Clinical trials: Birch Pollen Allergy
Hypersensitivity
DBPC-Dose-finding-trial of Vitamin D3 for SCIT in Birch Pollen Allergic Patients.
Low Vitamin D3 (VD3) levels have been reported to be associated with the risk of allergic diseases like asthma. VD3 has been demonstrated in vitro, ex vivo and in animal models to program the immune system towards…
- Trial name
- BM4SIT (NCT02686827)
- Testing
- Paricalcitol
- Where
- Netherlands
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Laurian Jongejan
Birch Pollen Related Apple Allergy, Birch Pollen Allergy
Sublingual Immunotherapy of Birch Pollen Associated Apple Allergy
More than 70% of birch pollen allergic patients suffer from allergic reactions to certain foods, e.g. stone fruits, hazelnut and some vegetables.
- Trial name
- NCT01449786
- Testing
- rMal d 1, rBet v 1
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Medical University of Vienna
Hay Fever, Birch Pollen Allergy
Probiotics for Reduction Of Markers In Subjects With Allergy
In vitro studies reveal immunomodulatory effects of probiotic bacteria that are strain-dependent. Differential immunomodulatory in vitro capacities can not be extrapolated directly to in vivo efficacy.
- Trial name
- PROMISA (NCT01137357)
- Testing
- Yoghurt with L. plantarum strain, Yoghurt with L.casei, Yoghurt
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Rijnstate Hospital
Birch Pollen-Related Rhinoconjunctivitis, Rhinitis, Allergic, Seasonal
Safety and Tolerability Study of rBet v1 SLIT Tablets
The purpose of this study is to determine the safety and tolerability of several doses of r Bet v1 administered as sub-lingual tablets in subjects sensitised to birch pollen.
- Trial name
- NCT00889460
- Testing
- rBet v 1
- Where
- Denmark
- Volunteers
- 55 people
- Sponsor
- Stallergenes Greer
Type I Hypersensitivity
Assessment of Residual Allergenicity of Tree (Birch, Hazel, and Alder) Pollen Allergoid Using Skin Prick Testing
The purpose of this study is to evaluate the residual allergenicity of Tree MATA (modified pollen allergen tyrosine adsorbate) by skin prick testing.
- Trial name
- NCT00107705
- Testing
- Tree MATA MPL
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Allergy Therapeutics
Birch Pollen Allergy
Study of DM-101PX in Adults With Birch Pollen Allergy
Randomized, double-blind placebo-controlled phase 2 trial with the aim to investigate safety and efficacy of DM-101-PX in reducing allergic symptoms provoked by nasal allergen challenge in birch pollen allergic adults.
- Trial name
- BASIT (NCT07254871)
- Testing
- DM-101PX
- Where
- Canada
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Desentum Oy
House Dust Mite Allergy, Birch Pollen Allergy
Evaluation of an Adjusted Cutoff Value for S.P.A.T (Skin Prick Automated Test) Device in Allergic Subjects
Skin prick test (SPT) is a first line diagnostic test to detect type I hypersensitivity in patients suspected of an inhalant allergy. A novel S.P.A.T.
- Trial name
- SPATprovocatio (NCT06803953)
- Testing
- Skin Prick Automated Test, Skin Prick Manual Test, Nasal Allergen Challenge
- Where
- France
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Hippocreates
Allergic Rhinitis, Rhinoconjunctivitis
Efficacy Study of a Preseasonal Treatment With AllerT in Subjects With Birch Pollen Allergy
The main objective of the trial is to demonstrate the efficacy of a two months pre-seasonal treatment with AllerT 100 µg maintenance dose in reducing symptoms of allergic rhinoconjunctivitis during the following birch pollen…
- Trial name
- NCT01720251
- Testing
- AllerT low dose, AllerT full dose
- Where
- 24 sites in Denmark, France and 5 more
- Volunteers
- 240 people
- Sponsor
- Anergis
Rhinitis, Allergic, Seasonal, Hay Fever
Methylprednisolone Injections Treating Birch Pollen Induced Allergic Rhinitis.
This study evaluates the effect of intramuscular injected methylprednisolone treating birch pollen induced rhinitis compared to placebo.
- Conditions
- Rhinitis, Allergic, Seasonal, Hay Fever, Pollen Allergy, Allergic Rhinitis
- Trial name
- NCT04622917
- Testing
- MethylPREDNISolone 40 Mg/mL Injectable Suspension, NaCl 9 MG/ML Injectable Solution
- Where
- Sweden
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Allergic Rhinitis, Seasonal Allergic Rhinitis
Threshold Concentrations for Ragweed and Birch Pollen in Seasonal Allergic Rhinitis
The ragweed Ambrosia artemisiifolia is spreading in northern Europe due to climate change. The pollen are considered highly allergenic and might trigger allergy symptoms at much lower concentrations than e.g.
- Conditions
- Allergic Rhinitis, Seasonal Allergic Rhinitis, Ragweed Allergy, Birch Pollen Allergy
- Trial name
- UBAMBI (NCT05346718)
- Where
- Germany
- Volunteers
- 18 people
- Sponsor
- Fraunhofer-Institute of Toxicology and Experimental Medicine
Allergic Rhinitis, Allergic Reaction
Efficacy and Safety of Birch Pollen Immunotherapy in Local Allergic Rhinitis
Local allergic rhinitis (LAR) is relatively new disease. The question of effect of allergen specific immunotherapy on LAR is open.
- Trial name
- LARbirch (NCT03157505)
- Testing
- Purethal Birch immunotherapy
- Volunteers
- 78 people
- Sponsor
- Medical University of Silesia
Allergic Conjunctivitis
A Study to Demonstrate the Effect of REGN5713-5715 on Reducing Ocular Allergy Signs and Symptoms in Adult Participants With Birch Pollen Allergy
This study is researching 2 experimental drugs, REGN5713 and REGN5715, which are called REGN5713-5715 when mixed together (called "study drug") to reduce eye allergy signs and symptoms due to birch tree pollen allergy.
- Trial name
- NCT06602739
- Testing
- REGN5713, REGN5715
- Where
- 3 sites in United States, Canada
- Volunteers
- 54 people
- Sponsor
- Regeneron Pharmaceuticals