Clinical trials: Bipolar Disorder (BD)
Bipolar Disorder (BD)
Anticipating Depressive and Manic Episodes in Bipolar Disorders Using Vocal Biomarkers
Bipolar disorder (BD) is a chronic, cyclical mental illness affecting over 1% of the global population. It is characterized by alternating episodes of elevated mood and energy (mania or hypomania) and episodes of decreased mood…
- Trial name
- SPEECHBIPO (NCT07298278)
- Testing
- Voice interviews and questionnaires carried out via the CALLYOPE application, Sleep measurements using an under-mattress sensor, Smartwatch for measuring activity, sleep, and skin temperature
- Volunteers
- 170 people
- Sponsor
- Centre Hospitalier St Anne
Neurologic Disorders, Schizophrenia
Characterization of High-Level Cognitive Impairments in Patients With Neuropsychiatric Disorders
Neuropsychiatric disorders are extremely common, severe, and disabling conditions. In the field of psychiatry, they notably include schizophrenia, mood disorders (depressive and bipolar disorders), autism spectrum or…
- Conditions
- Neurologic Disorders, Schizophrenia, Bipolar Disorder (BD), Depressive Disorder
- Trial name
- COGPSY (NCT07295652)
- Testing
- Cognitive assessment, Brain MRI (optional), Electroencephalography (optional)
- Where
- 3 sites in France
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Schizophrenia Disorder, Frontotemporal Dementia, Behavioral Variant
Understanding Mechanisms of Synaptic Degeneration Underlying Clinical Symptoms in Patients With MDs and NDs.
Clinical Study A. Retrospective Neuropathological Study of Synapse dysfunction. This is a cross-sectional study of patients retrospectively collected from existing postmortem collections and from existing collections of…
- Conditions
- Schizophrenia Disorder, Frontotemporal Dementia, Behavioral Variant, Major Depressive Disorder (MDD), Bipolar Disorder (BD)
- Trial name
- NCT07234851
- Where
- Spain
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Adolescent, Major Depressive Disorder (MDD
Multimodal Phenotyping in Adolescent Inpatient Depression: An Observational Study
This cohort study involves the dynamic collection of clinical information from adolescent patients with major depressive episodes (including both major depressive disorder and bipolar disorder), encompassing serum parameters…
- Conditions
- Adolescent, Major Depressive Disorder (MDD, Bipolar Disorder (BD)
- Trial name
- MAPS-IO (NCT07247344)
- Testing
- data collection and follow-up
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Jiangsu Province Nanjing Brain Hospital
Bipolar Disorder (BD), Major Depressive Episode (MDE)
Validation of a Composite Medical Device Using a Blood Biomarker-based Algorithm and MDQ for the Diagnosis of Bipolar Disorder
The goal of this interventional clinical trial is to assess the diagnostic performance of a composite diagnostic medical devise based on blood-based in vitro diagnostic device and Mood Disorder Questionnaire (MDQ) in identifying…
- Conditions
- Bipolar Disorder (BD), Major Depressive Episode (MDE), Primary Care, Major Depression
- Trial name
- BIPOVITE (NCT07031817)
- Testing
- Venous blood sample for measuring blood biomarkers related to bipolar disorder, Standardized psychiatric assessment tools
- Where
- France
- Volunteers
- 623 people
- Sponsor
- University Hospital, Montpellier
Bipolar Disorder (BD), Schizophrenia Disorders
Creating a Global Research Database That Connects Genetic Information and Long-term Health Data to Improve Personalized Treatment for People With Serious Mental Illness
This observational study aims to provide new insights into the nature and classification of severe mental illness and dementias that in time should help improve diagnostic practise, and enable the development of new and improved…
- Conditions
- Bipolar Disorder (BD), Schizophrenia Disorders, Major Depressive Diorder, Dementia
- Trial name
- GlobalMinds (NCT06641726)
- Testing
- Not applicable- observational study
- Where
- United Kingdom
- Volunteers
- 50,000 people
- Sponsor
- Akrivia Health
Bipolar Disorder (BD)
Real-world Lithium Intake
The aim of the present study is to study compliance with lithium therapy and patterns of lithium intake among a representative group of patients with bipolar disorder in a real-world clinical setting.
- Trial name
- NCT07167563
- Testing
- Lithium (LI) based on clinical indication
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- University of Aarhus
Autism Spectrum Disorder, Depression - Major Depressive Disorder
Mental Health, Intellectual and Neurodevelopmental Disorder Detection With Artificial Intelligence Models
This study investigates whether AI-driven analysis of speech can accurately predict clinical diagnoses and assess risk for various mental or behavioral health conditions, including attention-deficit/hyperactivity disorder (ADHD)…
- Conditions
- Autism Spectrum Disorder, Depression - Major Depressive Disorder, Anxiety, Generalized, Bipolar Disorder (BD)
- Trial name
- MINDAIM (NCT06792175)
- Testing
- Solicue Machine Learning Models, Mercuria Machine Learning Models
- Where
- 2 sites in United States
- Volunteers
- 500 people
- Sponsor
- Psyrin Inc.
Depression - Major Depressive Disorder, Depression Bipolar
Digital Phenotypes for Predicting Depression
This longitudinal study aims to identify and validate digital phenotypes that can predict recurrence of major depressive episodes using passively collected, real-time sensing data from smartphones and wearable devices.
- Conditions
- Depression - Major Depressive Disorder, Depression Bipolar, Bipolar Disorder (BD), Mood Disorders
- Trial name
- NCT07151846
- Where
- South Korea
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Korea University Anam Hospital
Bipolar Disorder (BD), Schizophrenia Disorder
Physical Fitness, Physical Activity Level, Depression and Quality of Life in Bipolar and Schizophrenia Patients
Assessment of physical activity levels, physical fitness and quality of life of bipolar and schizophrenia patients is necessary to verify the effectiveness of treatments and care activities in Community Mental Health Centers…
- Trial name
- NCT07140042
- Testing
- Survey
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
ADHD, BD
A Novel Psychological Intervention for Adults With Bipolar Disorder and Attention Deficit Hyperactivity Disorder Comorbidity (VECTOR)
Cognitive dysfunctions are present in Bipolar Disorder (BD) and Attention Deficit Hyperactivity Disorder (ADHD) and may negatively impact psychosocial functioning.
- Trial name
- VECTOR (NCT07039903)
- Testing
- Cognitive behavioral therapy (CBT) + Functional Remediation (FR)
- Where
- Spain
- Volunteers
- 68 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Bipolar Disorder (BD), Quality of Life (QOL)
'Thriving With Bipolar Disorder': Co-design and Evaluation of a Peer-Led Education Program Focused on Quality of Life
Self-management strategies can be used by individuals with bipolar disorder (BD) to cope with symptoms and improve quality of life (QoL).
- Trial name
- NCT06878937
- Testing
- Peer Delivered Psychoeducation Program
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- University of British Columbia
Schizophrenia and Schizoaffective Disorder, Bipolar Disorder (BD)
Survey on the Reproductive and Child-Rearing Situations of Patients With Severe Mental Disorders
Severe mental disorders represent a major public health concern, imposing substantial disease burden and adversely affecting multiple dimensions of patients' lives, while also creating intergenerational impacts on their offspring…
- Trial name
- NCT07005245
- Where
- China
- Volunteers
- 77,145 people
- Sponsor
- Peking University
Bipolar Disorder (BD), Organoids
Analysis of Early Neurodevelopmental Alterations in Bipolar Disorder Based on Cortical Organoid Models
Demonstrate the existence of neurodevelopmental alterations in organoids derived from samples of patients with bipolar disorder (BD) with a neurodevelopmental (ND) component, compared with patients with bipolar disorder (BD)…
- Conditions
- Bipolar Disorder (BD), Organoids, Neurodevelopmental Conditions
- Trial name
- BIPODEV (NCT06968598)
- Testing
- blood sample
- Volunteers
- 10 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Bipolar Disorder (BD)
Epigenetic and Neurochemical Correlates of Bipolar Disorder
Aim of Study: To assess DNA methylation of the IL1-B gene in individuals with BD compared to healthy controls. To evaluate the expression of 5-hydroxytryptamine (serotonin) receptors in BD and shed more light into its role into…
- Trial name
- NCT06829316
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Assiut University
Bipolar Disorder (BD), Suicidality
Neural Correlates of Ketamine's Anti-suicidal Effects in Bipolar Depression
Bipolar disorder is characterized by manic episodes and episodes of extreme depressive feelings, also known as bipolar depression (BD).
- Trial name
- DEEPP (NCT05177146)
- Testing
- Intravenous Ketamine (IV)
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- Centre for Addiction and Mental Health
Bipolar, Manic
Effect of Blue Light Blocking on Reducing Manic Symptoms in Bipolar Disorder
This study will be a randomized controlled trial (RCT) measuring the efficacy of wearing blue-blocking glasses (orange glasses) on manic symptoms in a population of patients suffering from Bipolar Disorder (BD), hospitalized for…
- Conditions
- Bipolar, Manic, Bipolar Disorder (BD), Dark Therapy
- Trial name
- BLUME (NCT06748716)
- Testing
- Blue-blocking glasses, Clear glasses
- Where
- Switzerland
- Volunteers
- 96 people
- Sponsor
- Rayan NASSERDINE
Depression - Major Depressive Disorder, Schizophrenia Disorders
Development and Application of Precision Treatment Strategies for Common Mental Disorders
Schizophrenia (SCH), major depressive disorder (MDD), and bipolar disorder (BPD) are prevalent, disabling psychiatric conditions that not only cause significant suffering for affected individuals and their families but also…
- Conditions
- Depression - Major Depressive Disorder, Schizophrenia Disorders, Bipolar Disorder (BD)
- Trial name
- NCT06729541
- Testing
- Multigenetic Pharmacogenomics-Guided Treatment (MPGT)
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Peking University
Dementia, Bipolar Disorder (BD)
Lithium for Prevention of Cognitive Declining in Mood Illnesses
INTRODUCTION: Mood disorders, bipolar disorder and recurrent unipolar depression, are among the most common mental health conditions worldwide.
- Conditions
- Dementia, Bipolar Disorder (BD), Depression - Major Depressive Disorder, Mild Cognitive Impairment (MCI)
- Trial name
- NCT06662526
- Testing
- Trace lithium dose plus treatment as usual
- Where
- 2 sites in Chile
- Volunteers
- 250 people
- Sponsor
- University of Chile
Bipolar Disorder (BD), Bipolar
Perspectives of Individuals With Bipolar Disorder and Siblings of Individuals With Bipolar Disorder; A Telephone Interview Study
This study will examine those who will seek and those who are most likely to benefit from genetic counseling for psychiatric disorders.
- Trial name
- NCT00300820
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Human Genome Research Institute (NHGRI)