, Standardized psychiatric assessment tools
- Where
- France
- Volunteers
- 623 people
- Sponsor
- University Hospital, Montpellier
Bipolar Disorder
Omega-3 Fatty Acids in Bipolar Disorder
This is a 12 month study of omega-3 fatty acids in bipolar disorder. This study will be a 12-month, parallel group, double-blind comparison of the prophylactic efficacy of omega-3 fatty acids vs.
- Trial name
- NCT00010868
- Testing
- Omega-3 Fatty Acids
- Where
- 2 sites in United States
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Bipolar Disorder
Observation of Clozapine Treatment Safety in Bipolar Disorder.
The purpose of the registry is to record incidence of adverse events during treatment with clozapine in patients suffering from bipolar disorder.
- Trial name
- CloGD (NCT06011460)
- Testing
- Clozapine
- Where
- Poland
- Volunteers
- 30 people
- Sponsor
- Medical University of Gdansk
Bipolar Disorder
Olanzapine Versus Comparator in the Treatment of Bipolar Disorder
The purpose of this trial is compare the efficacy of olanzapine and Lithium Carbonate in the treatment of bipolar disorder, manic or mixed episodes, in Chinese patients.
- Trial name
- NCT00485680
- Testing
- Olanzapine Hydrochloride, Lithium Carbonate
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Eli Lilly and Company
Major Depressive Disorder, Suicidal Behavior
Basal Plasma Lithium Levels and Suicidal Events
Suicidal behavior is a major public health issue and there are currently no specific treatments for it. However, lithium, the reference treatment for bipolar disorder, have been shown to be effective in preventing suicidal risk.
- Conditions
- Major Depressive Disorder, Suicidal Behavior, Bipolar Disorder
- Trial name
- LIPS (NCT05409794)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 158 people
- Sponsor
- University Hospital, Montpellier
Bipolar Disorder (BD)
Feasibility of eLi12
eLi12 represents a new method to estimate the serum-lithium (Se-Li) concentration at 12 hours after the most recent lithium dose.
- Trial name
- NCT07306039
- Testing
- Participants will have shown eLi12, Participants will not have shown eLi12
- Where
- 3 sites in Denmark
- Volunteers
- 200 people
- Sponsor
- Ole Köhler-Forsberg
Anxiety, Depression
Ginger.io Behavioral Health Study
This Study will evaluate the impact of a smartphone-based platform on a range of outcomes for medically-underserved patients with mood disorders (e.g.
- Conditions
- Anxiety, Depression, Bipolar I Disorder, Bipolar II Disorder
- Trial name
- NCT02491307
- Testing
- Ginger.io Smartphone Application
- Where
- 4 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Community Health Center, Inc.
Psychosis, Substance Use Disorders
Clozapine Versus Olanzapine as Treatment for Comorbid Psychotic Disorder and Substance Use Disorder
The purpose of this trial is to determine if patients with comorbid psychotic disorder and substance use disorder will continue in treatment longer if treated with clozapine than with olanzapine, and will have greater reductions…
- Trial name
- NCT03857581
- Testing
- Clozapine, Olanzapine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Augusta University