Clinical trials: Bipolar Disorder (BD)
Bipolar Disorder
Targeting Cognition in Bipolar Disorder With Pramipexole
Converging evidence suggests that patients with bipolar disorder suffer from deficits in neurocognitive functioning that persist, despite remission of acute affective symptoms.
- Trial name
- PRAM-BD (NCT02397837)
- Testing
- Pramipexole
- Where
- 3 sites in United States
- Volunteers
- 103 people
- Sponsor
- Brigham and Women's Hospital
Bipolar Disorder
Customized Medication Adherence Enhancement for Treating Adults With Bipolar Disorder
In this study, patients with bipolar disorder who do not take their medications as prescribed will receive specialized education and therapy treatment to determine whether the specialized treatment is effective in helping…
- Trial name
- NCT00763919
- Testing
- Psychoeducation module, Substance abuse module, Improved communication/rapport with provider module
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Case Western Reserve University
Bipolar Disorder (BD), Schizophrenia Disorders
Creating a Global Research Database That Connects Genetic Information and Long-term Health Data to Improve Personalized Treatment for People With Serious Mental Illness
This observational study aims to provide new insights into the nature and classification of severe mental illness and dementias that in time should help improve diagnostic practise, and enable the development of new and improved…
- Conditions
- Bipolar Disorder (BD), Schizophrenia Disorders, Major Depressive Diorder, Dementia
- Trial name
- GlobalMinds (NCT06641726)
- Testing
- Not applicable- observational study
- Where
- United Kingdom
- Volunteers
- 50,000 people
- Sponsor
- Akrivia Health
Bipolar Disorder (BD)
Research on the Efficacy and Safety of Targeted Suprachiasmatic Nucleus Electrical Stimulation for Improving Metabolic Disorders in Patients With Stable Bipolar Disorder Comorbid With Obesity
This study aims to stabilize the patients with bipolar disorder (BD) comorbid with obesity in the stable phase by using temporal interference stimulation (TIS ) intervention.
- Trial name
- NCT07589647
- Testing
- Temporal Interference Stimulation
- Where
- China
- Volunteers
- 70 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Bipolar Disorder (BD), Psychosis
Multimodal Intervention to Support Hospital-to-Community Transition in Bipolar Disorder
People with bipolar disorder (BD) are at high risk of relapse following hospital discharge, partly due to a lack of BD-specific expertise and resources within community services required for comprehensive treatment.
- Trial name
- BTBD (NCT07213492)
- Testing
- Group-Based Psychoeducation, Peer Support, Personalized Support for Community Healthcare Provider
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- McMaster University
ADHD, BD
A Novel Psychological Intervention for Adults With Bipolar Disorder and Attention Deficit Hyperactivity Disorder Comorbidity (VECTOR)
Cognitive dysfunctions are present in Bipolar Disorder (BD) and Attention Deficit Hyperactivity Disorder (ADHD) and may negatively impact psychosocial functioning.
- Trial name
- VECTOR (NCT07039903)
- Testing
- Cognitive behavioral therapy (CBT) + Functional Remediation (FR)
- Where
- Spain
- Volunteers
- 68 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Bipolar Disorder (BD)
Epigenetic and Neurochemical Correlates of Bipolar Disorder
Aim of Study: To assess DNA methylation of the IL1-B gene in individuals with BD compared to healthy controls. To evaluate the expression of 5-hydroxytryptamine (serotonin) receptors in BD and shed more light into its role into…
- Trial name
- NCT06829316
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Assiut University
Bipolar Disorder (BD), Depression - Major Depressive Disorder
Epigenetic Enhancement of Cognitive Training in Aging Mood and Schizophrenia Spectrum Disorder Populations
The aim of this clinical trial is to investigate the effects of a three-week virtual reality-based cognitive remediation training (VR-CRT) programme in combination with daily intake of a histone deacetylase inhibitor (HDACi)…
- Conditions
- Bipolar Disorder (BD), Depression - Major Depressive Disorder, Cognitive Impairment, Schizophrenia Disorders
- Trial name
- EPIC (NCT07404085)
- Testing
- Virtual Reality-based cognitive remediation therapy (VR-CRT), Virtual Reality-based control treatment (VR-CT), HDACi butyrate
- Where
- Denmark
- Volunteers
- 160 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Bipolar Disorder (BD), Bipolar Disorder Depression
Time Restricted Eating (TRE) in Bipolar Disorder
This is a randomized controlled trial investigating the effects of an 8-TRE intervention compared to a wait list (control) on metabolic health and body composition in people diagnosed with BD and who are currently obese and at…
- Conditions
- Bipolar Disorder (BD), Bipolar Disorder Depression, Overweight (BMI > 30)
- Trial name
- TREBD (NCT07211217)
- Testing
- Time Restricted Eating
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Bipolar Disorder (BD), Major Depressive Episode (MDE)
Validation of a Composite Medical Device Using a Blood Biomarker-based Algorithm and MDQ for the Diagnosis of Bipolar Disorder
The goal of this interventional clinical trial is to assess the diagnostic performance of a composite diagnostic medical devise based on blood-based in vitro diagnostic device and Mood Disorder Questionnaire (MDQ) in identifying…
- Conditions
- Bipolar Disorder (BD), Major Depressive Episode (MDE), Primary Care, Major Depression
- Trial name
- BIPOVITE (NCT07031817)
- Testing
- Venous blood sample for measuring blood biomarkers related to bipolar disorder, Standardized psychiatric assessment tools
- Where
- France
- Volunteers
- 623 people
- Sponsor
- University Hospital, Montpellier
Postpartum Depression
Quetiapine in the Treatment of Postpartum Depression (PPD) in Bipolar Disorder (BD), Type II
This is a 9-week single-centre, open-label, dose-escalating study evaluating the efficacy and safety of Quetiapine XR given as monotherapy in the treatment of non-lactating, post-partum women diagnosed with Bipolar II Disorder.
- Trial name
- NCT01527448
- Testing
- Quetiapine XR (seroquel)
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- BC Women's Hospital & Health Centre
Bipolar Disorder, Frontotemporal Dementia, Behavioral Variant
A Study of the Behavioral Variant of Frontotemporal Dementia and Bipolar Disorder: a Neuroimaging and Epigenetics Integrated Approach
The aim of this study is to investigate the selective epigenetic modifications and their effect on brain's morphology and functionality in the frontotemporal dementia behavioral variant and bipolar disorder.
- Trial name
- DISBAND (NCT06706687)
- Testing
- DISBAND protocol
- Where
- Italy
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Bipolar Disorder (BD)
A Study of Home-use Brain Stimulation to Treat Bipolar Depression
Bipolar depression is a long-lasting and disabling condition, and many people continue to experience depressive symptoms despite standard treatments.
- Trial name
- BDEP (NCT07556692)
- Testing
- Flow FL-100 tDCS headset
- Where
- United Kingdom
- Volunteers
- 212 people
- Sponsor
- King's College London
Bipolar Disorder (BD)
Adaptation and Validation of the Hypomanic Personality Scale (HPS-6) to Romanian
The HPS-6 (Hypomanic Personality Scale, 6 item version) could prove to be a valuable candidate for screening measures of high risk individuals.
- Trial name
- NCT07399626
- Testing
- Hypomanic Personality Scale - 6
- Where
- Romania
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Babes-Bolyai University
Schizophenia Disorder, Bipolar Disorder (BD)
Effects of Schizophrenia and Bipolar Disorder on Exercise Capacity, Pulmonary Function, and Quality of Life
This observational study aims to evaluate exercise capacity, pulmonary function, respiratory muscle strength, and quality of life in individuals diagnosed with schizophrenia and bipolar disorder.
- Trial name
- NCT07306468
- Testing
- Pulmonary Function Test, Respiratory Muscle Strength Evaluation, Quality of Life Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Çankırı Karatekin University
BD
The Effect of Methylphenidate on Cognitive Abilities of Adults With Bipolar Disorder
The purpose of the study is to explore the effect of MPH on working memory, attention and decision making in adults with BD in remission or in depressed state.
- Trial name
- NCT02020200
- Testing
- MPH
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Shalvata Mental Health Center
Treatment Adherence and Compliance, Severe Mental Disorders
Medication Adherence in Severe Mental Illness: a Promotion Program
People living with serious mental illnesses such as schizophrenia and bipolar disorder often need long-term medication to stay well.
- Conditions
- Treatment Adherence and Compliance, Severe Mental Disorders, Bipolar Disorder (BD), Schizophrenia Disorder
- Trial name
- ADHERA (NCT07445802)
- Testing
- Telehealth Psychoeducational Adherence Program
- Volunteers
- 1,640 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Bipolar Disorder (BD)
Pain, Sleep Quality, Eating Habits and Physical Activity Level in Patients With Bipolar Disorder
Bipolar disorder (BD) is a complex condition characterized by recurrence of mania, hypomania, and depression. It is characterized by changes in daily life activities, sleep status, focus problems, and cognitive fluctuations.
- Trial name
- NCT06954350
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Kutahya Health Sciences University
Bipolar Disorder
mHealth Estimate-based Algorithms Signaling Upcoming Recurrence of Episodes in Bipolar Disorders
Veterans with bipolar disorders (BD) experience recurrent and seemingly unpredictable periods of severe impairments in psychosocial functioning, such as participation in social roles and activities.
- Trial name
- MEASURE-BD (NCT06204705)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- VA Office of Research and Development
Borderline Personality Disorder, Borderline Personality Disorder (BPD)
Conceptualizing Borderline Personality Disorder as a Relationship Use Disorder
This study aims to explore a novel conceptualization of Borderline Personality Disorder (BPD) as a "Relationship Use Disorder." The research proposes that BPD shares key features with behavioral addictions, specifically addiction…
- Conditions
- Borderline Personality Disorder, Borderline Personality Disorder (BPD), Bipolar Disorder (BD)
- Trial name
- TLUR (NCT07337889)
- Testing
- Relationship-use questionnaire
- Where
- France
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier