Clinical trials: Biting
Tick Bites, Tick Resistance
Acquired Tick Resistance in Naturally Exposed Participants
Tick-borne diseases are increasing worldwide, and there are currently few effective ways to prevent them. One promising new strategy is to develop a vaccine that targets the tick itself ("anti-tick vaccine") to block the…
- Trial name
- TICK REACT (NCT07479537)
- Testing
- Tick challenge
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Snake Bite
Predictive Accuracy of the Snakebite Severity Score (SSS) in Identifying Syndrome-Specific Core Outcome Parameters Among Envenomated Patients Presenting to the Emergency Department
India reports ~58,000 snakebite deaths/year, over 50% of global mortality. Clinical outcomes of antivenom may vary due to regional venom differences, delayed access to care, ineffective use of existing polyvalent antivenom.
- Trial name
- SCOPE-Snake (NCT07079137)
- Testing
- History, examination, bite documentation, SSS scoring,Baseline labs as per institutional protocol
- Where
- India
- Volunteers
- 220 people
- Sponsor
- Jubilee Mission Medical College and Research Institute
Acute Lymphoblastic Leukemia
Efficacy and Safety of the BiTE Antibody Blinatumomab in Chinese Adult Subjects With Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia (ALL)
This study is being done to evaluate the rate of hematological response (complete remission/complete remission with partial hematological recovery [CR/CRh*]) induced by blinatumomab in Chinese adults with relapsed/refractory…
- Trial name
- NCT03476239
- Testing
- Blinatumomab, Dexamthasone
- Where
- 23 sites in China
- Volunteers
- 121 people
- Sponsor
- Amgen
Alzheimer Disease, Periodontal Diseases
Investigation of Alzheimer's Disease and Periodontal Status
The aim of this study is to investigate the effect of the current periodontal status on the progression rate of AD.
- Trial name
- NCT05807100
- Testing
- Baseline Standardized Mini Mental Test, 6th month Standardized Mini Mental Test
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Bezmialem Vakif University
Dental Occlusion, Occlusal Analysis
Trueness of Digital Occlusal Analysis
The aims of this observational study are to evaluate the trueness of two different digital occlusal analyzers; handheld occlusal analyzer versus intraoral scanner in comparison to conventional methods in identifying true occlusal…
- Trial name
- NCT06672627
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Snakebite, Epidemiology
Mapping Snakebite Risk in Kenya and Eswatini
The goal of this observational study is to learn about how snakebite risk varies in different environments in Kenya and understand how this information can be used to support decision makers.
- Trial name
- NCT06124872
- Testing
- Survey questionnaire, Key informant interview
- Where
- Kenya
- Volunteers
- 70,000 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
Endodontically Treated Teeth
Bite Force and Occlusal Force Distribution Following Root Canal Treatment.
Understanding the changes in bite force and occlusal force distribution in ETT is clinically important, as it can directly influence tooth prognosis, guide restorative treatment planning, and impact the long-term survival of the…
- Trial name
- B-FORCE RCT (NCT07626372)
- Where
- Thailand
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
QLB vs TAPB, Quadratus Lumborum Block
Comparison of the Effects of Bilateral Transversus Abdominis Plane Block and Bilateral Quadratus Lumborum Block on Postoperative Analgesia in Patients Undergoing Midline Laparotomy
Midline incisions provide easy, rapid and excellent exposure of the abdominal cavity and are particularly used for complex, diagnostic or emergency procedures.
- Conditions
- QLB vs TAPB, Quadratus Lumborum Block, Transversus Abdominis Plane (TAP) Block
- Trial name
- NCT06950502
- Testing
- transversus abdominis plane block, Quadratus Lumborum Block (QLB), quadratus lumborum block using bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Ankara University
Cancer, Bladder, Surgery
3 Ultrasound Guided Plane Blocks for Perioperative Analgesia in Patients Undergoing Radical Cystectomy
Radical cystectomy is the gold standard treatment for muscle invasive bladder cancer as well as some T1 and non-invasive disease. It is a major operation with significant perioperative morbidity and complications.
- Conditions
- Cancer, Bladder, Surgery, Anesthesia, Analgesia
- Trial name
- NCT05278598
- Testing
- Erector Spinae Plane Block, Thoracic Paravertebral Plane Block, Quadratus Lumborum Plane Block
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Nazmy Edward Seif
Anterior Openbite
Single Palatal Temporary Anchorage Device for Anterior Open Bite
Participants are orthodontic patients with anterior open bite (AOB) malocclusion. These patients will be treated by molar intrusion achieved using one of two interventions, either orthodontic fixed appliances incorporating a…
- Trial name
- SPaTAR (NCT04419805)
- Testing
- Single Palatal TAD, Two buccal TADs
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- University of Dundee
Abdominal Surgery Patients, Transversus Abdominis Plane (TAP) Block
Plasma Kinetics of Levobupivacaine After Transversus Abdominis Plane (TAP) Block in Abdominal Surgery
This prospective single-center observational pharmacokinetic study will evaluate plasma levobupivacaine concentrations after ultrasound-guided transversus abdominis plane (TAP) block in adult patients undergoing elective…
- Conditions
- Abdominal Surgery Patients, Transversus Abdominis Plane (TAP) Block, Pharmacokinetic Analysis, Levobupivacaine
- Trial name
- LEVO-TAP-PK (NCT07581275)
- Testing
- Ultrasound-Guided Transversus Abdominis Plane Block with Levobupivacaine
- Volunteers
- 26 people
- Sponsor
- University of Liege
Posterior Cross Bite
Evaluation of Modified Hyrax Versus Quad Helix in Treatment of Posterior Cross Bite
This study will be performed to evaluate the treatment of posterior cross-bite with modified hyrax \& Quad helix appliances and to compare which one will provide better results in relation to chewing difficulty in children with…
- Trial name
- NCT06300775
- Testing
- modified hyrax, quad helix
- Where
- Egypt
- Volunteers
- 10 people
- Sponsor
- Cairo University
Nutrition Disorders in Old Age
Adaptation of a Health Promotion Nutrition Program for Older Adults
Our overarching goal is to prove the benefit of a behavior change intervention designed to help older people overcome barriers associated with risk for inadequate nutrition, so that they can improve their nutritional intake of…
- Trial name
- BBHL (NCT03205007)
- Testing
- Health promotion nutrition program
- Where
- 2 sites in United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Alpha-Gal Syndrome
The α-gal Syndrome - Investigating Immune Reactions to Tick Bites
Tick bites can transmit pathogens, but they can also induce a food allergy to mammalian meat. The goal of this clinical trial is to follow immune response and antibody build-up in individuals bitten by a tick.
- Trial name
- ImmunoGal (NCT07177729)
- Where
- 2 sites in Luxembourg
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Luxembourg Institute of Health
Dementia, Oral Hygiene
Oral Health, Bite Force and Dementia
Study aims: The primary aim is to identify influencing variables on oral hygiene / oral health and bite force in patients with dementia.
- Conditions
- Dementia, Oral Hygiene, Chewing Problem
- Trial name
- OrBiD (NCT03775772)
- Testing
- Oral Health, Bite Force
- Where
- Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Orofacial Myofunctional Disorders, Anterior Open Bite Malocclusion
Oral Myofunctional Pattern in Children With Anterior Open Bite
Oral myofunctional disorders (OMD) are a key, internationally acknowledged environmental factor causing dental and skeletal malocclusion.
- Trial name
- OMBIT (NCT07045779)
- Testing
- Orofacial myofunctional therapy - traditional, Orofacial myofunctional therapy - reduced, Vocal warm up
- Where
- Belgium
- Volunteers
- 33 people
- Sponsor
- University Ghent
Gastric Disease
Novel Endoscopic Bite Block
This feasibility study aims to assess the safety and effectiveness of the Novel Endoscopic Bite Block. The device will be utilized in subjects undergoing routine outpatient upper endoscopy.
- Trial name
- NCT06958250
- Testing
- Novel Bite Block
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Pennsylvania
Root Canal Treatment, Obturation Quality
Diagnostic Accuracy of a Deep Learning Framework for Automated Evaluation of Root Canal Obturation Quality From Periapical Radiographs
This study aims to develop and evaluate an artificial intelligence (AI)-based system that can automatically assess the quality of root canal fillings using dental X-ray images.
- Trial name
- NCT07684482
- Testing
- Deep learning model
- Volunteers
- 490 people
- Sponsor
- Cairo University
Rheumatoid Arthritis, Osteoarthritis
Low Dose Dexamethasone in Supraclavicular Blocks
Brachial plexus nerve blocks provide superior analgesia over opioids while avoiding unwanted side effects. Single shot blocks with local anesthetic alone usually do not last the duration of the acute post-surgical pain period.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Nerve Entrapment, Ligament Injury
- Trial name
- NCT02666443
- Testing
- Control intervention (no dexamethasone), Peri-neural Dexamethasone 1 mg, Intravenous Dexamethasone 1 mg
- Where
- Canada
- Volunteers
- 306 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Bone Loss, Occlusion
Comparative Clinical and Radiographical Evaluation of Treatment of Angular Bone Defect Related to Over Erupted Tooth Using GTR Followed by Orthodontic Intrusion Versus Orthodontic Intrusion Followed by GTR
Occlusal prematurity leading to loss of vertical stopping points between teeth can lead to teeth over eruption creating abnormal contact area which favors food accumulation and plaque retention.
- Trial name
- NCT05371418
- Testing
- surgical (guided tissue regeneration), orthodontic intrusion followed by guided tissue regeneration GTR
- Where
- Egypt
- Volunteers
- 10 people
- Sponsor
- Tanta University