Clinical trials: Birth Disorder
Postpartum Hemorrhage \(PPH\)
Comparison of the Effect of Carbetocin Versus Oxytocin in the Prevention of Postpartum Hemorrhage After Emergency Caesarean Section in Antenatal Low-risk Patients
This study will be conducted to compare the effects of pabal and oxytocin administered to prevent postpartum hemorrhage in patients who were followed in the delivery room due to vaginal labor but underwent cesarean section due to…
- Trial name
- EMERGE-CS (NCT07380529)
- Testing
- Carbetocin, Oxytocin
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ankara Etlik City Hospital
HIV (Human Immunodeficiency Virus), Substance Abuse Disorder
TechMPower: Advancing HIV/SUD Care and Service Delivery for People in Re-entry
The goal of this clinical study in one NY county is to pilot and refine implementation strategies aimed at improving delivery and uptake of evidence-based practices (EBPs) for HIV prevention/treatment and substance use disorder…
- Trial name
- TMP Project (NCT07088770)
- Testing
- Community Coalition CLS Workgroup/Network of Providers, Tech-mediated Training and Service Delivery, Multidisciplinary Implementation Team with Champion
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Columbia University
Post Partum Hemorrhage
Evaluating Placental Thickness and Thickness of Uterine Muscle at Placenta Attachment in Prediction of Postpartum Blood Loss in Placenta Accreta
Aim of the Work is To determine the significance of the placental thickness and the thickness of the uterine muscle layer at placental attachment in the prediction of postpartum hemorrhage in cases of placenta previa accreta and…
- Trial name
- NCT06351969
- Where
- 2 sites in Egypt
- Volunteers
- 150 people
- Sponsor
- Benha University
Obesity, Lifestyle-related Condition
Lifestyle Intervention in Preparation for Pregnancy (LIPP)
Studies evaluating lifestyle intervention in obese women during pregnancy have reported limited success in decreasing excessive gestational weight gain, and have failed to achieve the key outcome of breaking the obesity cycle and…
- Conditions
- Obesity, Lifestyle-related Condition, Macrosomia, Fetal
- Trial name
- NCT03146156
- Testing
- Lifestyle Intervention
- Where
- 4 sites in United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
Preterm Birth
Direct Measurements of Cervical Remodeling for Predicting Preterm Birth
Racism and health care system distrust are potent stressors and may be associated with preterm birth (PTB). Additionally, cervical shortening is a common pathway leading to PTB.
- Trial name
- NCT01175551
- Where
- 2 sites in United States
- Volunteers
- 1,207 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Retinopathy of Prematurity, Retinal Detachment
Efficient Study of ACULAR in Inhibiting Proliferative Retinopathy in Prematurity
The purpose of this study is to test whether ACULAR, a nonsteroidal anti-inflammatory eye drop medication, can prevent the development of retinopathy of prematurity (ROP) and/ or decrease its severity.In this study ACULAR will be…
- Conditions
- Retinopathy of Prematurity, Retinal Detachment, Blindness
- Trial name
- ROP (NCT00634972)
- Testing
- ACULAR, REFRESH TEARS
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University of South Alabama
Glaucoma, Open-Angle Glaucoma Eye
MINIject (MINI SO627) in Patients With Open Angle Glaucoma Using Single Operator Delivery Tool
The study will assess safety and performance in patients with open-angle glaucoma uncontrolled by topical hypotensive medications who had previously been implanted with a MINIject glaucoma implant.
- Trial name
- NCT04517786
- Testing
- MINIject CS627 implant
- Where
- 2 sites in India, Panama
- Volunteers
- 21 people
- Sponsor
- iSTAR Medical
Pancreatic Adenocarcinoma Non-resectable
A First-in-Human Study to Evaluate Implantable Iontophoresis Chemotherapy Delivery Device With Gemcitabine Once Weekly or Twice Weekly in Participants With Pancreatic Cancer
This study is being done to find out if delivering gemcitabine using the ACT-IOP-003 device directly to the area where the tumor is in the pancreas is safe and tolerable.
- Trial name
- NCT07481383
- Testing
- ACT Implantable Iontophoresis Chemotherapy Delivery Device with Gemcitabine (ACT-IOP-003)
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Continuity Biosciences, LLC
Cervical Insufficiency, Preterm Birth
Investigation Into the Microorganisms in Pregnant Women
Pregnant women with short cervical length (<25 mm) in second-trimester ultrasonographic assessment are at high risk for preterm birth, a major cause of perinatal mortality and morbidity worldwide.
- Trial name
- NCT04688866
- Testing
- Sequencing
- Where
- Hong Kong
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Opioid Use Disorder, Injection Related Infections
Continuum of Care in Hospitalized Patients With Opioid/Stimulant Use Disorder and Infectious Complications From Drug Use
This is a two-group randomized controlled trial conducted at five hospitals across the U.S. designed to test the effectiveness of an Integrated infectious diseases/Substance Use Disorder outpatient clinic (IC) compared to…
- Conditions
- Opioid Use Disorder, Injection Related Infections, Stimulant Use Disorder
- Trial name
- CHOICE-STAR (NCT06513156)
- Testing
- Integrated Infectious Diseases and Substance Use Disorder Clinic (IC)
- Where
- 4 sites in United States
- Volunteers
- 304 people
- Sponsor
- Elana Rosenthal
Asthma in Children, Transplantation
Digital Delivery of Person-centered Transitional Care
Advances in medical care have extended the life expectancy of individuals with congenital and pediatric-onset diseases, leading to an increased need for effective transition programs as these individuals move from pediatric to…
- Trial name
- DigiStep (NCT06823622)
- Testing
- Stepstones transition program
- Where
- 2 sites in Sweden
- Volunteers
- 100 people
- Sponsor
- Göteborg University
Undernutrition
Nutritional Supplement Compliance Study
Disease-related malnutrition is common across healthcare settings in the UK and if left untreated, may have severe consequences.
- Trial name
- NSCS (NCT00688649)
- Testing
- Standard Oral Nutritional Supplement (ONS), High energy Oral Nutritional Supplement (ONS)
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- Nutricia UK Ltd
Delivery Problem, Delivery Fear
The Effect of Feng Shui Delivery Room Design on Maternal and Infant Health
The aim of the study is to compare the births that took place in the Feng Shui Birth unit and those that took place in the standard delivery unit in terms of mother-infant health outcomes.
- Conditions
- Delivery Problem, Delivery Fear, Delivery; Injury, Birth; Prolonged
- Trial name
- NCT05468658
- Testing
- Designing the birthing unit according to the philosophy of Feng Shui
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Stroke Sequelae
Telerehabilitation for Post-stroke Patients
In the last few years, there has been an increasing shift towards outpatients setting in the care of patients with stroke. Unfortunately, this led to a high percentage of discharged patients who did not receive an adequate amount…
- Trial name
- NCT04413240
- Testing
- Telerehabilitation, Conventional rehabilitation
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Universita di Verona
Infant, Premature, Hypoperfusion in Newborn
Monitoring of Systemic or Organ Perfusion for Preterm Infants
To investigate biomarker reflects systemic or specific organ perfusion well, we are going to the observational comparison study using several hemodynamic monitoring methods in the premature infants.
- Conditions
- Infant, Premature, Hypoperfusion in Newborn, Necrotizing Enterocolitis of Newborn, Sepsis Newborn
- Trial name
- NCT03136172
- Testing
- NIRS (near Infra-red spectroscopy)
- Where
- South Korea
- Volunteers
- 85 people
- Sponsor
- Inha University Hospital
Preterm Birth, Respiratory Distress Syndrome
Surfactant Nebulization for the Early Aeration of the Preterm Lung
Respiratory distress syndrome is the most common cause of respiratory failure in preterm infants. Treatment consists of respiratory support and exogenous surfactant administration.
- Conditions
- Preterm Birth, Respiratory Distress Syndrome, Surfactant Deficiency Syndrome Neonatal
- Trial name
- SUNSET (NCT04315636)
- Testing
- Surfactant nebulisation
- Where
- Switzerland
- Volunteers
- 32 people
- Sponsor
- University of Zurich
Prematurity, Respiratory Distress Syndrome
CPAP vs.Unsynchronized NIPPV at Equal Mean Airway Pressure
This study seeks to determine if standard continuous positive airway pressure, known as CPAP is as effective as a more complicated approach that generates intermittent increases in airway pressure applied to the nostrils via a…
- Conditions
- Prematurity, Respiratory Distress Syndrome, Apnea of Prematurity
- Trial name
- NICA (NCT03670732)
- Testing
- continuous positive airway pressure, nasal intermittent positive pressure ventilation
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Premature Birth
ADMA and Mechanical Ventilation in Preterm Infants
The purpose of this study is to study the relation between mechanical ventilation and ADMA concentrations at birth.
- Trial name
- NCT00460044
- Volunteers
- 35 people
- Sponsor
- Amsterdam UMC, location VUmc
Dental Caries
Delivery of Polyphenols in Gum as an Anti-Caries Agent
The short-term effects of chewing gum containing xylitol and/or blackberry extract on oral microbiota was studied. Fifty healthy adults participated in a randomized, placebo-controlled, cross-over design study.
- Trial name
- BBE (NCT05133557)
- Testing
- Chewing gum containing xylitol and blackberry extract (BBE)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Craig Miller
Premature Birth of Newborn
Body Composition at Discharge and Neurological Development at 2 Years in Very Preterm Infants (OPTIPREMA)
This study evaluates the perinatal factors influencing body composition at discharge in very preterm infants and the relationship between fat free mass and further neurocognitive development.
- Trial name
- OPTIPREMA (NCT02686801)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Hôpital de la Croix-Rousse