Clinical trials: Bipolar I Depression
Major Depressive Disorder, Bipolar Disorder
Transcranial Electric Stimulation Therapy (TEST) for Treatment Resistant Depression (TRD)
Background: People with TRD are often helped by electroconvulsive therapy (ECT). But ECT can affect memory and thinking. Researchers want to study a treatment called TEST that uses less electricity.
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Unipolar Major Depression
- Trial name
- NCT05172271
- Testing
- MagPro TMS Stimulator and coil, Thymatron(R) System IV, Magnetic Resonance Imaging Scanner
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- National Institute of Mental Health (NIMH)
Suicidal Ideation, Major Depressive Disorder
Low Amplitude Pulse Seizure Therapy Versus Standard Ultra-Brief Right Unilateral Electroconvulsive Therapy
This protocol proposes an initial randomized clinical trial that includes all patients with suicidal ideation (SI) at baseline, and with SI as the primary outcome measure to examine whether Right Unilateral Low-Amplitude Pulse …
- Conditions
- Suicidal Ideation, Major Depressive Disorder, Schizo Affective Disorder, Bipolar Disorder
- Trial name
- LAP-ST vs ECT (NCT06529029)
- Testing
- Sigma-Stim, RUL LAP-ST (Low-Amplitude Pulse Seizure Therapy - Right Unilateral)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Michigan State University
Bipolar II Disorder, Depression, Bipolar
Acceptability & Safety of Two Sequential Doses of Psilocybin in Bipolar Disorder II Depression and Suicidality
The purpose of the study is to assess the safety and acceptability of up to two sequential administrations of 25 mg psilocybin with additional therapeutic support in decreasing suicidality in patients with Bipolar Disorder (BD…
- Conditions
- Bipolar II Disorder, Depression, Bipolar, Suicidality
- Trial name
- NCT06706232
- Testing
- Psilocybin, Therapeutic Support
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The University of Texas Health Science Center, Houston
Serious Mental Illness, Psychotic Disorder
Changing Lives and Changing Outcomes-9 at Worcester Recovery Center and Hospital
People with serious mental illness (depression, bipolar, and schizophrenia spectrum disorders) have high rates of repeated criminal legal involvement and psychiatric hospitalizations.
- Conditions
- Serious Mental Illness, Psychotic Disorder, Depression, Bipolar
- Trial name
- CLCO-9 (NCT07359157)
- Testing
- Changing Lives and Changing Outcomes-9
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Bipolar Depression
Neurobiological Effects of Psilocybin in Treatment Resistant Bipolar Depression
This study is an open-label, single-arm, proof-of-concept study, wherein treatment resistant bipolar depression (TRBD) participants will receive one 25 mg dose of oral psilocybin accompanied by preparatory, monitoring, and…
- Trial name
- Psilo-BD (NCT06506019)
- Testing
- Psilocybin, Functional MRI
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Anxiety, Depression
The Combination of Pharmacotherapy and Cognitive Behavioral Psychotherapy Under the Recovery Perspective.
The combination of pharmacotherapy and individual cognitive behavioral therapy in a private practice.
- Conditions
- Anxiety, Depression, Obsessive-compulsive Disorder, Personality Disorder
- Trial name
- RAKGEOCBT (NCT06993662)
- Testing
- Group A. The combination of pharmacotherapy and individual cognitive behavioral psychotherapy by anxiety disorders and depression., Group B. The combination of pharmacotherapy and individual cognitive behavioral psychotherapy by PTSD, Group C. The combination of pharmacotherapy and individual cognitive behavioral psychotherapy by obsessive-compulsive disorder.
- Where
- Greece
- Volunteers
- 107 people
- Sponsor
- Rakitzi, Stavroula
Major Depression Moderate, Major Depression Severe
EEG Microstate and Neuroinflammatory Biomarkers in Older Age Patients With Major Depressive Disorder Receiving ECT
This study aims to investigate the neurophysiological and inflammatory changes associated with electroconvulsive therapy (ECT) in older age patients diagnosed with Major Depressive Episode, Major Depression, and Bipolar Disorder…
- Conditions
- Major Depression Moderate, Major Depression Severe, Major Depression With Comorbid Anxiety Symptoms, Major Depression With Panic Attacks
- Trial name
- NCT07740694
- Testing
- Electroconvulsive Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Borderline Personality Disorder (BPD), Treatment-Resistant Major Depressive Disorder
Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder (KET-DBT)
The goal of this clinical trial is to learn if intravenous (IV) ketamine with Dialectical Behavioural Therapy (DBT) reduces suicidal ideation in individuals with suicidality who have been diagnosed with Borderline Personality…
- Conditions
- Borderline Personality Disorder (BPD), Treatment-Resistant Major Depressive Disorder, Treatment-resistant Bipolar Depression, Major Depressive Disorder (MDD)
- Trial name
- KET-DBT (NCT07569198)
- Testing
- Ketamine Hydrochloride, Midazolam Hydrochloride, Dialectical Behavioral Therapy (DBT)
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Joshua Rosenblat
Depression, Bipolar I Disorder
A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.
Bipolar disorder is a severe chronic mood disorder that affects up to 4% of the adult population and 1.8% of the pediatric population in the United States.
- Trial name
- 3112 Ped BPD (NCT04777357)
- Testing
- Cariprazine
- Where
- 81 sites in United States, Puerto Rico and 1 more
- Volunteers
- 380 people
- Sponsor
- AbbVie
Bipolar Disorder, Bipolar Depression
A Pilot Study Investigating the Efficacy of Minocycline and N-Acetyl Cysteine for Bipolar Depression
The purpose of the Pilot Study Investigating the Efficacy of Minocycline and n-acetylcysteine for Bipolar Depression is to test the effectiveness of minocycline, n-acetylcysteine, and combined minocycline and n-acetylcysteine…
- Trial name
- NCT02719392
- Testing
- N-acetylcysteine, Minocycline
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Anxiety, Depression - Major Depressive Disorder
Profiling Vulnerability and Resilience for Mental Illness Following Viral Infections: Translating Epidemiology to Deep-phenotyping.
The study protocol was submitted to ERA-NET NEURON for funding on 28/06/2023. Description of the Israeli responsibilities was extracted from the full submitted research protocol. The protocol includes two studies (CHS1 and CHS2).
- Conditions
- Anxiety, Depression - Major Depressive Disorder, Bipolar, Schizophenia Disorder
- Trial name
- Viral-MI (NCT07453420)
- Where
- Israel
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Shalvata Mental Health Center
Bipolar Disorder, Bipolar I Depression
Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder
Lithium is highly effective in the treatment of bipolar disorder. This study aims to investigate, for the first time, the impact of lithium monotherapy on the structural and functional connectivity of the brain using MRI imaging.
- Conditions
- Bipolar Disorder, Bipolar I Depression, Bipolar II Depression, Bipolar Depression
- Trial name
- NCT03336918
- Testing
- Lithium
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Psychosis, Psychosis Nos/Other
EPI-MINN: Targeting Cognition and Motivation - National
The purpose of this study is to perform a practice-based research project designed to assess whether cognition and motivated behavior in early psychosis can be addressed as key treatment goals within real-world settings by using…
- Conditions
- Psychosis, Psychosis Nos/Other, Schizophrenia, Schizo Affective Disorder
- Trial name
- NCT05877716
- Testing
- Cognitive and Social Cognitive Training, Personalized Real-Time Intervention for Motivational Enhancement (PRIME) App, Early Psychosis Coordinated Specialty Care
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of Minnesota
Depression - Major Depressive Disorder, Depression Bipolar
Longitudinal Study on the Sustainability of Transcranial Magnetic Stimulation Protocols - Biomarkers
Despite advances in the effective treatment of major depressive disorder using repetitive transcranial magnetic stimulation (rTMS), the processes that determine a patient's response trajectory remain poorly understood.
- Conditions
- Depression - Major Depressive Disorder, Depression Bipolar, Depression Unipolar
- Trial name
- LONGISTIM-BIO (NCT07684911)
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospital Center Guillaume Régnier
Major Depressive Disorder, Treatment Resistant Depression
Ketamine Associated ACC GABA and Glutamate Change and Depression Remission:
This is a feasibility study and the goal of this project is to evaluate whether peak ACC GABA and glutamate, quantified as a CSF-corrected absolute concentration percent change from baseline, is associated with clinical…
- Conditions
- Major Depressive Disorder, Treatment Resistant Depression, Bipolar Depression
- Trial name
- NCT03573349
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Mayo Clinic
Bipolar II Disorder, Most Recent Episode Major Depressive, Current Depressive Episode
Accelerated Intermittent Theta-Burst Stimulation (aiTBS) in Treatment-Resistant Depression of Bipolar II Disorder
The purpose of this study is to investigate the effectiveness of accelerated intermittent theta-burst transcranial magnetic stimulation (aiTBS) in inducing anti-depressant responses in individuals with treatment-resistant…
- Conditions
- Bipolar II Disorder, Most Recent Episode Major Depressive, Current Depressive Episode, Treatment Resistant Depression
- Trial name
- NCT05849402
- Testing
- Active Comparator: Active aiTBS
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Stanford University
Bipolar Affective Disorder, Schizophrenia Disorders
Medical Phenotyping of NHS General Adult Psychiatry (GAP) Inpatients
This observational study will characterise the general psychiatric and general medical phenotypes of 100 adults, sequentially admitted to NHS General Adult Psychiatry (GAP) "mental health" inpatient wards, providing the first…
- Conditions
- Bipolar Affective Disorder, Schizophrenia Disorders, Depression Disorders, Personality Disorders
- Trial name
- NCT07398365
- Testing
- Questionnaires, rating scales, & review of notes
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Edinburgh
Bipolar I Disorder, Depression, Anxiety
Efficacy and Safety of Magnesium Vitamin B6 in First Episode Bipolar Disorder
This is a randomized, double-blind, placebo-controlled proof-of-concept clinical trial to assess the efficacy and safety of Magnesium-vitamin B6in combination with treatment as usual for treating symptoms of depression, stress…
- Conditions
- Bipolar I Disorder, Depression, Anxiety, Stress
- Trial name
- NCT05837104
- Testing
- Magnesium vitamin B6
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mclean Hospital
Schizophrenia Disorders, Major Depression
Non-Coding RNAs Gene Expression in Psychiatric Disorders
This study aims to investigate whether specific non-coding RNAs, molecules involved in the regulation of gene expression, are altered in individuals with psychiatric disorders such as schizophrenia, bipolar disorder, major…
- Conditions
- Schizophrenia Disorders, Major Depression, Bipolar Affective Disorders, Obsessive Compulsive Disorder (OCD)
- Trial name
- PsiRNA26 (NCT07649993)
- Testing
- Reverse Transcription Quantitative Polymerase Chain Reaction
- Where
- 5 sites in Italy
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- Carmen Concerto
Unipolar Depression, Bipolar Depression
RNA Editing as a Biomarker of Antidepressant Response in Unipolar and Bipolar Depression (EDIT-ANDRE)
The purpose of this research is to understand how changes in RNA editing relate to treatment response in unipolar and bipolar depression.
- Trial name
- NCT07266545
- Testing
- Vortioxetine, Cariprazine (Augmentation Phase)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Mayo Clinic