Clinical trials: Birth
Neuromyelitis Optica Spectrum Disorder, Pregnancy Related
Observational Safety Study in Women With Neuromyelitis Optica Spectrum Disorder (NMOSD) Exposed to UPLIZNA® During Pregnancy
This is an observational study to monitor female participants exposed to UPLIZNA during pregnancy. This study requires voluntary reporting of pregnancies in female participants with NMOSD exposed to UPLIZNA during pregnancy or…
- Trial name
- NCT05909761
- Testing
- UPLIZNA
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Amgen
Sepsis, Pneumonia
Improved Accessibility of EmONC Services for Maternal and Newborn Health: a Community Based Project
The purpose of this study is to determine whether an integrated EmONC package (community mobilization, training of community-based health care providers and a maternal and neonatal health pack) reduce perinatal and neonatal…
- Conditions
- Sepsis, Pneumonia, Omphalitis, Birth Asphyxia
- Trial name
- EmONC (NCT01751945)
- Testing
- EmONC package
- Where
- Pakistan
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Perinatal Depression, Chronic Pain
CSF/Serum Biomarkers in Predicting PND/Persistent Pain After Cesarean
The aim is to investigate if inflammatory biomarkers in the blood and cerebrospinal fluid (CSF) are associated with the development of perinatal depression and/or persistent pain after cesarean delivery.
- Trial name
- NCT04271072
- Testing
- No intervention
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Duke University
Prostate Cancer, Prostate Adenocarcinoma
Effects of Direct Artery Injection on Prostate Cancer Drug Delivery and Tumor Uptake: Imaging-Based Prediction of Treatment Effectiveness
The goal of this clinical trial is to learn whether intra-arterial (IA) administration of 68Ga-PSMA improves tumor uptake and distribution compared with standard intravenous (IV) administration in patients with localized…
- Trial name
- IAPSMA (NCT07656337)
- Testing
- Intraarterial injection of 68Ga-PSMA
- Where
- Lithuania
- Volunteers
- 10 people
- Sponsor
- Lithuanian University of Health Sciences
Premature Rupture of Fetal Membranes
Does Nipple Stimulation Shorten Time to Vaginal Birth in Women With Term PROM?
Premature Rupture of Membranes (PROM) is defined as the rupture of membranes before the onset of regular uterine contractions. PROM occurs in approximately 10% of all pregnancies (ranging from 2.7% to 17%), with 60% to 80% of…
- Trial name
- NIPROM (NCT03025581)
- Testing
- Nipple stimulation
- Where
- Israel
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Parkinson's Disease
Distant Delivery of a Mindfulness-based Intervention for People Affected by Parkinson's Disease
Psychological difficulties, especially depression and anxiety are the most prevalent non-motor symptoms in Parkinson's Disease (PD). Pharmacological treatments are not as effective in PD.
- Trial name
- MindPD (NCT02683330)
- Testing
- Mindfulness-based intervention (MBI)
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- City, University of London
Infertility
Effect of Vitamin D Supplementation in Live Birth Rate of in Vitro Fertilization Outcome
This is a randomized-controlled trial evaluating the effect of the use of vitamin D supplementation on the live birth rate in women undergoing in vitro fertilization (IVF).
- Trial name
- NCT04547530
- Testing
- Vitamin D
- Where
- 2 sites in Hong Kong
- Volunteers
- 1,150 people
- Sponsor
- The University of Hong Kong
Breech Presentation in Pregnancy, Midwifery Education
High-Fidelity Simulation-Based Breech Birth Education in Midwifery Students
The purpose of this randomized controlled clinical trial is to evaluate whether high-fidelity simulation-based breech birth management education improves knowledge, clinical skill performance, and satisfaction among midwifery…
- Conditions
- Breech Presentation in Pregnancy, Midwifery Education, Simulation Training
- Trial name
- NCT07635667
- Testing
- High-Fidelity Simulation-Based Breech Birth Education, Low-Fidelity Mannequin-Based Breech Birth Practice
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Karabuk University
Foot Ulcer, Diabetic
Negative Pressure Wound Therapy as a Drug Delivery System (ADANPWT)
The investigators plan a randomized clinical trial of 150 patients with infected diabetes-related lower extremity wounds to compare the clinical and economic effectiveness of negative pressure wound therapy with continuous…
- Trial name
- ADA NPWT (NCT02308800)
- Testing
- Quantum™ Therapy - NPWT with Prontosan, Quantum™ Therapy
- Where
- United States
- Sponsor
- University of Texas Southwestern Medical Center
Short Stature Children Born Small for Gestational Age (SGA)
A Phase II Study of PEG-rhGH Injection for Short Children Born Small for Gestational Age: Efficacy, Safety, and Pharmacokinetics
This study will take place at multiple sites and is divided into three phases:an initial 4-week getting-to-know-you phase,a 26-week main phase where participants receive medication,and a 4-week follow-up phase.Participants will…
- Trial name
- NCT07260500
- Testing
- PEG-rhGH Injection, hGH Injection
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.
Preterm Infant
Clinical Impact of Non-invasive Neurally Adjusted Ventilatory Assist in Very Preterm Infants
This is a prospective observational study investigating the impact of NIV-NAVA on short-term clinical outcomes and long-term neurodevelopment in very preterm infants.
- Trial name
- NCT06786039
- Testing
- Non-invasive NAVA
- Where
- 2 sites in South Korea
- Volunteers
- 80 people
- Sponsor
- Korea University Anam Hospital
Enteral Nutrition, Born Very Premature
Prolonged Minimal Enteral Nutrition Versus Slowly Advancing Enteral Nutrition in Very Low Birth Weight Infants:
Recent studies showed the benefits of early initiation and advancement enteral feeds with daily increments in preterm infants on decreasing invasive infections and early achievement of full enteral feedings.
- Conditions
- Enteral Nutrition, Born Very Premature, Infant, Very Low Birth Weight
- Trial name
- NCT02913677
- Testing
- nutrition
- Where
- Turkey (Türkiye)
- Volunteers
- 199 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Postpartum Hemorrhage, Systemic Autoimmune Diseases
Risk Factors for Postpartum Hemorrhage
Postpartum hemorrhage (PPH) is the most significant leading cause of pregnancy-related mortality in high-risk cesarean delivery women.
- Trial name
- NCT06730919
- Testing
- Estimated Blood Loss after cesarean delivery within 24 h
- Where
- 5 sites in China
- Volunteers
- 1,000 people
- Sponsor
- RenJi Hospital
Preterm Birth
Study of the Risk of PREMaturité According to the Balance of Bacterial Flora VAginale
Objective To compare vaginal microbiota in the first trimester of pregnancy between spontaneous preterm and term deliveries
- Trial name
- PREMEVA2 (NCT03618836)
- Testing
- Microbiological and biological patterns on vaginal samples
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Lille
Injections, Intradermal
Performance and Safety Evaluation of an Intradermal Delivery Device
The purpose of this study is to evaluate whether an investigational vaccine delivery device (the ID adapter) can safely and precisely inject liquid into the intradermal layer of the skin.
- Trial name
- NCT01359111
- Testing
- PATH ID Adapter
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- PATH
Opioid Use Disorder (OUD), Addictology
Autonomous Methadone Delivery System by Nurses
Initiations of methadone treatment for opiode use disorder (OUD) are carried out in France in specialized centers, known as centers for care, support and prevention in addictology (CSAPA) In this way, hospital practitioners…
- Trial name
- DIADEME (NCT07085377)
- Testing
- DIADEME strategy, Controle strategy, Individual semi directive interview
- Where
- 8 sites in France
- Volunteers
- 182 people
- Sponsor
- Hospices Civils de Lyon
Childbirth-Related Posttraumatic Stress Disorder, Childbirth-related Trauma
Cognitive Processing Therapy for Childbirth-Related Post-Traumatic Stress Disorder
The goal of this clinical trial is to determine whether participation in an individual 8-session cognitive processing therapy (CPT) is feasible, acceptable, and leads to clinically meaningful trauma symptom reduction in…
- Trial name
- CB-PTSDCPT (NCT07495228)
- Testing
- Individual Cognitive Processing Therapy
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Vitamin D Deficiency, Pregnancy
Effects of Vitamin D on Health Promotion During Pregnancy and Its Impact on Prematurity-Related Outcome
The VitDTracking study focuses on the relevance of maternal vitamin D levels and their association with prematurity, aiming to improve maternal and child health outcomes, particularly by reducing avoidable preterm births.
- Trial name
- VitDTracking (NCT06292195)
- Testing
- Exposure
- Where
- 3 sites in Portugal
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Évora
Preterm Birth
Repercussions of Respiratory Physiotherapy in Preterm Infants Under Mechanical Ventilation
Respiratory diseases are a major morbidity and mortality causes of neonatal requiring mechanical ventilation, especially in newborn preterm infants (PN), thus respiratory therapy becomes increasingly necessary in order to…
- Trial name
- preterm (NCT03159039)
- Testing
- Conventional Physiotherapy, Prolonged slow exhalation technique
- Volunteers
- 43 people
- Sponsor
- Universidade Cidade de Sao Paulo
Cesarean Section Complications
Topical Tranexamic Acid Plus Bilateral Uterine Artery Ligation During Cesarean Delivery
Placenta previa (PP) is an obstetric condition that is closely linked with massive obstetric hemorrhage with a varied incidence about once in every 200 live births.
- Trial name
- NCT03741075
- Testing
- BUA, topical tranexamic acid
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aswan University Hospital