Clinical trials: Birth
Pharmacokinetics
Effect of Delivery Route on PK of Sufentanil NanoTab
Determine whether the amount of drug absorbed is different if the tablet is placed under the tongue, placed between the cheek and gum, or swallowed.
- Trial name
- NCT01639729
- Testing
- Treatment A: Sufentanil IV, Treatment B: Sufentanil NanoTab Sublingual, Treatment C: Sufentanil NanoTab Buccal
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Talphera, Inc
Group B Streptococcus Carrier in Childbirth, Gastrointestinal Symptoms
The Efficacy of Probiotics to Reduce Antepartum Group B Streptococcus Colonization.
This study is a randomized double blind, placebo controlled trial to determine the efficacy of an oral probiotic in reducing antenatal Group B Streptococcus colonization.
- Trial name
- NCT03696953
- Testing
- Florajen3
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Marquette University
Healthy Male Subjects
A Study in Healthy Male Subjects to Investigate the Comparability of Pharmacokinetics of the Fixed-Dose Combination of Pertuzumab and Trastuzumab Administered Subcutaneously Using a Handheld Syringe or Using the On-Body Delivery System
This is a randomized, open-label, 2-arm, parallel-group, single-dose, multi-center study in healthy male subjects to investigate the comparability of the pharmacokinetics of the fixed-dose combination of pertuzumab and…
- Trial name
- NCT05275010
- Testing
- Fixed-Dose Combination of Pertuzumab and Trastuzumab SC (PH FDC SC), Handheld Syringe with Hypodermic Needle, On-Body Delivery System
- Where
- 5 sites in Australia, New Zealand
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Cardiovascular Diseases, Diabetes
Diabetes Remote Intervention to improVe Use of Evidence-based Medications
A randomized remote, implementation trial in the Mass General Brigham network was performed on 200 patients with T2D at high CV or kidney risk.
- Trial name
- DRIVE (NCT06046560)
- Testing
- SGLT2 inhibitor, GLP-1 RA, Education-First
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Post Partum Hemorrhage, Blood Loss
Estimating Blood Loss Using TritonTM in Vaginal Deliveries: A Validation Trial
This study will be a prospective cohort study. Patients who meet criteria for inclusion in the study will be approached for participation at same day of admission.
- Conditions
- Post Partum Hemorrhage, Blood Loss, Vaginal Bleeding, Vaginal Delivery
- Trial name
- ELUSIVE (NCT04277962)
- Testing
- Triton L and D system for estimation of blood loss at time of vaginal delivery
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Postpartum Contraception, Family Planning
Labor and Delivery Implant Insertion: A Randomized Controlled Trial
A barrier to initiating progestin contraceptives in the early postpartum period is the concern of interference with breastfeeding, specifically lactogenesis.
- Trial name
- LADII (NCT02866643)
- Testing
- Etonogestrel-Immediate, Etonogestrel-Delayed
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Stanford University
Postpartum Hemorrhage
Oxytocin Infusions and Blood Loss in Patients Undergoing Elective Cesarean Delivery.
Although prior dose-finding studies have investigated the optimal bolus dose of oxytocin to initiate adequate uterine tone, it is unclear what oxytocin infusion regimen is required to maintain adequate uterine tone after…
- Trial name
- NCT01932060
- Testing
- Oxytocin Infusion
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Stanford University
Pregnancy Related, Doula Care
Labor and Delivery Doula Program to Reduce Perinatal Morbidity and Mortality in Kansas
The study was done to learn how doula-enhanced care provided to Black birthing people improved perceived communication and quality care.
- Conditions
- Pregnancy Related, Doula Care, Black Maternal and Infant Health, Prenatal Care
- Trial name
- Doula (NCT07157059)
- Testing
- Doula Care
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Labor Pain, Virtual Reality
Virtual Reality in Labor and Delivery for Reduction in Pain
The purpose of this study is to identify whether use of virtual reality devices can improve the pain management of women in labor and delivery.
- Conditions
- Labor Pain, Virtual Reality, Alternative Medicine
- Trial name
- NCT03437031
- Testing
- Virtual Reality device
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Preoxygenation
Pre-Oxygenation Techniques in Pregnancy
A trial comparing outcomes of two pre-oxygenation techniques in obstetric patients.
- Trial name
- POP (NCT03310723)
- Testing
- Face Mask preoxygenation, OptiFlow preoxygenation
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Healthy, Pain
Intrathecal Hydromorphone for Post-cesarean Delivery Pain - a Dose Finding Study
Pain relief after cesarean delivery can be provided in a few ways. Most commonly, certain medications called opioids, such as morphine, are given through the vein or into the muscle.
- Conditions
- Healthy, Pain, Pregnancy
- Trial name
- NCT01943565
- Testing
- Hydromorphone 25mcg, Hydromorphone 50mcg, Hydromorphone 100mcg
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Pain, Postoperative
A Randomized Control Trial Comparing Analgesic Benefits of Ultrasound-guided Single vs Continuous Quadratus Lumborum Blocks (QLB)vs Intrathecal Morphine(ITM) for Post Cesarean Section Pain
the purpose of this study is to compare opioid consumption in morphine equivalents between the groups that received postoperative analgesia with intrathecal morphine versus US guided QL blocks versus US guided QL catheters
- Trial name
- NCT04368364
- Testing
- Intrathecal morphine sulfate (ITM), Bupivacaine hydrochloride, ropivacaine hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Healthy
Users Study Of The Caverject Delivery System
Usability testing of the dual-chambered syringe in conjunction with the proposed patient instructions for use.
- Trial name
- NCT01747928
- Testing
- dual-chamber syringe
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Pfizer
Low Birthweight, Pre-Term
Low-birthweight Infant Feeding Exploration
Globally, 15% of all babies, amounting to 20 million infants each year, are born low birthweight (LBW), defined less than 2500 grams (5.5 lbs).
- Trial name
- LIFE (NCT04002908)
- Where
- 3 sites in India, Malawi and 1 more
- Volunteers
- 3,188 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Postpartum
Home-based Delivery of the Contraceptive Implant in Postpartum Guatemalan Women
Abstract Background: Postpartum contraception is important to prevent unintended and closely spaced pregnancies following childbirth.
- Trial name
- NCT04005391
- Testing
- Offer of Participant's Choice of Contraception Method
- Where
- 2 sites in United States, Guatemala
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Preterm Infant, Full-term Infant
A Novel Parent Education Program for Early Intervention
One in ten infants born in the USA is born preterm before 37 weeks of gestation and 50% of those will have motor and cognitive delays requiring intervention at school age.
- Trial name
- NCT04266717
- Testing
- Baby Play Intervention, Milestone Education
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Preterm Birth, Tube Feeding
Maternal Role in Oral Feed Establishment in Preterm Neonates
Hypothesis Preterm babies who receive sensory motor stimulation from their mothers as compared to trained nurses will 1. Start taking oral feed at the same time as compared to control group 2.
- Conditions
- Preterm Birth, Tube Feeding, Swallowing Disorder, Maternal Care Patterns
- Trial name
- NCT05484726
- Testing
- perioral sensory motor stimulation
- Where
- Pakistan
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Fatima Memorial Hospital
Contraception
Transdermal Contraceptive Delivery System (TCDS), Also Known as AG200-15 Patch Arm
The purpose of the study is to evaluate the efficacy and safety of a low dose transdermal contraceptive delivery system containing ethinyl estradiol and levonorgestrel.
- Trial name
- ATI-CL13 (NCT01236768)
- Testing
- AG200-15, Levora
- Where
- 21 sites in United States
- Volunteers
- 407 people, healthy volunteers welcome
- Sponsor
- Agile Therapeutics
Nicotine Dependence
Impact of Alternative Nicotine-Delivery Products on Combustible Cigarette Use
The goal of this research is to understand the potential impact of two new FDA strategies to ensure the availability of safer Alternative Nicotine Delivery Systems (ANDS) and to reduce the nicotine content in combustible…
- Trial name
- NCT04084210
- Testing
- Juul Electronic cigarette, Very Low Nicotine Cigarettes, Active Nicotine Patch
- Where
- 2 sites in United States
- Volunteers
- 209 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Preeclampsia, Hypotension
Phenylephrine in Spinal Anesthesia in Preeclamptic Patients
Hypotension remains a common clinical problem after induction of spinal anesthesia for cesarean delivery. Maternal hypotension has been associated with considerable morbidity (maternal nausea and vomiting and fetal/neonatal…
- Trial name
- NCT00458003
- Testing
- Ephedrine, Phenylephrine
- Where
- 2 sites in United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Northwestern University